Abstract: The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; aryalkyl; OR.sub.8 or SR.sub.8 wherein R.sub.8 is hydrogen, loweralkyl or aminoalkyl; NR.sub.9 R.sub.10 wherein R.sub.9 and R.sub.10 are independently selected from hydrogen, loweralkyl, aminoalkyl, cyanoalkyl and hydroxyalkyl; ##STR2## wherein B is NH, alkylamino, S, O, CH.sub.2 or CHOH and R.sub.11 is loweralkyl, cycloalkyl, aryl, arylalkyl, alkoxy, alkenyloxy, hydroxyalkoxy, dihydroxyalkoxy, arylalkoxy, arylalkoxyalkyl, amino, alkylamino, dialkylamino, (hydroxyalkyl)(alkyl)amino, (dihydroxyalkyl)(alkyl)amino, carboxylic acid-substituted alkyl, alkoxycarbonylalkyl, aminoalkyl, N-protected aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, (N-protected)-(alkyl)aminoalkyl, (heterocyclic)alkyl or a substituted or unsubstituted heterocyclic; R.sub.1 is loweralkyl, cycloalkylmethyl, benzyl, .alpha.-methylbenzyl, .alpha.,.alpha.

Abstract: A container having two compartments for keeping two materials in separated relation. When it is desired that the two materials be intermixed, an actuator carrying a pair of piercing pins is inserted into ports of the compartments until membranes blocking exit of the materials from their respective compartment are punctured. When these membranes are punctured the materials are received at a mixing chamber where the materials are mixed.

Abstract: The invention is an integral container system designed for separately storing a liquid, such as a diluent, and a second substance, such as a medicament, and subsequently adding the second substance to the liquid in a simple and sterile operation. In one embodiment, a flexible I.V. bag is provided with a second substance dispensing cup containing a powdered medicament, which cup fits slidably in a sleeve passing through the walls of the bag. Fitted in the open end of the cup is a pierceable plunger. A hollow needle is held in position to pierce the plunger when the cup is pushed toward the needle. The needle is slidably held so that when it is pushed by the plunger, it will also pierce a diaphragm fitting over the sleeve. When both the plunger and the diaphragm are pierced, fluid access between the cup and the bag is had through the hollow needle. Diluent can then be injected into the cup to dissolve or slurry the powdered medicament.

Abstract: Semisynthetic antibiotics with improved therapeutic properties made from erythromycin are disclosed. 11,12-Cyclic carbamates of erythromycin, its derivatives, and their salts and esters show superior in vitro antimicrobial activity and reduced hepatotoxicity compared to the parent compounds.

Abstract: Semisynthetic antibiotics with improved therapeutic properties made from erythromycin are disclosed. Certain 4"-carbamates of erythromycin, its derivatives, and their salts and esters show superior in vitro antimicrobial activity and reduced gastrointestinal stimulation compared to the parent compounds.

Abstract: A plug is provided within a port in a flexible container. Extending from the port is a piece of flexible tubing which is used to connect with other tubing in a fluid system. Fluid is dispensed from the flexible container by grasping the end of the plug extending into the flexible container. The plug is then pulled into the interior of the container so that the opposite end of the plug which seals the flexible tubing extending from the port is unseated. The flexible tubing extending from the port is now open to the flow of fluid from the flexible container.

Abstract: A closure device for severing the frangible section between the cap and body of a blow-fill-seal plastic container comprising an expandable ring constructed and arranged to encircle the container cap, an outer ring having at one end internal threads compatible with the external threads located on the neck of the container body and a tamper proof overcap.Counterclockwise rotation of the outer ring transmits uniform upward pressure to the expandable ring which causes tension between the container cap and container body, rupturing the frangible line of weakness on the container, to permit opening of the container. Conversely, clockwise rotation of the outer ring causes compression to rupture the frangible line of weakness. Subsequent counterclockwise rotation opens the container. In either case the container cap is retained within the outer ring and is replaceable on the container.

Abstract: A fluid infusion positive displacement pump includes a plunger driven by a stepping motor which is operated by a motor control system. The control system advances the plunger to expel liquid in a series of incremental steps at a user-set pumping rate and until a preset total dosage has been delivered with the pumping rate being determined by the waiting time between each step. In order to minimize shock to the patient, the pump is operated at a plurality of increasing fractional rates during the start of pumping and at a plurality of decreasing fractional rates at the termination of pumping with the user-set (maximum) pumping rate occurring between such fractional rate pumping periods.

