Patents Represented by Attorney JoAnn Villamizar
  • Patent number: 5045556
    Abstract: The invention relates to aralkyl-4H-1,2,4-triazole derivatives, especially 5-phenyl-lower alkyl-4H-1,2,4-triazole-3-carboxamides of the formula ##STR1## in which Ph represents phenyl substituted by lower alkyl, halogen and/or by trifluoromethyl, alky represents lower alkylidene, R.sub.1 is hydrogen or lower alkyl, and R.sub.2 represents carbamoyl that is unsubstituted or is substituted by lower alkyl or by lower alkanoyl, and their salts and, as the case may be, their tautomers and the salts thereof. These compounds can be used as anti-convulsive pharmaceutical active ingredients.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: September 3, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Hans Allgeier
  • Patent number: 5045577
    Abstract: The addition of hindered amines in combination with a phosphorus-III-ester to the polymerization of olefins on spherical Ziegler-Natta catalysts effects a thermo-oxidative stabilization of the prepared polymers. Phenolic antioxidants may be used additionally.
    Type: Grant
    Filed: June 21, 1989
    Date of Patent: September 3, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Mulhaupt, Paul Dubs
  • Patent number: 5036058
    Abstract: Compounds of the formula I ##STR1## in which R.sub.1 is an aromatic radical, n is 0, 1, 2 or 3, X is an oxy group, a thio group which can be oxidized or an imino group which is unsubstituted or has aliphatic substituents, alk.sub.1 and alk.sub.2 are identical or different divalent aliphatic radicals, and R.sub.2 is hydrogen or a monovalent aliphatic radical and salts thereof have properties which regulate calcium metabolism and can be employed for the treatment of diseases connected with disturbances in this metabolism. They are prepared, for example, by reacting a compound of the formula ##STR2## in which X.sub.3 is carboxyl with a phosphorylating agent and hydrolysing the primary product.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: July 30, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Knut A. Jaeggi
  • Patent number: 5034439
    Abstract: Flame-resistant polyester moulding compounds comprising(A) 70-95% by weight of a specific polyester mixture made up of polyethylene terephthalate, polybutylene terephthalate copolyester with 3-30 mol % of an aliphatic dicarboxylic acid containing up to 36 C atoms, and, if desired, polybutylene terephthalate, and(B) 30-5% by weight of a flame-retardant additive made up of a bromine-containing organic compound and an antimony compound selected from the group comprising Sb.sub.2 O.sub.5, NaSbO.sub.3 and Sb.sub.2 O.sub.3, with a mean particle size of not less than 2 .mu.m,are particularly suitable for the production of partially crystalline mouldings by means of injection moulding. The mouldings are distinguished by a light self-colour with comparatively good thermal, mechanical and electrical properties.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: July 23, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Franz Breitenfellner, Thomas Kainmuller
  • Patent number: 5032403
    Abstract: The invention relates to a transdermal therapeutic system in the form of a multilayer plaster for the administration of active substances which are able to permeate, in the form of a matrix system containing at least three layers:(a) a covering layer which is impermeable for the constituents of the reservoir b);(b) a reservoir layer which is able to deliver active substance and which consists of optionally crosslinked block copolymer based on styrene, alkadienes and optionally alkenes mixed with adhesive polymers and is optionally provided with an additional adhesive membrane layer and contains at least one active substance capable of skin permeation, at least one agent promoting the skin permeability of active substances and optionally further pharmaceutical auxiliaries, and(c) a protective film which can be pulled off the reservoir layer.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: July 16, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Joel Sinnreich
  • Patent number: 5032309
    Abstract: A functional fluid comprising:1) a base fluid selected from one or more ofi) a phosphate fluid andii) a carboxylic acid ester; andb) as a hydrolytic stabilizer, at least one compound of the formula IA-NHC(=X)NHZ (1)wherein A is C.sub.3 -C.sub.18 alkenyl, C.sub.6 -C.sub.10 aryl or C.sub.7 -C.sub.13 alkaryl; X is oxygen; and Z is hydrogen.
