Patents Represented by Attorney James L. Rowe

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  • Substituted pyrroloquinoxalinones and diones
    Patent number: 4087527
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: September 26, 1977
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma
    Patent number: 4087547
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones in treatment of glaucoma.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger
  • Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs
    Patent number: 4087546
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger
  • Des-N-methylvindoline
    Patent number: 4082754
    Abstract: Vindoline and vinblastine demethylated by submerged culture fermentation with S. albogriseolus.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: April 4, 1978
    Assignee: Eli Lilly and Company
    Inventors: Donald R. Brannon, Norbert Neuss
  • Penniclavine acetonide
    Patent number: 4082753
    Abstract: Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.
    Type: Grant
    Filed: June 17, 1977
    Date of Patent: April 4, 1978
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach
  • 8-Aryl-9-ergolenes
    Patent number: 4075213
    Abstract: 8-Aryl-9-ergolenes, .alpha.-blockers, serotonin inhibitors, prolactin inhibitors.
    Type: Grant
    Filed: March 2, 1977
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach
  • Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
    Patent number: 4075212
    Abstract: 8,8-Disubstituted-6-methylergolines and 9-ergolenes, are prepared by alkylation of lysergic, or isolysergic acid or their 9,10-dihydro analogues.
    Type: Grant
    Filed: January 19, 1976
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmund C. Kornfeld
  • Substituted pyrroloquinoxalinones and diones
    Patent number: 4075206
    Abstract: Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: February 25, 1977
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • Preparation of leurosidine and novel leurosidine 4'-ethers and esters
    Patent number: 4075214
    Abstract: Vincaleukoblastine (VLB, vinblastine) is converted to leurosidine, its 4' epimer, by reaction with thionyl chloride to form a bis-sulfite ester followed by treatment of the bis-sulfite ester with silver perchlorate. The bis-sulfite ester is covertible to novel 4' ethers by treatment with a lower alkanol or 4' esters of leurosidine perchlorate with acetic anhydride.
    Type: Grant
    Filed: May 17, 1976
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventors: Allen S. Katner, Gerald E. Gutowski, Jean C. Miller
  • Novel 3-(oxygenated alkyl)-1,9-dihydroxy and 1-hydroxy-9-keto dibenzo[b,d]p y
    Patent number: 4064009
    Abstract: 1-Hydroxy-9-keto-3-alkyl-dibenzo[b,d]pyrans or 1,9-dihydroxy-3-alkyl-dibenzo[b,d]pyrans are oxygenated on the penultimate carbon of the alkyl side chain by fermentation with a strain of the micro-organism Bacillus cereus.
    Type: Grant
    Filed: June 9, 1976
    Date of Patent: December 20, 1977
    Assignee: Eli Lilly and Company
    Inventors: David S. Fukuda, Bernard J. Abbott, Robert A. Archer
  • Method of inhibiting prolactin
    Patent number: 4054660
    Abstract: D-2-halo-6-alkyl-8-substituted ergolines and related compounds are inhibitors of prolactin in mammals.
    Type: Grant
    Filed: August 19, 1976
    Date of Patent: October 18, 1977
    Assignee: Eli Lilly and Company
    Inventors: James A. Clemens, Edmund C. Kornfeld, Nicholas J. Bach
  • 6-Methyl-8.beta.-hydroxymethyl-8-.gamma.-substituted-9-ergolene compounds
    Patent number: 4054567
    Abstract: Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: October 18, 1977
    Assignee: Eli Lilly and Company
    Inventors: Edmund C. Kornfeld, Nicholas J. Bach
  • Modification of methadone synthesis process step
    Patent number: 4048211
    Abstract: Alkylation of diphenylacetonitrile in methadone synthesis is carried out in presence of sodium hydroxide and DMF.
    Type: Grant
    Filed: May 10, 1976
    Date of Patent: September 13, 1977
    Assignee: Eli Lilly and Company
    Inventor: Charles J. Barnett
  • N-(6-acyloxybenzothiazol-2-yl)-N'-phenyl (or substituted phenyl)ureas
    Patent number: 4046770
    Abstract: N-(6-Acyloxybenzimidazol-2-yl)-N'-phenyl (or substituted pehnyl)ureas are useful as immune regulants.
    Type: Grant
    Filed: November 28, 1975
    Date of Patent: September 6, 1977
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Paget, James H. Wikel
  • Descarboxylysergic acid
    Patent number: 4031097
    Abstract: Descarboxylysergic acid prepared from 2,3-dihydro-8.beta.-hydroxy-6-methyl-9-ergolene or from penniclavine has oxytocic, serotonin antagonist, prolactin inhibition and muscle contracting activities.
    Type: Grant
    Filed: November 3, 1975
    Date of Patent: June 21, 1977
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, David A. Hall, Edmund C. Kornfeld
  • Novel N-cycloalkylmethyl decahydroisoquinolines for producing opiate-like analgesia
    Patent number: 4029796
    Abstract: 1-Cycloalkylmethyl-3a-(substituted-phenyl) decahydroisoquinolines, useful as analgetic agonists or analgetic antagonists.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: June 14, 1977
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • Dimeric anhydro-vinca derivatives
    Patent number: 4029663
    Abstract: Dimeric Vinca alkaloids are converted to three separable anhydro derivatives, useful as mitotic inhibitors or as intermediates for the preparation of other oncogenetically active alkaloids.
    Type: Grant
    Filed: July 10, 1975
    Date of Patent: June 14, 1977
    Assignee: Eli Lilly and Company
    Inventors: Gerald E. Gutowski, Jean C. Miller
  • 3-Substituted propanoic acid derivatives and pharmaceutical composition
    Patent number: 4027036
    Abstract: The invention provides 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)-propanoic acid and derivatives thereof having anti-thrombotic activity coupled with low toxicity. Also provided is a method for preparing such compounds by subjecting a 3-[3-hydroxy-5-oxo-2-(.beta.-styryl)cyclopent-1-enyl]-propanoic acid or derivative thereof to oxidative cleavage.
    Type: Grant
    Filed: April 10, 1974
    Date of Patent: May 31, 1977
    Assignee: Lilly Industries, Ltd.
    Inventors: William Dawson, Michael John Foulis, Norman James Albert Gutteridge, Colin William Smith
  • Psoriasis treatment with mycophenolic acid
    Patent number: RE29465
    Abstract: Psoriasis is treated orally .[.and topically.]. with mycophenolic acid or its .beta.-D-glucuronide.
    Type: Grant
    Filed: November 24, 1976
    Date of Patent: November 1, 1977
    Assignee: Eli Lilly and Company
    Inventor: Irving S. Johnson
  • Benzoxazole derivatives
    Patent number: RE29608
    Abstract: The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclizing an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.
    Type: Grant
    Filed: February 1, 1977
    Date of Patent: April 11, 1978
    Assignee: Lilly Industries Limited
    Inventors: Delme Evans, David William Dunwell, Terence Alan Hicks