Patents Represented by Attorney JoAnn Villamizar
  • Patent number: 5106832
    Abstract: Insulin-like growth factor I (IGF I) and pharmaceutical compositions comprising IGF I are useful in improving glomerular filtration and renal plasma flow and can be used for the treatment of patients suffering from renal diseases and for the preparation of therapeutic combinations for treatment of renal diseases.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: April 21, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Ernst R. Froesch, Hans-Peter Guler, Christoph Schmid, Jurgen Zapf
  • Patent number: 5102457
    Abstract: Compounds of formula I: ##STR1## in which R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are as defined in claim 1, are suitable as corrosion inhibitors in surface coatings for metals.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: April 7, 1992
    Assignee: Ciba-Geigy Corp.
    Inventors: Adalbert Braig, Emyr Phillips
  • Patent number: 5100894
    Abstract: Compounds of the general formula: ##STR1## in which R is a lower alkyl group, and R.sub.1 is a tri-lower alkylmethylcarbonyl group, the structure elements --A.sub.1 --A.sub.2 --, A.sub.3 --A.sub.4 -- or A.sub.5 --A.sub.6 -- each represent ethylene or vinylene, or the elements --A.sub.1 --A.sub.2 -- and --A.sub.3 --A.sub.4 -- each represent ethylene and --A.sub.5 --A.sub.6 -- represents vinylene, their optical isomers and their salts exhibit valuable pharmaceutical properties.
    Type: Grant
    Filed: April 12, 1991
    Date of Patent: March 31, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter W. Taylor, Ian T. W. Matthews, Jane I. Lowrie, Keith A. Menear, Wilhelm Kump
  • Patent number: 5100987
    Abstract: Monethylenically unsaturated compounds whose polymers are useful as polymeric photoinitiators are of formula Ar.sup.1 COC(R.sup.1)(R.sup.2)R.sup.3 where R.sup.1 is C.sub.1 -C.sub.10 alkyl or alkoxy, R.sup.2 is C.sub.1 -C.sub.10 alkyl, --X--O--R.sup.4 --OCOC(R.sup.5).dbd.CH.sub.2 (II) --X--NH--R.sup.6 --OCOC(R.sup.5).dbd.CH.sub.2 (III), or --CH.sub.2 [OCH.sub.2 CH(OH)CH.sub.2 ].sub.a OCOC(R.sup.5).dbd.CH.sub.2 (IIIA) or R.sup.1 and R.sup.2, together with the attached carbon, denote C.sub.4 -C.sub.8 cycloalkyl, R.sup.3 is a C.sub.6 -C.sub.20 aromatic group, OH, tert.amino, --OCOC(R.sup.5).dbd.CH.sub.2 (VI) or --OCH.sub.2 CH(OH)CH.sub.2 OCOC(R.sup.5).dbd.CH.sub.2 (VIA), R.sup.4 is C.sub.1 -C.sub.4 alkylene, which may be substituted by --OH or by C.sub.2 -C.sub.20 acyloxy, R.sup.5 is H or C.sub.1 -C.sub.4 alkyl, R.sup.6 is C.sub.1 to C.sub.4 alkylene, X is a group of formula R.sup.7 CO-- or ##STR1## where R.sup.7 is C.sub.1 -C.sub.4 alkylene, R.sup.8 is C.sub.1 to C.sub.4 alkyl, and is 0 or 1, Ar.sup.1 is a C.
    Type: Grant
    Filed: October 25, 1990
    Date of Patent: March 31, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Kevin B. Hatton, Edward Irving, Josephine M. A. Walshe, Anne Mallaband
  • Patent number: 5098945
    Abstract: A composition containing a) a polystyrene, substituted polystyrene, copolymer or terpolymer of styrene or of a substituted styrene, polycarbonate, polyester-carbonate, polyurethane, polyamide copolyamide, polyacetyl or polyphenylene oxide and b) at least one compound of the formula I ##STR1## in which R.sub.1 is methyl or ethyl and R.sub.2 is C.sub.2 -C.sub.30 alkyl.Compounds of the formula I in which R.sub.2 is C.sub.8 -C.sub.30 alkyl are novel and are suitable for stabilizing organic materials against thermal, oxidative and actinic degradation.