    Type: Grant
    Filed: February 5, 1990
    Date of Patent: July 16, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Peter Miles
  • Patent number: 5032606
    Abstract: 4-Acylresorcinol ethers of the formula ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 is fluorinated lower alkyl, R.sub.3 is hydrogen, lower alkoxy, trifluoromethyl or halogen, alk is an alkylene or hydroxyalkylene radical which is uninterrupted or interrupted by oxygen, one of the radicals R.sub.4, R.sub.5 and R.sub.7 is a group of the formula --NH--C(.dbd.O)--R.sub.8, a radical R.sub.4 or R.sub.5 which differs from this is a radical R.sub.9 and a radical R.sub.7 which differs from this is a radical R.sub.10, R.sub.6 is hydrogen, lower alkyl, trifluoromethyl, halogen, carboxyl which is free, esterified or amidated, cyano or lower alkanoyl, R.sub.8 is carboxyl which is free, esterified or amidated or 5-tetrazolyl, R.sub.9 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and R.sub.10 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, cyano or carboxyl which is free, esterified or amidated, and their salts have antiallergic and antiinflammatory properties.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: July 16, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas Beck, Alfred Sallmann, Robert W. Lang, Paul Wenk
  • Patent number: 5030698
    Abstract: Curable compositions are described comprising(A) an epoxy resin having on average more than one epoxide group per molecule,(B) a curing agent which can be activated at an elevated temperature for component (A),(C) a liquid copolymer based on butadiene, acrylonitrile and, if appropriate, further ethylenically unsaturated comonomers, and(D) a selected segmented copolymer consisting essentially of recurring soft segments containing polypropylene glycol units or polybutylene glycol units and selected hard segments having a softening point above 25.degree. C. These compositions are suitable for use as, for example, adhesives.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: July 9, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Mulhaupt, Werner Rufenacht
  • Patent number: 5030671
    Abstract: A composition containing a) a chlorine-containing polymer, b) at least one Me(II) carboxylate and/or Me(II) phenolate, wherein Me(II) represents Ba, Ca, Mg, Sr or Zn, and c) at least one compound of formula I ##STR1## wherein n is 1, 2, 3, 4 or 6 and, when n is 1, X is C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.20 -alkenyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.5 -C.sub.12 cycloalkyl substituted by C.sub.1 -C.sub.4 alkyl, phenyl, C.sub.7 -C.sub.9 phenylalkyl, phenyl substituted by from 1 to 3 radicals or C.sub.7 -C.sub.9 phenylalkyl substituted on the phenyl ring by from 1 to 3 radicals, the radicals being selected from the group consisting of C.sub.1 -C.sub.4 alkyl, chlorine, hydroxy, methoxy and ethoxy; when n is 2, X is C.sub.2 -C.sub.12 alkylene, C.sub.2 -C.sub.12 alkylene substituted by phenyl, or C.sub.2 -C.sub.12 alkylene interrupted by oxygen or sulfur atoms; when n is 3, X is, for example, C.sub.3 -C.sub.7 alkanetriyl; when n is 4, X is, for example, C.sub.4 .varies.C.sub.
    Type: Grant
    Filed: October 16, 1989
    Date of Patent: July 9, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Wolfgang Wehner, Gerd Abeler
  • Patent number: 5028645
    Abstract: Di-(2,2,6,6-tetramethyl-4-piperidinyl) succinate and glutarate are very effective light stabilizers for thermoplastics, particularly for polyolefins.
    Type: Grant
    Filed: August 8, 1989
    Date of Patent: July 2, 1991
    Assignees: Ciba-Geigy Corp., Sankyo Company Ltd.
    Inventors: Francois Gugumus, Jean Rody
  • Patent number: 5028704
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein R.sub.c is carboxy, esterified carboxy or amidated carboxy;R.sub.2 is hydrogen or lower alkyl or joins with R.sub.a and R.sub.b and the atoms therebetween to form a fused ring ##STR2## and either R.sub.a is methyl and R.sub.b is ##STR3## or R.sub.2 and R.sub.b and the atoms therebetween form a group wherein R.sub.3 and R.sub.4 are either both hydrogen, or together are propylene, butylene, or with the two atoms to which they are attached form a benzene ring. Methods of manufacture and use thereof in the production of angiotensin converting enzyme inhibitors are disclosed.
    Type: Grant
    Filed: February 8, 1990
    Date of Patent: July 2, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Stephen K. Boyer
  • Patent number: 5025095
    Abstract: Substituted diallylphenol derivatives are useful as reactive diluents for bismaleimides. Formulations comprising bismaleimides and substituted diallylphenol derivatives are particularly useful in resin transfer molding and filament winding techniques.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: June 18, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Yefim Blyakhman, Byung H. Lee
  • Patent number: 5021448
    Abstract: A method of reducing serum uric acid and/or increasing renal clearance of uric acid in a mammal in need thereof comprising administering to such mammal a uricosuric effective amount of a thromboxane synthetase inhibitor, a thromboxane receptor antagonist, or both in a combined uricosuric effective amount is disclosed. Compositions having one or more of the foregoing in combination with one or more known uricosurics are also set forth.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: June 4, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Anthony J. Piraino, Steven D. Saris
  • Patent number: 5021491
    Abstract: Compounds of the formula I ##STR1## in which R is C.sub.8 -C.sub.14 alkyl, phenyl, C.sub.7 -C.sub.9 aralkyl or R"OOC-CH.sub.2 --CH.sub.2, R' is C.sub.2 -C.sub.18 alkyl, C.sub.5 -C.sub.12 cycloalkyl, phenyl, C.sub.7 -C.sub.30 alkaryl or C.sub.7 -C.sub.18 -aralkyl and R" is C.sub.1 -C.sub.14 alkyl, phenyl or C.sub.7 -C.sub.9 aralkyl and x is 1 or 2, are heat stabilizers for chlorine-containing thermoplastics, in particular for PVC.
