Patents Represented by Attorney Mario A. Monaco
  • Patent number: 4208232
    Abstract: Insulation members having spaced apart walls, and at least a partial vacuum in the chamber defined by the walls are filled with activated carbon. The filling is accomplished under vacuum conditions, and activated carbon, degassed and having a density of greater than 0.3 grams/cm.sup.3 is employed to at least partially fill the chamber.
    Type: Grant
    Filed: June 15, 1978
    Date of Patent: June 17, 1980
    Assignee: Calgon Corporation
    Inventor: Norman J. Wagner
  • Patent number: 4206075
    Abstract: Use of amino tris(methylene phosphonic acid) and 1-hydroxyethylidene-1,1-diphosphonic acid in a ratio of from about 1:1 to about 3:1 by weight to inhibit corrosion of low carbon steel in aqueous systems.
    Type: Grant
    Filed: May 5, 1978
    Date of Patent: June 3, 1980
    Assignee: Calgon Corporation
    Inventor: Bennett P. Boffardi
  • Patent number: 4202671
    Abstract: Composition containing organic magnesium and organic manganese compounds as a fuel conditioner to reduce fuel requirements and sulfur trioxide emissions and method of using same.
    Type: Grant
    Filed: July 21, 1978
    Date of Patent: May 13, 1980
    Assignee: Calgon Corporation
    Inventors: Richard C. Diehl, Jerry L. Walker
  • Patent number: 4195085
    Abstract: Antiglaucoma compositions containing t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy)-2-propanol hydrogen maleate and method of treating elevated intraocular pressure.
    Type: Grant
    Filed: August 29, 1978
    Date of Patent: March 25, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Clement A. Stone
  • Patent number: 4194424
    Abstract: This invention relates to an apparatus for slicing cylindrically shaped columns of gels. More particularly, it relates to an apparatus for firmly holding cylindrical columns of acrylamide gel while making a longitudinal slice through the entire length of the column.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: March 25, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward C. O'Rourke, W. Wardle Fullerton
  • Patent number: 4195091
    Abstract: (9-Carboxy-11H-pyrrolo[2,1-b][3]benzazepine-11-ylidene)piperidines useful as appetite stimulants, are prepared by hydrolysis of the corresponding ester or cyano derivatives.
    Type: Grant
    Filed: November 15, 1978
    Date of Patent: March 25, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Patrice C. Belanger, David C. Remy, Clarence S. Rooney
  • Patent number: 4192844
    Abstract: Use of methoxypropylamine as a neutralizing amine in combination with hydrazine to prevent corrosion in steam condensate systems or in other low solids aqueous systems.
    Type: Grant
    Filed: August 23, 1978
    Date of Patent: March 11, 1980
    Assignee: Calgon Corporation
    Inventors: William L. Trace, Jerry L. Walker
  • Patent number: 4191759
    Abstract: Amides of 17.beta.-carboxy-4-androsten-3-one having the formula: ##STR1## where R.sup.1 and R.sup.2 are hydrogen (only one may be hydrogen), C.sub.1-4 alkyl, cyclo C.sub.5-6 alkyl, phenyl, or together with the nitrogen are a 5 or 6 membered heterocycle with up to one other heteroatom selected from oxygen and nitrogen; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are hydrogen or C.sub.1-3 alkyl; R.sup.7 is hydrogen or cyano; Z is oxygen, N-R.sup.8 where R.sup.8 is C.sub.1-3 alkyl, or CH--R.sup.9 where R.sup.9 is hydrogen, .alpha.-fluoro, or .alpha.-C.sub.1-3 alkyl,active as testosterone 5.alpha.-reductase inhibitors, and thus useful topically for treatment of acne, seborrhea, female hirsutism and male pattern baldness.
    Type: Grant
    Filed: April 13, 1978
    Date of Patent: March 4, 1980
    Assignee: Merck & Co., Inc.
    Inventors: David B. R. Johnston, Glen E. Arth, deceased
  • Patent number: 4187284
    Abstract: This invention relates to a novel diagnostic kit for use in radiographic bone scanning. More particularly, it relates to a kit comprising ingredients employed in the preparation of an intravenous injection of a complex of Technetium-99m, stannous ion, and an organic phosphonate identified as triethylene tetramine hexa (methylene phosphonic acid).
    Type: Grant
    Filed: October 3, 1977
    Date of Patent: February 5, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Richard E. Rolleston, Jacques A. Nadeau
  • Patent number: 4185082
    Abstract: A carbon supported catalyst used for carbon monoxide oxidation is chemically modified by treating the activated carbon support with an oxidizing agent and/or a hydrophobic compound prior to impregnation with the catalyst mixture. The thus treated catalytic carbon is capable of oxidizing carbon monoxide in an air stream containing sulfur dioxide over an extended period of time.
    Type: Grant
    Filed: May 11, 1978
    Date of Patent: January 22, 1980
    Assignee: Calgon Corporation
    Inventor: Rabindra K. Sinha
  • Patent number: 4182926
    Abstract: Methanol is vaporized at a temperature of from about 200.degree. C.-455.degree. C. and passed over a cobalt molybdate catalyst or a doped cobalt molybdate catalyst at a flow rate of from 60-200 cc./minute. The effluent gas comprises essentially methane and hydrogen in addition to some water vapors and CO.sub.2.
