Abstract: The present invention relates to 2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-methylamino)ethyl]amino]indazolo[ 4,3-gh]isoquinolin-6(2H)-one and the pharmaceutically acceptable acid addition salts thereof, of formula (I). This compound has shown a high a antitumor activity.
Type:
Grant
Filed:
June 22, 1998
Date of Patent:
March 7, 2000
Assignee:
Novuspharma S.p.A.
Inventors:
Ernesto Menta, Ambrogio Oliva, Silvano Spinelli, Paul Krapcho
Abstract: A data processor is provided with a data input mode and a data output mode. The data input mode is set by an external signal. A serial data supplied from an external apparatus to a data input register has a signal to specify the start of the operation at its specific bit. The data processor is provided with a circuit which starts to operate by the operation start signal. This circuit generates an operation completion signal. Based on the operation completion signal, the mode of the data processor is automatically changed to the data output mode.
Abstract: In accordance with the present invention, there are provided 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives of the formula: ##STR1## wherein n is 1, 2 or 3; in which R.sub.1, R.sub.2 and R.sub.3 are as defined herein, and salts thereof, which exhibit excellent cysteine proteinase inhibitory activity and which can be used for treatment of different diseases such as muscular dystrophy, myocardial infarction, bone resorption, arthritis, cancer metastasis, pulmonary emphysema, septic shock, cerebral ischemia, memory function, Alzheimer and cataract, malaria, glomerular basement membrane degradation, bacterial infection, inflammatory diseases, parasitic infections, and viral infections.
Type:
Grant
Filed:
April 1, 1999
Date of Patent:
March 7, 2000
Assignee:
National Research Council of Canada
Inventors:
Rajeshwar Singh, Nian E. Zhou, Enrico O. Purisima, Ronald G. Micetich
Abstract: A method of determining the charge and/or discharge capacities of non-aqueous batteries with an operating voltage of about 4 volts, is provided including determining an inverse molar susceptibility value at each of a plurality of different temperatures for a plurality of lithium manganese spinel oxide cathode materials having different respective Mn valencies; plotting the inverse molar susceptibility values against temperatures for each of the plurality of lithium manganese spinel oxide cathode materials; determining values of at least one of two paramagnetic parameters, Weiss temperature and effective magnetic moment, by obtaining the temperature dependence of the above inverse molar susceptibility from a plot derived from the Curie-Weiss law, the Weiss temperature corresponding to a temperature value extrapolated to a zero point of the inverse molar susceptibility and the effective magnetic moment being obtainable from the gradient value of the plot; producing plural rechargeable lithium batteries in which
Type:
Grant
Filed:
December 19, 1996
Date of Patent:
March 7, 2000
Assignee:
Agency of Industrial Science & Technology
Abstract: A foamed styrene resin material has a density .rho. of 0.02 to 0.008 and a melt tension of the styrene resin of 5 to 40 gf. The relation between an average cell diameter d (.mu.m) and the density .rho. is given by the expression: ##EQU1## and a relation between a thermal conductivity .lambda. (kcal/m.multidot.h.multidot..degree. C.) and the density .rho. given by the expression: ##EQU2## Accordingly, the foamed styrene resin material has a low thermal conductivity and excellent insulating property in spite of a low density (high expansion ratio foam) thereof.
Abstract: A hair styling iron having an elongated barrel having a front end and a rear end, the barrel including a heat plate with a corrugated surface composed of a plurality of concavities and convexities arranged along a direction transverse to the length of the barrel and extending along the length of the barrel, the heat plate formed with a plurality of steam vents; a hand grip extending from the rear end of the barrel; a heater mounted in the barrel to heat the heat plate; a steam generator incorporated in the barrel to generate steam which is discharged from the steam vents; and a hair clamping member pivoted at a connection between the barrel and the hand grip for pivotal movement between a closed position of mating with the heat plate and an open position disengaged from the heat plate.