    Type: Grant
    Filed: February 11, 1991
    Date of Patent: March 24, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Rita Pitteloud, Paul Dubs
  • Patent number: 5098527
    Abstract: A method of making a pattern on an electrically conductive material such as a printed circuit comprises(i) electrodepositing on an electrically conductive surface a film of an organic polymer having, per average molecule, more than one reactive functional group,(ii) forming on the electrodeposited film a predetermined pattern of a heat-curable resist having, per average molecule, more than one group reactive with the reactive groups in the electrodeposited film on heating, thereby leaving predetermined areas of the electrodeposited film uncovered,(iii) removing the uncovered areas of the electrodeposited film by treatment with a solvent therefor, thereby forming a surface comprising bare conductive material in predetermined areas and, in other predetermined areas, conductive material coated by areas of the electrodeposited film covered by the resist, and(iv) heating to complete adhesion of the resist to the electrically conductive surface through the areas of the electrodeposited film covered by the resist,st
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: March 24, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Christopher P. Banks, Edward Irving
  • Patent number: 5095139
    Abstract: Rhizocticines of the formula ##STR1## in which X represents hydrogen or a hydrophobic amino acid radical and Y represents a basic amino acid radical, the C2 atoms of the amino acid radicals having the L-configuration, and protected derivatives and salts thereof.The compounds are obtained from culture broths of Bacillus subtilis or synthetically and have especially fungicidal action.
    Type: Grant
    Filed: April 26, 1990
    Date of Patent: March 10, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Wolfgang Loeffler, Martin Kugler, Gunther Jung, Armin Kern, Claudius Rapp
  • Patent number: 5093494
    Abstract: The present invention provides a melamine phosphonic acid salt of the general formula (I) ##STR1## in which R is hydrogen, methyl or a negative valency bond, and n is 1 when R is hydrogen or methyl, or 2 when R.sup.1 is a negative valency bond.The salts are useful as flame retardants in polymers.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: March 3, 1992
    Assignee: Ciba-Geigy Corporation
    Inventor: James Gainer
  • Patent number: 5093530
    Abstract: A synthetic resin based on a polystyrene that can be used as a support for solid phase peptide synthesis and that has been cross-linked with from 0 to 5 mol % of divinyl benzene, characterized in that it has been substituted at benzene rings of its skeletal structure by groups of the formula ##STR1## in which X represents --O-- or --NH-- and R represents C.sub.1 -C.sub.4 -alkyl, as a support renders possible the solid phase synthesis of peptides and peptide amides that are, if desired, protected at the N-terminal and/or at other functional groups. The resin is manufactured by reaction of a customary chloromethylated polystyrene resin with an alkali metal salt of the corresponding 4-hydroxybenzophenone and subsequent reduction of the carbonyl group and, optionally, amination.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: March 3, 1992
    Assignee: Ciba-Geigy Corporation
    Inventor: Hans Rink
  • Patent number: 5093330
    Abstract: N-substituted derivatives of staurosporine of the general formula[Stau]--N(CH.sub.3)--R (I)in which [Stau] represents a residue of the partial formula ##STR1## and R represents a hydrocarbyl radical R.sup.o or an acyl radical Ac, which radicals preferably have a maximum of 30 carbon atoms, and salts of compounds of the formula I having salt-forming properties, are distinguished as selective inhibitors of proteinkinase C. They are manufactured by conventional alkylation or acylation, respectively, of staurosporine.
    Type: Grant
    Filed: March 21, 1991
    Date of Patent: March 3, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Giorgio Caravatti, Andreas Fredenhagen
  • Patent number: 5093247
    Abstract: The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.
    Type: Grant
    Filed: February 8, 1990
    Date of Patent: March 3, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Gabriele Fendrich, Willy Zimmermann, Johannes Gruner, John A. L. Auden
  • Patent number: 5091099
    Abstract: Phosphite-free lubricating oil composition which comprises a) a mineral oil or a synthetic oil or a mixture thereof, and b) a mixture containing at least one aromatic amine of the formula (I), ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.3 ' are as defined in claim 1, and at least one phenol of the formula ##STR2## in which R.sup.4, R.sup.5 and A are as defined in claim 1, and the compounds are present in the mixture in a ratio of 2 to 6 parts by weight of the aromatic amine(s) of the formula I to 1 part by weight of the phenol(s) of the formula II.The lubricating oil compositions are highly resistant to ageing and are effective in preventing black sludge formation.
    Type: Grant
    Filed: June 1, 1989
    Date of Patent: February 25, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Samuel Evans, Rolf Schumacher
  • Patent number: 5089400
    Abstract: Recombinant DNA molecules and hosts transformed with them are described which produce polypeptides displaying a human lymphoblastoid interferon activity. There are also provided processes for the preparation of said recombinant DNA molecules, said hosts, and said lymphoblastoid interferon-like polypeptides. The polypeptides of the invention are useful as immunomodulators, especially as antiviral, antitumor and anticancer agents.
