Patents Represented by Attorney Licata & Tyrrell P.C.

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  • Methods and compositions for modulating proteins modified in preconditioning against ischemia/hypoxia
    Patent number: 7195890
    Abstract: Proteins modified by pharmacological preconditioning are provided. Compositions, methods and events for modulating these proteins and priming cells for preconditioning and inducing preconditioning in a cell, tissue or organ as well as methods for identifying new compositions and methods for such priming and induction are also provided. In addition, methods for diagnosing and monitoring preconditioning or ischemic, hypoxic, ischemic/reperfusion and hypoxic/reperfusion conditions or the ability of a cell, tissue or organ to survive injury by measuring modulation of one or more of these preconditioning proteins are provided.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: March 27, 2007
    Assignee: Queen's University at Kingston
    Inventors: Jennifer E. Van Eyk, Steven T. Elliott, David Kent Arrell
  • Method for detecting intracellular cholesterol
    Patent number: 7186519
    Abstract: The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled C? complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cell are also provided.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: March 6, 2007
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Shigeki Sugii
  • Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
    Patent number: 7172760
    Abstract: Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: February 6, 2007
    Assignees: Trustees of the University of Pennsylvania, University of Virginia Patent Foundation
    Inventors: Vladimir R. Muzykantov, Abd Al-Roof Higazi, Juan Carlos Murciano, Douglas Cines, Ronald P. Taylor
  • Frequency selective terahertz radiation detector
    Patent number: 7170085
    Abstract: The present invention provides a device for frequency-selective detection of electromagnetic radiation in the terahertz region of the electromagnetic spectrum using a lateral semiconductor superlattice, a metal antenna attached to the lateral semiconductor superlattice; and a resonator comprising two mirrors and a substrate. A method for detecting electromagnetic radiation using the device is also provided.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: January 30, 2007
    Assignee: Stevens Institute of Technology
    Inventors: Alexander S. Raspopin, Hong-Liang Cui
  • Method and apparatus for separating polynucleotides using monolithic capillary columns
    Patent number: 7169298
    Abstract: Methods and devices based on capillary monolithic columns, preferably consisting of an underivatized poly(styrene-divinylbenzene) monolith, for separating a mixture of polynucleotides by ion pair-reverse phase-high performance chromatography (IP-RP-HPLC).
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: January 30, 2007
    Assignee: Transgenomic, Inc.
    Inventors: Christian Huber, Herbert Oberarcher, Andreas Premstaller
  • Mammalian MDM2 binding proteins and uses thereof
    Patent number: 7166712
    Abstract: Isolated nucleic acid sequences encoding mammalian MDM2 binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and antibodies targeted to these proteins. In addition, methods and compositions for modulating the G1 phase of the cell cycle via altering expression and/or activity of a mammalian MDM2 binding protein are provided.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 23, 2007
    Assignee: Philadelphia, Health and Education Corporation
    Inventors: Mark Thomas Boyd, Dale Stewart Haines, Nikolina Vlatkovic
  • Mouse model of myxomatous valvular disease
    Patent number: 7166763
    Abstract: An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for identifying agents which prevent, delay or treat myxomatous valvular disease. Methods of diagnosing myxomatous valvular disease are also provided.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: January 23, 2007
    Assignees: Trustees of Dartmouth College, Massachusetts Institute of Technology (MIT)
    Inventors: Nicholas W. Shworak, Robert D. Rosenberg, Robert T. Palac
  • Methods and compositions for inhibiting angiogenesis
    Patent number: 7160858
    Abstract: Methods for inhibiting angiogenesis in endothelial cells and selectively inducing apoptosis in endothelial cells via compounds which binds annexin II are provided. These compounds and methods for using these compounds are useful in the treatment of diseases or disorders characterized by unwanted angiogenesis. Also provided are pharmaceutical compositions containing a compound which binds annexin II and a pharmaceutically acceptable vehicle and methods for identifying such compounds.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: January 9, 2007
    Assignee: Philadelphia, Health and Education Corporation
    Inventors: Mahesh C. Sharma, George P. Tuszynski
  • Method of diagnosing, monitoring, and staging lung cancer
    Patent number: 7160679
    Abstract: The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating lung cancer.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: January 9, 2007
    Assignee: diaDexus, Inc.
    Inventors: Fei Yang, Roberto A. Macina, Yongming Sun
  • Enhancement of intracellular delivery and tissue targeting of drugs and genes
    Patent number: 7157087
    Abstract: A method for enhancing intracellular delivery of effector molecules is provided. The method involves modifying selected antibodies with biotin and streptavidin, conjugating these antibodies with an effector molecule, and delivering the conjugated effector to an intracellular target specifically recognized by the antibody.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: January 2, 2007
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Vladimir R. Muzykantov, Steve M. Albelda
  • Fluorescent tags for amino acid and nucleic acid analysis
    Patent number: 7150967
    Abstract: Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are highly reactive with thiol containing species are provided. Fluorescent reactions products of the mercurimethyl-dihydropsoralen compounds or derivatives thereof attached to a thiol containing species and nucleic acids fluorescently labeled with these reaction products are also provided.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: December 19, 2006
    Assignees: University of Medicine & Dentistry of New Jersey, Rutgers, the State University, Lehigh University, Buckman Laboratories International, Inc.
