Patents Represented by Attorney JoAnn Villamizar
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Patent number: 5071898Abstract: Composition containing a) a polymer containing chlorine and b) at least one compound of the formula I ##STR1## in which R.sub.1 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 hydroxyalkyl, phenyl, hydroxyphenyl, C.sub.7 -C.sub.10 phenylalkyl or C.sub.7 -C.sub.10 phenylalkyl which is substituted on the phenyl ring by an OH group, and R.sub.2 is C.sub.2 -C.sub.10 hydroxyalkyl, hydroxyphenyl or C.sub.7 -C.sub.10 phenylalkyl which is substituted on the phenyl ring by an OH group, subject to the condition that R.sub.2 is other than hydroxyphenyl if R.sub.1 is phenyl or hydroxyphenyl, and/or at least one compound of the formula I in which the OH groups present in the radicals R.sub.1 and R.sub.2 have been replaced by C.sub.2 -C.sub.12 alkanoyloxy.The compounds of the formula IA ##STR2## in which R is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 hydroxyalkyl, phenyl, hydroxyphenyl, C.sub.7 -C.sub.10 phenylalkyl or C.sub.7 -C.sub.10 phenylalkyl which is substituted on the phenyl ring by an OH group, are novel.Type: GrantFiled: June 2, 1989Date of Patent: December 10, 1991Assignee: Ciba-Geigy CorporationInventors: Hermann O. Wirth, Hans-Helmut Friedrich, Gerd Abeler
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Patent number: 5071993Abstract: Compounds of the formula ##STR1## in which R.sup.1 and R.sup.3 independently of one another are C.sub.1 -C.sub.8 alkyl, cyclopentyl, cyclohexyl, C.sub.7 -C.sub.9 aralkyl, phenyl or a group of the formula--C.sub.m H.sub.2m+1-q (X).sub.q (II)in which m is a number from 0-10 and q is 1 or 2, with q=1 in the case of m=0, R.sup.2 and R.sup.4 independently of one another are each a group of the formula II or, in the case that R.sup.1 and R.sup.3 are each a group of the formula II, R.sup.2 and R.sup.4 independently of one another can also be C.sub.1 -C.sub.8 alkyl, cyclopentyl, cyclohexyl, C.sub.7 -C.sub.9 aralkyl or phenyl, R.sup.5 and R.sup.6 independently of one another are hydrogen, methyl, ethyl or together are trimethylene or tetramethylene, and X is a group of the formula ##STR2## in which the general symbols are as defined in claim 1, are suitable as fluorescent brighteners especially for photographic recording materials and for synthetic polymers.Type: GrantFiled: September 12, 1989Date of Patent: December 10, 1991Assignee: Ciba-Geigy CorporationInventors: David G. Leppard, Eric Vieira
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Patent number: 5071761Abstract: Novel hybrid interferons are produced which are derived from lymphoblastoid interferons .alpha.-2 and .alpha.-3 belonging to the interferon .alpha.B and .alpha.D groups, respectively. The novel hybrid interferons possess valuable antiviral and antiproliferative properties.Type: GrantFiled: July 18, 1989Date of Patent: December 10, 1991Assignee: Ciba-Geigy CorporationInventors: Francois Meyer, Albert Hinnen, Andreas Meister, Markus G. Grutter, Sefik Alkan
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Patent number: 5071967Abstract: Compounds of the formula I ##STR1## in which R is a radical of the formula --OR.sub.5 or --NHR.sub.5, A is a radical of the formula II or III ##STR2## in which B is a radical of the formula ##STR3## in which n is the number 1 or 2, R.sub.1 and R.sub.3 independently of one another are --H or Cl, R.sub.2 and R.sub.4 independently of one another are --H, halogen, --NO.sub.2, --CN, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --CF.sub.3, C.sub.2 -C.sub.5 alkoxycarbonyl, or --CONH-phenyl, --NHCO-phenyl or phenyloxy which is unsubstituted or substituted on the phenyl nucleus by one or two chlorine atoms or one or two methyl, methoxy or ethoxy groups, R.sub.5 is alkyl having at least 10 C atoms, R.sub.6 and R.sub.7 independently of one another are --H, halogen, --NO.sub.2, --CN, --CF.sub.3, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, R.sub.8 is --H, --Cl, --Br, --CH.sub.3 or --OCH.sub.3 and X is --H, --Br, --OCH.sub.3, --CN or --NO.sub.2, are particularly suitable as pigments for coloring polyolefins.Type: GrantFiled: February 11, 1991Date of Patent: December 10, 1991Assignee: Ciba-Geigy CorporationInventors: Stefan Hari, Jost von der Crone