    Type: Grant
    Filed: March 7, 1989
    Date of Patent: February 18, 1992
    Assignee: Ciba-Geigy Corporation
    Inventor: Francois Meyer
  • Patent number: 5084539
    Abstract: Polymers having repeating units of the general formula I ##STR1## where Y and Z are the same or different and each denote --H, --COOR.sup.1 or --CON(R.sup.2)R.sup.3, with the proviso that Y and Z do not both denote --H, or Y and Z together with the carbon atoms to which they are attached denote a divalent cyclic group of formula ##STR2## A denotes --O-- or --N(R.sup.4)--, R.sup.1 denotes --H, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl, R.sup.2 and R.sup.3 each denote --H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 hydroxyalkyl, and R.sup.4 denotes --H, --OH, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or C.sub.1 -C.sub.4 alkoxy. The carboxyl-containing polymers are useful in water treatment.
    Type: Grant
    Filed: August 23, 1990
    Date of Patent: January 28, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: William J. Feast, David B. Harrison, Alan F. Gerrard, Donald R. Randell
  • Patent number: 5081028
    Abstract: The invention concerns polypeptides related to human immunoglobulin E binding factors (IgE-Bfs), mRNa, DNAs and hybrid vectors coding for said polypeptides, hosts containing said hydrid vectors, processes for the preparation of said polypepties, mRNAs, DNAs, hybrid vectors, and hosts. The polypeptides can be used for the prevention and/or the treatment of allergic diseases, and accordingly the invention concerns also pharmaceutical preparations containing them.
    Type: Grant
    Filed: November 21, 1990
    Date of Patent: January 14, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Hofstetter, Erich Kilchherr, Albert Schmitz
  • Patent number: 5079008
    Abstract: The invention relates to a monolith transdermal therapeutic system for the delivery of permeable drugs, especially formoterol, in the form of a matrix system comprising three layers: a) a backing layer which is impermeable to the components of the adhesive layer b),b) an adhesive layer capable of releasing the drug and consisting of a permeable polymeric material which is compatible with the skin and contains at least one drug which is capable of permeation across the skin, a combination of eucalyptol having a purity of at least 70% with an additional flux enhancer and further optional pharmaceutical excipients, andc) a protective release liner which can be peeled from the adhesive contact layer b).
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: January 7, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Joel Sinnreich, Peter Fankhauser
  • Patent number: 5079229
    Abstract: Novel elgin mutants that differ from the natural eglins B and C by the replacement of one, two or three amino acids in the region of the active center (amino acids 45 and 46, Leu-Asp) by other amino acids are provided. The mutants, which can be produced by recombinant genetic engineering, have valuable pharmacological properties.
    Type: Grant
    Filed: March 7, 1989
    Date of Patent: January 7, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Markus G. Grutter, Dirk Heinz, Manfred Liersch
  • Patent number: 5075456
    Abstract: Imides of the formula I ##STR1## In which R.sub.1, R.sub.2 and R.sub.4 independently of one another are hydrogen or methyl, R.sub.3 is a direct bond or a C.sub.2 -C.sub.20 aliphatic radical which can be interrupted by O atoms or a mononuclear or polynuclear C.sub.5 -C.sub.20 cycloaliphatic or C.sub.6 -C.sub.20 aromatic radical or is a group of the formula II ##STR2## in which T is methylene, isopropylidene, CO, O, S or SO.sub.2 and R.sub.5 is hydrogen or phenyl, can be crosslinked either photochemically or by heat and produce polymers having excellent properties, in particular a very high resistance to heat. They are particularly suitable for the production of heat-resistant photolithographs or as matrix resins for the production of composite materials.
    Type: Grant
    Filed: February 27, 1990
    Date of Patent: December 24, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Alfred Renner, Christian Vonlanthen, Edward Irving, Christopher P. Banks
  • Patent number: 5073448
    Abstract: Recording materials for ink jet printing containing, as a stabilizer, at least one compound of the formula I ##STR1## The symbols R.sub.1, R.sub.2, R.sub.3, R.sub.3 'R.sub.4 and R.sub.4 ' are as defined in claim 1.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: December 17, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Eric Vieira, Hugh S. Laver
  • Patent number: 5073601
    Abstract: The invention relates to compositions containing A) a liquid copolymer based on butadiene and at least one polar, ethylenically unsaturated comonomer, and B) a polyether prepolymer capped with hydroxyarylcarboxylic or hydroxyaralkylcarboxylic acids, or a capped polyester, polythioester or polyamide containing polyether segments. The phenolic hydroxyl group in component B) can also be etherified with epichlorohydrin and this product can be converted to an episulfide, if desired, or the phenolic hydroxyl group can be reacted with cyanogen halide to form a cyanate group.The stock compositions can be used in combination with epoxy resins to manufacture structural adhesives or sealing compounds.
    Type: Grant
    Filed: July 25, 1989
    Date of Patent: December 17, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Mulhaupt, Werner Rufenacht