Patents Represented by Attorney Mario A. Monaco

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  • N-Substituted-benzyl-11-endo-amino-5,6,7,8,9,10-hexahydro-2-hydroxy (or methoxy)-6,9-methanobenzocyclooctene (or nonene) centrally-acting analgesics
    Patent number: 4332807
    Abstract: Novel substituted-benzyl derivatives of 11-endo-amino-5,6,7,8,9,10-hexahydro-2-hydroxy (or methoxy)-6,9-methanobenzocyclooctene (or nonene) of the formula: ##STR1## are centrally-acting analgesics effective in the relief of pain.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: June 1, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Patrice C. Belanger, Robert N. Young
  • Allylsulfoxide enzyme inhibitors
    Patent number: 4332813
    Abstract: Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K.sub.cat type.
    Type: Grant
    Filed: May 7, 1980
    Date of Patent: June 1, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Raymond A. Firestone
  • N-(Substituted)-2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine centrally-acting analgesics
    Patent number: 4332810
    Abstract: Novel N-(substituted) derivatives of 2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine of the formula: ##STR1## are centrally acting analgesics effective in the relief of pain.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: June 1, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Patrice C. Belanger, Robert N. Young
  • Substituted mercapto acid amides and their use
    Patent number: 4329363
    Abstract: The present application discloses a method of correcting an imbalance of immune homeostasis caused by cytostatic treatment or radiotherapy by administering to a patient in need of such treatment an effective amount of a novel substituted mercapto acid amide and pharmaceutical compositions containing such novel substituted mercapto acid amides.
    Type: Grant
    Filed: January 16, 1980
    Date of Patent: May 11, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Conrad P. Dorn, Howard Jones
  • Displacement purification of salts
    Patent number: 4329469
    Abstract: An optically impure diastereomeric salt is purified by treating a suspension of the salt in an appropriate solvent or solvent mixture with the required amount of the desired, optically pure, acid or base.
    Type: Grant
    Filed: November 24, 1980
    Date of Patent: May 11, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Torleif Utne, Ronald B. Jobson
  • Dibenzo[a,d]cycloocten-6,12-imines
    Patent number: 4329465
    Abstract: Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: May 11, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Paul S. Anderson, Marcia E. Christy, Ben E. Evans, David C. Remy
  • Process for the manufacture of fused polyphosphate glasses
    Patent number: 4326873
    Abstract: Process for the manufacture of fused polyphosphate glasses in which a hydrocarbon is used as the carrier for the slurry of reactants that are fed to the high temperature furnace.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: April 27, 1982
    Assignee: Calgon Corporation
    Inventors: Phillip B. Reilly, Paul H. Ralston
  • Substituted biphenyl-2-carboxaldehydes
    Patent number: 4322563
    Abstract: Substituted biphenyl-2-carboxaldehydes are prepared in good yield by reacting palladium complexes of substituted benzaldehyde aniline Schiff bases with substituted phenylmagnesium bromides in the presence of at least six, preferably eight, molar equivalents of triphenylphosphine.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: March 30, 1982
    Assignee: Merck & Co., Inc.
    Inventor: William F. Hoffman
  • Preparation of ammonium salt of hypocholesteremic fermentation product
    Patent number: 4319039
    Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
    Type: Grant
    Filed: August 11, 1980
    Date of Patent: March 9, 1982
    Assignee: Merck & Co., Inc.
    Inventor: George Albers-Schonberg
  • [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahy dro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives
    Patent number: 4317922
    Abstract: The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkano ic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
    Type: Grant
    Filed: February 19, 1981
    Date of Patent: March 2, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Gerald E. Stokker, Norman P. Gould
  • Water-insensitive electroconductive article comprising a substrate coated with polymers of diallyldimethyl-ammonium chloride and N-methylolacrylamide and method of coating
    Patent number: 4316943
    Abstract: Electroductive article comprising a coating composition of copolymers containing from 70 percent to 85 percent by weight diallyldimethylammonium chloride and at least 15 percent but less than 30 percent by weight N-methylolacrylamide and optional comonomers is disclosed. These electroconductive polymers are coated onto a substrate and become water-insensitive thereafter.
