Patents Represented by Attorney John J. Maitner
  • Patent number: 4276302
    Abstract: Novel 2-(phenoxy-.alpha.-alkyl)-imidazolines of the formula ##STR1## wherein R.sub.1 and R.sub.2, each independently of the other, are methyl or chlorine, or together they are --(CH.sub.2).sub.3 or --(CH.sub.2).sub.4 group and R.sub.3 is ethyl, n-propyl or isopropyl, processes for obtaining these compounds and compositions containing them for the control of plant-damaging mites and mites which are parasites of animals.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: June 30, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans U. Brechbuhler, Gunter Mattern, Walter Traber
  • Patent number: 4246283
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, R.sub.2 is C.sub.1 -C.sub.12 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl or cyclopropylmethyl, R.sub.3 is C.sub.1 -C.sub.4 -alkyl or phenyl optionally mono-, or di- or trisubstituted by halogen and/or methyl and either (i) X.sub.1 is methyl, chlorine, bromine or hydrogen and X.sub.2 is methyl or (ii) X.sub.1 is methyl, chlorine or bromine and X.sub.2 is hydrogen exhibit valuable pesticidal, in particular acaricidal and insecticidal, properties.
    Type: Grant
    Filed: June 1, 1977
    Date of Patent: January 20, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek
  • Patent number: 4241075
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 and R.sub.2 are each chlorine or methyl, R.sub.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl and R.sub.4 is C.sub.1 -C.sub.6 -alkyl optionally substituted by cyano or phenyl optionally substituted by halogen and/or methyl are novel and are pesticidally in particular acaricidally active.
    Type: Grant
    Filed: September 17, 1979
    Date of Patent: December 23, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek, Gunter Mattern, Walter Traber
  • Patent number: 4238481
    Abstract: Sulphur-free cyclopeptides with somatostatin-analogous aminoacid partial sequences, of the formula ##STR1## in which R is Asn, Ala or de-R, trp is D-Trp or L-Trp, which can be substituted in the benzene ring by halogen atoms or nitro groups, W is a free or etherified hydroxyl group or halogen atom present as a substituent on the benzene ring of the L-phenylalanine radical, or is hydrogen, X is the radical of an .omega.-amino-lower alkane-(mono or di)-carboxylic acid or de-X and Y is the radical of an .omega.-amino-lower alkane-(mono or di)-carboxylic acid or de-Y, and also acid addition salts and complexes thereof have biological properties similar to those of somatostatin and can be used, especially in the form of pharmaceutical preparations, for the treatment of excessive secretion of somatotropin, insulin and/or glucagon. The compounds according to the invention are obtained by cyclising a corresponding linear peptide compound in which the .epsilon.
    Type: Grant
    Filed: September 15, 1978
    Date of Patent: December 9, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Rink, Bruno Kamber, Peter Sieber
  • Patent number: 4238504
    Abstract: Cyclopropanecarboxylic acid-phenoxy-.alpha.-vinyl-benzyl esters of the formula ##STR1## in which Y is chlorine or bromine, and R.sub.1 is --CH.dbd.CH.sub.2 or ##STR2## processes for producing them, and their use in combating pests.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: December 9, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Jozef Drabek, Peter Ackermann, Saleem Farooq, Laurenz Gsell, Odd Kristiansen
  • Patent number: 4235895
    Abstract: The substituted 5H-dibenz[b,f]azepine of the formula ##STR1## a process for its manufacture, pharmaceutical compositions which contain the novel compound, and a method of treating epilepsy which comprises the use thereof.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: November 25, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Blattner, Angelo Storni
  • Patent number: 4234573
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 is fluorine or chlorine and R.sub.2 is hydrogen, fluorine or chlorine having valuable insecticidal properties.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: November 18, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek
  • Patent number: 4234578
    Abstract: 6.beta.-(R.sub.a)(R.sub.b)N-methylaryl-acetylamino-6.alpha.-methoxy-2,2-dim ethylpenam-3-carboxylic acid compounds and 7.beta.-(R.sub.a)(R.sub.b)N-methylaryl-acetylamino-7.alpha.-methoxy-3-ceph em-4-carboxylic acid compounds, wherein R.sub.a and R.sub.b independently of each other represent hydrogen or optionally substituted lower alkyl, or wherein R.sub.a and R.sub.b conjointly denote optionally substituted lower alkylene, wherein the aminomethyl-substituted aryl radical represents a corresponding thienyl, furyl or phenyl radical, and wherein the 3-position in 3-cephem compounds is unsubstituted or substituted by a modified hydroxyl group or an optionally substituted methyl group, exhibit antibiotic action against Gram-negative or Gram-positive micro-organisms.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: November 18, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Beat Muller, Peter Schneider, Heinrich Peter, Hans Bickel
  • Patent number: 4233306
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 and R.sub.2 are each chlorine or methyl, R.sub.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl and R.sub.4 is cyano or a group of the formula A or B. ##STR2## and their acid addition salts possess useful pesticidal in particular acaricidal properties.
    Type: Grant
    Filed: August 3, 1979
    Date of Patent: November 11, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek, Gunter Mattern, Walter Traber
  • Patent number: 4232011
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 and R.sub.2 are each methyl or chlorine, R.sub.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.4 is methyl or ethyl, R.sub.5 is methoxy, ethoxy, C.sub.1 -C.sub.4 -alkylthio or phenyl and X is oxygen or sulphur have valuable pesticidal in particular acaricidal properties.
