Patents Represented by Attorney JoAnn Villamizar
  • Patent number: 4992493
    Abstract: The compounds of the formula (I) ##STR1## in which R.sub.1 is C.sub.1 -C.sub.8 -alkyloxy, allyloxy, allylamino, di(C.sub.1 -C.sub.4 -alkyl)-amino, diallylamino, a 5-membered to 7-membered nitrogen containing heterocyclic group with the nitrogen atom linked to the triazine ring, or a group of the formula (II), ##STR2## R.sub.2 is hydrogen, O, OH, NO, CH.sub.2 CN, C.sub.1 -C.sub.8 -alkyl, allyl, benzyl, C.sub.1 -C.sub.8 -acyl, C.sub.1 -C.sub.18 -alkyloxy, C.sub.5 -C.sub.12 -cycloalkyloxy or OH-monosubstituted C.sub.2 -C.sub.4 -alkyl, R.sub.3 and R.sub.5 independently are hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.12 -cycloalkyl, C.sub.7 -C.sub.9 -phenylalkyl, tetrahydrofurfuryl, C.sub.2 -C.sub.4 -alkyl monosubstituted by OH, by C.sub.1 -C.sub.4 -alkyloxy or by di(C.sub.1 -C.sub.4 -alkyl)amino, or a group of the formula (III) ##STR3## with R.sub.2 as defined above, R.sub.4 is hydrogen, C.sub.1 -C.sub.
    Type: Grant
    Filed: September 6, 1989
    Date of Patent: February 12, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Giuseppe Cantatore, Valerio Borzatta, Franca Masina
  • Patent number: 4988675
    Abstract: The invention concerns a method for treating and preventing secondary effects of hyperinsulinemia by application of insulin-like growth factor I (IGF I), and pharmaceutical compositions comprising IGF I which are useful for this purpose.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: January 29, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Ernst R. Froesch, Hans-Peter Guler, Christoph Schmid, Jurgen Zapf
  • Patent number: 4978768
    Abstract: Tetrachloro-2-cyanobenzoic acid alkyl esters of formula ##STR1## wherein R is C.sub.1 -C.sub.5 alkyl, can be very conveniently prepared by (a) reacting the ammonium salt of tetrachloro-2-cyanobenzoic acid, in the presence of water and an inert organic solvent, with a hydroxide of formula MOH, wherein M is Na or K, and removing the ammonia evolved, and(b) reacting the resultant salt of the formula ##STR2## wherein M is as defined above, with at least 1 mole of a dialkyl sulfate of formula SO.sub.2 (OR).sub.2 or an alkyl halide of formula RHal, wherein R is as defined above and Hal is Cl, Br, I or F, also in the presence of water and an inert organic solvent.
    Type: Grant
    Filed: January 8, 1987
    Date of Patent: December 18, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Jost von der Crone, Gonzague Overney, Peter Dario
  • Patent number: 4977214
    Abstract: Curable compositions comprise(A) a polyglycidyl ether of a polyhydric phenol,(B) a polyglycidyl ether of a polyhydric alcohol,(C) a nitrogen-containing latent hardener for epoxide resins and(D) as cure accelerator dispersed as a powder in the composition, a solid solution of a polymeric phenol with an aliphatic polyamine having two or more amine groups, each of the amine groups being tertiary and at least two of the amine groups being dimethylamino groups.The compositions are useful as adhesives, sealants, laminating resins and coatings.
    Type: Grant
    Filed: October 12, 1989
    Date of Patent: December 11, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Madan M. Bagga
  • Patent number: 4975466
    Abstract: Pharmaceutical preparations for topical, i.e. dermal, application that contain as active ingredient a compound of the formula I ##STR1## especially 2-hydroxy-5-[(RS)-1-hydroxy-2-[[(RS)-1-(p-methoxyphenyl)-prop-2-yl]-amino] -ethyl]-formanilide (formoterol), or one of its pharmaceutically acceptable salts, especially its semifumarate, are proposed for the treatment of inflammatory skin diseases.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: December 4, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Irmgard Bottcher, Werner Pignat
  • Patent number: 4973653
    Abstract: Linear polyether resins containing 100 to 1 mol % of the repeating structural unit of formula I ##STR1## and 99 to 0 mol % of the repeating structural unit of formula II ##STR2## wherin A is a linear unsubstituted or methyl-substituted alkylene group containing 1 to 100 carbon atoms in the linear alkylene chain, X denotes bridging groups as defined in claim 1, and Y is an aromatic radical of a divalent phenol as defined in claim 1, are thermoplastics with high glass transition temperatures and excellent mechanical strength properties.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: November 27, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Sameer H. Eldin
  • Patent number: 4973648
    Abstract: An epoxy resin composition comprising an epoxy resin which is solid at room temperature and contains on average more than epoxy group per molecule, and a quaternary morpholinium salt as advancement catalyst.When advanced with compounds containing two phenolic hydroxyl groups, these compositions give excellent products of low viscosity which are suitable, for example, for use in powder resin coating.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: November 27, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Arnold Hofer, Hans Gempeler
  • Patent number: 4971802
    Abstract: The invention relates to pharmaceutical compositions containing synthetic, substantially pure phosphatidyl serine and phosphatidyl choline and a substance or a mixture of substances having biological activity. The invention also relates to mixtures comprising synthetic, substantially pure phosphatidyl serine and phosphatidyl choline, and also to processes for the manufacture of the pharmaecutical compositions, and the use thereof.
