Patents Represented by Attorney Michael J. Roth
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Patent number: 6084093Abstract: The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.Type: GrantFiled: May 16, 1995Date of Patent: July 4, 2000Assignee: G. D. Searle & Co.Inventors: Dennis P. Riley, Randy H. Weiss, William L. Neuman, Anil S. Modak, Patrick J. Lennon, Karl W. Aston
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Patent number: 5874421Abstract: The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.Type: GrantFiled: June 6, 1995Date of Patent: February 23, 1999Assignee: G. D. Searle & Co.Inventors: Dennis P. Riley, Randy H. Weiss, William L. Neuman, Anil S. Modak, Patrick J. Lennon, Karl W. Aston
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Patent number: 5721361Abstract: A process for preparing a substituted polyazamacrocycle is provided which comprises contacting a diamine or triamine and a dicarboxylic acid or ester or anhydride thereof in the presence of a suitable base and a suitable solvent to produce the substituted polyazamacrocycle provided that when an ester of said dicarboxylic acid is used, said suitable base is optional, and when said dicarboxylic acid or an anhydride of said dicarboxylic acid is used, the reaction mixture further comprises a suitable coupling agent.Type: GrantFiled: June 11, 1996Date of Patent: February 24, 1998Assignee: The Monsanto CompanyInventors: Patrick J. Lennon, Susan L. Henke, Karl W. Aston
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Patent number: 5506367Abstract: According to the invention, there is provided an inbred corn line, designated PHP38. This invention thus relates to the plants and seeds of inbred corn line PHP38 and to methods for producing a corn plant produced by crossing the inbred line PHP38 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHP38 with another corn line or plant and to crosses with related species.Type: GrantFiled: December 23, 1992Date of Patent: April 9, 1996Assignee: Pioneer Hi-Bred International, Inc.Inventor: Joseph W. Keaschall
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Patent number: 5350686Abstract: A method of enhancing the enzyme-catalyzed modification of macromolecules comprising exposure of the enzyme and its macromolecule substrate to microwaves is disclosed. A frequency of from 1800 to 3000 MHz and a power of from 50 to 100 watts is preferred. The procedure is rapid, efficient, and suitable for many enzyme-catalyzed reactions. The method can be used for restriction endonuclease digestion of DNA samples and facilitates one of the time-consuming procedures of nucleic acid research. The method is also adaptable for automated procedures in biological research.Type: GrantFiled: April 16, 1992Date of Patent: September 27, 1994Assignee: Pioneer Hi-Bred International, Inc.Inventor: Anil K. Jhingan
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Patent number: 5276264Abstract: Sunflower seed, plants and oil are described which have a total level of saturated fatty acids equal to 6% or less relative to the total fatty acid content, a total level of stearic acid less than 1% of the total fatty acid content, and a total level of palmitic acid less than 3% of the total fatty acid content.Type: GrantFiled: December 19, 1991Date of Patent: January 4, 1994Assignee: Pioneer Hi-Bred International, Inc.Inventors: Thomas C. Heaton, Glenn S. Cole, Barry A. Martin
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Patent number: 5276265Abstract: According to the invention, there is provided an inbred corn line, designated PHR31. This invention thus relates to the plants and seeds of inbred corn line PHR31 and to methods for producing a corn plant produced by crossing the inbred line PHR31 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHR31 with another corn line or plant.Type: GrantFiled: February 3, 1992Date of Patent: January 4, 1994Assignee: Pioneer Hi-Bred International, Inc.Inventor: Samuel G. Fullerton
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Patent number: 5245125Abstract: According to the invention, there is provided an inbred corn line, designated PHJ90. This invention thus relates to the plants and seeds of inbred corn line PHJ90 and to methods for producing a corn plant produced by crossing the inbred line PHJ90 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHJ90 with another corn line or plant.Type: GrantFiled: February 1, 1991Date of Patent: September 14, 1993Assignee: Pioneer Hi-Bred International, Inc.Inventor: Joseph K. Gogerty
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Patent number: 5157206Abstract: According to the invention, there is provided an inbred corn line, designated PHN82. This invention thus relates to the plants and seeds of inbred corn line PHN82 and to methods for producing a corn plant produced by crossing the inbred line PHN82 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHN82 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: October 20, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventor: Stephen W. Noble
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Patent number: 5097096Abstract: According to the invention, there is provided an inbred corn line, designated PHW20. This invention thus relates to the plants and seeds of inbred corn line PHW20 and to methods for producing a corn plant produced by crossing the inbred line PHW20 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHW20 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: March 17, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventor: Terrill E. Williams
