Patents Represented by Attorney Licata & Tyrrell P.C.

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  • Six degrees of freedom precision measuring system
    Patent number: 7040033
    Abstract: The present invention relates to apparatuses and methods for calibrating relative motions of moveable parts using plurality of balls, rods, and liner encoders which form configurations to measure multiple translational, angular and squareness errors simultaneously.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: May 9, 2006
    Assignee: Trustees of Stevens Institute of Technology
    Inventors: Zhenqi Zhu, Hongliang Cui
  • Compositions and methods for selective dissolution of nascent intravascular blood clots
    Patent number: 7041287
    Abstract: Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed intravascularly, with minimal risk of unwanted dissolution of pre-existing hemostatic clots, are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: May 9, 2006
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Vladimir R. Muzykantov, Juan Carlos Murciano, Douglas Cines
  • Neuroepithelial stem cells and glial-restricted intermediate precursors
    Patent number: 7037720
    Abstract: Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: May 2, 2006
    Assignee: University of Utah Reseach Foundation
    Inventors: Mahendra S. Rao, Margot Mayer-Proschel
  • Method for the treatment of vitamin D related disease
    Patent number: 7033996
    Abstract: The present invention provides a method for treating diseases caused by either an excess or diminution of Vitamin D3. It provides pharmaceutical compositions for the treatment of such diseases and the methods by which these compositions are to be used. Also provided are methods for testing the activity of both 24(OH)ase and CCAATT/Enhancer Binding Protein ? (C/EBP?), as well as, for testing the effect of a compound on 24(OH)ase and C/EBPB activity activity. In particular embodiments, a method is provided for reducing the risk of hypercalcemia when administering 1,25(OH)2D3 or its analogs for the treatment of vitamin D diseases. Methods for both enhancing and diminishing 24(OH)ase activity are also provided.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: April 25, 2006
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventor: Sylvia Christakos
  • Pressure-sensitive adhesive and patch employing the same
    Patent number: 7034083
    Abstract: An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: April 25, 2006
    Assignee: Hisamitsu Pharmaceuticals Co., Inc.
    Inventors: Takashi Yasukochi, Toshiro Yamaguchi, Tetsuro Tateishi, Naruhito Higo
  • Methods of diagnosing, prognosticating and treating matrix metalloproteinase-1 related diseases via a matrix metalloproteinase-1 single nucleotide polymorphism
    Patent number: 7033756
    Abstract: Methods and kits for diagnosing and prognosticating matrix metalloproteinase-1 related disease by detecting a single nucleotide polymorphism in the promoter of the gene are provided. Also provided are methods of identifying agents which inhibit binding of transcriptions factors to the Ets transcription factor binding site created by or resulting from this single nucleotide polymorphism and methods of using these agents to treat matrix metalloproteinase-1 related diseases.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: April 25, 2006
    Assignee: Trustees of Dartmouth College
    Inventors: Constance E. Brinckerhoff, Joni L. Rutter
  • Methods and formulations for the efficient delivery of water-insoluble drugs by nebulizer
    Patent number: 7029656
    Abstract: Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs are provided. Also provided are methods for minimizing wastage of drugs administered by nebulizer, and for the achievement of quantitative dosing with diluent from a mass marketed formulations, which because of the mass market is much less costly per dose than formulations manufactured specifically for much lower volume medical use.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: April 18, 2006
    Inventor: Robert E. Coifman
  • Oral bacteriotherapy compositions and methods
    Patent number: 7026160
    Abstract: A composition for treatment of renal failure with selected bacteria which converts nitrogenous waste into non-toxic compounds in vivo is provided. Also provided is a method of inhibiting build up of toxins and metabolic wastes and overgrowth of undesirable bacteria in a subject by administering the composition to the subject.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: April 11, 2006
    Assignee: Kibow Biotech, Inc.
    Inventor: Nataragan Ranganathan
  • Genotyping assay to predict CYP3A5 phenotype
    Patent number: 7022475
    Abstract: Genetic polymorphisms responsible or associated with altered expression of cytochrome P450 CYP3A5 enzyme are described. Single nucleotide polymorphisms are provided. Methods for identifying subjects having a low or high drug metabolizing phenotype associated with CYP3A5 expression are provided. Assays, kits and methods for determining and assaying the CYP3A5 genotype and phenotype of individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's metabolism of drugs and therapeutic agents, the potential for drug interactions, and thereby toxicity and effectiveness of certain drugs and treatment modalities, are provided.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: April 4, 2006
    Assignee: St. Jude Children's Research Hospital
    Inventors: Erin Schuetz, Jiong Zhang, Mahfoud Assem
  • Compositions and methods for regulating RNA stability using polypyrimidine tract proteins
    Patent number: 7022487
    Abstract: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3?-untranslated region of CD154.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: April 4, 2006
    Assignee: Trustees of Dartmouth College
    Inventor: William F. C. Rigby
  • Mutations in human MLH1 and human MSH2 genes useful in diagnosing colorectal cancer
    Patent number: 7022472
    Abstract: Variant human MLH1 and MSH2 genes are provided. Methods of using these variant genes to diagnose hereditary non-polyposis colorectal cancer (HNPCC) and/or determine a patient's susceptibility to developing HNPCC are also provided. Methods and compositions for identifying new variant MLH1 of MSH2 genes are also provided. In addition, experimental models for hereditary non-polyposis colorectal cancer comprising these variant genes are provided.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: April 4, 2006
    Assignee: diaDexus, Inc.