    Type: Grant
    Filed: August 16, 1989
    Date of Patent: November 20, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Lajos Tarcsay, Hansjorg Eibl, Peter Fankhauser, Anita Peil
  • Patent number: 4971986
    Abstract: Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: November 20, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Jaroslav Stanek, Giorgio Caravatti, Jorg Frei, Hans-Georg Capraro
  • Patent number: 4971670
    Abstract: Described is an isoelectric focusing electrophoretic process for the separation and purification of an amphoteric or neutral chemical compound from one or more electrically charged chemical compound(s). Said process is illustrated below at the example of the purification of a protein from contaminating proteins and salts. It may be carried out in an apparatus especially designed therefor, e.g. an apparatus as depicted in FIG. 1. Said apparatus and various modifications thereof are also claimed. The mixture to be separated is present within a hydraulic flow in chamber 8. Cylinders 5 and 12 contain immobilized pH-gradients or are replaced by amphoteric isoelectric pH-membranes. Each of said pH-gradients and pH-membranes has conductivity and both buffering and titrant capacity in its pH-interval.
    Type: Grant
    Filed: April 8, 1988
    Date of Patent: November 20, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Daniel M. Faupel, Pier G. Righetti
  • Patent number: 4968615
    Abstract: Deoxyribonucleic acid (DNA) molecules consisting of or recombinant DNA molecules containing transcription enhancers from murine cytomegalovirus (MCMV) which can be used to enhance the transcription of structural genes in eukaryotic cells.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: November 6, 1990
    Assignee: CIBA-GEIGY Corporation
    Inventors: Ulrich H. Koszinowski, Gunther M. Keil, Karoline Dorsch-Hasler, Walter Schaffner
  • Patent number: 4965260
    Abstract: Compounds of the formula ##STR1## in which R.sub.1 is lower alkyl substituted by hydroxy or by protected hydroxy, R.sub.2 represents carboxy or functionally modified carboxy, R.sub.3 is hydrogen, amino, mono- or di-substituted amino, carbamoyl, hydroxy, protected hydroxy, carbamoyloxy, lower alkoxy, halogen, lower alkanoyl, sulphamoyl or heteroarylthio, each of R.sub.4 and R.sub.5, independently of the other, represents hydrogen, lower alkyl, hydroxy, protected hydroxy, lower alkoxy, halogen, amino, protected amino, lower alkanoylamino or carbamoyl, or R.sub.4 and R.sub.5 together represent methylenedioxy, Y represents a group of the formula --O--, --S-- or --NR.sub.6 --, R.sub.6 is hydrogen or lower alkyl, A.sub.1 represents lower alkylene or unsubstituted or substituted phenylene and A.sub.2 represents a direct bond or lower alkylene, and salts of such compounds, have antibacterial activity. The compounds of the formula I are manufactured by processes that are known per se.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: October 23, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Marc Lang
  • Patent number: 4960840
    Abstract: Polyglycidyl ethers which are obtainable by reacting acetophenone with 0.7 to 1.4 mol of formaldehyde per mol of acetophenone, in the presence of an alkaline catalyst and in the temperature range from 50.degree. to 100.degree. C., to a carbonylated acetophenone/formaldehyde resin, hydrogenating said carbonylated resin to a modified hydroxylated acetophenone/formaldehyde resin, subsequently converting said resin with epichlorohydrin, in the presence of a phase transfer catalyst, into the corresponding polychlorohydrin ether, and dehydrochlorinating said ether with a base, are suitable for use as epoxy resins, for example for the preparation of powder coating compositions having good resistance to chemicals and good adhesion.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: October 2, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Jacques-Alain Cotting, Alfred Renner
  • Patent number: 4959394
    Abstract: The L-arginine salt of N-(D)-{[2-(2,6-dichlorophenylamino}phenyl]acetyl]aspartic acid, represented by the formula ##STR1## in which AmH .sym. represents the cation derived from L-arginine Am of the formula ##STR2## and its hydrates exhibit and excellent water-solubility and a physiologically favorable pH value and also a pleasant taste in aqueous solutions and are therefore excellently suitable for enternal and parenteral forms of administration. It is manufactured by reacting L-arginine with D-{[2-(2,6-dichlorophenylamino)phenyl]-acetyl}aspartic acid.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: September 25, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Gerhard Baschang, Alfred Sallman
