Patents Represented by Attorney Licata & Tyrrell P.C.
  • Patent number: 7256200
    Abstract: Composition and methods of treating pain and reducing, reversing, or preventing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and a calcium calmodulin kinase (CaMKII) inhibitor as active agents to treat pain in mammals, including humans.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: August 14, 2007
    Assignee: The Board of Trustees of the University of Illinois, a body corporate and politic of the State of Illinois
    Inventor: Zaijie Wang
  • Patent number: 7256027
    Abstract: Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: August 14, 2007
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Robert A. Lazarus, Mark Hurle, Stephen Anderson, David B. Powers
  • Patent number: 7247614
    Abstract: A human prolactin-binding protein and compositions and methods using this protein are provided.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: July 24, 2007
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Charles V. Clevenger, J. Bradford Kline
  • Patent number: 7244814
    Abstract: Variants of the HIV-1 Tat protein exhibiting higher transcriptional activation and stronger P-TEFb binding than wild-type Tat are provided. In addition variants that can inhibit transcription activation by wild-type Tat are provided. Nucleic acid sequences encoding these variants, vectors and host cells for expression of these variants, and antibodies raised against these variants are also provided. In addition, methods for use of these variants and compositions containing these variants as research tools, as diagnostic tools and in the treatment of viral infections are provided.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: July 17, 2007
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventors: Michael B. Mathews, Tsafi Pe'ery, Syed Reza
  • Patent number: 7244704
    Abstract: Compositions and methods of using compositions with a nuclear targeting peptide containing a nonclassical nuclear localization signal to deliver selected molecules to the nucleus of eukaryotic cells are provided. The compositions are particularly useful in gene transfer methods.
    Type: Grant
    Filed: February 16, 2005
    Date of Patent: July 17, 2007
    Assignee: Trustees of the University of Pennsylvania
    Inventor: Scott L. Diamond
  • Patent number: 7241446
    Abstract: Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be used to modulate angiogenesis through blocking release of VEGF from a VEGF-heparin complex. Furthermore the rPAI-1 proteins may be used to inhibit cell proliferation and migration, induce apoptosis, and produce proteolytic fragments corresponding to angiostatin kringles 1–3 and kringles 1–4.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: July 10, 2007
    Assignee: Trustees of Dartmouth College
    Inventors: Mary Jo Mulligan-Kehoe, Richard J. Powell
  • Patent number: 7238471
    Abstract: Diagnostic markers for breast cancer referred to herein breast cancer specific genes or BCSGs are provided. Also provided are methods for using BCSGs to detect, diagnose, monitor, stage, prognosticate, image and treat breast cancer. Antibodies which specifically bind BCSGs and methods of using these antibodies to image and treat breast cancer are also provided.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: July 3, 2007
    Assignee: DiaDexus, Inc.
    Inventors: Susana Salceda, Robert Cafferkey, Herve Recipon, Yongming Sun
  • Patent number: 7238420
    Abstract: A method for preparing an ?-Al2O3 nanotemplate of fully crystalline ?-Al2O3 directly on the surface of a metal alloy is provided. Also provided is a related apparatus.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: July 3, 2007
    Assignee: Trustees of Stevens Institute of Technology
    Inventors: Woo Y. Lee, Yi-Feng Su, Limin He, Justin Daniel Meyer
  • Patent number: 7238361
    Abstract: The present invention provides prodrug and multi-prodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the presence of a targeted pathophysiologic receptor. Methods for preparation and use of these prodrug complexes in drug delivery systems are also provided.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: July 3, 2007
    Assignee: Molecular Machines, Inc.
    Inventor: Roger S. Cubicciotti
  • Patent number: 7238782
    Abstract: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3?-untranslated region of CD154.
