Abstract: A method of preparation of a liquid electrostatographic toner or liquid ink jet ink which includes the steps of heating a marking particle mix of particles of a resin and a colourant blend in a carrier liquid to a temperature between about the first softening point of the resin and about the second softening point of the resin, maintaining the temperature of the heated marking particle mix for a selected period of time, cooling the marking particle mix to room temperature, and mixing the marking particle mix with high shear. The particle mix can be produced by coarse grinding in a ball mill. The resultant toner or ink has an improved Newtonian like flow behaviour, improved electrical properties, reduced sedimentation and agglomeration and significantly improved optical density and reduced background. The invention also includes toners and inks produced by the method.

Abstract: The present invention refers to a microporous crystalline material of zeolitic nature (ITQ-22) which, in the calcined state, has the empirical formula x(M1/nX02):yYO2:zR:wH20 wherein M is H+ or at least one inorganic cation of charge +n; X is at least one chemical element of oxidation state +3, preferably selected from the group consisting of Al, Ga, B, Fe and Cr; Y is at least one chemical element with oxidation state +4 other than Si and Ge, preferably selected from the group consisting of Ti, Sn and V; x has a value less than 0.2, preferably less than 0.1 and can take the value zero, y has a value less than 0.1, preferably less than 0.05 and can take the value zero, z has a value less than 0.8, preferably between 0.005 and 0.5 and can take the value zero, with a characteristic X-ray diffraction pattern, to the method of preparation and to the use of the material in separation and transformation processes of organic compounds.

Abstract: Cardboard boxes are formed starting from a stamped sheet which is vertically pushed by a descending core (13) for folding the sectors (6) that are going to form the sides and those that are going to form the front ends (7), including equipment for folding of the extensions and/or flaps (8, 10) which are folded on the front ends and/or sides. The mold is intended to shape boxes having an upper horizontal bridge (9) in the sides (6), bridges presenting flaps (10) which fold over the front ends (7), being fixed to the outer face of them, with these front ends (7) in turn presenting end extensions (8) which are folded in the inner face of the sides (6). The mold includes runners (11) adjustable in height, permitting to fold the end extensions (8) of the front ends (7), also having wedges in ramp (14) and presses (15) with an inclined plane (16), for folding the flaps (10) of the upper bridges (9) of the sides (6), these flaps (10) being folded on the front ends (7).

Abstract: The present invention relates to a composition of matter comprising novel prostaglandin E2 receptor antagonists, and their use in treatments for regulating the fluid filtration in the kidney, preventing bone mineral loss in osteoporosis and dental disease and additionally, closure of ductus arteriosus (DA) in premature infants or fetal animals. Additionally, the compositions include linear peptides, peptide analogs, and peptidomimetics.

Abstract: The present invention relates to a method for detecting the presence of circulating mutant BRAF DNA, which may be present in circulating melanoma cells or as DNA shed from tumor cells. Methods, compositions and kits which employ one or more sets of BRAF mutant specific primer pairs for detection of circulating mutant BRAF DNA are presented. Also provided are methods for diagnosing and/or determining stage/progression of a melanoma in a mammal based on detection of a BRAF mutant nucleic acid sequence. Such methods are also well suited to monitoring disease activity in patients with active disease or those in remission.

Abstract: The invention provides an improved display board apparatus which can be folded down when not in use so as to be substantially flat. The apparatus 41 when in its assembled erect condition, has a front panel 12, a rear panel 14 joined to the front panel along opposite vertical sides thereof, and a plurality of elastic traction members 42 attached to the rear panel 14 and arranged to tension rear panel 14 so that the front panel 12 assumes a convex shape. The improvement consists of an integrally formed rearwardly projecting spine 44 in the rear panel 14 extending between the upper and lower edges thereof, the spine 44 being delineated by a plurality of parallel spaced apart fold lines 24, 26, 26?. Each of the elastic traction members 42 extends across and through the spine and has its opposite ends anchored at locations adjacent the sides of the spine 44.

Abstract: The present invention relates to cytokine activity regulator molecules (CARMs) and their use in controlling the action of cytokines, particularly chemokines. In particular, the invention relates to CARMs that are derived from parasite salivary glands. The invention also relates to the use of CARMs in the treatment of diseases and allergies and in the production of vaccines that protect mammals, including humans, against the transmission of pathogenic (disease-causing) micro-organisms by certain parasites.