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Patent number: 5070163Abstract: Compounds of the formula I ##STR1## in which a is 1, 2 or 3, b is 0, 1, or 2, R.sup.1 and R.sup.2, independently of one another are hydrogen or methyl, R.sup.3 is C.sub.1 -C.sub.6 alkyl, R.sup.4 is selected from the group consisting of the formulas IIa, IIb, IIc, IId, IIe or IIf ##STR2## X is --O--, --S--, --CO--, --COO--, --CO--NR.sup.5 -- or --CR.sup.6 R.sup.7 --, Z.sup.1 is --CR.sup.6 R.sup.7 --, Z.sup.2 is --SO.sub.2 -- or --CO--, Y is a direct C--C bond, --O--, --S--, --SO--, --SO.sub.2 --, --CO--, --P(O)R.sup.9 --, --COO--, --CO--NR.sup.5 --, --C.sub.n H.sub.2n -- or --CR.sup.10 R.sup.11 --, n is an integer from 1 to 12, R.sup.5 is hydrogen or C.sub.1 -C.sub.6 alkyl, R.sup.6 and R.sup.7, independently of one another, are hydrogen, or C.sub.1 -C.sub.6 alkyl, --CF.sub.3, cyclohexyl or phenyl, or R.sup.6 and R.sup.7 together with the common C atom are a cycloalkylidene radical having 5 to 7 ring carbon atoms, R.sup.8 is C.sub.1 -C.sub.6 alkyl, chlorine or bromine, R.sup.Type: GrantFiled: August 31, 1989Date of Patent: December 3, 1991Assignee: Ciba-Geigy CorporationInventors: Friedrich Stockinger, Andreas Kramer
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Patent number: 5066695Abstract: High-molecular weight organic material containing at least one metal complex of a ligand of formula I: ##STR1## wherein A is a carbocyclic aromatic or heterocyclic aromatic radical, B is a carbocyclic aromatic radical or a heterocyclic aromatic radical containing at least one N atom, it being necessary for at least one of the radicals A and B to be heterocyclic, and R.sub.1 is --C.sub.1 -C.sub.18 -alkyl, a carbocyclic aromatic radical or a heterocyclic aromatic radical containing at least one N atom, and the metal is a transition metal cation carrying a double positive charge selected from Ni.sup.2+, Cu.sup.2+, Co.sup.2+, Zn.sup.2+, Mn.sup.2+, Fe.sup.2+, Cd.sup.2+ or Pt.sup.2+ or the radical VO.sup.2+.Type: GrantFiled: June 29, 1989Date of Patent: November 19, 1991Assignee: Ciba-Geigy CorporationInventors: Georg Cseh, Paul Lienhard, Walter Wiedemann
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Patent number: 5066801Abstract: The invention relates to novel sulfonic acid esters of formula I ##STR1## wherein R.sup.1 is C.sub.5 -C.sub.6 cycloalkyl which is unsubstituted or substituted by C.sub.1 -C.sub.7 alkyl, unsubstituted or substituted phenyl, R.sup.2 is C.sub.1 -C.sub.7 alkyl, R.sup.3 is phenyl which is substituted by halogen or nitro, and the asterisk denotes a carbon atom that is either present in the preponderant number of molecules in the S configuration or in the preponderant number of molecules in the R configuration.These compounds can be prepared by enantio-selective reduction of 4-R.sup.1 -substituted .alpha.-oxobutyric acid compounds and subsequent conversion of the resultant .alpha.-hydroxy group into the --OSO.sub.2 --R.sup.3 group. The compounds of formula I are suitable intermediates for the preparation of ACE inhibitors or precursors thereof.Type: GrantFiled: June 26, 1990Date of Patent: November 19, 1991Assignee: Ciba-Geigy CorporationInventors: Hans-Ulrich Blaser, Hans-Peter Jalett, Gottfried Sedelmeier
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Patent number: 5066761Abstract: An amine hardener comprising diethyltoluenediamine or t-butyl-meta-toluenediamine and 4,4'-methylene orthoethylaniline and curable polyurethane casting systems comprising said hardener and an isocyanate resin.Type: GrantFiled: February 5, 1990Date of Patent: November 19, 1991Assignee: Ciba-Geigy CorporationInventor: Teruko Miyazaki
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Patent number: 5064654Abstract: The invention relates to the art of transdermal administration of drug substances, particularly those drug substances having a greater solubility in ethanol than in water and those drug substances having cationic or anionic substituent groups. It is especially useful for the administration of nitroglycerin.Type: GrantFiled: April 20, 1990Date of Patent: November 12, 1991Assignee: Ciba-Geigy CorporationInventors: Bret Berner, Charles Ebert, Gerard C. Mazzenga, John H. Otte
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Patent number: 5064832Abstract: Compounds of formula I ##STR1## wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, Y, Z and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are especially active against tumors. They are prepared in a manner known per se.Type: GrantFiled: August 16, 1990Date of Patent: November 12, 1991Assignee: Ciba-Geigy CorporationInventors: Jaroslav Stanek, Giorgio Caravatti, Jorg Frei, Hans-Georg Capraro