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Patent number: 5097093Abstract: According to the invention, there is provided an inbred corn line, designated PHJ33. This invention thus relates to the plants and seeds of inbred corn line PHJ33 and to methods for producing a corn plant produced by crossing the inbred line PHJ33 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHJ33 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: March 17, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventors: Walter E. Vandeventer, Joseph W. Keaschall
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Patent number: 5097092Abstract: According to the invention, there is provided an inbred corn line, designated PHR62. This invention thus relates to the plants and seeds of inbred corn line PHR62 and to methods for producing a corn plant produced by crossing the inbred line PHR62 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHR62 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: March 17, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventor: Loren J. Hoffbeck
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Patent number: 5097094Abstract: According to the invention, there is provided an inbred corn line, designated PHP60. This invention thus relates to the plants and seeds of inbred corn line PHP60 and to methods for producing a corn plant produced by crossing the inbred line PHP60 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHP60 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: March 17, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventors: Philip R. Martin, Robert R. Fincher, James A. Wright
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Patent number: 5097095Abstract: According to the invention, there is provided an inbred corn line, designated PHM10. This invention thus relates to the plants and seeds of inbred corn line PHM10 and to methods for producing a corn plant produced by crossing the inbred line PHM10 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHM10 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: March 17, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventor: Robert W. Rosenbrook
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Patent number: 5095174Abstract: According to the invention, there is provided an inbred corn line, designated PHK35. This invention thus relates to the plants and seeds of inbred corn line PHK35 and to methods for producing a corn plant produced by crossing the inbred line PHK35 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHK35 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: March 10, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventors: Walter E. Vandeventer, Joseph W. Keaschall
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Patent number: 5082992Abstract: According to the invention, there is provided an inbred corn line, designated PHP02. This invention thus relates to the plants and seeds of inbred corn line PHP02 and to methods for producing a corn plant produced by crossing the inbred line PHP02 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHP02 with another corn line or plant and to crosses with related species.Type: GrantFiled: November 1, 1988Date of Patent: January 21, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventors: William B. Ambrose, Thomas C. Kevern
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Patent number: 5082991Abstract: According to the invention, there is provided an inbred corn line, designated PHN37. This invention thus relates to the plants and seeds of inbred corn line PHN37 and to methods for producing a corn plant produced by crossing the inbred line PHN37 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHN37 with another corn line or plant and to crosses with related species.Type: GrantFiled: August 30, 1989Date of Patent: January 21, 1992Assignee: Pioneer Hi-Bred International, Inc.Inventor: Jack A. Cavanah
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Patent number: 4857507Abstract: The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; arylalkyl; OR.sub.10 or SR.sub.10 wherein R.sub.10 is hydrogen, loweralkyl or aminoalkyl; NR.sub.11 R.sub.12 wherein R.sub.11 and R.sub.12 are independently selected from hydrogen, loweralkyl, aminoalkyl, cyanoalkyl and hydroxyalkyl; ##STR2## wherein B is NH, alkylamino, S, O, CH.sub.2 or CHOH and R.sub.13 is loweralkyl, cycloalkyl, aryl, arylalkyl, alkoxy, alkenyloxy, hydroxyalkoxy, dihydroxyalkoxy, arylalkoxy, arylalkoxyalkyl, amino, alkylamino, dialkylamino, (hydroxyalkyl)(alkyl)amino, (dihydroxyalkyl)(alkyl)amino, aminoalkyl, alkoxycarbonylalkyl, carboxyalkyl, N-protected aminoalkyl, alkylaminoalkyl, (N-protected)(alkyl)aminoalkyl, dialkylaminoalkyl, (heterocyclic) alkyl or a substituted or unsubstituted heterocyclic; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloaklylmethyl, benzyl, .alpha.,.alpha.Type: GrantFiled: January 9, 1987Date of Patent: August 15, 1989Assignee: Abbott LaboratoriesInventors: Saul H. Rosenberg, Joseph Dellaria, Anthony K, L. Fung, Dale J. Kempf, Jay R. Luly, Jacob J. Plattner
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Patent number: 4840621Abstract: A device for automatically transferring a piercing pin from the port of one medical liquid container to the port of another medical liquid container. The ports are mounted to the device in opposing relationship. The piercing pin is inverted at an intermediate position between the ports.Type: GrantFiled: January 19, 1988Date of Patent: June 20, 1989Assignee: Abbott LaboratoriesInventors: Mark E. Larkin, John E. Ogden
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Patent number: D305150Type: GrantFiled: May 1, 1987Date of Patent: December 19, 1989Assignee: Abbott LaboratoriesInventor: John Pastrone