Abstract: The invention relates to a method of preparing an alkylated aromatic compound. The inventive method is characterized in that it comprises an alkylation reaction of an aromatic compound with an alkylating agent which is selected from an olefin, an alcohol and a polyalkylated aromatic compound, in the presence of a catalyst which is a porous crystalline material with the following chemical composition in the calcined form: X2O3:n YO2:m ZO2, wherein (n+m) is at least 5, X is at least a trivalent element, Z is Ge, Y is at least a tetravalent element different from Ge and the n/m ratio is at least 1. Said method is particularly suitable for obtaining cumene.

Abstract: A chamber dropper bottle is disclosed that is sized to contain medicine. The dropper bottle includes a central recess in a bottom wall of the bottle. The recess is sized to accommodate a single dose of medicine. A central tapered cylindrical dropper chamber extends into the recess, while an annular medicine chamber is positioned about the central tapered cylindrical dropper chamber. The central tapered cylindrical dropper chamber includes one or more apertures sized to allow fluid to flow between the annular medicine chamber, the central tapered cylindrical dropper chamber and the recess.

Abstract: The present invention relates to a novel method for screening to identify/detect polypeptides capable of translocating into or out of the nucleus of a cell in response to induction by an external stimulus or stimuli. Kits for practicing the method of the invention are also encompassed by the present invention.

Abstract: This method reduces the variance of the estimation of the signal-to-noise rate in a multiuser digital communications system. These communications require a sending of a phase reference symbol prior to sending a information, where the estimation is made of the signal-to-noise rate in order to use a modulation with a maximum number of bits per symbol, maintaining a bit error probability in reception within certain given margins. The method minimizes and equalizes the variance of the samples obtained for the different values, even and odd of bits per carrier, which the system uses. The estimation is necessary for selecting the number of bits per carrier in order to be adapted to the channel and as back-up information in the event of using a receiver with diversity.

Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.

Abstract: The system in this invention is applicable to bi-directional communication over the electricity network between a head-end and a plurality of users, and permits the synchronization in time and frequency of multiple users in a multi-carrier OFDM communication system. It is characterized in that it consists of the generation of synchronization sequences by means of two identical synchronization symbols, periodically transmitted in the downstream, from the head-end to the users to estimate and correct the sampling frequency and simultaneously estimate the moment in which each OFDM symbol commences.

Abstract: Sealing device for the flap track for the flap-actuating shaft, in the belly fairing of an aircraft, with a top hollow body 1 and a bottom hollow body 7 which are flexibly compressible, each comprising at least one interior chamber 2, 8 with open sides 2a, 2b, a wall 3, 9 with respective external contact surfaces 3a which are in flexible contact with each other, the outer surfaces 4a, 10a of the front walls 4, 10 of the hollow bodies 1, 7 jointly forming an outer sealing surface 11 which covers the flap track 19, said hollow bodies 1,7 having jointly a vertical compression flexibility such that the contact surfaces 3a, 9a retract around the actuating shaft 20, the interior chambers 2, 8 extending between the front walls 4, 10 and rear walls 5, 11 of the hollow bodies 2, 7.

Abstract: The invention concerns the use of dermal sheath tissue and/or cells derived therefrom in wound healing systems. Specifically, the relevant features of this tissue type have been exploited to provide a novel wound healing material that has application in the provision of new therapeutic compositions and new surgical dressings where wound closure and minimal scarring is desirable.

Abstract: Compositions useful in the prevention and treatment of osteoporosis and for bone and fracture repair. Slow-releasing calcium phosphate-based materials are disclosed, incorporating Mg, Zn, F and carbonate, which will promote bone formation and inhibit bone resorption and thus be agents for the cited uses.

Abstract: The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.

Abstract: A catalytic testing device comprising a reaction block comprising a set of reaction chambers, each chamber comprising a fluid inlet and outlet connected to an outgoing fluid duct connected to analysis means, fluid feed means capable of performing regulated dosing of flows of the fluid at the required pressure independently in each of the reaction chambers, automatic and dynamic pressure control means, capable of performing pressure regulation in each reaction chamber, which comprise a non-return valve in the outgoing fluid duct between the outlets of the reaction chambers and a common regulating tank that receives the outgoing fluid from the chambers, a pressure sensor provided in a first outlet duct and an automatic needle valve provided in a second outlet duct from the tank.