    Type: Grant
    Filed: September 21, 1978
    Date of Patent: January 8, 1980
    Assignee: Merck & Co., Inc.
    Inventor: David D. Saperstein
  • Patent number: 4181661
    Abstract: 2-(Substituted imino)thiazolidines and thiazolines are inhibitors of indoleamine-N-methyl transferase in vivo. They are prepared by alkylation or acylation of the free imino group.
    Type: Grant
    Filed: February 6, 1978
    Date of Patent: January 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Clarence S. Rooney, Joshua Rokach, Edward J. Cragoe, Jr.
  • Patent number: 4179497
    Abstract: Solid unit dosage medicaments which are suitable for use in animals and humans are prepared with hydroxypropyl cellulose as the primary formulating excipient. These medicaments are particularly suitable for ophthalmic use since they are slowly but completely water soluble when they are inserted in the cul-de-sac of the eye and thus provide for a convenient means of prolonged treatment of the eye with concomitant reduced dosing frequency.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: December 18, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward M. Cohen, Wayne M. Grim, Richard J. Harwood, Gunvant N. Mehta
  • Patent number: 4179453
    Abstract: A process for preparing 17.beta.-carboxy-4-androsten-3-ones comprising the steps of (1) reacting a 17.beta.-(1-ketoethyl)-5-androsten-3-ol, for example, pregnenolene, with pyridine and iodine to form a pyridinium iodide compound; (2) reacting the pyridinium iodide compound with alkali metal methoxide in methanol to form a methyl-5-androsten-3-ol-17.beta. carboxylate; (3) oxidizing the product of Step (2) preferably with aluminum isopropoxide to form methyl-4-androsten-3-one-17.beta.-carboxylate; and (4) hydrolyzing the product of Step (3) to the corresponding 17.beta.-carboxylic acid, salt, or ester. The 17.beta.-carboxy-4-androsten-3-ones are useful as intermediates for preparation of N-substituted-17.beta.-carbamoylandrost-4-en-3-one and 4-aza-17.beta.-substituted-5.alpha.-androstan-3-one 5.alpha. reductase inhibitors.
    Type: Grant
    Filed: April 13, 1978
    Date of Patent: December 18, 1979
    Assignee: Merck & Co., Inc.
    Inventor: David B. R. Johnston
  • Patent number: 4173626
    Abstract: A sustained release indomethacin pharmaceutical product is provided that utilizes a pellet formulation encapsulated in a hard gelatin capsule. A portion of the pellets is uncoated for immediate and rapid release of indomethacin for elevating the plasma level. The remainder of the pellets are coated with a polymer to sustain the plasma level. The uncoated and coated pellets may be mixed with non-medicated pellets as a capsule filler.
    Type: Grant
    Filed: December 11, 1978
    Date of Patent: November 6, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Dempski, Gunvant N. Mehta, Joseph C. Saboe
  • Patent number: 4171417
    Abstract: Copolymers useful in making electroconductive paper which impart improved solvent holdout properties to the electroconductive paper, comprising monomer units of quaternary diallyldialkylammonium and a monomer of the formula: --CH.sub.2 .dbd.C(R.sub.1)--C(O)--O--R.sub.2, where R.sub.1 is hydrogen or methyl; R.sub.2 is an alkyl group of 2 to 12 carbon atoms, that number being designated n, substituted with fluorine atoms in number equal to from n to 2n; and for the quaternary diallyldialkylammonium monomer, the alkyl groups are independently selected from alkyl groups of one to 18 carbon atoms, and the counterion is an anion.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: October 16, 1979
    Assignee: Calgon Corporation
    Inventor: Kenneth W. Dixon
  • Patent number: 4167640
    Abstract: Invention relates to improved processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetic acid, to intermediates thereof, and to the preparation of said intermediates.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: September 11, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Roger J. Tull, David G. Melillo
  • Patent number: 4166894
    Abstract: Novel functional ionene polymer compositions useful in a wide variety of applications, including, among others, as wet and dry strength additives, corrosion inhibitors, and electroconductive coatings.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: September 4, 1979
    Assignee: Calgon Corporation
    Inventor: Raymond J. Schaper
  • Patent number: 4166177
    Abstract: The invention relates to novel 2,2-dioxo-1,2,3-benzoxathiazines substituted in the benzene nucleus, as well as the 3,4-dihydro analogs thereof, useful as anti-inflammatory, antipyretic, analgesic agents.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: August 28, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Robert L. Smith, Gerald E. Stokker
  • Patent number: 4163849
    Abstract: Substituted piperazinylpyrazines and pharmaceutically acceptable salts thereof which have pharmacological activity as anorexigenic agents.
    Type: Grant
    Filed: March 17, 1978
    Date of Patent: August 7, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William C. Lumma, Jr., Walfred S. Saari, Anthony G. Zacchei