    Type: Grant
    Filed: October 22, 1979
    Date of Patent: November 4, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek, Gunter Mattern, Walter Traber
  • Patent number: 4230722
    Abstract: Dihalovinylcyclopropanethiolic acid esters of the formula ##STR1## wherein X.sub.1 represents fluorine, chlorine or bromine, R.sub.1 represents hydrogen, methyl, ethynyl or cyano, and Y represents hydrogen, fluorine, chlorine or bromine, processes for their manufacture, and a method of controlling pests which comprises the use of these compounds.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: October 28, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Roger Malherbe, Daniel Bellus, Laurenz Gsell
  • Patent number: 4228175
    Abstract: Compound of the formula I ##STR1## wherein R.sub.1, R.sub.1 ', R.sub.2 and R.sub.2 ' are each chlorine or methyl and R.sub.3 and R.sub.3 ' are each hydrogen or C.sub.1 --C.sub.4 -alkyl possess valuable pesticidal in particular acaricidal properties.
    Type: Grant
    Filed: August 23, 1979
    Date of Patent: October 14, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Josef Drabek, Gunter Mattern, Water Traber
  • Patent number: 4225616
    Abstract: Cyclopropanecarboxylic acid esters of the formula ##STR1## in which X.sub.1 is fluorine, chlorine or bromine, R.sub.1 and R.sub.2 are each hydrogen, fluorine, chlorine, bromine or methyl, R.sub.3 and R.sub.4 are each hydrogen, fluorine, chlorine, bromine, methyl, methoxy, nitro or dimethylamine, or together are methylenedioxy, and R.sub.5 is hydrogen or methyl, processes for producing them, and their use in controlling insect pests.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: September 30, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Ackermann, Jozef Drabek, Saleem Farooq, Laurenz Gsell, Odd Kristiansen, Rudolf Wehrli
  • Patent number: 4223027
    Abstract: Phenylformamidines of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen, R.sub.4 represents methyl or ethyl, and R.sub.5 represents C.sub.1 -C.sub.8 -alkyl or C.sub.3 -C.sub.6 -cycloalkyl, processes for producing them, and their use for combating pests.
    Type: Grant
    Filed: January 15, 1979
    Date of Patent: September 16, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek
  • Patent number: 4221806
    Abstract: Novel benzothiopyran derivatives of the general formula ##STR1## in which R is free, esterified or amidated carboxyl or free or etherified hydroxymethyl, Ph is 1,2-phenylene which contains the group R--CO--NR.sub.3 -- and can be substituted, X is a group of the formula --CO--CR.sub.1 .dbd.CR.sub.2 --, in which R.sub.1 and R.sub.2 independently of one another are hydrogen, acyl or a substituted or unsubstituted hydrocarbon radical or a hetero-analogue thereof or together are 3-membered to 5-membered lower alkylene, and R.sub.2 can also be free or etherified hydroxyl or hydroxyl esterified by an organic carboxylic acid, and R.sub.3 is hydrogen or lower alkyl, possess antiallergic properties and can be used as medicaments.
    Type: Grant
    Filed: February 8, 1979
    Date of Patent: September 9, 1980
    Assignee: Ciba-Geigy Corporation
    Inventor: Pier G. Ferrini
  • Patent number: 4217350
    Abstract: A process known per se for the manufacture of oxygenated N-aryl-diazacyclic compounds of the formula ##STR1## wherein each of R.sub.1 and R.sub.2 represents a substituted or unsubstituted aryl group and alk represents a lower alkylene group which separates both nitrogen atoms from each other by 2 or 3 carbon atoms, or salts thereof.The novel compounds can be used as antihypertensives, antitachycardiac agents and .alpha.-receptor blockers.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: August 12, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Kurt Eichenberger, Hans Kuhnis, Franz Ostermayer, Herbert Schroter
  • Patent number: 4216155
    Abstract: The present invention relates to novel benzopyrane derivatives, especially 3-oxaloamino-4-oxo-4H-1-benzopyrane derivatives of the formula I ##STR1## in which Ph is substituted or unsubstituted 1,2-phenylene, R is free, esterified or amidated carboxyl and R.sub.1 is hydrogen or a substituted or substituted hydrocarbon radical, in the free form or in the form of a salt, exhibit antiallergic activities and are accordingly useful as active ingredients of antiallergic pharmaceutical preparations.
    Type: Grant
    Filed: July 11, 1978
    Date of Patent: August 5, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Georges Haas, Alberto Rossi, Knut A. Jaeggi, Alex Sele
  • Patent number: 4213980
    Abstract: 3,4-Dihydro-2H-1,2-benzothiazine 1,1-dioxides of the formula ##STR1## wherein Ph represents a substituted or unsubstituted 1,2-phenylene radical, R represents a substituted or unsubstituted benzopyrone radical, and R.sub.1 represents hydrogen or a substituted or unsubstituted hydrocarbon radical of aliphatic character, and their salts, possess antiinflammatory properties and are useful as medicaments.
    Type: Grant
    Filed: January 17, 1979
    Date of Patent: July 22, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Alex Sele, Pier G. Ferrini, Georges Haas, Knut A. Jaeggi, Alberto Rossi
  • Patent number: 4213993
    Abstract: New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: July 22, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Ernst Habicht, Pier G. Ferrini, Alfred Sallmann
  • Patent number: 4210655
    Abstract: Compounds of the class of (2-benzofuranyl)-1,2,3,6-tetrahydropyridines and (2-benzofuranyl)-piperidines which at the ring nitrogen atom are unsubstituted or substituted by a substituent of the class of certain aliphatic, cycloaliphatic and araliphatic radicals, and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties. In particular, they inhibit monoamine oxidase and antagonize the action of tetrabenazine. They are useful as active ingredients for therapeutic compositions for the treatment of mental depression. Specific embodiments are 4-(2-benzofuranyl)-piperidine, 2-(5,6-dimethyl-2-benzofuranyl)-piperidine and their hydrochlorides.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: July 1, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Karl Schenker, Raymond Bernasconi