    Type: Grant
    Filed: December 12, 1980
    Date of Patent: February 23, 1982
    Assignee: Calgon Corporation
    Inventors: Gloria D. Sinkovitz, Kenneth W. Dixon
  • [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alka noic and cycloalkanoic acids and their analogs, esters, salts and derivatives
    Patent number: 4316043
    Abstract: The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkano ic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
    Type: Grant
    Filed: December 19, 1980
    Date of Patent: February 16, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Gerald E. Stokker, Norman P. Gould
  • Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one s
    Patent number: 4308378
    Abstract: Biologically inactive cis-6-(substituted-arylethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-on es are isomerized to the corresponding anti-hypercholesterolemic trans-isomers by heating in the presence of a heavy metal salt.
    Type: Grant
    Filed: September 2, 1980
    Date of Patent: December 29, 1981
    Assignee: Merck & Co., Inc.
    Inventor: Gerald E. Stokker
  • Tamperproof container
    Patent number: 4306357
    Abstract: An improved tamperproof container for lyophilized material wherein the container comprises a vial having flange about its opening. Below the flange, but spaced apart therefrom is a shoulder to define an indented neck therebetween. The opening is sealed with a pierceable stopper. An overcap extends over the flange and about the neck to form a skirt about the neck. The skirt has at least a portion thereof extending inwardly in gripping reaction with the neck and limited in removal by contact with the underside of the flange whereby the cap cannot be removed without destroying its structural integrity.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: December 22, 1981
    Assignee: Merck & Co., Inc.
    Inventor: Miguel Villarejos
  • Electroconductive polymer composition
    Patent number: 4306996
    Abstract: An electroconductive polymer composition containing an electroconductive polymer and an agent that imparts improved tack properties to paper coated with the composition.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: December 22, 1981
    Assignee: Calgon Corporation
    Inventor: Robert H. Windhager
  • 2-(4-Aminopiperidino)pyrazines
    Patent number: 4302455
    Abstract: 2-(4-Aminopiperidino)pyrazines are useful as analgesic and antidepressant agents. They are prepared by reductive amination of the corresponding 2-(4-oxopiperidino)pyrazines.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: November 24, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Joel R. Huff, Stella W. King, Walfred S. Saari
  • Red blood cell labelling kit
    Patent number: 4300569
    Abstract: This invention relates to a method for efficiently labelling red blood cells , which permits the imaging of blood pools in the intact animal or human patient, accomplished by injection of a saline solution of an alkaline earth metal salt of glucoheptonic acid and a non-toxic stannous salt followed by injection with a solution of sodium pertechnetate Tc 99 m to tag the red blood cells. The invention also relates to the kit used in the method of our invention consisting of a single vial containing 25 mg. calcium glucoheptonate and 3 mg. of stannous chloride dihydrate in 2 ml. of saline solution.
    Type: Grant
    Filed: February 25, 1980
    Date of Patent: November 17, 1981
    Assignee: Merck & Co., Inc.
    Inventor: Paul-Emile Bonneau
  • Long-lasting agonists of enkephalin
    Patent number: 4301151
    Abstract: Novel peptides of the formula: ##STR1## wherein X is S or (CH.sub.2).sub.n and n is 0, 1 or 2, and R.sub.1 through R.sub.6 are various amino acid and other substituents; having long-lasting enkephalin agonist activity; useful in treating pain and in treating schizophrenia.
    Type: Grant
    Filed: September 15, 1980
    Date of Patent: November 17, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Roger M. Freidinger
  • Preparation of benzotriazole
    Patent number: 4299965
    Abstract: Low temperature process for the preparation of benzotriazole at high solids concentrations by the reaction of orthophenylenediamine, sodium nitrite and acetic acid in an aqueous medium at a temperature in the range of from 5.degree. to 25.degree. C., and neutralizing with caustic to liberate benzotriazole in quantitative yield.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: November 10, 1981
    Assignee: Calgon Corporation
    Inventors: Marie S. Chan, Wood E. Hunter
  • Process for removing color bodies from brown phosphoric acid
    Patent number: 4297334
    Abstract: A system and process for decolorizing and purifying brown phosphoric acid using an activated carbon characterized by having a total pore volume of 1.0 cc/g or greater with about half of the total pore volume located in pores 35A or less in radius.
    Type: Grant
    Filed: August 4, 1980
    Date of Patent: October 27, 1981
    Assignee: Calgon Corporation
    Inventors: Thomas A. McConomy, Bruce D. Wells