    Inventors: Jeffrey D. Laskin, Christine Martey, Ned Heindel, Marilyn Whittemore, Diane Heck
  • Compositions and methods for regulating autolytic processes in bacteria
    Patent number: 7148328
    Abstract: A nucleic acid sequence required for regulating the autolytic activity of bacteria is provided. Also provided are polypeptides encoded by the gene or mutant gene as well as vector and host cells for expressing these polypeptides. Methods for identifying and using agents which interact with the gene or mutant gene or polypeptides encoded thereby to inhibit bacterial growth and infectivity are also provided.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: December 12, 2006
    Assignee: Trustees of Dartmouth College
    Inventor: Ambrose Cheung
  • Method of treating bone metastasis
    Patent number: 7148210
    Abstract: The invention provides a drug combination for the treatment of diseases associated with bone metastasis. The combination provides adenosine or a derivative thereof, a bisphosphonate, and a targeting agent(s) to decrease the signs or symptoms associated with such diseases.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: December 12, 2006
    Assignee: Trustees of Dartmouth College
    Inventor: Edward H. Abraham
  • Method for detecting inflammation and inflammatory conditions
    Patent number: 7144710
    Abstract: Methods for detecting the inflammatory biomarkers molecule CD 163 in biological samples are provided. Also provided are methods for monitoring the course of an inflammatory process or condition in a patient and compositions and methods for preventing and treating inflammation and inflammatory processes.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: December 5, 2006
    Assignee: Trustees of Dartmouth College
    Inventors: Paul M. Guyre, Peter M. Morganelli, Nicholas J. Goulding
  • Washing liquid composition for semiconductor substrate
    Patent number: 7138362
    Abstract: There is provided a washing liquid composition for a semiconductor substrate having a contact angle between the surface thereof and water dropped thereon of at least 70 degrees, the washing liquid composition including an aliphatic polycarboxylic acid and a surfactant, and the washing liquid composition having a contact angle of at most 50 degrees when dropped on the semiconductor substrate. It is thereby possible to effectively remove particles and metals on the surface of a hydrophobic substrate without corroding it.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: November 21, 2006
    Assignees: Kanto Kagaku Kabushiki Kaisha, NEC Electronics Corporation
    Inventors: Yumiko Abe, Norio Ishikawa, Hidemitsu Aoki, Hiroaki Tomimori, Yoshiko Kasama
  • Liquid chromatographic separation of polynucleotides
    Patent number: 7138518
    Abstract: In one aspect, the invention provides a method for separating a mixture of polynucleotides, such as DNA or RNA, including (a) applying the mixture to a polymeric separation medium having non-polar surfaces, wherein the surfaces are characterized by being substantially free from multivalent cations, such as metal ions, which are free to interfere with polynucleotide separation, and (b) eluting the mixture with a mobile phase containing organic solvent and counter ion agent. In the separation of single-stranded polynucleotides, improved separation is obtained at a temperature effective to fully denature secondary structure within the polynucleotides.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: November 21, 2006
    Assignee: Transgenomic, Inc.
    Inventors: Douglas T. Gjerde, Robert M. Haefele, Paul D. Taylor, Christopher P. Hanna, Alezander I. Kuklin, David P. Hornby
  • Methods and compositions for mutation analysis of polynucleotides by liquid chromatography
    Patent number: 7135289
    Abstract: Methods, compositions, and kits for separating heteroduplex and homoduplex DNA molecules in a test mixture by temperature-compression denaturing high performance liquid chromatography (tcDHPLC). The method includes use of nitrogen-containing additives in the mobile phase that allow detection of diverse heteroduplex molecules to be performed at the same pre-selected temperature. An example of a preferred additive is betaine. Standard mixtures of DNA fragments, such as mutation standards containing known heteroduplex and homoduplex molecules, can be used to select the concentration of additive and temperature. Compositions and kits including the mobile phase, mutation standards, PCR primers, separation media, and DNA polymerase are also provided.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: November 14, 2006
    Assignee: Transgenomic, Inc.
    Inventors: Paul D. Taylor, Liem T. Nguyen
  • Inhibition of transglutaminase-mediated microbial interaction with a mammalian host
    Patent number: 7135182
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the mammalian host. These compounds may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: November 14, 2006
    Assignee: Trustees of Dartmouth College
    Inventors: Paula Sundstrom, Steven D. Bradway
  • Group B streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
    Patent number: 7128919
    Abstract: This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: October 31, 2006
    Assignees: St. Jude Children's Research Hospital, University of Utah Research Foundation
    Inventors: Elisabeth Adderson, John Bohnsack
  • Isolated CEL II endonuclease
    Patent number: 7129075
    Abstract: The present invention relates to the isolation and characterization of CEL I and CEL II endonuclease proteins. Methods and kits for identifying mismatches in double-stranded DNA are also provided.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: October 31, 2006
    Assignee: Transgenomic, Inc.
    Inventors: Gary F. Gerard, Harini Shandilya, Peter Qiu, James M. D'Alessio