Abstract: The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.

Abstract: An oral pharmaceutical composition comprising a capsule dosage form containing a liquid fill composition including an anilinopyrimidine derivative of Formula (I) and a pharmaceutically acceptable excipient selected from the group consisting of polyethylene glycol, a glyceryl ester of capric acid or a mixture thereof. The liquid fill composition is formulated in a hard gelatin capsules and can be used for the preparation of a medicament for the treatment of cancer in particular AML.

Abstract: A method for manufacturing an organic semiconductor device having a plurality of pixels, said method comprising: providing a substrate comprising a patterned layer of well-defining banks (308); depositing a first conductive material (310, 312) in the wells and over the well-defining banks (308), the first conductive material forming first electrodes (310) in the wells and bus-bars (312) over the well-defining banks (308) with an electrical break therebetween; depositing an organic semiconductive layer (318) over the first electrodes (310) in the wells; and depositing a second conductive material (320) over both the organic semiconductive layer (318) and the bus-bars (312) forming a continuous second electrode (320) over the organic semiconductive layer (318) and the bus-bars (312).

Abstract: A labelling machine for containers, including a basic machine provided with a docking station for a labelling unit, the labelling unit being adapted to be docked to and undocked from a target position at the basic machine with a predetermined sequence of relative movements, and respective media connector parts being arranged on the basic machine and on the labelling unit, respectively, and adapted to be coupled to one another. The media connector parts are implemented in such a way that and are arranged on the labelling unit and the docking station with respect to the target position in such a way that they are adapted to be automatically coupled by means of the docking sequence of movements and automatically decoupled by means of the undocking sequence of movements.

Abstract: The present invention relates to materials and methods for human antibodies specific for the peptide hormone gastrin and uses of these antibodies in the treatment of subjects having cancer and other conditions or disorders related to gastrin expression.

Abstract: The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.

Abstract: Methods for making antimicrobial resins and for forming coatings comprising antimicrobial resins on substrate surfaces are disclosed. The methods involve providing a mixture comprising about 15 weight % to about 80 weight % of a hydrophilic acrylic oligomer, about 10 weight % to about 80 weight % of a multifunctional acrylic monomer, about 5 weight % to about 40 weight % of an adhesion-promoting acrylic or vinyl monomer, and about 0.1 weight % to about 15 weight % of a metal salt; and exposing the mixture to a radiation source to cure at least a portion of the mixture, thereby forming an antimicrobial resin.

Abstract: In an oscilloscope probe with a transistor amplifier constructed on a semiconductor substrate using integrated circuit technology, at least one part of the input-voltage divider is also constructed together with the amplifier using integrated-circuit technology on the semiconductor substrate.

Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold.

Abstract: A package of cigarettes, having: a group of cigarettes; an inner package enclosing the group of cigarettes and made from a sheet of wrapping folded about the group of cigarettes; and a U-shaped stiffener made of rigid material and located inside the inner package, contacting the group of cigarettes; the sheet of wrapping has two flaps which are superimposed and heat sealed to each other at a rear wall or front wall of the group of cigarettes defined by the cylindrical lateral walls of the cigarettes.

Abstract: An adaptive process controller performs continuously scheduled process model parameter interpolation to determine a particular set of process model parameters which are used to develop controller tuning parameters for controller tuning. More particularly, a state-based, adaptive PID controller described herein uses a new technique to determine an appropriate process model to be used to perform adaptive tuning over the various operating regions of the plant, and in particular, uses a process model parameter determination technique that enables continuously scheduled process model parameter update over the various plant operating regions or points. The use of this continuously scheduled process model parameter update method provides for smoother transitions between tuning parameters used in the PID controller during adaptive tuning procedures which are implemented based on changes in the operating region or the operating point of the process, thereby providing for better overall control.

Abstract: A method of manufacturing a nonvolatile memory device wherein first gate lines and second gate lines are formed over a semiconductor substrate. The first gate lines are spaced-from each other at a first width, the second gate lines are spaced-from each other at a second width, and the first width is wider than the second width. A first ion implantation process of forming first junction regions in the semiconductor substrate between the first gate lines and the second gate lines is performed. A second ion implantation process of forming second junction regions in the respective first junction regions between the first gate lines is then performed.

Abstract: Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided.

Abstract: This invention discloses a method, using pure niobium as a transient liquid reactive braze material, for fabrication of cellular or honeycomb structures, wire space-frames or other sparse builtup structures or discrete articles using Nitinol (near-equiatomic titanium-nickel alloy) and related shape-memory and superelastic alloys. Nitinol shape memory alloys (SMAs), acquired in a form such as corrugated sheet, discrete tubes or wires, may be joined together using the newly discovered joining technique. Pure niobium when brought into contact with nitinol at elevated temperature, liquefies at temperatures below the melting point and flows readily into capillary spaces between the elements to be joined, thus forming a strong joint.

Abstract: A semiconductor device includes a PMOS transistor of a peripheral circuit region. The PMOS transistor is formed over a silicon germanium layer to have a compressive strain structure, thereby increasing hole mobility of a channel region in operation of the device. The semiconductor device may include a second active region including a silicon layer connected to a first active region of a semiconductor substrate, a silicon germanium layer formed over the silicon layer expected to be a PMOS region, and a PMOS gate formed over the silicon germanium layer.

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract: A bottle treatment system having a safety unit that improves the operational process, including a first accessible safety region, a second accessible safety region and a shut-off device. The first safety region is delimited by a first protection in which a first machine has a drive associated with the first protective region. The second accessible protective region is delimited by a second protection direction following the first protection, with a second machine having at least one further drive associated to the second protective region. A bottle transport from the first machine to the second machine is provided via a transport device, as provided with an individual drive and exceeds the protective region. The shut-off device turns off the machine drive associated with at least one of the respective protective regions and the drive of the transport device exceeding the protective region, if access to protective region is detected.