Patents Represented by Attorney Miller, White, Zelano & Branigan, P.C.
  • Patent number: 5896439
    Abstract: The invention relates to a process for avoiding radiation injury in diagnostic radiology by measuring the change in concentration of endogenous substances in bodily fluids. In addition, the invention comprises a device for implementing this process.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: April 20, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Krause, Uwe Kruger, Peter Muschik
  • Patent number: 5891360
    Abstract: Novel phenylcyclohexanes of the formula I ##STR1## in which n is 0 to 7, Q.sup.1 and Q.sup.2 are H, or one of these radicals is alternatively CH.sub.3, r is 0, 1, 2, 3, 4 or 5, A is trans-1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene or a single bond, X is F, Cl, --CF.sub.3, --CN, --OCF.sub.3 or --OCHF.sub.2, and Y and Z are each, independently of one another, H or F, with the proviso that, in the case where A is a single bond, Q.sup.1 =Q.sup.2 =H and simultaneously X=CN, Y and/or Z are F.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: April 6, 1999
    Assignee: Merck Patent Gesellschaft MIT Beschrankter
    Inventors: Andreas Wachtler, Reinhard Hittich, Eike Poetsch, Herbert Plach, David Coates, Bernhard Rieger, Joachim Krause
  • Patent number: 5886233
    Abstract: Described are cyclohexanone derivatives of the formula (I), a method of preparing them and intermediates used in their preparation.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: March 23, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Andreas Steinmeyer, Gunter Neef, Gunnar Muller, Hans-Joachim Knolker
  • Patent number: 5885548
    Abstract: The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds, their use as contrast media and antidotes, and process for the production of pharmaceutical agents.
    Type: Grant
    Filed: November 30, 1995
    Date of Patent: March 23, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Franz-Karl Maier, Michael Bauer, Werner Krause, Ulrich Speck, Gabriele Schuhmann-Giampiere, Andreas Muhler, Thomas Balzer, Wolf-Rudiger Press
  • Patent number: 5882887
    Abstract: The invention provides a process of manufacture of a recombinant protein called Asp-Pallidipin. Asp-Pallidipin inhibits the collagen-induced platelet aggregation of mammalian platelets. The Asp-Pallidipin comprises(i) a protein (Pallidipin) selected from the group of Pallidipin proteins, and(ii) the amino acid aspartic acid,wherein the aspartic acid is connected by a peptide bond with the N-terminal end of Pallidipin.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: March 16, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Christiane Noeske-Jungblut, Andreas Becker, Bernard Haendler
  • Patent number: 5883185
    Abstract: A fiber-treating agent is obtained by dissolving in water a reaction product resulting from co-hydrolysis and condensation of (A) a fluorinated alkyl group-containing alkoxysilane, (B) an alkyl group-containing alkoxysilane, (C) an amino group-containing alkoxysilane, and (D) an epoxy group-containing alkoxysilane. The fiber-treating agent is water soluble and thus safe while it imparts satisfactory water repellency, oil repellency, stain-proof property and even durable water repellency.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: March 16, 1999
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Kazuyuki Matsumura, Mitsuo Asai, Shoji Ichinohe
  • Patent number: 5881666
    Abstract: The present application is directed to an improved trim tab actuator. A ram adapted to be connected at a first end to the trim tab and connected at a second end to the drive. The ram has a longitudinal portion equal to at least the maximum stroke of the ram and is received in the longitudinal bore of which longitudinal bore has a length equal to or greater than the maximum stroke of the ram. An inboard seal is disposed between the ram and bore, the inboard seal being positioned inboard of the longitudinal portion of the ram when the ram is retracted.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: March 16, 1999
    Inventor: L. Jeremy Crews, Jr.
