Patents Represented by Attorney Miller, White, Zelano & Branigan, P.C.
  • Patent number: 7268192
    Abstract: A process for production a high purity epoxy compound with total chlorine content of 500 ppm or less is characterized in that alkali metal hydroxide is added to a bifunctional epoxy compound represented by the general formula (I), in which content of the component with n=0 is not less than 70% and less than 100%, and that reaction is caused to take place at a temperature of 95-150° C.
    Type: Grant
    Filed: February 16, 2004
    Date of Patent: September 11, 2007
    Assignee: Tohto Kasei Co., Ltd
    Inventors: Hideyasu Asakage, Nobuhisa Saito, Yukio Nakamura
  • Patent number: 7262283
    Abstract: The present invention relates to a method and a kit for the sequential extraction of proteins for the production of partial proteomes from a complete proteome. In particular, the method according to the invention, besides other partial proteomes, gives a partial proteome of proteins from the cell nucleus interior separated from proteins of the cytoskeleton and of the nuclear matrix.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: August 28, 2007
    Assignee: Merck Patent GmbH
    Inventors: Robertus Hendriks, Afsaneh Abdolzade-Bavil
  • Patent number: 7238444
    Abstract: A lithium secondary battery which comprises a negative electrode, a positive electrode, and disposed therebetween a polymer electrolyte comprising an ionically conductive polymer. The polymer electrolyte has a two-layer structure composed of a positive-electrode-side layer and a negative-electrode-side layer. The polymer electrolyte on the positive-electrode side contains a nonaqueous electrolytic solution containing a lithium salt in a higher concentration than that in the polymer electrolyte on the negative-electrode side. The battery is improved in charge/discharge cycling characteristics and high-load discharge characteristics.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: July 3, 2007
    Assignees: Dai-Ichi Kogyo Seiyaku Co., Ltd., Sharp Corporation
    Inventors: Tsutomu Sada, Kazunari Takeda, Yumiko Takashima, Naoto Nishimura, Takehito Mitate, Kazuo Yamada, Motoaki Nishijima, Naoto Torata
  • Patent number: 7195626
    Abstract: Disclosed is an electrode device for microwave surgery which is provided with a marker securely fixed to the central electrode, which marker can provide a magnetic susceptibility artifact of a uniform size and shape free of fluctuation among electrode devices. The electrode device comprise a central conductor body, a tubular insulator body which covers the central conductor body except its distal end, a tubular external electrode which covers the tubular insulator body except its distal end part, and a central electrode which covers the distal end part of the central conductor body. The central conductor body, the insulator body, the external electrode and the central electrode are made of a nonmagnetic material, and a cylindrical member made of a magnetic material is fit around the distal end part of the central conductor body.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: March 27, 2007
    Assignee: Alfresa Pharma
    Inventors: Koichi Wakikaido, Yoshimasa Kurumi, Shigeyuki Naka, Shigehiro Morikawa
  • Patent number: 7182885
    Abstract: Fluorinated indenes and 1,7-dihydroindacenes of the general formulae (I) and (II) of negative dielectric anisotropy (??<0) in which T, A, R, L, X, Y, U, W, Z, n, m, p and q are as defined herein are suitable for use in liquid crystal display elements.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: February 27, 2007
    Assignee: Merck Patent GmbH
    Inventors: Lars Lietzau, Melanie Klasen-Memmer, Matthias Bremer
  • Patent number: 7183397
    Abstract: Nkx2-C4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Nkx2-C4 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: February 27, 2007
    Assignee: Merck Patent GmbH
    Inventor: Claudia Wilm
  • Patent number: 7163726
    Abstract: There are provided laminated bodies or laminated body-containing windows, which comprise isotropic aqueous solutions obtained by dissolving a water-soluble polysaccharide derivative having nonionic amphipathic functional groups in an aqueous medium composed of water and an amphipathic substance, laminated between plates that are at least partially transparent and allow direct vision of the isotropic aqueous solutions, wherein there are added to the isotropic aqueous solutions in appropriate amounts ultraviolet absorbers comprising nonionic or ionic benzophenone derivatives or benzotriazole derivatives which are highly weather resistant and uniformly dissolve in the isotropic aqueous solutions. The isotropic aqueous solutions are transparent and become opaque upon irradiation with light, and exhibit stable reversible change, in order to provide vastly improved weather resistance to the laminated bodies against exposure to sunlight rays over prolonged periods of time.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: January 16, 2007
    Assignee: Affinity Co, Ltd.
