Abstract: Novel tricyclic arylsulfonamides useful for treating hypertension and bronchoconstiction, as well as to their pharmaceutical compositions and methods for using the same.

Abstract: Methods and pharmaceutical compositions are disclosed for reducing intraocular pressure. The methods and compositions employ an active ingredient which comprises certain benzothiadiazinyl and quinazolinyl substituted carboxyalkyl dipeptides wherein the benzothiadiazinyl or quinazolinyl portions are joined to the dipeptide portions by an aminocarbonyl group.

Abstract: Pharmaceutical compositions and a method for reducing intraocular pressure by topically applying a carboxyalkyl dipeptide are disclosed.

Abstract: Cyclopentyl purine derivatives, novel intermediate thereof and processes for their preparation are disclosed.

Abstract: Novel process for preparing cyclopentyl purine derivatives is disclosed.

Abstract: A sensor and a method for determining the concentration or the partial pressure of oxygen comprising:(a) means for transmitting and collecting light to and from a light modifying medium; and(b) a light modifying medium containing a luminescent dye dispersed in or upon a matrix and the dye is accessible to oxygen, wherein said luminescent dye contains a hexanuclear core of molybdenum, tungsten or mixtures thereof having 14 coordination sites, wherein each coordination site is occupied by a ligand.

Abstract: Novel compounds and compositions which inhibit SRS-A in mammals are disclosed. Methods for preparing said compounds and compositions and methods for their use for treating allergic reactions, inflammation and for reducing the severity of myocardial infarction resulting from heart attack are disclosed.Useful intermediates for preparing said compounds are also disclosed.

Abstract: There is disclosed a novel microorganism Aspergillus niveus, ATCC 20922, and a process for chiral reduction of ketones using said microorganisms.

Abstract: The present invention relates to ophthalmological pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the treatment of glaucoma.

Abstract: Methods and pharmaceutical compositions are disclosed for reducing intraocular pressure. The methods and compositions employ an active ingredient which comprises certain benzothiadiazinyl and quinazolinyl substituted carboxyalkyl dipeptides wherein the benzothiadiazinyl or quinazolinyl portions are joined to the dipeptide portions by an aminocarbonyl group.

Abstract: Processes for preparing bicyclic compounds useful as anti-allergic, anti-inflammatory and/or cytoprotective agents are described, together with a process for preparing intermediates thereof.

Abstract: The invention features a novel hybrid interferon species that comprises a chain of 161 and/or 162 amino acids. The hybrid is novel not only for its new structure, but also because the hybrid comprises a shortened or truncated segment of alpha interferon, and hence, an entirely new interferon species which is not occurring in nature.

Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain aryl-substituted naphthyridines and pyrido-pyrazines.

Abstract: Novel and useful silylenol intermediates for preparing penem and carbapenem antibacterials and a process for making selected intermediates are disclosed.

Abstract: A method of manufacture and the product made thereby are set forth; in the preferred and illustrated embodiment, a core including an insect poison is encapsulated by shell material melting and hardening for encapsulation. The core is primarily soybean extract mixed with DURSBAN.RTM. insecticide, an example of a toxicant. The surrounding shell or encapsulation is formed by melt extrusion of shell material. The surrounding shell encloses the core material to form an impervious shell. The surrounding shell includes soy protein as an insect attractant mixed in gelatin or poly(vinyl alcohol). A gelling agent such as carrageenan and the attractant were added to the shell. The beads formed by the melt extrusion encapsulation has sufficient shell strength to enable mechanical handling for dispensing, are resistant to water, do not bleed from the inside to the outside, and yet can be penetrated by the insect.

Abstract: Certain substituted sulfonamide quinolines and isoquinolines are disclosed having anti-allergic activity. A preferred use is for the treatment of chronic obstructive lung disease, and in particular, asthma.

Abstract: The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treatment of glaucoma.

Abstract: Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is defined hereinbelow.

Abstract: A method for reducing intraocular pressure by topically applying 7-{N-[1(S)-Carboxy-3-phenylpropyl]-(S)-alanyl}-1,4-dithia-7-azaspiro[4.4]n onane-8(S)-carboxylic acid is disclosed.

Abstract: In accordance with the present invention, 2,3,5,6-tetrachloropyridine is advantageously prepared by contacting pentachloropyridine in a solvent selected from the group consisting of alkylnitriles, water, alkylsulfoxides, tetramethylsulfone, C-1 to C-5 alcohols, alkyl carbonates and mixtures thereof, in the presence of an ammonium salt of an organic or inorganic acid with about 0.7 to about 1.1 g atoms of zinc per mole of pentachloropyridine.