Patents Represented by Attorney John J. Maitner
  • Patent number: 4424235
    Abstract: Hydrodynamically balanced controlled release compositions for the preparation of pharmaceutical capsules or tablets which contain L-Dopa and a decarboxylase inhibitor and which provide superior blood levels of L-Dopa are disclosed.
    Type: Grant
    Filed: November 1, 1982
    Date of Patent: January 3, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Prabhakar R. Sheth, Jacques L. Tossounian
  • Patent number: 4423042
    Abstract: Insecticidal compositions, and methods for their use, which comprise a combination of O,O-diethyl-O-(2-isopropyl-4-methylpyrimid-6-yl)-thionophosphoric acid ester with a pyrethroid which synergizes the insecticidal activity of the thionophosphoric acid ester.
    Type: Grant
    Filed: April 5, 1982
    Date of Patent: December 27, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Silvia Dorn, Ulrich Schwieter
  • Patent number: 4421749
    Abstract: Organoaluminum compounds of the formula ##STR1## wherein m, n and R are as defined hereinafter, and processes for their preparation are disclosed. The compounds of formula I possess antimicrobial properties and are useful in cosmetic compositions, such as hair-care compositions and foot-care compositions.
    Type: Grant
    Filed: June 26, 1981
    Date of Patent: December 20, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Horst Pauling
  • Patent number: 4413010
    Abstract: Carbamic acid compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and Y are as hereinafter set forth, processes for their preparation, pesticidal compositions containing one or more of the carbamic acid compounds as the active ingredient and methods for using the pesticidal compositions for the control of pests, particularly insects, mites and nematodes, are described.
    Type: Grant
    Filed: September 14, 1981
    Date of Patent: November 1, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Rene Zurfluh
  • Patent number: 4411894
    Abstract: Pharmaceutical compositions useful for the parenteral administration of fat-soluble medicaments are disclosed. The compositions comprise, in addition to the medicaments, a sugar-containing liposome solution or lyophilizates thereof.
    Type: Grant
    Filed: August 17, 1981
    Date of Patent: October 25, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jurg Schrank, Hans Steffen
  • Patent number: 4402968
    Abstract: Imidazole compounds of the formula ##STR1## wherein A is a group of the formula ##STR2## and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or a halogen atom,pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing these compounds are described. The compounds of formula I are useful as antifungal agents. Processes for preparing the novel compounds are also disclosed.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: September 6, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Joseph A. Martin
  • Patent number: 4384116
    Abstract: The invention relates to an improved process for the preparation of fungicidally active compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 individually are lower alkyl of from 1 to 4 carbons or halo-(lower alkyl) of from 1 to 4 carbons or R.sub.1 and R.sub.2 together with the carbon to which they are attached form a 3 to 7 membered cycloalkyl ring or lower alkyl-substituted cycloalkyl of from 4 to 9 carbons, R.sub.3, R.sub.4 and R.sub.5 individually are hydrogen or lower alkyl of from 1 to 4 carbons and X is methylene or oxygen, and salts of those compounds which are basic.The improved process comprises the reaction of a compound of the formula, ##STR2## wherein R.sub.3, R.sub.4, R.sub.5 and X have the significance given hereinabove, with a compound which forms a carbonium ion of the formula ##STR3## wherein R.sub.1 and R.sub.2 have the significance as given hereinabove.
    Type: Grant
    Filed: February 2, 1981
    Date of Patent: May 17, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Albert Pfiffner
  • Patent number: 4380544
    Abstract: 1,3-Dioxolane derivatives of the formula ##STR1## wherein R is hydrogen or C.sub.1-4 -alkyl, and acid addition salts of these compounds, a process for their preparation, fungicidal compositions containing these compounds as the active ingredient and methods for the use of such compounds or compositions for combatting fungi in agriculture and in horticulture are disclosed.
    Type: Grant
    Filed: March 25, 1982
    Date of Patent: April 19, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Franz Dorn
  • Patent number: 4380661
    Abstract: 2-[p-(p-substituted phenoxy)phenoxy]propionyl oximes, processes for their preparation, herbicidal compositions containing these oximes and methods of use of the herbicidal compositions are disclosed.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: April 19, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Milos Suchy
  • Patent number: 4366166
    Abstract: 2-Nitroimidazoles having filaricidal activity of the formula ##STR1## wherein A is one of the groups ##STR2## --C(R.sup.3).dbd.C(R.sup.1)(R.sup.2),--CHBr--CH.sub.2 Br or --CH.sub.2 --CCl.dbd.CH.sub.2 ;n is 1, 2, 3 or 4;R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 -alkyl andR.sup.3 is hydrogen, C.sub.1-3 -alkyl, chlorine or bromine, andprocesses for their preparation are described. The compounds of formula I and compounds of formula ##STR3## wherein R.sup.4 is --CH.sub.2 --CH.sub.2 OH, --CH.sub.2 --CHOH--CH.sub.2 OCH.sub.3, --CH.sub.2 --CHOH--CH.sub.2 OH or ##STR4## are useful in the treatment of filariasis is also described.
