Abstract: Compounds of the formula ##STR1## where R.sub.1 is H, or C.sub.1 to C.sub.6 alkyl; R.sub.2 is selected from C.sub.1 to C.sub.22 alkyl, cycloalkyl, aralky or alkenyl; and M is a pharmaceutically acceptable cation, are potent inhibitors of the enzymes 5-, 12- and 15-lipoxygenase.

Abstract: A port system for a blow molded intravenous solution container in which microbial contamination is prevented upon administration of the solution. The port system includes an integrally formed tube projecting outwardly from the container with a pierceable diaphragm positioned over the entry portion of the tube. Preferably, with respect to the tube entry portion, the diaphragm is concave, and may be made thinner in the center to facilitate proper placement of a piercing pin. In one embodiment, the port tube is inwardly flared adjacent the diaphragm so that as the piercing element is pushed through the diaphragm, the remnants of the pierced diaphragm can be pressed into the flared portion of the tube.

Abstract: This invention relates to a product which will provide a high caloric source upon I.V. administration. More particularly, this invention relates to glucosyl esters of malonic acids and substituted malonic acid derivatives which will permit the assimilation of glucose into the body at high concentrations but with low toxicity.

Abstract: The disposable transducer includes a small housing constructed of lightweight plastic material. The housing is shaped so as to form a transparent chamber within which is situated a very small piezoresistive strain gauge in the form of a resistive bridge network diffused onto a semiconductor substrate. The semiconductor substrate is electrically isolated by means of a nonconductive gel which partially fills the transparent chamber in which the semiconductor substrate is positioned. The resistive bridge network of the semiconductor substrate is also electrically connected to a plurality of calibration resistors which are separately formed on the semiconductor substrate, making the entire apparatus economically disposable after a single use.

Abstract: Cookie products, having distributed therein (1) discrete regions providing a stable, crisp texture; and (2) discrete regions providing a stable, chewy texture, have a desirable, storage-stable plurality of textures. This can be accomplished, for example, by manipulation of sugar crystallization in different parts of the product.

Abstract: Vegetable protein particle-containing sauces, such as spaghetti sauces, which are organoleptically superior to the same sauces containing real meat can be prepared by providing protein particles having a specified particle size distribution. This is preferably accomplished by agglomerating finely comminuted protein particles with binder in a heating step.

Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is O or S; wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, aryl or haloaryl, C.sub.3 -C.sub.22 alkenyl, branched or unbranched, or benzyl; wherein R.sub.1 is H, OH or OCH.sub.3, and R.sub.2 is H or OH, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These carbamates have analgesic and anti-irritant activity when administered to humans and lower animals.

Abstract: The chiral phosphine ligand (R)-1,2-bis(diphenylphosphino)-1-cyclohexylethane, when complexed to Rh(I), functions as a superior chiral hydrogenation catalyst. The chiral phosphine ligand is more stereochemically rigid than previous compounds; consequently, virtually optically pure materials can be produced from the chiral hydrogenation of prochiral compounds using the catalyst of this invention. This catalyst is especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.

Abstract: (S)-3-amino-4-[(S,S)-1-(1-hydroxyethyl)alkylamino]-4-oxo-butyric acid compounds are non-nutritive sweeteners having favorable chemical and physiological properties.

Abstract: An improved extract decaffeination process. Roast coffee extract is contacted with a water-immiscible organic solvent to form decaffeinated extract and caffeine-containing spent solvent. The spent solvent is contacted with water to form decaffeinated spent solvent and caffeine-containing spent water. The spent water can be concentrated to a caffeine content of from about 7 to about 30% by weight. The caffeine in the concentrated spent water can be crystallized out and then separated from the residual spent water. The noncaffeine solubles present in the residual spent water can then be recovered.

Abstract: A compound, or pharmaceutically acceptable salt thereof, having the formula: ##STR1## wherein X is ##STR2## wherein R is C.sub.3 -C.sub.12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C.sub.3 -C.sub.22 alkenyl, branched or unbranched; wherein R.sub.1 is H, OH or OCH.sub.3, and wherein R.sub.2 is OH or H, at least one of R.sub.1 and R.sub.2 being OH or OCH.sub.3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.

