Patents Represented by Attorney Michael J. Roth
  • Patent number: 6084093
    Abstract: The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: July 4, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Dennis P. Riley, Randy H. Weiss, William L. Neuman, Anil S. Modak, Patrick J. Lennon, Karl W. Aston
  • Patent number: 5874421
    Abstract: The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 23, 1999
    Assignee: G. D. Searle & Co.
    Inventors: Dennis P. Riley, Randy H. Weiss, William L. Neuman, Anil S. Modak, Patrick J. Lennon, Karl W. Aston
  • Patent number: 5721361
    Abstract: A process for preparing a substituted polyazamacrocycle is provided which comprises contacting a diamine or triamine and a dicarboxylic acid or ester or anhydride thereof in the presence of a suitable base and a suitable solvent to produce the substituted polyazamacrocycle provided that when an ester of said dicarboxylic acid is used, said suitable base is optional, and when said dicarboxylic acid or an anhydride of said dicarboxylic acid is used, the reaction mixture further comprises a suitable coupling agent.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: February 24, 1998
    Assignee: The Monsanto Company
    Inventors: Patrick J. Lennon, Susan L. Henke, Karl W. Aston
  • Patent number: 5506367
    Abstract: According to the invention, there is provided an inbred corn line, designated PHP38. This invention thus relates to the plants and seeds of inbred corn line PHP38 and to methods for producing a corn plant produced by crossing the inbred line PHP38 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHP38 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: April 9, 1996
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Joseph W. Keaschall
  • Patent number: 5350686
    Abstract: A method of enhancing the enzyme-catalyzed modification of macromolecules comprising exposure of the enzyme and its macromolecule substrate to microwaves is disclosed. A frequency of from 1800 to 3000 MHz and a power of from 50 to 100 watts is preferred. The procedure is rapid, efficient, and suitable for many enzyme-catalyzed reactions. The method can be used for restriction endonuclease digestion of DNA samples and facilitates one of the time-consuming procedures of nucleic acid research. The method is also adaptable for automated procedures in biological research.
    Type: Grant
    Filed: April 16, 1992
    Date of Patent: September 27, 1994
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Anil K. Jhingan
  • Patent number: 5276265
    Abstract: According to the invention, there is provided an inbred corn line, designated PHR31. This invention thus relates to the plants and seeds of inbred corn line PHR31 and to methods for producing a corn plant produced by crossing the inbred line PHR31 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHR31 with another corn line or plant.
    Type: Grant
    Filed: February 3, 1992
    Date of Patent: January 4, 1994
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Samuel G. Fullerton
  • Patent number: 5276264
    Abstract: Sunflower seed, plants and oil are described which have a total level of saturated fatty acids equal to 6% or less relative to the total fatty acid content, a total level of stearic acid less than 1% of the total fatty acid content, and a total level of palmitic acid less than 3% of the total fatty acid content.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: January 4, 1994
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Thomas C. Heaton, Glenn S. Cole, Barry A. Martin
  • Patent number: 5245125
    Abstract: According to the invention, there is provided an inbred corn line, designated PHJ90. This invention thus relates to the plants and seeds of inbred corn line PHJ90 and to methods for producing a corn plant produced by crossing the inbred line PHJ90 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHJ90 with another corn line or plant.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: September 14, 1993
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Joseph K. Gogerty
  • Patent number: 5157206
    Abstract: According to the invention, there is provided an inbred corn line, designated PHN82. This invention thus relates to the plants and seeds of inbred corn line PHN82 and to methods for producing a corn plant produced by crossing the inbred line PHN82 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHN82 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: October 20, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Stephen W. Noble
  • Patent number: 5097092
    Abstract: According to the invention, there is provided an inbred corn line, designated PHR62. This invention thus relates to the plants and seeds of inbred corn line PHR62 and to methods for producing a corn plant produced by crossing the inbred line PHR62 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHR62 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: March 17, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Loren J. Hoffbeck
  • Patent number: 5097096
