Patents Represented by Attorney Mario A. Monaco
  • Patent number: 4230610
    Abstract: Use of polyacrylates to reduce slurry viscosity and permit utilization of higher solids slurries of magnesium oxide.
    Type: Grant
    Filed: August 1, 1979
    Date of Patent: October 28, 1980
    Assignee: Calgon Corporation
    Inventors: Ronald J. Falcione, Ronald R. McManis, Joseph A. Aufman
  • Patent number: 4229455
    Abstract: Benzocycloheptapyridines with an imine bridge in the cycloheptane ring, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease.
    Type: Grant
    Filed: October 18, 1978
    Date of Patent: October 21, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, Wasyl Halczenko
  • Patent number: 4228676
    Abstract: Improved probe for collecting oil ash samples having a porous, closed end tube.
    Type: Grant
    Filed: May 23, 1979
    Date of Patent: October 21, 1980
    Assignee: Calgon Corporation
    Inventor: John G. Myers
  • Patent number: 4228161
    Abstract: A novel drug combination for more effective treatment of pain, fever, and inflammation with reduced ulcerogenicity comprising (a) 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid (indomethacin), and (b) a member selected from phenyl benzoic acid compounds, especially 2-hydroxy-5-(2',4'-difluorophenyl)benzoic acid (diflunisal), wherein the molar ratio of (b) to (a) is from 0.5 to 1.0 to 15.0 to 1.0.
    Type: Grant
    Filed: March 28, 1979
    Date of Patent: October 14, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Tsung-Ying Shen
  • Patent number: 4225445
    Abstract: Acids, thickened with branched emulsion or suspension polymers of diallyldimethylammonium chloride are useful as oil well drilling and fracturing fluids for stimulating well production and in other applications, such as thickeners for cosmetics, paints, adhesives, textiles and printing inks.
    Type: Grant
    Filed: November 15, 1978
    Date of Patent: September 30, 1980
    Assignee: Calgon Corporation
    Inventor: Kenneth W. Dixon
  • Patent number: 4225609
    Abstract: This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of biological activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives.
    Type: Grant
    Filed: August 30, 1978
    Date of Patent: September 30, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Ta-jyh Lee, John B. Bicking
  • Patent number: 4223788
    Abstract: A rigid blister package includes a rigid thermoformed plastic cover piece and a flexible backing sheet, a score line for opening said package, and a slide fastener for reclosing the blister package, along with stops to hold the slide fastener in the open or closed position.
    Type: Grant
    Filed: November 16, 1978
    Date of Patent: September 23, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Arthur Jaeger, Richard Gunderlock, Richard J. Harwood
  • Patent number: 4222901
    Abstract: Electroconductive copolymers of diallyldimethylammonium chloride and at least 15 percent by weight acrylamide which exhibit improved solvent holdout.
    Type: Grant
    Filed: November 15, 1978
    Date of Patent: September 16, 1980
    Assignee: Calgon Corporation
    Inventor: Gloria D. Sinkovitz
  • Patent number: 4221790
    Abstract: The invention relates to novel 2,2-dioxo-1,2,3-benzoxathiazines substituted in the benzene nucleus, as well as the 3,4-dihydro analogs thereof, useful as anti-inflammatory, antipyretic, analgesic agents.
    Type: Grant
    Filed: April 16, 1979
    Date of Patent: September 9, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Robert L. Smith, Gerald E. Stokker
  • Patent number: 4220584
    Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo
  • Patent number: 4220485
    Abstract: Process for sealing phosphatized metal components to improve corrosion resistance and paint adhesion which involves coating said components with a zinc-containing sealant.