  • Patent number: 4957928
    Abstract: The invention relates to novel hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds of formula ##STR1## in which the variable R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, alk, X, Z, m, n and p, the dotted line and the substituents of the ring A have the meanings indicated in the specification and in the claims, and to their tautomers and/or salts. These compounds can be used as pharmaceutical active ingredients and can be prepared in a manner known per se.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: September 18, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Wolfgang Frostl, Armin Zust
  • Patent number: 4957904
    Abstract: Novel nonionic perfluoroalkylthioglycosides of the formula, R.sub.f -E-S-saccharide are described, wherein R.sub.f is a straight or branched chain perfluoroalkyl of 1 to 18 carbon atoms or said perfluoroalkyl substituted by perfluoroalkoxy of 2 to 6 carbon atoms, E is a connecting group, and the saccharide is a mono-, di-, or higher oligosaccharide, comprising 1 to 30 units of 5, 6 or 7 carbon-membered sugars.
    Type: Grant
    Filed: May 18, 1989
    Date of Patent: September 18, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Robert A. Falk, Kirtland P. Clark, Gregory R. Coughlin
  • Patent number: 4954546
    Abstract: The invention relates to compositions comprising 20-80% of a vinyl chloride homopolymer (PVC) and 80-20% of at least one copolymer selected from the group consisting of polystyrene/polyethylene/butylene, acrylate/rubber, acrylate/rubber/styrene, acrylonitrile/styrene/acrylate, ABS, NBR, NAR, SAN, EVA and modified EVA, which compositions are stabilized with at least one tin compound of formula(n-C.sub.12 H.sub.25).sub.2 Sn[S(CH.sub.2).sub.n COOR].sub.2 (I) or(n-C.sub.12 H.sub.25)Sn[S(CH.sub.2).sub.n COOR.sup.1 ].sub.3 (II)or with a mixture of compounds of formulae I and II, wherein n is 1 or 2 and R and R.sup.1 are each independently of the other C.sub.6 -C.sub.18 alkyl. These compositions have improved heat storage properties and are particularly suitable for fabricating sheets and hollow bodies for use in the automotive industry.
    Type: Grant
    Filed: February 28, 1989
    Date of Patent: September 4, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Gerd Abeler, Hans J. Sander
  • Patent number: 4954634
    Abstract: Described is a novel process for the introduction of an organic acyl radical selectively at the nitrogen atom of the amino group of desferrioxamine B or of a partially O-acylated derivative thereof. It comprises treating a derivative of desferrioxamine B, in which the amino nitrogen and the hydroxy oxygen of at least one of the hydroxamic acid groupings carries an organic silyl group, with an organic acylating agent and then removing the silyl groups present. The novel N- and O-silylated starting materials can be manufactured, preferably in situ, by reacting an appropriate derivative of desferrioxamine B that has at least one hydroxy group and the amino group in free form, with an organic silicon halide.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: September 4, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Heinrich, Theophile Moerker
  • Patent number: 4952690
    Abstract: The invention relates to azetidin-2-ones of the formula ##STR1## wherein R.sub.a represents hydroxy-lower alkyl, R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group, R.sub.2.sup.A together with the carbonyl group to which it is attached is a protected carboxyl group and Z' is oxygen, sulfhur or an optionally substituted methylidene group, functional groups in the radicals R.sub.a, R.sub.1 and Z' optionally being in protected form. The azetidinones are useful intermediates for the preparation of penem antibiotics.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: August 28, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Jacques Gosteli, Ivan Ernest, Marc Lang, Robert B. Woodward
  • Patent number: RE33489
    Abstract: Sterically hindered cyclic amines which are substituted by a photoactivatable acyl group at the basic nitrogen atom can be deacylated by irradiation with UV light. This is advantageous if the basicity of the amines proves troublesome during application. Examples of such photoactivatable acyl groups are phenylglyoxyl, phenylacetyl or naphthylacetyl groups.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: December 11, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Godwin Berner, Mario Slongo