    Inventor: Haruo Watanabe
  • Patent number: 7153974
    Abstract: An ionic liquid of the formula K+A? wherein K+ and A? are as defined herein, are suitable for use in electrochemical cells and capacitors. These ionic liquids can also be used in catalysis, as inert solvents, and as hydraulic liquids.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: December 26, 2006
    Assignee: Merck GmbH
    Inventors: Michael Schmidt, Udo Heider, Winfried Geissler, Nikolai Ignatyev, Volker Hilarius
  • Patent number: 7138417
    Abstract: Novel biphenyl derivatives of the general formula I in which R1, R1?, R1?, R2, R2?, R3 and n are as defined in Patent claim 1, stereoisomers thereof and physiologically acceptable salts or solvates thereof are novel integrin inhibitors which preferentially inhibit the ?v?6 integrin receptor.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: November 21, 2006
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Oliver Schadt, Alfred Jonczyk, Simon Goodman
  • Patent number: 7125195
    Abstract: Locking bracket for a slider in a dovetail slot (3), where a further dovetail slot (4) is arranged perpendicularly to the first dovetail slot (3), in which a locking bracket (5) can be displaced from a position whereby the glider is locked by the locking bracket (5) to a position where the glider is free to be moved passed the locking bracket (5) and that a screw (6) captures the locking bracket (5) through a countersunk hole in the locking bracket (5), whereby the locking bracket is maintained or released by loosening the screw (6).
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: October 24, 2006
    Inventor: Øystein Hagen
  • Patent number: 7122228
    Abstract: The invention relates to indanes having negative ?? of the formula Ia or Ib in which R, A, Z, X, Y, V, W, n and m are as defined in claim 1. The compounds are particularly suitable for producing VA-TFT displays.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: October 17, 2006
    Assignee: Merck Patent GmbH
    Inventors: Volker Reiffenrath, Michael Heckmeier, Matthias Bremer
  • Patent number: 7115755
    Abstract: The invention relates to new reactive mesogenic azulene derivatives, their use as semiconductors or charge transport materials, in optical, electro-optical or electronic devices like for example liquid crystal displays, optical films, organic field effect transistors (FET or OFET) for thin film transistor liquid crystal displays and integrated circuit devices such as RFID tags, electroluminescent devices in flat panel displays, and in photovoltaic and sensor devices, and to a field effect transistor, light emitting device or ID tag comprising the reactive mesogenic azulenes.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: October 3, 2006
    Assignee: Merck Patent GmbH
    Inventors: Louise Diane Farrand, Michael Findlater, Mark Giles, Martin Heeney, Steven Tierney, Marcus Thompson, Maxim Shkunov, David Sparrowe, Iain McCulloch
  • Patent number: 7105586
    Abstract: The invention relates to an optical retardation film comprising two layers of an anisotropic polymer adjacent to each other or adjacent to both sides of a substrate, characterized in that each layer exhibits a tilted structure with an optical symmetry axis having a tilt angle ? relative to the plane of the layer, to a means to produce substantially linear polarized light comprising such an optical retardation film and to a liquid crystal display comprising such an optical retardation film.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: September 12, 2006
    Assignee: Merck KGaA
    Inventors: Mark Verrall, Mark Goulding, Quentin Hodges, Ben Godden
  • Patent number: 7095941
    Abstract: A fused optical fiber optical device system comprises at least one optical component comprising optical fibers and at least one other optical component with which light transmitted in the optical fibers interacts, wherein the optical fiber comprises a core glass of the following composition: La2O3 1–23 mole %, ZrO2 1–10 mole %, WO3?2.5 mole %, ZnO 1–15 mole %, BaO 0–9 mole %, B2O3 20–70 mole %, Ta2O5 0–3 mole %, CaO 0–7 mole %, PbO 6–35 mole %, SiO2 0–40 mole %, As2O3 and/or Sb2O3 0–0.1 mole %, Nb2O50–3 mole % and Al2O3 0–8 mole %. The core glass is essentially free of CdO, has a refractive index nd of at least 1.8 and a CTE of ?about 74×10?7.