    Abstract: According to the invention, there is provided an inbred corn line, designated PHW20. This invention thus relates to the plants and seeds of inbred corn line PHW20 and to methods for producing a corn plant produced by crossing the inbred line PHW20 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHW20 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: March 17, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Terrill E. Williams
  • Patent number: 5097094
    Abstract: According to the invention, there is provided an inbred corn line, designated PHP60. This invention thus relates to the plants and seeds of inbred corn line PHP60 and to methods for producing a corn plant produced by crossing the inbred line PHP60 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHP60 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: March 17, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Philip R. Martin, Robert R. Fincher, James A. Wright
  • Patent number: 5097093
    Abstract: According to the invention, there is provided an inbred corn line, designated PHJ33. This invention thus relates to the plants and seeds of inbred corn line PHJ33 and to methods for producing a corn plant produced by crossing the inbred line PHJ33 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHJ33 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: March 17, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Walter E. Vandeventer, Joseph W. Keaschall
  • Patent number: 5097095
    Abstract: According to the invention, there is provided an inbred corn line, designated PHM10. This invention thus relates to the plants and seeds of inbred corn line PHM10 and to methods for producing a corn plant produced by crossing the inbred line PHM10 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHM10 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: March 17, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Robert W. Rosenbrook
  • Patent number: 5095174
    Abstract: According to the invention, there is provided an inbred corn line, designated PHK35. This invention thus relates to the plants and seeds of inbred corn line PHK35 and to methods for producing a corn plant produced by crossing the inbred line PHK35 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHK35 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: March 10, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Walter E. Vandeventer, Joseph W. Keaschall
  • Patent number: 5082991
    Abstract: According to the invention, there is provided an inbred corn line, designated PHN37. This invention thus relates to the plants and seeds of inbred corn line PHN37 and to methods for producing a corn plant produced by crossing the inbred line PHN37 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHN37 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: January 21, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: Jack A. Cavanah
  • Patent number: 5082992
    Abstract: According to the invention, there is provided an inbred corn line, designated PHP02. This invention thus relates to the plants and seeds of inbred corn line PHP02 and to methods for producing a corn plant produced by crossing the inbred line PHP02 with itself or with another corn plant. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line PHP02 with another corn line or plant and to crosses with related species.
    Type: Grant
    Filed: November 1, 1988
    Date of Patent: January 21, 1992
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: William B. Ambrose, Thomas C. Kevern
  • Patent number: 4857507
    Abstract: The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; arylalkyl; OR.sub.10 or SR.sub.10 wherein R.sub.10 is hydrogen, loweralkyl or aminoalkyl; NR.sub.11 R.sub.12 wherein R.sub.11 and R.sub.12 are independently selected from hydrogen, loweralkyl, aminoalkyl, cyanoalkyl and hydroxyalkyl; ##STR2## wherein B is NH, alkylamino, S, O, CH.sub.2 or CHOH and R.sub.13 is loweralkyl, cycloalkyl, aryl, arylalkyl, alkoxy, alkenyloxy, hydroxyalkoxy, dihydroxyalkoxy, arylalkoxy, arylalkoxyalkyl, amino, alkylamino, dialkylamino, (hydroxyalkyl)(alkyl)amino, (dihydroxyalkyl)(alkyl)amino, aminoalkyl, alkoxycarbonylalkyl, carboxyalkyl, N-protected aminoalkyl, alkylaminoalkyl, (N-protected)(alkyl)aminoalkyl, dialkylaminoalkyl, (heterocyclic) alkyl or a substituted or unsubstituted heterocyclic; W is CO or CHOH and U is CH.sub.2 or NR.sub.2 with the proviso that when W is CHOH then U is CH.sub.2 ; R.sub.1 is loweralkyl, cycloaklylmethyl, benzyl, .alpha.,.alpha.
    Type: Grant
    Filed: January 9, 1987
    Date of Patent: August 15, 1989
    Assignee: Abbott Laboratories
    Inventors: Saul H. Rosenberg, Joseph Dellaria, Anthony K, L. Fung, Dale J. Kempf, Jay R. Luly, Jacob J. Plattner
  • Patent number: 4840621
    Abstract: A device for automatically transferring a piercing pin from the port of one medical liquid container to the port of another medical liquid container. The ports are mounted to the device in opposing relationship. The piercing pin is inverted at an intermediate position between the ports.
    Type: Grant
    Filed: January 19, 1988
    Date of Patent: June 20, 1989
    Assignee: Abbott Laboratories
    Inventors: Mark E. Larkin, John E. Ogden
  • Patent number: D305150
    Type: Grant
    Filed: May 1, 1987
    Date of Patent: December 19, 1989
    Assignee: Abbott Laboratories
    Inventor: John Pastrone