Abstract: Rotation fitting secured to a frame (6) of the fuselage of an aircraft and linked to a receiving element secured to the empennage (5) which comprises a central fitting (1) and two side fittings (2,3), the central fitting (1) presenting two lugs (1d,1k) with an opening (1e,1j) each and four side wings (1g,1f,1i,1h), and each one of the side fittings (2,3) presenting a lug (2d,3d) with an opening (2e,3e) each and two side wings (2g,2f,3g,3f), the central fitting (1) being secured to a surface of the frame (6) and the side fittings (2,3) in an opposite surface of the frame (6), such that the frame (6) is arranged between the central fitting (1) and the two side fittings (2,3), such that the lugs (1d,1k) of the central fitting (1) make contact with the lugs (2d,3d) of the side fittings, with all the openings (1e,1j,2e,3e) being aligned in order to house a pin (4) associated with the receiving element secured to the empennage (5).
Abstract: A method for fabrication of nanometer scale metal fibers, followed by optional further processing into cables, yarns and textiles composed of the primary nanofibers. A multicomponent composite is first formed by drilling a billet of matrix metal, and inserting rods of the metal desired as nanofibers. Hexed or round rods can also be inserted into a matrix metal can. The diameter of this composite is then reduced by mechanical deformation methods. This composite is then cut to shorter lengths and reinserted into another billet of matrix metal, and again the diameter is reduced by mechanical deformation. This process of large scale metal stacking followed by mechanical deformation is repeated until the desired fiber size scale is reached, the fibers being contained in the matrix metal. After size reduction, the composite metal wires may be further processed into built up configurations, depending on intended application, by stranding, cabling, braiding, weaving, knitting, felting, etc.
Type:
Grant
Filed:
September 26, 2005
Date of Patent:
July 21, 2009
Assignee:
Oxford Superconducting Technology
Inventors:
Seung Hong, William G. Marancik, Jeff Parrell, Michael Field, Kenneth Marken, Youzhu Zhang
Abstract: The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.
Type:
Grant
Filed:
November 8, 2004
Date of Patent:
June 30, 2009
Assignee:
Illumina Cambridge Limited
Inventors:
Darren James Ellis, Colin Lloyd Barnes, Harold Philip Swerdlow, Tom Brown
Abstract: The invention relates to a material which, once calcined and in the anhydrous state has general formula x (M1/n XO2):z ZO2:y GeO2:(1?y) SiO2, wherein x has a value of less than 0.2, preferably less than 0.15 and can equal zero; z has a value of between 0 and 0.1, preferably between 0 and 0.05; y has a value of between 0 and 1, preferably between 0 and 0.75; M represents one or more +n charged inorganic cations; X represents one or more +3 oxidation state chemical elements (Al, B, Ga, Fe); and Z represents one or more +4 oxidation state cations different from silicon and germanium, preferably Ti or Sn. Said material can be used as a component of catalysts in acid catalysis processes or as a metal or oxide support in separation and absorption/adsorption processes.
Type:
Grant
Filed:
September 8, 2006
Date of Patent:
June 30, 2009
Assignees:
Consejo Superior De Investigaciones Cientificas, Universidad Politecnica De Valencia
Inventors:
Avelino Corma Canós, María José Sabater Picot, Fernando Rey García, Susana Valencia Valencia
Abstract: The present invention relates to sunflower seeds which have been genetically modified through two artificial induction cycles of mutations followed in each case by processes for the identification of mutant individuals which have the desired character. The disclosed seeds are characterised in that they contain between 26% and 80% of the tocopherols as delta-tocopherol. This high delta-tocopherol production is determined by the genotype of the seeds which have been modified to this effect, and is always obtained independently of the culture conditions, thereby obtaining an inheritable character. Today, sunflower seeds producing such high levels of delta-tocopherol do not exist. Genetically modified sunflower plants which produce through self-fertilization seeds with high delta-tocopherol levels and the oil with high natural delta-tocopherol concentration, extracted from the seeds, are also objectives of the present invention.
Type:
Grant
Filed:
October 7, 2005
Date of Patent:
June 9, 2009
Assignee:
Consejo Superior De Investigaciones Cientificas
Inventors:
Leonardo Velasco Varo, José M. Fernández Martínez
Abstract: The present invention relates to a tracheal intubation device and method for placing an endotracheal tube within a patient's trachea. More particularly, the endotracheal tube includes primary and secondary cuffs, in the form of inflatable balloons. A stillette is positioned within the endotracheal tube. The tracheal intubation device includes a guiding mechanism for guiding the stillette and the endotracheal tube within a patent's body. The guiding mechanism is positioned external to a patient and sized and shaped so as to transmit a signal and to receive a signal indicating the location of the stillette in a patient's body. After the endotracheal tube is positioned in the oropharynx, inflating the secondary cuff urges the endotracheal tube toward the trachea of a patient.
Type:
Grant
Filed:
December 16, 2005
Date of Patent:
June 9, 2009
Assignee:
University of Medicine & Denistry of New Jersey
Abstract: The system includes a plurality of user kits and a head-end kit in bi-directional communication over the electricity network. Its essential characteristics are: carrier by carrier treatment of transmission and reception signals and control of transmission power in each kit. The system makes it possible to reach the maximum the number of users, it maximizes transmission capacity, it admits signals coming from users situated at varying distances both near and far, it avoids the production of overflows, it introduces the maximum average power for the range available to the communication and it minimizes the number of bits necessary for the analog/digital conversion in reception.