  • Patent number: 5883090
    Abstract: This invention relates to pyridizinone derivatives of formula I ##STR1## wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: March 16, 1999
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus Jochen Schmitges, Maria Christadler
  • Patent number: 5880050
    Abstract: A process for the regeneration of a sulfur containing catalysts, wherein the catalyst is stripped of sulfur before the oxychlorination treatment of the regeneration process, typically before the catalyst is sent to the regeneration zone. The process is particularly useful for catalyst employed in hydrocarbon conversions such as dehydrogenation reactions, particularly those which comprise the injection of sulfur and/or at least one sulfur compound before or simultaneously to the introduction of the charge into the first reaction zone.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: March 9, 1999
    Assignee: Institut Francais du Petrole
    Inventors: Jean-Paul Boitiaux, Jean De Bonneville, Jean-Pierre Burzynski, Gerard Leger, Fabienne Le Peltier, Germain Martino
  • Patent number: 5880126
    Abstract: 9H-Pyrido?3,4-b!indole compounds have a pronounced leukotriene-B.sub.4 antagonistic action, and thus show a completely different spectrum of activity than known .beta.-carbolines.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: March 9, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Bernd Buchmann, Hartmut Rehwinkel, Frank Schneider, Wolfgang Frohlich, Claudia Giesen, Hartwig Hennekes
  • Patent number: 5876586
    Abstract: A highly conductive polymer is obtained by electrochemically oxidizing a polysilane.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: March 2, 1999
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Motoo Fukushima, Shigeru Mori
  • Patent number: 5876900
    Abstract: A chemically amplified positive resist composition contains (A) an organic solvent, (B) a base resin in the form of a polyhydroxystyrene having phenolic hydroxyl groups some of which are protected with alkoxyalkyl groups and having a weight-average molecular weight of 3,000-300,000 and a dispersity of 1.0 to 1.5, (C) a photoacid generator, and (D) a vinyl ether group-containing compound. The composition is sensitive to actinic radiation, especially KrF excimer laser beam, has high sensitivity and resolution, and forms a resist pattern having improved plasma etching resistance and heat resistance.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: March 2, 1999
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Satoshi Watanabe, Toshinobu Ishihara, Shigehiro Nagura, Tsuguo Yamaoka
  • Patent number: 5874422
    Abstract: The use of nonsteroidal anti-inflammatory agents as an addition to particulate pharmaceutical agent preparations can reduce side-effects on the cardiovascular system during administration.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: February 23, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Krause, Peter Muschick
  • Patent number: 5871761
    Abstract: Proposed is a reliable method for the preparation of a water-base hair-care or skin-care toiletry preparation capable of imparting the hair or skin of the user with excellent touch feeling of smoothness and sleekness. The method comprises (a) preparing an aqueous dispersion of globular particles of a cured silicone rubber having a specified average particle diameter by the in situ crosslinking hydrosilation reaction in liquid droplets of a vinyl group-containing dimethylpolysiloxane and an organohydrogenpolysiloxane in combination in the presence of a surface active agent and (b) admixing a base mixture consisting of the principal ingredients of a water-base toiletry composition with a specified amount of the aqueous dispersion of the cured silicone rubber particles.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: February 16, 1999
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Satoshi Kuwata, Morizo Nakazato, Yoshinori Inokuchi
  • Patent number: 5869516
    Abstract: 5-Pyrazolinone derivatives of the general formula I: ##STR1## in which the R.sup.1 -R.sup.3 variables are as defined herein and the physiologically acceptable salts thereof; processes for the preparation of these compounds, and in particular their use as selective inhibitors of cGMP-specific phosphodiesterase (cGMP PDE), thus as pharmaceutically active compounds.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: February 9, 1999
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Michael Arlt, Rochus Jonas, Maria Christadler, Gunter Schneider, Michael Klockow
  • Patent number: 5866673
    Abstract: The invention relates to polymerisable double-bond derived polyamides obtainable by reacting the polyamide in an aqueous solution with a compound which contains both a polymerisable double bond and an oxirane ring. These derived polyamides may be processed to provide graft polymers with improved properties.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: February 2, 1999
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Egbert Muller, Anja Seiler, Roland Gensert