Abstract: A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a proteasome inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the proteasome inhibitor alone or the telomerase inhibitor alone. Preferably, efficacy is supraadditive or synergistic in nature relative to the combined effects of the individual agents, with minimal exacerbation of side effects.

Abstract: An apparatus and method is characterized by providing an optical transfer function between a predetermined illuminated surface pattern, such as a street light pattern, and a predetermined energy distribution pattern of a light source, such as that from an LED. A lens is formed having a shape defined by the optical transfer function. The optical transfer function is derived by generating an energy distribution pattern using the predetermined energy distribution pattern of the light source. Then the projection of the energy distribution pattern onto the illuminated surface is generated. The projection is then compared to the predetermined illuminated surface pattern to determine if it acceptably matches. The process continues reiteratively until an acceptable match is achieved.

Abstract: A method of changing or otherwise converting the biological activity of a PKC peptide agonist to a peptide antagonist is described. The method involves substituting one or more amino acid residues so as to effect a change in charge in the peptide and/or to otherwise make the sequence similar to a sequence derived from the PKC binding site on the RACK protein for the respective PKC enzyme. Methods of inhibiting the activity of a PKC enzyme, and various peptide antagonists of ?PKC are also disclosed.

Abstract: A recessed light fixture includes an LED light source and a reflector extending 360 degrees around a center line of light output from the light source. A cross-sectional geometry of the reflector includes a bell-shaped curve with two radii of curvature that join together at an inflection point. One of the radii defines a top portion of the curve, which is disposed above the inflection point and reflects light in a concentrated manner to achieve desired light at higher angles. The other radii defines a bottom portion of the curve, which is disposed below the inflection point and is more diverging than the top portion.

Abstract: A greeting card display includes an upper tier and a lower tier positioned below the upper tier. The upper and lower tiers include multiple rows of pockets for displaying greeting cards. The pockets of the upper tier typically present greeting cards in a full-facing manner to display the full face of each greeting card. The pockets of the lower tier typically present greeting cards in a partial-facing manner. The upper tier can include a card highlighter positioned along one of the rows of pockets and having pockets to present and highlight cards placed therein. Shadowboxes capable of displaying a greeting card in a full-facing manner can be positioned above the upper tier on the display and are designed to attract the attention of the consumer. A display panel, designed to evoke emotions associated with greeting cards in the shadowboxes, can be positioned between one or more of the shadowboxes.

Abstract: Device protection using temperature compensation. A logic module associated with groups of capacitors adjusts complex impedance planes associated with the capacitor groups to account for ambient temperature variations. In particular, the logic module is configured to adjust a center of a circle of each complex impedance plane based on an average impedance. The average impedance for a selected capacitor group includes impedance measurements for groups other than the selected group, to prevent capacitor failures in that group from skewing the average. The logic module can adjust the circle center in response to changes in average impedance over periods of time. For example, the logic module can filter measured differences in average impedance using a low pass filter, to distinguish slow impedance changes caused by temperature variations and rapid impedance changes caused by capacitor failures. The logic module can adjust the circle center in accordance with the filtered difference value.

Abstract: Systems and methods for installing row-mounted suspended light fixtures. Each of a row of suspended light fixtures includes brackets disposed on opposite ends of the fixture. Each bracket includes a slot configured to slidably receive an adjustment clip coupled to a support member, such as a ceiling cable or pendant. Each adjustment clip includes first and second segments disposed at a non-zero, acute angle relative to one another such that a space separates the first and second segments. The space is configured to receive a portion of one or more brackets associated with the adjustment clip, proximate the bracket slot(s). An operator can install the light fixtures by positioning a fastener through each adjustment clip, outside the bracket slot(s). He also can adjust an alignment and balance of one or more of the light fixtures by sliding one or more of the adjustment clips along the slot(s) associated therewith.

Abstract: Float charging a battery comprises charging a battery to a reference voltage that is less than a maximum voltage of the battery. A power source provides power to a charging circuit. The circuit supplies a reference voltage. An operational amplifier float charges the battery to the reference voltage. A comparator determines whether the battery's voltage exceeds the reference voltage. Another comparator determines whether current through the battery exceeds a reference current. A thermistor determines whether the battery's temperature exceeds a safe range. A microprocessor monitors the inputs from the comparators and the thermistor and outputs of the circuit. If the comparators or the thermistor reports a safety fault to the microprocessor, the microprocessor shuts down the charging current to the battery. If an output circuit draws too much current from the battery, the microprocessor can disconnect the battery from the output circuit.

Abstract: Compositions and methods relating to aromatic imine compounds and methods of their use are described. The compounds are formed from aromatic aldehydes and amino or amino derivatives. The compounds and their derivatives are useful, for example, as hydrogen sulfide and mercaptan scavengers for use in both water and petroleum products.

Abstract: A method of reducing damage to cells and tissue caused by an ischemic or hypoxic event is disclosed. The method includes administering to the cell or tissue, either in vivo or ex vivo, ??RACK peptide. The peptide can be administered before, during or after the ischemic or hypoxic event.

Abstract: A locking device for a rail adjustment system of a vehicle seat, with a number of locking bolts and with a lever element, which is pivotable about a pivoting axis, for unlocking the locking bolt is provided, wherein the locking bolts can be unlocked by an application of force to an adjusting surface of the lever element in the unlocking direction. Furthermore, a rail adjustment system is provided which comprises an upper rail which can be connected to a vehicle seat, a lower rail which can be mounted in a positionally fixed manner, an articulation shaft and a locking device of the type mentioned at the beginning.

Abstract: Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.

Abstract: A device for inducing weight loss in a patient includes a tubular prosthesis positionable at the gastro-esophageal junction region, preferably below the z-line. In a method for inducing weight loss, the prosthesis is placed such that an opening at its proximal end receives masticated food from the esophagus, and such that the masticated food passes through the pouch and into the stomach via an opening in its distal end.