    Type: Grant
    Filed: March 1, 1990
    Date of Patent: June 4, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Gerd Abeler
  • Patent number: 5021513
    Abstract: Curable compositions comprise(A) a polyglycidyl ether of a polyhydric phenol,(B) a polyglycidyl ether of a polyhydric alcohol,(C) a nitrogen-containing latent hardener for epoxide resins and(D) as cure accelerator dispersed as a powder in the composition, a solid solution of a polymeric phenol with an aliphatic polyamine having two or more amine groups, each of the amine groups being tertiary and at least two of the amine groups being dimethylamino groups.
    Type: Grant
    Filed: October 4, 1990
    Date of Patent: June 4, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Madan M. Bagga
  • Patent number: 5021485
    Abstract: Synergistic light stabilizer combinations comprising(a) a compound of formula I ##STR1## wherein m is 2 or 3 and R is hydrogen, C.sub.1 -C.sub.4 alkyl, 2-hydroxyethyl, 2-hydroxypropyl, allyl, benzyl, acetyl or acryloyl, and(B) a compound which contains at least one group of formula II ##STR2## and has a molecular weight higher than 700, are most suitable for stabilizing organic polymers, especially polyolefins.
    Type: Grant
    Filed: August 7, 1989
    Date of Patent: June 4, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Francois Gugumus
  • Patent number: 5021474
    Abstract: Moulding compositions comprising(a) a melamine/formaldehyde resin, a melamine/phenol/formaldehyde resin or a mixture of said resins,(b) organic and/or inorganic fillers,(c) a lubricant, and(d) 0.1 to 2% by weight, based on the total composition, of 3-chloro-1,2-propanediol as latent hardener,are suitable for the production of mouldings by injection moulding. The latent hardener employed permits extremely short cycle times coupled with long residence times at the cylinder temperature of the injection moulding machine. The moulding compositions are distinguished at the same time by very good flow properties.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: June 4, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Gunther, Hermann O. Wirth, Wilhelm Endlich
  • Patent number: 5019639
    Abstract: Advanced epoxy resins are disclosed which can be obtained by reacting liquid or semi-solid aromatic opoxy resins with aliphatic diols, and subsequently reacting the reaction product with mono- or binuclear bisphenols in the presence of a cyclic quaternary ammonium salt.
    Type: Grant
    Filed: April 2, 1990
    Date of Patent: May 28, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Arnold Hofer, Alex Wegmann
  • Patent number: 5013863
    Abstract: Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.2 denotes hydrogen or alkyl, denotes an alkali metal or ammonium ion R.sup.6, or Z represents a protected or latent amino group Z.sup.0 and R.sup.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: May 7, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Eric K. Baylis, Helmut Bittiger, Wolfgang Froostl, Roger G. Hall, Ludwig Maier, Stuart J. Mickel, Hans-Rudolf Olpe
  • Patent number: 5013814
    Abstract: Sulfonium salts of the formulae I to IV ##STR1## in which A is C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.10 cycloalkylalkyl, phenyl which is unsubstituted or mono- or polysubstituted by C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, nitro, phenyl, phenoxy, alkoxycarbonyl having 1-4 C atoms in the alkoxy radical or acyl having 1-12 C atoms, Ar, Ar.sup.1 and Ar.sup.2, independently of one another, are each unsubstituted or mono- or polysubstituted phenyl, or naphthyl which is unsubstituted or mono- or polysubstituted each arylene is an unsubstituted or mono- or polysubstituted phenylene or unsubstituted or mono- or polysubstituted naphthylene and Q.sup..crclbar. is SbF.sub.6 --, AsF.sub.6 -- or SbF.sub.5 OH-- are valuable curing agents and curing accelerators in the heat-curing of cationically polymerizable compounds, preferably epoxy resins.
    Type: Grant
    Filed: January 9, 1990
    Date of Patent: May 7, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Martin Roth, Beat Muller