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Patent number: 5064761Abstract: A process for the manufacture of a compound of the formula IIIa ##STR1## wherein R.sup.2 is lower alkyl and R.sup.3 is lower alkanoyl or arylcarbonyl comprising reducing a compound of formula II ##STR2## wherein R.sup.2 is lower alkyl and R.sup.3 is lower alkanoyl or arylcarbonyl or a salt thereof with Saccharomyces cerevisiae.Type: GrantFiled: March 9, 1990Date of Patent: November 12, 1991Assignee: Ciba-Geigy CorporationInventors: Peter Schneider, Gerardo Ramos, Jacques Bersier
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Patent number: 5064819Abstract: Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, or wherein R denotes methyl, R.sub.1 denotes hydrogen or hydroxy, R.sub.2 denotes an aromatic radical and R.sub.3 represents hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.Type: GrantFiled: March 30, 1990Date of Patent: November 12, 1991Assignee: Ciba-Geigy CorporationInventors: Eric K. Baylis, Helmut Bittiger, Wolfgang Frostl, Roger G. Hall, Ludwig Maier, Stuart J. Mickel, Hans-Rudolf Olpe
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Patent number: 5059689Abstract: Compounds which contain at least one group of the formula I ##STR1## in which X is a group which completes the ring to form a piperidine ring, are effective stabilizers for organic materials against damage by light, oxygen and heat.Type: GrantFiled: January 30, 1989Date of Patent: October 22, 1991Assignee: Ciba-Geigy CorporationInventors: Jean Rody, Gerhard Rytz, Mario Slongo
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Patent number: 5059698Abstract: Polymeric .beta.-keto-ester acetals which, in combination with compounds which release acid under the action of actinic radiation, are suitable as positive photoresists, which are suitable for the production of printing plates, printed circuit boards, integrated circuits or silver-free films, can be prepared by free-radical polymerization from compounds of the formula I or II ##STR1## in which n is zero, 1 or 2 and, for example, R.sup.1 is an H atom, C.sub.1 -C.sub.10 -alkyl, phenyl or benzyl, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently of one another are each an H atom, halogen atom, C.sub.1 -C.sub.10 alkyl, phenyl, naphthyl or the radical --COOR.sup.9, ##STR2## or --SO.sub.2 R.sup.9, in which R.sup.9 is C.sub.1 -C.sub.6 alkyl or phenyl, X is O, S or NR.sup.10, in which R.sup.10 is an H atom, C.sub.1 -C.sub.6 alkyl or phenyl, Y is a radical of the following formulae ##STR3## in which R.sup.11 is an H atom, C.sub.1 -C.sub.Type: GrantFiled: June 9, 1989Date of Patent: October 22, 1991Assignee: Ciba-Geigy CorporationInventors: Adrian Schulthess, Max Hunziker
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Patent number: 5057505Abstract: Heteroarylaminomethanediphosphonic acids of the formula ##STR1## in which R.sub.1 represents an optionally benzo- or cyclohexeno-fused 5-membered heteroaryl radical that contains, as hetero atom(s), either from 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O-atom or S-atom and that is unsubstituted or is substituted by lower alkyl; by phenyl that is unsubstituted or is substituted by lower alkyl, lower alkoxy and/or by halogen; by lower alkoxy; by hydroxy; by di-lower alkylamino; by lower alkylthio and/or by halogen; and R.sub.2 represents hydrogen or lower alkyl, and their salts, have a regulatory action on the calcium metabolism and can be used as active ingredients in medicaments for the treatment of illnesses that can be attributed to disorders of the calcium metabolism. They are manufactured, for example, as follows: in a compound of the formula ##STR2## in which X.sub.1 represents a functionally modified phosphono group X and X.sub.Type: GrantFiled: May 19, 1989Date of Patent: October 15, 1991Assignee: Ciba-Geigy CorporationInventors: Leo Widler, Knut Jaeggi
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Patent number: 5051421Abstract: Benzo[b]thiophene derivatives of formula ##STR1## their tautomers and salts, in which the index n is 0, 1 or 2, alk is lower alkylene, Ar is phenyl, naphthyl or a monocyclic, five- or six-membered heteroaryl radical, wherein the aromatic radical is unsubstituted or is mono- or poly-substituted by lower alkyl, halo-lower alkyl, halogen and/or by nitro, and the ring A is unsubstituted or is mono- or poly-substituted by lower alkyl, lower alkoxy, lower alkylthio, lower alkanesulfinyl, lower alkanesulfonyl, halo-lower alkyl, halogen and/or by nitro, can be used, for example, as active ingredients in medicaments.Type: GrantFiled: January 18, 1990Date of Patent: September 24, 1991Assignee: Ciba-Geigy CorporationInventor: Pier G. Ferrini
