Patents Represented by Attorney James L. Rowe

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  • Trifluoromethyl substituted 1-aminoindanes
    Patent number: 4132737
    Abstract: 4(5 or 6 or 7)-Trifluoromethyl-1-aminoindanes, useful as inhibitors of N-methyl transferase.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: January 2, 1979
    Assignee: Eli Lilly and Company
    Inventor: Bryan B. Molloy
  • Phenylpiperazine derivatives
    Patent number: 4123529
    Abstract: Phenylpiperazine derivatives of formula (I): ##STR1## where R.sup.1 is benzyl, C.sub.1-6 alkyl or optionally substituted phenyl; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; Q is furan, thiophene, oxazole or thiazole; m is 1 to 3 and n is 0 or 1; and pharmaceutically-acceptable salts thereof are active in the chemotherapy of immediate hypersensitivity conditions such as asthma.
    Type: Grant
    Filed: July 8, 1977
    Date of Patent: October 31, 1978
    Assignee: Lilly Industries Limited
    Inventors: John P. Verge, William B. Jamieson
  • Benzimidazole insecticides
    Patent number: 4122184
    Abstract: 2,6-Di(fluoroalkyl)-4-nitrobenzimidazoles and certain N-acyl derivatives thereof, including sulfonates, thiocarboxamides, and carboxylates, are used to control a broad spectrum of mites and insects with particularly good effect against members of the orders Hemiptera, Coleoptera, Orthoptera, and Lepidoptera.
    Type: Grant
    Filed: December 21, 1977
    Date of Patent: October 24, 1978
    Assignee: Eli Lilly and Company
    Inventor: Quentin F. Soper
  • 5'-Hydroxyleurosine and related compounds
    Patent number: 4122081
    Abstract: 5'-Hydroxyleurosine, 5'-hydroxyleuoformine and related compounds, useful in inhibiting the growth of experimental tumors.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: October 24, 1978
    Assignee: Eli Lilly and Company
    Inventors: Gerald L. Thompson, Gloria C. Paschal, Robert A. Conrad
  • 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds
    Patent number: 4115388
    Abstract: 3'-hydroxy and 3'-keto derivatives of 4'-deoxy VLB (deoxy VLB "A"), 4'-deoxyleurosidine (deoxy VLB "B"), 4'-deoxyvincristine and 4'-deoxy-1-desmethyl-1-formylleurosidine and related 4-desacetyl and C-3 carboxamide derivatives, useful as anti-tumor agents in mammals.
    Type: Grant
    Filed: March 30, 1977
    Date of Patent: September 19, 1978
    Assignee: Eli Lilly and Company
    Inventors: Gerald L. Thompson, Gloria C. Paschal
  • 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
    Patent number: 4110339
    Abstract: 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]-indole, useful as prolactin inhibitor and in treatment of Parkinsonisn.
    Type: Grant
    Filed: November 25, 1977
    Date of Patent: August 29, 1978
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmund C. Kornfeld
  • 7-Amino and 7-alkanoylamino 2-oxo-3-phenylindolines
    Patent number: 4110465
    Abstract: 7-Amino and 7-alkanoylamino-2-oxo-3-phenylindolines, useful as anti-inflammatory and anti-thrombotic agents.
    Type: Grant
    Filed: November 25, 1977
    Date of Patent: August 29, 1978
    Assignee: Eli Lilly and Company
    Inventor: Richard E. Holmes
  • 5'-Acetonylvincristine and related compounds
    Patent number: 4110330
    Abstract: 5'-Acetonylvincristine and related compounds including the corresponding 1-desmethyl derivative, useful in inhibiting the growth of experimental tumors.