    Type: Grant
    Filed: December 14, 1978
    Date of Patent: September 2, 1980
    Assignee: Calgon Corporation
    Inventors: George D. Howell, Donald A. Lange
  • Patent number: 4220638
    Abstract: An antigenic, immunogenic, non-toxic complex is obtained from the cell surface of N. gonorrhoeae.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Yashwant D. Karkhanis, Dennis J. Carlo
  • Patent number: 4220651
    Abstract: The levorotatory enantiomers of 3-halocyproheptadines and related compounds are antipyschotic agents and certain members of the group are novel compounds. Their dextrorotatory counterparts find utility as a source for additional levorotatory enantiomer.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventor: David C. Remy
  • Patent number: 4220775
    Abstract: A method of preparing a compound of the formula: ##STR1## where Formula (I) may also have the structure of partial Formula (III); wherein, ##STR2## R' is hydrogen or methyl; R" is hydrogen or .beta.-methyl;R'" is .beta.-methyl or hydroxy;Z is (1) oxo;(2) .beta.-hydrogen and .alpha.-hydroxy; or .alpha.-hydrogen or .alpha.-hydroxyl and(3) (Y).sub.n Q where n=0 or 1, Y is a straight or branched hydrocarbon chain of 1 to 12 carbon atoms andQ is ##STR3## where R.sup.8 is, ##STR4## where the dashed bond replaces the 17.alpha. hydrogen; (6) cyano; or(7) tetrazolyl;and pharmaceutically acceptable salts of the above compounds;CHARACTERIZED IN THAT(I.) a compound of the formula: ##STR5## , where A has the meanings above except --CH.dbd.CH--, is (1) treated with an oxidizing agent at reduced temperatures to form the corresponding 5-oxo-3,5-seco-androstan-3-oic acid compound;(2) treating the product of step (1) with an amine of formula: R.sup.1 NH.sub.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Gary H. Rasmusson, David B. R. Johnston, Donald F. Reinhold, Torleif Utne, Ronald B. Jobson
  • Patent number: 4217340
    Abstract: A novel, rapid acting drug combination comprising a phenyl benzoic acid compound and magnesium hydroxide. The combination results in earlier, higher plasma levels of the analgesic, anti-inflammatory drug.
    Type: Grant
    Filed: March 21, 1979
    Date of Patent: August 12, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Jonathan A. Tobert
  • Patent number: 4216160
    Abstract: Substituted mercapto acid amides are prepared, and are useful as immunoregulants for correcting an imbalance of immune homeostasis, particularly as immunostimulants in the treatment of autoimmune and immune deficient diseases and disorders.
    Type: Grant
    Filed: September 8, 1978
    Date of Patent: August 5, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Conrad P. Dorn, Howard Jones
  • Patent number: 4216340
    Abstract: Improved method of preparing 5-(2,4-difluorophenyl)salicylic acid and derivatives which favors formation of the desired end product over other undesired isomers, comprising the steps of(a) diazotizing an aniline compound,(b) treating the diazonium salt with a salicylic acid ester compound blocked in the 3-position with an easily removed blocking group, preferably cloro,(c) removing the blocking group, and(d) hydrolyzing the ester to form the acid final product.
    Type: Grant
    Filed: May 2, 1979
    Date of Patent: August 5, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Leonard M. Weinstock, Arthur S. Wildman, Carl Bagner
  • Patent number: 4215096
    Abstract: Gas streams contaminated with acid and acid precursor gases and vapors are purified by contacting the gas streams with activated carbon impregnated with sodium hydroxide.
    Type: Grant
    Filed: November 9, 1978
    Date of Patent: July 29, 1980
    Assignee: Calgon Corporation
    Inventors: Rabindra K. Sinha, Charles K. Polinsky, S. David Cifrulak, Norman J. Wagner
  • Patent number: 4212871
    Abstract: 3-Hydroxymethyl derivatives of cyproheptadine and related compounds are appetite stimulants and antihistaminic agents.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: July 15, 1980
    Assignee: Merck & Co., Inc.
    Inventor: John D. Prugh
  • Patent number: 4211333
    Abstract: An improved tamperproof container for lyophilized material wherein the container comprises a vial having flange about its opening. Below the flange, but spaced apart therefrom is a shoulder to define an indented neck therebetween. The opening is sealed with a pierceable stopper. An overcap extends over the flange and about the neck to form a skirt about the neck. The skirt has at least a portion thereof extending inwardly in gripping relation with the neck and limited in removal by contact with the underside of the flange whereby the cap cannot be removed without destroying its structural integrity.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: July 8, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Miguel Villarejos