Patents Represented by Attorney Paul L. Sabatine
  • Patent number: 6224907
    Abstract: A dosage form is disclosed for administering a leukatriene-receptor antagonist to a patient over time.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: May 1, 2001
    Assignee: Alza Corporation
    Inventors: Nipun Davar, Atul Devdatt Ayer, Paul Minn Hwang, Padmaja Shivanand, Brenda J. Pollock
  • Patent number: 6210712
    Abstract: A dosage form comprising a composition comprising a drug surrounded by a first coat and a second coat with an exit for administering the drug to a patient; and a method of using the dosage form are disclosed for an indicated therapy.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: April 3, 2001
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Robert R. Skluzacek
  • Patent number: 6124355
    Abstract: A composition comprising oxybutynin, a dosage form comprising oxybutynin, and a method for administering oxybutynin are disclosed for oxybutynin therapy.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: September 26, 2000
    Inventors: George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando E. Gumucio
  • Patent number: 6096339
    Abstract: The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: August 1, 2000
    Assignee: ALZA Corporation
    Inventors: Atul D. Ayer, Andrew Lam, Judy A. Magruder, Lawrence G. Hamel, Patrick S. L. Wong
  • Patent number: 6077538
    Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: June 20, 2000
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
  • Patent number: 6036973
    Abstract: A dosage form is disclosed for administering 10 ng to 1200 mg tacrine to a patient in need of tacrine therapy.
    Type: Grant
    Filed: July 15, 1997
    Date of Patent: March 14, 2000
    Assignee: ALZA Corporation
    Inventors: George V. Guittard, Jerry D. Childers, Patrick S.-L. Wong, Fernando E. Gumucio, David J. Kidney
  • Patent number: 6034101
    Abstract: A dosage form and a method are disclosed and claimed for administering a drug in a sustained and constantly ascending rate per unit time to provide an intended therapeutic effect while concomitantly lessening the development of unwanted effects.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: March 7, 2000
    Assignee: ALZA Corporation
    Inventors: Suneel K. Gupta, Diane R. Guinta, Carol A. Christopher, Samuel R. Saks
  • Patent number: 6008187
    Abstract: The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: December 28, 1999
    Assignee: Alza Corporation
    Inventors: Heechung Yang, Vu Anh Nguyen, Liang C. Dong, Patrick S. L. Wong
  • Patent number: 5955103
    Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: September 21, 1999
    Assignee: ALZA Corporation
    Inventors: Frank Jao, Patrick S. -L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
  • Patent number: 5948787
    Abstract: An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 7, 1999
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Paul M. Hwang, Anthony L. Kuczynski, Nils W. Ahlgren, Deborah J. Johnson
  • Patent number: 5925015
    Abstract: A nutritional system is disclosed, for delivering a colorant dye to a nutritional fluid that flows through the nutritional system.
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: July 20, 1999
    Assignee: ALZA Corporation
    Inventors: Richard G. Weyers, Atul D. Ayer, Brenda J. Pollock, Brian L. Barclay, Ernest S. Quan
  • Patent number: 5914131
    Abstract: A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: June 22, 1999
    Assignee: ALZA Corporation
    Inventors: Sonya Merrill, Atul D. Ayer, Navjot Chadha, Anthony L. Kuczynski
  • Patent number: 5912268
    Abstract: A composition comprising oxybutynin, a device comprising oxybutynin, and a method for administering oxybutynin are disclosed for oxybutynin therapy.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: June 15, 1999
    Assignee: Alza Corporation
    Inventors: George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando E. Gumucio
  • Patent number: 5906832
    Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises for maintaining the integrity of the dosage form and of the antiepileptic drug.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: May 25, 1999
    Assignee: ALZA Corporation
    Inventors: Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
  • Patent number: 5897878
    Abstract: A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: April 27, 1999
    Assignee: ALZA Corporation
    Inventors: Liang C. Dong, Michael H. Dealey, Terry L. Burkoth, Patrick S.-L. Wong, Jerry D. Childers, Brian L. Barclay
  • Patent number: 5876750
    Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: March 2, 1999
    Assignee: ALZA Corporation
    Inventors: Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
  • Patent number: 5869097
    Abstract: An osmotic caplet is disclosed comprising an osmotic caplet exit for delivering a preselected dose of drug to a patient in need of therapy.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: February 9, 1999
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, George V. Guittard, Atul D. Ayer
  • Patent number: 5863558
    Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises a laminated wall for maintaining the integrity of the dosage form and of the antiepileptic drug.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: January 26, 1999
    Assignee: Alza Corporation
    Inventors: Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
  • Patent number: 5858407
    Abstract: A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient. A method is provided for administering the drug of the formula for producing the intended therapy.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: January 12, 1999
    Assignee: Alza Corporation
    Inventors: Atul Devdatt Ayer, Dana A. Ridzon
  • Patent number: 5842476
    Abstract: An osmotic device is disclosed comprising an exterior coat comprising an estrogenic and a progestogenic steroid that are delivered immediately as a contraceptive pair for fertility regulation in a female, and a compartment comprising an estrogenic steroid that is delivered at a controlled rate over a prolonged period of time for fertility regulation in a female.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: December 1, 1998
    Assignee: ALZA Corporation
    Inventors: Jeri Dawn Wright, Jerry D. Childers, Brian L. Barclay, Patrick S.-L. Wong, Linda E. Atkinson