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Patent number: 5051413Abstract: The invention relates to unsaturated amino acids of the formula I ##STR1## in which R.sup.1 represents hydroxy or etherified hydroxy, R.sup.2 represents hydrogen, alkyl, hydroxy or etherified hydroxy, R.sup.3 represents hydrogen, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl, R.sup.4 represents hydrogen, alkyl or aryl, R.sup.5 represents hydrogen or alkyl, R.sup.6 represents carboxy or esterified or amidated carboxy, R.sup.7 represents amino or amino substituted by alkyl or acyl, A represents unsubstituted or alkyl-substituted .alpha.,.omega.-alkylene having from 1 to 3 carbon atoms or represents a bond, and B represents methylene or a bond, with the proviso that A is other than a bond when B represents a bond, and salts thereof. They can be manufactured, for example, in accordance with the Michaelis-Arbuzov reaction and can be used as pharmacologically active substances.Type: GrantFiled: December 18, 1989Date of Patent: September 24, 1991Assignee: Ciba-Geigy CorporationInventors: Christof Angst, Derek E. Brundish, John G. Dingwall, Graham E. Fagg, Hans Allgeier, Guido Bold, Rudolf Duthaler, Roland Heckendorn, Antonio Togni
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Patent number: 5051524Abstract: Compounds of the formula I ##STR1## wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R.sup.1, R.sup.2 and R.sup.3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen or, in the case of R.sup.1 and R.sup.2, is hydroxy, and the remaining one of R.sup.1, R.sup.2 and R.sup.3 is hydrogen, or wherein R denotes methyl, R.sub.1 denotes hydrogen or hydroxy, R.sub.2 denotes an aromatic radical and R.sub.3 represents hydrogen, and their salts have GABA.sub.B -antagonistic properties and can be used as GABA.sub.B -antagonists. They are obtained when in a compound of formula II ##STR2## in which R, R.sup.1, R.sup.2 and R.sup.3 have their previous significances, Z represents --NH.sub.2 and R.sup.4 denotes a hydroxy-protective group R.sup.5 or, when R.sup.1 and R.sup.3 denote hydrogen and R.sup.Type: GrantFiled: February 26, 1990Date of Patent: September 24, 1991Assignee: Ciba-Geigy CorporationInventors: Eric K. Baylis, Helmut Bittiger, Wolfgang Frostl, Roger G. Hall, Ludwig Maier, Stuart J. Mickel, Hans-Rudolf Olpe
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Patent number: 5049689Abstract: Described is a novel process for the introduction of an organic acyl radical selectively at the nitrogen atom of the amino group of desferrioxamine B or of a partially O-acylated derivative thereof. It comprises treating a derivative of desferrioxamine B, in which the amino nitrogen and the hydroxy oxygen of at least one of the hydroxamic acid groupings carries an organic silyl group, with an organic acylating agent and then removing the silyl groups present. The novel N- and O-silylated starting materials can be manufactured, preferably in situ, by reacting an appropriate derivative of desferrioxamine B that has at least one hydroxy group and the amino group in free form, with an organic silicon halide.Type: GrantFiled: January 23, 1990Date of Patent: September 17, 1991Assignee: Ciba-Geigy CorporationInventors: Heinrich Peter, Theophile Moerker
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Patent number: 5047557Abstract: Compounds of the formula I ##STR1## in which Me is Ti, Zr or Hf, R.sub.1 is a group transferable to aldehyde, keto or imine groups, for example methyl, allyl, vinyl or the radical of an enol or enamine, R.sub.2 is, for example, cyclopentadienyl, R.sub.3 and R.sub.4 are, for example, H or alkyl, R.sub.5 is, for example, phenyl and the C(1) and C(2) atoms are chiral and have predominantly one configuration, are suitable for use as chiral reactants for aldehydes, ketones and imines for the preparation of both enantiomers of secondary or tertiary alcohols or tertiary amines.Type: GrantFiled: February 16, 1990Date of Patent: September 10, 1991Assignee: Ciba-Geigy CorporationInventors: Andreas Hafner, Rudolf Duthaler, Guido Bold