    Type: Grant
    Filed: May 14, 1981
    Date of Patent: December 28, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Hofheinz, Harro Stohler
  • Patent number: 4349531
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: September 14, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur R. Mlodozeniec, Arthur H. Goldberg
  • Patent number: 4337080
    Abstract: Plant growth regulant compounds represented by the formula: ##STR1## wherein, when n is 1, R is hydrogen, sodium, potassium, ammonium, substituted ammonium, straight or branched chain alkyl of from 1 to 20 carbon atoms, straight or branched chain alkenyl of from 1 to 20 carbon atoms, straight or branched chain alkynyl of from 1 to 20 carbon atoms or halo-lower alkyl and, when n is 2, R is calcium, magnesium or lower alkylene, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen, straight or branched chain alkyl of from 1 to 7 carbon atoms, straight or branched chain alkenyl of from 1 to 7 carbon atoms, straight or branched chain alkynyl of from 1 to 7 carbon atoms, halo-lower alkyl, aryl or R.sub.1 and R.sub.2 together and R.sub.3 and R.sub.4 together are each a saturated ring containing from 3 to 8 carbon atoms, n is an integer from 1 to 2 and X is a number from 0 to 1; enantiomers and racemic mixtures.These compounds are useful as post-emergence and pre-emergence plant growth regulants and herbicides.
    Type: Grant
    Filed: October 18, 1976
    Date of Patent: June 29, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventor: William Szkrybalo
  • Patent number: 4333473
    Abstract: An apparatus for the simultaneous determination of the cutaneous blood gas concentration and of the blood gas availability for the correction of physiologically caused errors of the measured value of the cutaneous blood gas concentration by means of two heated blood gas electrodes in structural unity, of which one is distinguished by maximum gas consumption.
    Type: Grant
    Filed: September 5, 1979
    Date of Patent: June 8, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrick Eberhard, Wolfgang Mindt
  • Patent number: 4332789
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited theron or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: August 24, 1977
    Date of Patent: June 1, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Arthur R. Mlodozeniec
  • Patent number: 4330438
    Abstract: A unique powder shampoo concentrate is disclosed comprising a mixture of an anionic surfactant and a nonionic derivative of a polygalactomannan gum together with conventional shampoo ingredients, which upon dilution with water, rapidly forms a viscous, rich lathering shampoo with superior cleansing and conditioning properties.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: May 18, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Dierassi, David Murray
  • Patent number: 4328222
    Abstract: Colloidal aqueous vehicles, useful for the solubilization of insoluble or slightly soluble medicaments and suitable for parenteral or local administration, are disclosed. The vehicles contain, in addition to the medicaments, pharmaceutical adjuvants and a micelle-forming agent comprising short-chain lecithin and a non-hemolytic lipid.
    Type: Grant
    Filed: January 19, 1981
    Date of Patent: May 4, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Dieter Schmidt
  • Patent number: 4307555
    Abstract: Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: December 29, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur R. Mlodozeniec, Arthur H. Goldberg
  • Patent number: 4299815
    Abstract: An improved process for the determination of carcinoembryonic antigen in a sample of serum or plasma is disclosed. The improved process, in essence, comprises negating potentially interfering substances in the sample by diluting the sample with water and heating to a temperature below that which, at the ionic strength and pH of the sample, would cause coagulation of the proteins present and carrying out a radioimmunoassay for carcinoembryonic antigen on said sample.
    Type: Grant
    Filed: February 8, 1980
    Date of Patent: November 10, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans J. Hansen, Alfred D. Myl, Jacques P. Vandevoorde
  • Patent number: 4287204
    Abstract: Novel N-substituted 7-amino-6-nitro-4-trifluoromethyl-1,3-benzodithiol-2-ones of the formula ##STR1## wherein X is --O-- or --S--, R is C.sub.1 -C.sub.4 alkyl, R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl, and n is 2 or 3, processes for the production of these compounds, and compositions containing them for use in pest control, especially for controlling representatives of the order Acarina and insects that are parasites of plants and animals. The novel compounds are especially effective against phytophagous mites.
    Type: Grant
    Filed: April 15, 1980
    Date of Patent: September 1, 1981
    Assignee: Ciba-Geigy Corporation
    Inventor: Saleem Farooq
  • Patent number: 4277494
    Abstract: Acetates of the formula ##STR1## wherein X.sub.1 represents hydrogen, halogen or C.sub.1 -C.sub.4 alkyl, X.sub.2 represents hydrogen or halogen, and Y represents hydrogen, halogen or methyl, processes for their manufacture and a method of controlling pests which comprises the use of these compounds.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: July 7, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Saleem Farooq, Peter Ackermann, Jozef Drabek, Laurenz Gsell, Odd Kristiansen, Rudolf Wehrli