Abstract: A method for cleaning elastomeric articles comprising contacting the elastomeric article with at least one supercritical fluid under conditions and for a time sufficient to remove the phtalates and/or polynuclear aromatic hydrocarbons (PAHs) contained therein. Elastomeric articles having a reduced phtalate and/or PAH content prepared by the above method are also claimed. Such elastomeric articles having reduced phtalate contents can be utilized as gaskets, valves, seats, flaps or plugs in metered dose delivery devices such as aerosols for demanding medicinal and pharmaceutical uses.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
January 19, 1999
Assignee:
Schering Corporation
Inventors:
Michelle A. DeCrosta, Indradat Jagnandan
Abstract: A pharmaceutical composition comprising:i) substantially inert beads; wherein said beads are coated withii) an antifungal agent which is (-)-(2R-cis)-4-?4-?4-?4-??-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-tr iazol-1-ylmethyl)furan-3-yl!methoxy!phenyl!-1-piperazinyl!phenyl!-2,4-dihyd ro-2-?(S)-1-ethyl-2(S)-hydroxypropyl!-3H-1,2,4-triazol-3-one;iii) a binder to enables the antifungal compound to adhere to said beads.The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.
Type:
Grant
Filed:
June 20, 1997
Date of Patent:
December 8, 1998
Assignee:
Schering Corporation
Inventors:
Surendra A. Sangekar, Winston A. Vadino, Ping I. Lee
Abstract: A pharmaceutical composition comprising:i) an antifungal agent which is (-)-(2R-cis)-4-?4-?4-?4-??-5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-t riazol-1-ylmethyl)furan-3-yl!methoxy!phenyl!-1-piperazinyl!phenyl!-2,4-dihy dro-2-?(S)-1-ethyl-2(S)-hydroxypropyl!-3H-1,2,4-triazol-3-one;ii) at least one non-ionic surfactant; andiii) a diluent.The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.
Type:
Grant
Filed:
May 21, 1997
Date of Patent:
November 10, 1998
Assignee:
Schering Corporation
Inventors:
Surendra A. Sangekar, Winston A. Vadino, Ping I. Lee
Abstract: The compound of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are as defined herein, are described. These compounds are antibacterial agents.
Type:
Grant
Filed:
December 20, 1996
Date of Patent:
August 18, 1998
Assignee:
Schering Corporation
Inventors:
Viyyoor M. Girijavallabhan, Anil K. Saksena, Frank Bennett, Edwin Jao, Naginbhai M. Patel, Ashit Ganguly
Abstract: A stable sulfide containing composition is disclosed, including a process for preparation thereof and a method for using the composition to soften nails or to treat ingrown toenail.
Type:
Grant
Filed:
July 26, 1995
Date of Patent:
June 23, 1998
Assignee:
Schering-Plough HealthCare Products, Inc.
Inventors:
Joseph A. Haslwanter, Gerald R. Dever, Thomas J. Laughlin
Abstract: A colored, sunscreen emulsion is disclosed which employs a water-soluble dye or a blend of water-soluble dyes whose color substantially disappears when the sunscreen emulsion dries after it is spread on the skin and/or is rubbed out. The coloration in the sunscreen enables the user to more effectively protect against sunburn by allowing more complete and uniform coverage of the sunscreen on the skin.
Type:
Grant
Filed:
November 25, 1996
Date of Patent:
May 5, 1998
Assignee:
Schering-Plough HealthCare Products, Inc.
Abstract: A stable powder composition comprising an anti-fungal effective amount of an imidazole antifungal compound and talc coated with a hydrophobic coating is described. A method for stabilizing an imidazole antifungal compound in a talc composition is also described which comprises either using talc coated with a hydrophobic coating or coating talc with a hydrophobic coating, prior to adding the imidazole antifungal compound to the talc.
Type:
Grant
Filed:
March 7, 1995
Date of Patent:
January 27, 1998
Assignee:
Schering-Plough HealthCare Products, Inc.
Abstract: The present invention relates to ophthalmo-logical pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the treatment of glaucoma.