    Inventors: David Robbins, Juili Lillian Lin-Goerke, Jessica C. Ling
  • Compositions and methods for sensitizing and inhibiting growth of human tumor cells
    Patent number: 7018631
    Abstract: Polynucleotides encoding a carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a chemotherapeutic prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing tumor cells to a prodrug chemotherapeutic agent and inhibiting tumor growth with this enzyme are also provided. In addition, screening assay for identification of drugs activated by this enzyme are described.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: March 28, 2006
    Assignee: St. Jude Children's Research Hospital
    Inventors: Mary K. Danks, Philip M. Potter, Peter J. Houghton
  • Mammalian catalase-dependent oxidation processes and methods for stimulating oxidative activities
    Patent number: 7015022
    Abstract: A catalase-dependent enzymatic oxidation process wherein a substrate to be oxidized is contacted with catalase in the absence of hydrogen peroxide is provided. Also provided are methods for using this process in a variety of biomedical, clinical and diagnostic applications as well as industrial processes. A method for stimulating the enzymatic oxidation process by treatment with ultraviolet light and uses for this method are also provided.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: March 21, 2006
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventors: Jeffrey D. Laskin, Anna Marie Vetrano, Diane Heck
  • Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers
    Patent number: 7014996
    Abstract: The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating gynecologic cancers including uterine, breast, endometrial and ovarian cancer.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: March 21, 2006
    Assignee: diaDexus, Inc.
    Inventor: Roberto A. Macina
  • Compositions and methods for detection of active proteases
    Patent number: 7015023
    Abstract: A novel assay system is disclosed for detecting the presence or amount of selected active proteases in biological samples. The assay system utilizes a chimeric protease detector protein composed of three domains: (1) a repressor domain, (2) a protease cleavage domain specific for the protease to be assayed, and a reporter domain. The reporter domain is not detectable when linked to the repressor domain, but becomes detectable upon release from the repressor domain by protease-mediated cleavage. Thus, the activity of the selected protein can be determined by measuring the amount of detectable reporter in the sample. Methods and test kits for using the novel assay system in a variety of in vitro and in vivo applications are also disclosed.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: March 21, 2006
    Assignee: Rutgers, the State University
    Inventors: Eric Lam, Olga del Pozo
  • Compositions and methods for producing and using homogenous neuronal cell transplants
    Patent number: 7011827
    Abstract: Methods of treating individuals suspected of suffering from diseases, conditions or disorders of the Central Nervous System including nerve damage are provided wherein stable, homogeneous post-mitotic human neurons are into the individual's brain or at or near a site of nerve damage. Pharmaceutical compositions of stable, homogeneous post-mitotic human neurons and a pharmaceutically acceptable medium are also disclosed. Methods of generating non-human animal models of human CNS diseases, conditions or disorders by implanting stable, homogeneous post-mitotic human neurons into the brain of a non-human animal are disclosed. Non-human animals eith stable, homogeneous post-mitotic human neurons implanted in their brain are also disclosed.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: March 14, 2006
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Virginia M.-Y. Lee, John Q. Trojanowski
  • Compositions and methods for thionation during chemical synthesis reactions
    Patent number: 7012148
    Abstract: Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: March 14, 2006
    Assignee: Trustees of Dartmouth College
    Inventor: Thomas J. Curphey
  • Electrolytic cell and electrodes for use in electrochemical processes
    Patent number: 7001494
    Abstract: An electrolytic cell with an anode and cathode for the electrolysis of hydrochloric acid and brine is provided. The anodes and cathodes of the present invention are made of a bulk ceramic or intermetallic material.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: February 21, 2006
    Assignee: 3-One-2, LLC
    Inventors: Vladimir Jovic, Michel Barsoum
  • Alginate gel based adsorbents for heavy metal removal
    Patent number: 6989102
    Abstract: An alginate gel adsorbent to remove heavy metal ions according to the present invention is prepared by adding dropwisely 0.1-5 wt % alginate solution to a polyvalent cationic solution thereby cross-linking alginic acid with polyvalent cations. An alginate gel adsorbent containing activated carbon capable of simultaneously removing heavy metal ions and organotoxic materials, that is, activated carbon/alginate gel adsorbent, is prepared by adding dropwisely a mixed solution of 0.17-10 wt % of alginate and 0.1-10 wt % of activated carbon powder to a polyvalent cationic solution thereby cross-linking alginic acid with polyvalent cations in order to immobilize polyvalent cation to alginic acid containing activated carbon. The polyvalent cationic solution is selected from the group consisting of calcium chloride (CaCl2), strontium chloride (SrCl2), barium chloride (BaCl2) and aluminium chloride (AlCl3).
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: January 24, 2006
    Assignee: Samsung General Chemicals Co., Ltd.
    Inventors: Hyun Gyu Park, Kyung Hwa Kim, Myeong Yun Chae, Eu Gene Oh, Eun Yeol Lee
  • Direct encapsulation of biomacromolecules in surfactant templated mesoporous and nanoporous materials
    Patent number: 6989254
    Abstract: Biomacromolecules encapsulated or immobilized within mesoporous or nanoporous materials via surfactant-templated sol-gel reactions and methods for production of these encapsulated or immobilized biomacromolecules are provided.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: January 24, 2006
    Assignee: Drexel University
    Inventors: Yen Wei, Jigeng Xu, Hua Dong, Qiuwei Feng