Abstract: Rhodium (1) complexes containing the chiral phosphine ligand (R)-1,2-bis(diphenylphosphino)-1-cyclohexylethane which are useful as chiral hydrogenation catalysts. These catalysts are especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.

Abstract: At least part of an antimicrobial catheter for use in humans and lower animals comprises a permeable polymer. The polymer must be in contact with both the environment external to the catheter and with a liquid reservoir of antimicrobial agent flowing through the lumen of the catheter, said liquid reservoir comprising an aqueous solution containing at least a minimum lethal concentration of a straight-chain carboxylic acid or carboxylic acid salt having from 4 to 9 carbon atoms. In use, the antimicrobial agent diffuses from the liquid reservoir through the polymer and provides a zone of microbial inhibition around the external surface of the catheter. The invention thus prevents nosocomial infections resulting from the use of catheters by inhibiting microorganisms at and around the placement site of the catheter when the catheter is inserted into the body of a human or lower animal.

Abstract: A margarine or other emulsified spread and methods for making these are disclosed. A water-in-oil emulsion is formed by mixing an aqueous base with an oil phase containing a margarine fat which comprises a soft oil and a structural fat having a unique melting profile and triglyceride composition. The emulsion is chilled to a temperature of from about 15.degree. F. (-9.degree. C.) to about 45.degree. F. (7.degree. C.) over a time period of at least about 0.5 minutes. The chilled emulsion is then crystallized over a time period of at least about 3 minutes. Due to heat generated during crystallization, the crystallized emulsion is preferably chilled further to a temperature of from about 15.degree. F. (-9.degree. C.) to about 40.degree. F. (4.degree. C.) over a time period of at least about 0.2 minutes.

Abstract: High emulsifier levels and freely available water in baked-good doughs provide dough systems with an apparent lipid-continuous, rather than sugar syrup-continuous liquid phase. When this lipid-continuous system is present, the contact surfaces of the dough mass exhibit the non-sticky character of a shortening, rather than the inherently sticky character of a sugar syrup. The dough can then be easily rolled, extruded, scooped, etc., with minimal adherence to mixing and forming equipment surfaces.

Abstract: High emulsifier levels and fluid shortening in baked good dough provide a shortening-continuous dough system, which markedly enhances shortening transfer in the baked goods. After the dough is baked, the fluid shortening readily transfers from the baked dough matrix to the incorporated flavor chips or a mixture thereof, making their texture desirably soft during storage.

Abstract: Incorporation of a carbohydrase into cookie dough provides, via a special baking process, a cookie having a storage stable texture which emulates that of freshly baked, home-style, drop-type cookies. The process for making these cookies involves (1) retarding enzyme activity in the finished dough before baking; (2) deactivating the enzyme in a portion of the cookie, preferably the surface; (3) activating the remainder of the enzyme; (4) allowing the remaining active enzyme to operate on the carbohydrates in the cookie; and (5) final baking.

Abstract: The present invention relates to medical polymers and devices made therefrom, and is based on the discovery that certain carboxylate antimicrobial agents can be releasably incorporated into permeable polymers. The walls of medical devices such as catheters can be fashioned from such polymers. In use, the antimicrobial agent diffuses from the walls to the surface of the device to form an antimicrobial barrier on the surface of the device and a zone of microbial inhibition on tissue surfaces surrounding the device, thereby effectively supplementing the body's own natural microbial barriers where they have been compromised. The bacterial contamination-resistant carboxylate-plus-polymer compositions herein can be used in the manufacture of a wide variety of medical devices, especially urinary catheters, intravenous catheters, wound dressings, and the like.

Abstract: An aromatized instant coffee comprising the combination of aroma-enriched carrier and instant coffee. The product has an aroma intensity of at least 70,000 gas chromatograph counts, a pore factor of at least 0.9, and a retention factor of at least 0.80. Also part of the invention are preferred methods of applying aroma-enriched carrier to coffee products whose roast and ground coffee aroma is desired to be increased. An especially preferred method comprises adding aroma frost-enriched coffee oil in a dropwise addition manner to the coffee product. In a most preferred embodiment, dropwise addition is accomplished by injection, preferably by a syringe member, which is extended from the open end of a coffee container to near the bottom of the container and while the syringe is being pulled upward out of said container a predetermined amount of aroma-enriched coffee oil is injected into the product.