    Type: Grant
    Filed: October 27, 2004
    Date of Patent: August 22, 2006
    Assignee: Schott Corporation
    Inventor: Paige Higby
  • Patent number: 7090986
    Abstract: A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: August 15, 2006
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Strittmatter, Detlef Güssow, Uwe Hofmann, Jürgen Hemberger, Zisi Fotev, Bernhard Scheuble
  • Patent number: 7060707
    Abstract: Isoquinoline derivatives of the general formula (I) in which X, Y, Z, R1, R2 and n are as defined in Patent Claim (1), and physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart diseases, arteriosclerosis, inflammation, tumors, osteoporosis, infections and restenosis after angioplasty or in pathological processes which are maintained or propagated by angiogenesis.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: June 13, 2006
    Assignee: Merck Patent GmbH
    Inventors: Matthias Wiesner, Simon Goodman, Horst Kessler, Georgette Thumshirn, Dirk Weber, Dirk Gottschling
  • Patent number: 7051798
    Abstract: The invention relates to a plate heat exchanger with a heat exchanger block which has a multiplicity of heat exchange passages. The heat exchanger block has mounted on it a header which extends over at least part of one side of the heat exchanger block and makes a flow connection between part of the heat exchange passages. The header is provided with a fluid connection which is arranged essentially perpendicularly to that side of the heat exchanger block over which the header extends. (FIG.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: May 30, 2006
    Assignee: Linde Aktiengesellschaft
    Inventors: Stefan Moeller, Alfred Wanner, Gabriele Engl, Thomas Hecht, Wolfgang Suessmann, Herbert Aigner
  • Patent number: 7012081
    Abstract: Substituted anthranilamides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis as well as their intermediate products for the production of anthranilamides are described.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: March 14, 2006
    Assignee: Schering AG
    Inventors: Martin Krueger, Andreas Huth, Orlin Petrov, Dieter Seidelmann, Karl-Heinz Thierauch, Martin Haberey, Andreas Menrad, Alexander Ernst
  • Patent number: 6956130
    Abstract: 2-Ethylhexyl acrylate is manufactured according to a process for the direct esterification of acrylic acid with 2-ethylhexanol catalysed by sulphuric acid, the acrylic acid subjected to the esterification being stabilized by at least one stabilizing agent, the said esterification being followed by the neutralization by a base of the crude reaction mixture (B1) obtained, the resulting salts passing into the aqueous phase (A1) of the said mixture, the organic phase (O1) and the aqueous phase (A1) resulting from this neutralization being separated and the 2-ethylhexyl acrylate being recovered from the organic phase (O1). To suppress the emulsions which appear during the said neutralization, the stabilizer or stabilizers of acrylic acid is/are chosen with the exclusion of hydroquinone, in the absence of which the aqueous phase of the process is stabilized before and/or during the neutralization.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: October 18, 2005
    Assignee: Atofina
    Inventors: Alain Riondel, Jacqueline Bessalem
  • Patent number: 6841702
    Abstract: The invention relates to novel selective inhibitors of the urokinase plasminogen activator (uPA, EC, of the arylguanidine type.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: January 11, 2005
    Assignees: Wilex Biotechnology GmbH, Max-Planck-Gesellschaft zur Forderung der Wissenschaften EV
    Inventors: Viktor Magdolen, Stefan Sperl, Joerg Stuerzebecher, Olaf Wilhelm, Nuria Arroyo De Prada, Luis Moroder, Robert Huber, Uwe Jacob, Wolfram Bode