Abstract: A method of producing a loudspeaker vibrating diaphragm comprising the steps of injecting an amount of resin containing a foaming agent into a metallic mold of an injection molding machine, the mold including a fixed part and a movable part, reducing a mold pressing force of the injection molding machine upon completion of the resin injection, so as to enlarge a space formed between the fixed part and the movable part by a predetermined distance, so that the foaming agent is foamed to obtain a foam layer in the diaphgram.
Abstract: In producing a sandwich-shaped synthetic resin-molded article of a high quality comprised of a core and an outer layer covering the core, the following steps are used: a first step of injecting an outer layer forming material into a forming cavity in a mold through a gate at an injecting speed V.sub.1, a second step including an injecting stage in which an injection speed V.sub.2 of the core forming material is set to be higher than the injection speed V.sub.1 at the first step, in order to inject a core forming material under the injection of the outer layer forming material to flow into the outer layer forming material present within the gate and the cavity and to allow the outer layer and core forming materials to flow within the cavity, and a third step of injecting said outer layer forming material at an injection speed V.sub.
Abstract: An air-fuel ratio control system for an internal combustion engine includes an air-fuel ratio sensor arranged in the exhaust system of the engine. An ECU determines activation of the air-fuel ratio sensor and carries out feedback control of the air-fuel ratio of a mixture supplied to the engine in response to the output from the air-fuel ratio sensor. An intermediate state of the air-fuel ratio sensor corresponding to a transient state of the air-fuel ratio sensor from an inactive state thereof to an active state thereof is determined. The output from the air-fuel ratio sensor for use in execution of the feedback control is corrected when the air-fuel ratio sensor is in the intermediate state.
Abstract: A water-based pigment-type ink containing at least water, a pigment and a dispersant, the pigment particles having an average particle diameter of not larger than 0.1 .mu.m, the weight ratio of the pigment to the dispersant being from 1.2 to 5. The water-based pigment-type ink exhibits more excellent color tone and chroma, by adding the fluorescent pigment in an amount of from 0.1% by weight to 3% by weight with respect to the amount of the ink. Furthermore, the water-based pigment-type ink comprises at least a pigment, a high-molecular dispersant, a surfactant and water, the pigment particles having an average particle diameter of not larger than 80 nm, a maximum particle diameter not being larger than 0.1 .mu.m, the high-molecular dispersant being added in an amount of from 3% by weight to 20% by weight with respect to the amount of the ink, and the surfactant being added in an amount of from 2% by weight to 4% by weight with respect to the amount of the ink.
Abstract: A biological-signal detecting device of a non-wrapper type for accurately detecting a biological signal of a user such as heartbeat number, respiration number or blood pressure, comprises a frame, a spring net fixed to the frame and having an elastic deformation capability to support a weight of the user, and a biological-signal detecting unit. The detecting unit is disposed on a second supporting surface of the spring net opposed to a first supporting surface of the spring net for receiving the weight of the user. The detecting unit determines the biological signal of the user according to a biological vibration which is a cyclic, minute load-variation of the user transmitted through the spring net when the weight of the user is supported by the spring net.
Abstract: A flange portion formed on an inner periphery of a flywheel is facet-fitted to an end of a crankshaft. A spline piece is facet-fitted to an inner peripheral surface of the flywheel. The flange portion of the flywheel and a flange portion of the spline piece are commonly fastened to the end of the crankshaft by bolts. An upper end of a driving shaft is spline-fitted at a point into a driving shaft coupled portion of the spline piece which is accommodated in an internal hole in the crankshaft. Thus, in coaxially coupling the flywheel and the driving shaft to the end of the crankshaft, it is possible to make such a coupled area compact and to reduce vibration by an accurate centering thereof.
Abstract: The present invention provides a corrosion- and chipping-resistant resin coating structure for stainless steel pipes with a small diameter and thin wall. The coating structure comprises a stainless steel pipe (1) and a polyolefin or polyamide layer (4) formed on the outer surface thereof. In a preferred embodiment, the coating structure further comprises adhesive layer (2), a fluoroplastic layer (3), and a polyamide adhesive layer (5). The coating structure exhibits good resistance to corrosion with mud and chipping by splashed pebbles.