Abstract: A device for infusing a secondary fluid through a primary fluid administration set without mixing the primary and secondary fluids is disclosed. Two pistons which are releasably locked in tandem slide within a chamber having an output port, dividing the chamber into two portions. The portion having the outlet port contains the secondary fluid. One piston faces the secondary fluid, while the other has a bore which is in fluid communication with the primary administration set. The pistons can be decoupled, allowing them to move apart to create a third portion in the chamber which can fill with fluid from the primary administration set through the piston which is not in contact with the secondary fluid. When the latter piston is locked in position, a pump in the primary administration set generates pressure in the portion between the pistons. This pressure drives the piston facing the secondary fluid, forcing the secondary fluid out of the chamber and into the patient.

Abstract: Disclosed herein are erythromycin derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl, aryl, alkene, aryl halide, alkylamino, hydroxyalkyl and furanyl, and pharmaceutically acceptable salts thereof. These compounds have improved oral absorption, reduced effects on gastrointestinal motility, increased acid stability and longer serum half-lives.

Abstract: An erythromycin A derivative with high antimicrobial activity and improved pharmacokinetics is disclosed. 4"-Deoxyerythromycin A 11,12-carbonate and derivatives show superior in vitro and in vivo antimicrobial activity compared to erythromycin A, and when administered to animals has a serum half-life much prolonged over that of erythromycin A.

Abstract: Erythromycin A derivatives with high antimicrobial activity are disclosed. 14-hydroxyerythromycin A and derivatives show superior in vitro antimicrobial activity compared to the parent compounds.

Abstract: A suction drainage system for body cavities includes a suction collection container, and a disposable suction control chamber through which an essentially constant level of suction is applied to a body cavity. Drained fluids flow into the suction collection container, into the suction control chamber through an elastomeric check valve which precludes backflow of fluids to the patient. A pressure monitoring tube in the suction control chamber has a lower end communicating with ambient pressure and an upper end communicating with the interior of the suction control chamber. A ball in the tube rises to a level which is proportional to the negative pressure inside the suction control chamber. The suction control chamber can be removably mounted to the collection container.

Abstract: Novel O-alkylsilyl derivatives of macrolide antibiotics are disclosed. These compounds have markedly superior taste properties when compared to the corresponding parent compounds.

Abstract: An improved additive transfer device for storing and subsequently transferring a fluid material from an additive container to a rigid or semirigid solution container having an exposed closure. The improved additive transfer device is mounted on the additive container and includes a closure assembly fabricated from three components; a pierceable stopper, a slidable piercing pin and a hood member. The closure assembly is adapted to be positioned on the solution container. The two ended slidable piercing pin is disposed in a central opening in the pierceable stopper so that one end will pierce a diaphragm contained in the pierceable stopper. Resistance elements are provided between the slidable piercing pin and the central opening in the pierceable stopper to hold the slidable piercing pin away from the diaphragm in the pierceable stopper in one position and allow the slidable piercing pin to pierce the diaphragm and retain it within the central opening in a second position.

Abstract: Compounds of the formula ##STR1## where R.sub.1 is a trinuclear aromatic or biaryl group; R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl or cycloalkyl; n is 0 or 1; and M is a pharmaceutically acceptable cation, are potent inhibitors of the enzymes 5-, 12-, and 15-lipoxygenase.

Abstract: A system for separately storing and sterilely mixing a diluent and a medicament within a dual chambered flexible container for eventual use in an I.V. administration system. Mixing of the contents of the two chambers is accomplished by compressing the sides of the flexible container thus causing a weakened portion in the partition between the two chambers in the flexible container to rupture, thereby providing fluid communication between the chambers and effecting intermixing of the contents thereof.

Abstract: Compounds of the formula ##STR1## where X is selected from hydrogen, C.sub.1 to C.sub.22 alkyl or alkenyl, or an electron withdrawing group;n=0 or 1 and m=0, 1, 2 or 3; but n and m are not O simultaneously;R.sub.1 and R.sub.2 independently are hydrogen, C.sub.1 to C.sub.6 alkyl, an electron withdrawing group, or R.sub.4 ;R.sub.3 is H, C.sub.1 to C.sub.6 alkyl or cycloalkyl, or R.sub.4 ; andR.sub.4 independently at each occurrence, has the formula ##STR2## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation, are potent inhibitors of lipoxygenase enzymes.