    Type: Grant
    Filed: May 27, 1977
    Date of Patent: August 29, 1978
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Barnett, Richard A. Bimm, George C. Cullinan
  • Novel 3-(oxygenated alkyl)-1,9-dihydroxy and 1-hydroxy-9-keto dibenzo[b,d]p y
    Patent number: 4104282
    Abstract: 1-Hydroxy-9-keto-3-alkyl-dibenzo[b,d]pyrans or 1,9-dihydroxy-3-alkyl-dibenzo[b,d]pyrans are oxygenated on the penultimate carbon of the alkyl side chain by fermentation with a strain of the micro-organism Bacillus cereus.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: August 1, 1978
    Assignee: Eli Lilly and Company
    Inventors: David S. Fukuda, Bernard J. Abbott, Robert A. Archer
  • 2,5 OR 2,6-Disubstituted benzoxazoles
    Patent number: 4100168
    Abstract: Benzoxazoles substituted in the 2-position with sulfhydryl or halogen and substituted in the 5- or 6-position with an acetic or propionic acid group or a salt or ester thereof or a nitrile convertible thereto useful as intermediates in the preparation of 5- or 6-Substituted benzoxazole propionic or acetic acid derivatives, substituted in the 2-position of the oxazole nucleus by a group of the formula AR.sup.4 wherein A is --CH.sub.2 --, --CO--, --CHOR--, or --NR--, wherein R is hydrogen, C.sub.1-6 alkyl or C.sub.2-7 acyl, and R.sup.4 is optionally substituted phenyl, useful as non-steroidal, non-narcotic, analgesic, antipyretic and anti-inflammatory agents.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: July 11, 1978
    Assignee: Lilly Industries Ltd.
    Inventors: David William Dunwell, Delme Evans, Terence Alan Hicks
  • 1,3-Dialkyl-6,7-methoxy-1H-1,2,4-benzothiadiazine-1-oxides
    Patent number: 4100280
    Abstract: 1,3-Dialkyl-6,7-methoxy-1H-1,2,4-benzothiadiazine-1-oxides, useful as hypotensive agents.
    Type: Grant
    Filed: August 8, 1977
    Date of Patent: July 11, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert D. Dillard, Donald E. Pavey
  • Novel cis N-cyclopropylmethyl decahydroisoquinoline
    Patent number: 4100166
    Abstract: Cis-1-cyclopropylmethyl-3a-(substituted-phenyl) decahydroisoquinoline, useful as analgetic agonist and analgetic antagonist.
    Type: Grant
    Filed: October 22, 1976
    Date of Patent: July 11, 1978
    Assignee: Eli Lilly and Company
    Inventors: Dennis M. Zimmerman, Winston S. Marshall
  • Ergoline chlorination process
    Patent number: 4098790
    Abstract: Ergolines are chlorinated with SO.sub.2 Cl.sub.2 /BF.sub.3 .multidot.etherate, preferentially in the 2 position.
    Type: Grant
    Filed: September 15, 1976
    Date of Patent: July 4, 1978
    Assignee: Eli Lilly and Company
    Inventor: Nicholas J. Bach
  • Oxazolidinedione derivatives of Vinca alkaloids
    Patent number: 4096148
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: June 20, 1978
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • Chlorinated 1-aminoindane N-methyl transferase inhibitors
    Patent number: 4096173
    Abstract: 4-Chloro and 4,5-, 5,6- and 6,7-dichloro-1-aminoindanes, useful as inhibitors of norephineprine N-methyl transferase.
    Type: Grant
    Filed: March 28, 1977
    Date of Patent: June 20, 1978
    Assignee: Eli Lilly and Company
    Inventor: Bryan B. Molloy
  • Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs
    Patent number: 4088777
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 9, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger
  • N-heterocyclic ureas as immune regulants
    Patent number: 4088768
    Abstract: Benzimidazolyl, benzothiazolyl and benzoxazolyl ureas and thioureas are employed as immune regulatory agents, as agents capable of altering the immune response in mammals.
    Type: Grant
    Filed: January 21, 1976
    Date of Patent: May 9, 1978
    Assignee: Eli Lilly and Company
    Inventors: Charles J. Paget, John L. Sands
  • 5' Acetoxy vinblastine 4' bis-sulfite
    Patent number: 4087429
    Abstract: Vincaleukoblastine (VLB, vinblastine) is reacted with thionyl chloride to form a bis-sulfite ester which is converted to various 5'-oxygenated derivatives.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Allen S. Katner, Gerald E. Gutowski, Jean C. Miller
  • 2-Phenyl-5-benzoxazolylalkanoic acid purification process
    Patent number: 4087437
    Abstract: Crude preparations of 2-phenyl-5-benzoxazolylalkanoic acids are purified by forming the ammonium salt thereof in an organic solvent and thermally reconverting the separated ammonium salt to the acid. Gaseous ammonia is a by-product.
    Type: Grant
    Filed: September 7, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventor: Erwin A. Stephan
  • Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
    Patent number: 4087545
    Abstract: Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as antiemetic drugs.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, Louis Lemberger