Abstract: A connecting terminal for a stator which is fitted and fixed in a fitting bore provided in a bobbin included in the stator, includes an external-conductor connecting terminal section fitted and fixed in the fitting bore with one end connected to an external conductor protruding from the fitting bore, a flat plate-shaped connecting plate section connected at one end at right angles to the other end of the external-conductor connecting terminal section and extending outwards in a radial direction of the stator, and a coil connecting terminal section which extends away from the bobbin and which is connected at right angles to the other end of the connecting plate section, so that the coil connecting terminal section can be folded to a position superposed onto the connecting plate section.
Type:
Grant
Filed:
November 5, 1998
Date of Patent:
February 29, 2000
Assignees:
Sawafuji Electric Co., Ltd., Honda Giken Kogyo Kabushiki Kaisha
Abstract: A thin-film magnetic head includes a recording gap layer, lower and upper magnetic pole layers deposited to sandwich the recording gap layer, the upper magnetic pole layer having side surfaces facing toward a track width direction, and non-magnetic conductive material members being in contact with at least a part of the respective side surfaces of the upper magnetic pole layer and in contact with the lower magnetic pole layer.
Abstract: A semiconductor integrated circuit is adapted to make invalid an external clock, externally supplied to the semiconductor integrated circuit, when the semiconductor integrated circuit is set in an active power-down state. The semiconductor integrated circuit includes a delay locked loop DLL circuit which outputs an internal clock which phase is synchronized to the external clock. A latch circuit retains control signals in synchronism with the internal clock output by the DLL circuit. An internal circuit performs a predetermined process based on the control signals supplied from the latch circuit.
Abstract: A system for controlling motive force of a vehicle having an engine and a continuously variable automatic transmission connected to the engine to transmit engine torque to a drive shaft of the vehicle. In the system, a desired motive force is calculated or determined from the detected accelerator (pedal) position and vehicle speed, and based on the determined motive force a desired engine speed, more specifically a drive shaft speed of the transmission, is calculated or determined. Then inertia torque acting on the vehicle is calculated or determined based on at least the determined speed and detected speed, and a desired throttle opening is corrected by the determined inertia torque when the vehicle accelerates or decelerates. With the arrangement, the vehicle response delay due to the inertia torque is adjusted and hence, drivability and fuel economy performance are enhanced.
Abstract: Method and kit for the quantitative detection of specific oligonucleotide or polynucleotide sequences which is characterized in that a sample mixture containing RNA or single-stranded DNA is hybridized with an oligonucleotide or polynucleotide probe(s) which are complementary to the nucleotide sequence to be determined and carry(ies) a specificplly bindable and a detectable chemical group subsequently it is admixed with an agent that cleaves single-stranded polynucleotide sequences and the immobilized or non-immobilized nucleotide probe is determined after transfer into a suitable reaction vessel. It has proven to be particularly advantageous when a mixture is used which is composed of different cleaving reagents.
Type:
Grant
Filed:
December 20, 1996
Date of Patent:
February 22, 2000
Assignee:
Roche Diagnostics GmbH
Inventors:
Hermann Leying, Matthias Hinzpeter, Heiko Wittor, Hans-Peter Fritton
Abstract: A system and a semiconductor device for realizing such a system are disclosed. The system uses at least a semiconductor device for retrieving an input signal in synchronism with an internal clock generated from an external clock, the input signal remaining effectively in synchronism with the external clock. Even in the case where a phase difference develops between a clock and a signal at the receiving end, or even in the case where a phase difference develops between a clock input circuit and other signal input circuits in the semiconductor device at the receiving end, data can be transferred at high speed. Each input circuit of the semiconductor device at the receiving end includes an input timing adjusting circuit for adjusting the phase of the clock applied to the input circuit in such a manner that the input circuit retrieves the input signal in an effective and stable state.