    Type: Grant
    Filed: March 27, 2006
    Date of Patent: July 3, 2007
    Assignee: Trustees of Dartmouth College
    Inventor: William F. C. Rigby
  • Patent number: 7223596
    Abstract: An immortalized hemangiosarcoma cell line of malignant canine endothelial cells which possesses surface expression characteristics and growth factor and cytokine expression profiles typical of nonmalignant activated endothelial cells is provided. In vitro and in vivo models for angiogenesis produced from this cell line as well as methods for identifying antiangiogenic agents using these models are also provided.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: May 29, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Stuart Charles Helfand, Nasim Akhtar, Erin Beth Dickerson, Marcia Lillian Padilla
  • Patent number: 7225079
    Abstract: In an extensive Matched Ion Polynucleotide Chromatography (MIPC) system and method, and the computer programs or software associated therewith, the system provides automated options for sample selection, mobile phase gradient selection and control, column and mobile phase temperature control, and fragment collection for a wide variety of MIPC separation processes. MIPC separation processes can be applied to effect size-based separation of DNA fragments, mutation detection, DNA fragment purification, PCR process monitoring and other novel processes. This invention is directed to the system and software which automates many of these procedures, facilitating use of the system to achieve complex separation methods. In one embodiment of the invention, a user specifies a size range of double stranded DNA fragment(s) in a mixture, the software calculates a solvent gradient to elute the fragment(s), and the system performs the chromatographic separation using the calculated gradient.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: May 29, 2007
    Assignee: Transgenomic, Inc.
    Inventors: Douglas T. Gjerde, Paul D. Taylor, Christopher P. Hanna
  • Patent number: 7220473
    Abstract: This present invention concerns a cover layer that is impermeable to the active substances and/or a removable protective layer of a transdermal therapeutic system, comprising a thermoplastic film which either directly contains the absorbing agents and channel-forming agents or is coated with a polymer support (thermoplast) containing these substances. The polymer support can either be applied over the entire surface of the film or in patterns, directly during production. The thermoplastic film that is used and the polymer support can be made from either the same or different materials.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: May 22, 2007
    Assignee: Hexal AG
    Inventors: Cornelia Beier, Ralf Kibele
  • Patent number: 7217907
    Abstract: Durable, stick resistant, stain resistant, dishwasher safe, and thermal shock resistant cooking utensils produced from a MAX phase and methods for their production are provided.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: May 15, 2007
    Assignee: 3-One-2 LLC
    Inventors: Tamer El-Raghy, Patricia Lyons
  • Patent number: 7217535
    Abstract: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: May 15, 2007
    Assignee: SmithKline Beecham P.L.C.
    Inventors: Colin H. MacPhee, David Graham Tew
  • Patent number: 7214372
    Abstract: A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM? glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5? fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: May 8, 2007
    Assignee: University of Utah Research Foundation
    Inventors: Mahendra S. Rao, Mark Noble, Margot Mayer-Proschel
  • Patent number: 7211396
    Abstract: Various antibodies with different binding characteristics for MBL A or MBL B bound to mannan or MBL A or MBL B bound to an antibody against MBL are provided. Also provided are methods for selecting antibodies against MBL with different binding characteristics and methods and kits for using these antibodies to measure MBL capable of binding to mannan or oligomerized MBL and abnormal, poorly oligomerized MBL in a sample. The methods and kits are useful in diagnosing increased susceptibility to and exacerbation of infections and autoimmune diseases.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: May 1, 2007
    Assignee: AntibodyShop A/S
    Inventor: Lars Otto Uttenthal
  • Patent number: 7202217
    Abstract: The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for direct interaction with the ?7 subunit of such proteasomes as one present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with proteasomes is a decrease in the intracellular degradation of active peptides such as HIF-1? and a consequential stimulation of angiogenesis in-situ.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: April 10, 2007
    Assignee: Beth Israel Deacones Medical Center
    Inventors: Michael Simons, Youhe Gao
  • Patent number: 7198909
    Abstract: A long-lived, myeloid-committed stem cell population is disclosed. Also disclosed are methods and compositions for targeting this population with retrovirus vectors in gene therapy protocols for correcting congenital disorders of myeloid system and for potentiating immune responses to defined tumor and viral antigens.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: April 3, 2007
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventors: Yacov Ron, Joseph P. Dougherty, Chiann-Chyi Chen
  • Patent number: 7196169
    Abstract: Isolated phosphorylated troponin I proteins useful in diagnosing and monitoring the phosphorylation state of injured muscle tissue are provided. Also provided are compounds, kits and methods for assessing the phosphorylation state of these troponin I proteins and modulating the phosphorylation state of these troponin I proteins in a subject.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: March 27, 2007
    Assignee: Queen's University at Kingston
    Inventors: Jennifer E. Van Eyk, Jeremy A. C. Simpson, Ninetta Buscemi, Michelle K. Quick