Type:
Grant
Filed:
November 17, 2003
Date of Patent:
June 9, 2009
Assignee:
Diseno de Sistemas en Silicio, SA
Inventors:
Jorge Vicente Blasco Claret, Juan Carlos Riveiro Insua, José Abad Molina, Salvador Iranzo Molinero, Alejandro Matas Bonilla, Francisco Javier Jimenez Marquina, Nils Hakan Fouren
Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is ex
Type:
Grant
Filed:
August 22, 2003
Date of Patent:
June 2, 2009
Assignee:
Illumina Cambridge Limited
Inventors:
John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
Abstract: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.
Type:
Grant
Filed:
July 30, 2007
Date of Patent:
June 2, 2009
Assignees:
Acorda Therapeutics, Inc., Ludwig Institute for Cancer Research
Inventors:
Andrew Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchioni, Mario Su Chen, Ian Hiles
Abstract: The invention relates to a process of producing polyunsaturated fatty acids through the incorporation of olefinic or acetylenic fatty acids with a chain length of 13-18 carbon atoms as substrates with a haploid or diploid wild strain of Saccharomyces cerevisiae yeast W 303a or ?Elo1, which can be used to generate a novel linkage with configuration Z in position 9 of said substrates. The novel desaturation is only produced if the original unsaturation in the administered products has configuration E or is an acetylene. Moreover, if the original linkage has configuration Z, the substrate is recovered unaltered.
Type:
Grant
Filed:
March 31, 2005
Date of Patent:
May 26, 2009
Assignee:
Consejo Superior De Investigaciones Cientificas
Inventors:
Francisco Camps Díez, Sergio Rodríguez Ropero, Gemma Fabriàs Domingo, Benjamin Piña Capo
Abstract: An enzymatic process to obtain 4-O-?-D-galactopyranosyl-D-xylose useful in compositions or solutions in the in vivo evaluation of intestinal lactose activity in humans, that comprises the steps of preparing a reaction mixture of D-xylose, a ?-D-galactopyranoside and a reaction medium that comprises water buffered to a pH between 5.0 and 9.0; adding 10 to 1,000 units of ?-D-galactosidase per gram of ?-D-galactopyranoside; subjecting the reaction mixture to a reaction or a temperature between a temperature higher than the freezing point of the reaction mixture and 45° C., for 2 to 48 hours; for the reaction by deactivation of the ?-D-galactosidase; and to isolate and crystallize the fractions that contain 4-O-?-D-galactopyranosyl-D-xylose from a crystallization mixture selected between mixtures of acetone/methanol in a ratio between 5/1 to 20/1 and mixtures of acetone/water in a ratio between 5/1 to 20/1.
Type:
Grant
Filed:
December 17, 2003
Date of Patent:
May 26, 2009
Assignees:
Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid
Inventors:
Francisco Javier Cañada Vicinay, Guillerno Corrales Morales, Alfonso Fernández-Mayoralas Alvarez, Manuel Martín Lomas, Juan José Aragón Reyes
Abstract: A method is disclosed for producing an energetic metastable nano-composite material. Under pre-selected milling conditions a mixture of powdered components are reactively milled. These components will spontaneously react at a known duration of the pre-selected milling conditions. The milling is stopped at a time at which the components have been compositionally homogenized to produce nanocomposite powder, but prior to said known duration, and thereby before the spontaneous reaction occurs. The milled powder is recovered as a highly reactive nanostructured composite for subsequent use by controllably initiating destabilization thereof.
Abstract: There is disclosed a prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement.
Type:
Grant
Filed:
July 16, 2004
Date of Patent:
April 14, 2009
Assignee:
Solexa Limited
Inventors:
Mark Osborne, Jason Bryant, Bojan Obradovic, Harold Swerdlow
Abstract: The present invention relates to human Rif1 (hRif1) nucleic acid sequences and human Rif1 amino acid sequences encoded therefrom. The invention also encompasses antibodies that are immunologically specific for human Rif1 polypeptides. Also included in the present invention are methods directed to detecting Rif1 foci formed in response to various treatments that induce DNA damage. The formation of foci comprising Rif1 in response to DNA damage serves as a positive indicator of the presence of wild type ATM kinase activity in a cell, whereas the absence of detectable Rif1 foci under such circumstances serves to identify a cell with reduced ATM kinase activity. Modulators of ATM kinase activity and/or Rif1 activity and methods for identifying such modulators are also included in the present invention.
Abstract: Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.
Type:
Grant
Filed:
May 30, 2007
Date of Patent:
March 10, 2009
Assignee:
Galapagos, NV
Inventors:
Martin James Inglis Andrews, Paul Edwards, Mark Stuart Chambers, Wolfgang Schmidt, Juha Andrew Clase, Gregory Bar, Kim Louise Hirst, Angus MacLeod
Abstract: The present invention relates to the mounting of electronic display devices with portals for attaching various other electronic devices using cables in a streamlined, versatile fashion. More specifically, the present system relates to an apparatus that provides cable management for electronic devices such as audio speakers, LCD projectors, electronic text boards, televisions, liquid crystal display (LCD) or other flat panel monitors (“display monitors”), and many other electronic devices. Furthermore, the present invention provides a versatile mounting system whereby any of the above electronic devices can be conveniently affixed to a variety of surfaces, such as walls, desks, and even unconventional bases such as store displays or mannequins.
Abstract: The present invention relates to a biodegradable polymeric nanocapsule composition, adaptable for encapsulation of an agent of therapeutic interest for enhancing the in vivo circulation time of thereof and uses thereof.
Type:
Grant
Filed:
August 28, 2002
Date of Patent:
March 3, 2009
Inventors:
Thomas M. S. Chang, Wei-Ping Yu, Douglas Powanda
Abstract: The invention relates to surfactant-free reagent spheres useful for biological tests particularly those involving antigen/antibody reactions.