Patents Represented by Attorney John J. Maitner

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  • Certain aryloxy-benzoyl sulfoximines having herbicidal activity
    Patent number: 4556413
    Abstract: Benzoic acid compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, n and X are as defined hereinafter, processes for their preparation, herbicidal compositions containing these compounds and methods for the use of the compounds and the herbicidal compositions are disclosed. Novel compounds which useful as starting materials for the preparation of the benzoic acid compounds of formula I are also disclosed.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: December 3, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Frater, Milos Suchy, Jean Wenger, Paul Winternitz
  • Oxime ester herbicides
    Patent number: 4545807
    Abstract: Oxime ester compounds of the formula ##STR1## wherein A is one of the groups ##STR2## wherein B is --CH.dbd. or nitrogen and R.sub.1 is one of the groups ##STR3## wherein R.sub.2 -R.sub.7, m and n are as hereinafter set forth, processes for their preparation, herbicidal compositions containing these compounds as the active ingredient and methods of use of the herbicidal compositions are disclosed.
    Type: Grant
    Filed: December 5, 1983
    Date of Patent: October 8, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Frater, Milos Suchy, Jean Wenger, Paul Winternitz
  • 4,5,6,7-Tetrahydro-4,4,7,7-tetramethylbenzo[b]thien-2-yl or furan-2-yl derivatives
    Patent number: 4535086
    Abstract: Heterocyclic compounds of the formula ##STR1## wherein X is --CH.dbd.CH--, --O-- or --S--; R.sup.1 is a group Ar--R.sup.2 or --CH.dbd.CH--C(CH.sub.3).dbd.CH--R.sup.21 ; Ar is phenyl, pyridyl, furyl or thienyl; R.sup.2 is a group --CO.sub.2 R.sup.3, --C(O)R.sup.4, --CH.sub.2 OR.sup.3, lower-alkylsulphonyl or formyl; R.sup.21 is a group--CO.sub.2 R.sup.3, --C(O)R.sup.4, --CH.sub.2 OR.sup.3 or formyl; R.sup.3 is hydrogen or lower-alkyl and R.sup.4 is hydrogen, hydroxy, amino, lower alkylamino, di-(lower alkyl)amino or lower-alkyl; at least one ring of the molecule being heterocyclic, salts thereof, processes for their preparation, rodenticidal compositions containing these compounds as the active ingredient and methods of use of the rodenticidal compositions are disclosed.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: August 13, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Klaus, Peter Loeliger, Harald Weiser
  • Pharmaceutical compositions
    Patent number: 4532245
    Abstract: Pharmaceutical compositions of sulfonamide and sulfonamide-potentiator are disclosed. These compositions, which are suitable for injection administration, comprise an aldehyde in addition to the sulfonamide and its potentiator.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: July 30, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Ivan Kompis
  • Phenoxy phenoxy propionic hydrazides
    Patent number: 4526609
    Abstract: Propionic acid amides of the formula ##STR1## wherein R, R.sub.1 and R.sub.2 are as defined hereinafter, processes for their preparation, herbicidal compositions containing these amides and methods of use of the herbicidal compositions are disclosed.
    Type: Grant
    Filed: May 21, 1982
    Date of Patent: July 2, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Frater, Milos Suchy, Jean Wenger, Paul Winternitz
  • Process for preparing .beta.' form of copper 8-hydroxyquinoline
    Patent number: 4517362
    Abstract: A process for the preparation of the .beta.' form of the copper chelate of 8-hydroxyquinoline (copper oxinate), stabilized compositions containing said chelate, fungicidal compositions containing said chelate, and the methods for using said .beta.' form chelate or compositions for combatting fungi are disclosed.
    Type: Grant
    Filed: January 20, 1984
    Date of Patent: May 14, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernard Muller, Rene Piat, Cornelis Rensing, Jean-Paul Trajin
  • Antiprotozoal 2-nitroimidazole compounds
    Patent number: 4515790
    Abstract: 2-Nitroimidazoles having protozoocidal activity of the formula ##STR1## wherein R.sup.1 is 1-methyl-2-pyrrolidinyl or a group --CH.sub.2 -- NR.sup.2 R.sup.3 in which R.sup.2 and R.sup.3 each represent C.sub.1-4 -alkyl or --NR.sup.2 R.sup.3 is the residue of a five-membered or six-membered saturated heterocyclic ring system which optionally contains an additional nitrogen or oxygen atom in the ring, physiologically acceptable acid addition salts thereof, processes for their preparation, and pharmaceutical compositions containing these compounds are described.
