Abstract: Heavily perfumed detergent compositions having both immediate and long lasting perfume emitting properties are prepared by a process in which perfume is emulsified in a water solution of water-soluble polymer, and the emulsion is mixed with a powdered hydratable material, in such a ratio that all of the water in the emulsion can be bound in the resulting hydrate, eliminating a separate drying step. The result is a dry, free flowing granular material which can be readily dry mixed into fully formulated detergent compositions. The perfume is retained in the polymeric matrix and is released at the point of product use when contacted with water.

Abstract: L-1-hydroxymethyl alkaneamide derivatives of .alpha.-L-aspartic acid have been prepared and have been discovered to be non-nutritive sweeteners having favorable chemical and physiological properties for use in compositions ingested orally.

Abstract: A method for the direct condensation of gaseous food volatiles, such as coffee aroma, on a food substrate, such as coffee, at cryogenic temperatures. A bed of particulated solid substrate is placed in a vessel cooled by a cryogenic fluid such as liquid nitrogen. The substrate is fluidized to provide an adsorbent bed thereof. Gaseous aroma volatiles are then adsorbed onto the cooled and fluidized bed of substrate having a temperature preferably below -150.degree. F. The aromatized substrate formed is preferably equilibrated to insure uniformity of aromatization, binding of volatiles to the substrate and storage stability. The resultant aromatized substrate can then be added to unaromatized food material for aroma and/or flavor enhancement.

Abstract: Compositions for topical application of erythromycin and derivatives or erythromycin comprising ethanol, isopropyl myristate, glycerol monooleate and the erythromycin compounds are especially useful as a treatment for acne.

Abstract: The chiral phosphine ligand (R)-1,2-bis(diphenyl-phosphino)-1-cyclohexylethane, when complexed to Rh(I), functions as a superior chiral hydrogenation catalyst. The chiral phosphine ligand is more stereochemically rigid than previous compounds; consequently, virtually optically pure materials can be produced from the chiral hydrogenation of prochiral compounds using the catalyst of this invention. This catalyst is especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.

Abstract: Capsaicin (8-methyl-N-vanillyl-6-noneanamide) is a useful, potent analgesic.

Abstract: Improved reinforced devices, which can be retained in the vagina during intercourse, deliver spermicidal surfactants and provide contraceptive benefits. Lobed devices provide channels through which menses and other biological fluids can pass. Multi-compartment devices provide added protection against leakage, rupture or perforation during manufacture, handling and use.

Abstract: The anti-inflammatory activity of fenoprofen, ketoprofen, MK-830 and other phenylacetic acid-based anti-inflammatory drugs is enhanced by administration thereof in conjunction with a phosphonate compound such as EHDP or Cl.sub.2 MDP.

Abstract: Dihydroxybenzoic acid derivatives and compositions containing same are useful for topical application to the skin as well as for systemic administration. The compounds are especially effective for providing an analgesic, anti-pyretic, and anti-inflammatory effect.

Abstract: The anti-inflammatory activity of indomethacin, indoxole, and other indole-based drugs is enhanced by administration thereof in conjunction with a phosphonate compound such as EHDP or Cl.sub.2 MDP.

Abstract: A process for preparing primary substituted n-alkane compounds, comprising contacting the olefin product of an olefin metathesis reaction having an alpha-olefin as the reactant with a bis-cyclopentadienyl zirconium hydrohalide and, after contacting the product of the olefin-zirconium hydrohalide reaction with an electrophilic reagent, recovering said primary substituted n-alkane compound.

Abstract: The anti-inflammatory activity of ibuprofen, ibufenac and other p-(isobutylphenyl)acetic acid-based anti-inflammatory drugs is enhanced by adminstration thereof in conjuction with a phosphonate compound such as EHDP or Cl.sub.2 MDP.

Abstract: Polyol fatty acid polyesters are safe and effective agents for dissolving radiolucent gallstones when administered orally, either alone or, preferably, in conjunction with a litholytic bile acid.

Abstract: Saturated triglycerides are reacted with glycerol in the presence of either a glycerolysis catalyst or a pre-formed glycerate to provide a product which is a mixture of monoglycerides, triglycerides, 1,2-diglycerides and 1,3-diglycerides. The mixture is stored in the presence of a low temperature rearrangement catalyst at a storage temperature below the melting point of the glyceride ester components of the mixture and substantially all of the mixture is converted into 1,3-diglycerides. In this way there are prepared, for example, 1-palmitoyl,3-stearoyl diglyceride, 1,3-distearoyl diglyceride and 1,3-dipalmitoyl diglyceride, which are appropriate precursors for the synthesis of confectioner's hard butters, and the like.

Abstract: Zinc compounds, especially zinc salts of carboxylic acids, react with erythromycin to provide zinc erythromycin. Topical compositions containing zincerythromycin are especially useful as a topical treatment for acne.

Abstract: A method of selectively controlling pyrophosphate-utilizing microorganisms comprises contacting said microorganisms with an organism controlling amount of certain organophosphonate compounds. Accordingly, a method of treating amoebiasis in a human or lower animal comprises administering to a human or lower animal in need of such treatment a safe and effective amount of such organophosphonate compound. Similarly, a method of selectively controlling Propionibacteria species in the manufacture of cheese comprises incorporating an organism controlling amount of an organophosphonate compound in the raw materials for said cheese.

Abstract: A composition and method for the preparation of a technetium-99m-based scanning agent are disclosed. The scanning agent is prepared from .sup.99m Tc, in a +3, +4 and/or +5 oxidation state, and a methanehydroxydiphosphonate bone-seeking agent which carries the radionuclide to bone mineral. The methanehydroxydiphosphonate agent provides scan sharpness equivalent or superior to commercial scanning agents, and is superior for detecting myocardial infarcts, as compared with commercial scanning agents such as ethane-1-hydroxy-1,1-diphosphonate and methanediphosphonate.

Abstract: A skin conditioning composition containing a guanidine inorganic salt. The compositions are in the form of lotions, creams, solutions, gels, and solids.

Abstract: Non-absorbable polyol polyesters dissolve toxic lipophilic compounds in the stomach and intestine of humans and lower animals and thus decrease their absorption. The polyol polyesters also dissolve the toxic, lipophilic materials and their metabolites if they are excreted in bile, and prevent their resorption. The invention thus provides a means for detoxifying humans and lower animals which have ingested toxic lipophilic materials (e.g., DDT, Kepone, PCB, PBB) by accelerating the excretion of such materials that have accumulated in the body. The process involves oral administration to a human or lower animal in need of such treatment of a sufficient amount of a non-absorbable polyol fatty acid polyester to effect detoxification.

Abstract: Stable compositions, useful as technetium-99m-based scintigraphic agents, comprise gentisic acid or a pharmaceutically-acceptable salt or ester thereof in combination with a pertechnetate reducing agent or dissolved in pertechnetate-99m (.sup.99m TcO.sub.4.sup.-) solution. The compositions are especially useful in combination with a phosphate or phosphonate material which carries the radionuclide to bone, thus providing a skeletal imaging agent.