    Type: Grant
    Filed: November 24, 1982
    Date of Patent: May 7, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Werner Hofheinz
  • 5-Oxo-3-thiazoline oxime and 2-oxo-5,6-dihydro-2H-1,4-thiazine oxime derivatives
    Patent number: 4514566
    Abstract: Carbamoyl-oxime compounds of the formula ##STR1## wherein A, R.sup.3, R.sup.4 and R.sup.5 are as hereinafter set forth, a process for their preparation, pesticidal compositions containing one or more of these compounds as the active ingredient, methods of use of such compositions for the control of pests, particularly insects, mites, nematodes and molluscs, and intermediates for the production of such compounds are described.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: April 30, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christoph Luthy, Paul Winternitz
  • Enzyme-immunoassay for carcinoembryonic antigen
    Patent number: 4467031
    Abstract: A solid phase-sandwich enzyme-immunoassay method for the rapid determination of carcinoembryonic antigen (CEA). The sample to be investigated is incubated with a first CEA antibody, which is bound to a water-insoluble carrier, and a second CEA antibody, to which peroxidase is bound directly or via a biotin/avidin bridge. The immunological reaction can be carried out in one or two steps. By the presence of 0.4-1.0 mol/l of phosphate ions, 0.3-0.4 mol/l of sulfate ions or 0.2-0.4 mol/l of tartrate ions in the immunological reaction or in the second step thereof (insofar as it is carried out in two steps) the incubation time period is shortened considerably. After the immunological reaction, the phases are separated, whereupon the peroxidase activity is measured either in the solid or in the liquid phase as the amount of CEA present in the sample.
    Type: Grant
    Filed: August 16, 1982
    Date of Patent: August 21, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Harald Gallati, Hans Brodbeck
  • Filaricidal 2-nitroimidazoles
    Patent number: 4456610
    Abstract: 2-Nitroimidazoles having filaricidal activity of the formula ##STR1## wherein A is one of the groups ##STR2## --C(R.sup.3).dbd.C(R.sup.1)(R.sup.2),--CHBr--CH.sub.2 Br or --CH.sub.2 --CCl.dbd.CH.sub.2 ;n is 1, 2, 3 or 4;R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 -alkyl andR.sup.3 is hydrogen, C.sub.1-3 -alkyl, chlorine or bromine, andprocesses for their preparation are described. The compounds of formula I and compounds of formula ##STR3## wherein R.sup.4 is --CH.sub.2 --CH.sub.2 OH,--CH.sub.2 --CHOH--CH.sub.2 OCH.sub.3,--CH.sub.2 --CHOH--CH.sub.2 OH or ##STR4## are useful in the treatment of filariasis is also described.
    Type: Grant
    Filed: September 23, 1982
    Date of Patent: June 26, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Hofheinz, Harro Stohler
  • Nasal administration of dextromethorphan
    Patent number: 4454140
    Abstract: The invention relates to a novel method of administering dextromethorphan, a known anti-tussive agent used for the suppresion of coughs due to colds and allergies. The novel method utilizes dosage forms of dextromethorphan which are adapted for nasal administration.
    Type: Grant
    Filed: September 7, 1982
    Date of Patent: June 12, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur H. Goldberg, Meyer Matluck, Joseph A. Ranucci
  • Breast cyst fluid protein assay
    Patent number: 4452904
    Abstract: This disclosure relates to assay of a glycoprotein component of human breast gross cystic disease fluid which has been designated GCDFP-15. This material is a useful marker in monitoring the efficacy of therapy in women with metastatic breast carcinoma and also in determining the maturity of the fetus in pregnant women. The assay for GCDFP-15 can also be used in conjunction with other assays for breast carcinoma such as an assay for carcinoembryonic antigen (CEA) whereby the utilization of both tests is more effective in monitoring for recurrence of disease than using either assay alone.
    Type: Grant
    Filed: August 13, 1981
    Date of Patent: June 5, 1984
    Assignee: Duke University
    Inventor: Darrow E. Haagensen, Jr.
  • Thiazoline derivatives
    Patent number: 4450157
    Abstract: Heterocyclic compounds of the formula ##STR1## wherein A is a group ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined hereinafter, process for their preparation, as well as pesticidal compositions containing one or more of these compounds as the active ingredient and methods for using the pesticidal compositions for the control of pests, particularly insects, mites and nematodes, are described.
    Type: Grant
    Filed: June 11, 1982
    Date of Patent: May 22, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Christoph Luthy
  • Stabilized peroxidase compositions
    Patent number: 4448882
    Abstract: A method for the stabilization of peroxidase in a medium containing a serum or serum protein by the addition of 4-amino-antipyrine and stabilized peroxidase compositions are described.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: May 15, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Brodbeck, Harald Gallati
  • Breast cyst fluid protein assay
    Patent number: 4440863
    Abstract: This disclosure relates to assay of a glycoprotein component of human breast gross cystic disease fluid which has been designated GCDFP-15. This material is a useful marker in monitoring the efficacy of therapy in women with metastatic breast carcinoma and also in determining the maturity of the fetus in pregnant women. The assay for GCDEP-15 can also be used in conjunction with other assays for breast carcinoma such as an assay for carcinoembryonic antigen (CEA) whereby the utilization of both tests is more effective in monitoring for recurrence of disease than using either assay alone.
    Type: Grant
    Filed: August 13, 1981
    Date of Patent: April 3, 1984
    Assignee: Duke University
    Inventor: Darrow E. Haagensen, Jr.
  • Quinyloxy-phenyloxy-oxime ester compounds having herbicidal activity
    Patent number: 4435207
    Abstract: Oxime ester compounds of the formula ##STR1## wherein A is one of the groups ##STR2## wherein B is --CH.dbd. or nitrogen and R.sub.1 is one of the groups ##STR3## wherein R.sub.2 -R.sub.7, m and n are as hereinafter set forth, processes for their preparation, herbicidal compositions containing these compounds as the active ingredient and methods of use of the herbicidal compositions are disclosed.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: March 6, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Frater, Milos Suchy, Jean Wenger, Paul Winternitz
  • Fungicidal compositions
    Patent number: 4434165
    Abstract: Fungicidal compositions which contains at least one compound of the formula ##STR1## wherein R.sup.1, R.sup.2 and X are as hereinafter set forth, and at least one compound of the formula ##STR2## wherein R.sup.3, Y and Z are as hereinafter set forth, and, where required, formulation adjuvants, processes for their preparation and methods for using the compositions for the control of plant fungi are disclosed.
    Type: Grant
    Filed: September 22, 1981
    Date of Patent: February 28, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Klaus Bohnen
  • Antiperspirants
    Patent number: 4434178
    Abstract: Aluminum compounds containing organic groups of the formula ##STR1## when R.sup.1 and R.sup.2 are as hereinafter set forth are disclosed as having activity as antiperspirants. Antiperspirant compositions containing one or more of these compounds as transpiration-inhibiting active ingredients and methods for preparing the compounds are also disclosed.
    Type: Grant
    Filed: September 29, 1981
    Date of Patent: February 28, 1984
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Hans U. Hostettler, Horst Pauling
  • Thiazoline carbamoyl-oximes
    Patent number: 4427687
    Abstract: Carbamoyl-oxime compound of the formula ##STR1## wherein A, R.sup.3, R.sup.4 and R.sup.5 are as hereinafter set forth, a process for their preparation, pesticidal compositions containing one or more of these compounds as the active ingredient, methods of use of such compositions for the control of pests, particularly insects, mites, nematodes and molluscs, and intermediates for the production of such compounds are described.
    Type: Grant
    Filed: April 24, 1981
    Date of Patent: January 24, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christoph Luthy, Paul Winternitz
  • Leucocyte adherence inhibition assay for detection of cancer
    Patent number: 4426446
    Abstract: Methods for carrying the leucocyte adherence inhibition (LAI) assay for detecting the presence of cancer in responsive patients. One aspect of the invention utilizes incubation with agents which maximize the intracellular cycle 3',5'-adenosine monophosphate (cAMP) levels in the leucocytes as a means to expand the percentage of responding subjects in different cancers. A second aspect utilizes measurement of extracted, vital cell dye to avoid the need of counting the adhering or non-adhering leucocytes.
    Type: Grant
    Filed: February 3, 1981
    Date of Patent: January 17, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventor: David M. P. Thomson