Patents Represented by Attorney Paul L. Sabatine

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  • Method and apparatus for delivering first agent followed by second agent
    Patent number: 5840074
    Abstract: The invention provides a dispensing device (10) comprising a loading dose (32) (first agent delivery device) for short-term and continuous delivery of agent, retained together with a long-term dispensing device (12) (second agent delivery device) capable of long-term and continuous delivery of agent. The combination of first and second agent delivery device provides a device in which a substantially constant dose of beneficial agent is delivered to the environment of use over time. A rapid delivery of beneficial agent is followed by continuous and prolonged delivery of agent.
    Type: Grant
    Filed: June 2, 1992
    Date of Patent: November 24, 1998
    Assignee: ALZA Corporation
    Inventors: Atul Devdatt Ayer, James B. Eckenhoff, Jeremy C. Wright, Anthony L. Kuczynski
  • Dosage form comprising oxybutynin
    Patent number: 5840754
    Abstract: A composition comprising oxybutynin, a device comprising oxybutynin, and a method for administering oxybutynin are disclosed for oxybutynin therapy.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: November 24, 1998
    Assignee: ALZA Corporation
    Inventors: George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando Gumucio
  • Injection-molded dosage form
    Patent number: 5830502
    Abstract: A dosage form is disclosed comprising an injection-molded housing member free of organic solvents.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: November 3, 1998
    Assignee: ALZA Corporation
    Inventors: Liang C. Dong, Patrick S. L. Wong, Crystal Pollock, Vincent J. Ferrari
  • Dosage form comprising hydrophilic polymer
    Patent number: 5830501
    Abstract: A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: November 3, 1998
    Assignee: ALZA Corporation
    Inventors: Liang C. Dong, Michael H. Dealey, Terry L. Burkoth, Patrick S. -L. Wong, Jerry D. Childers, Brian L. Barclay
  • Method for administering drug to gastrointestinal tract
    Patent number: 5785994
    Abstract: A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: July 28, 1998
    Assignee: ALZA Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, Atul Devdatt Ayer, Anthony L. Kuczynski
  • Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
    Patent number: 5785991
    Abstract: Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 28, 1998
    Assignee: Alza Corporation
    Inventors: Terry L. Burkoth, Lina T. Taskovich, Nieves Crisologo
  • Progesterone replacement therapy
    Patent number: 5770227
    Abstract: A hormone replacement composition, a hormone replacement dosage form, and a method of hormone replacement are disclosed and indicated for the management of hormone replacement therapy.
    Type: Grant
    Filed: July 17, 1996
    Date of Patent: June 23, 1998
    Assignee: Alza Corporation
    Inventors: Liang C. Dong, Patrick S. L. Wong, Steven Espinal
  • Monoglyceride/lactate ester permeation enhancer
    Patent number: 5750137
    Abstract: A composition of matter for application to a body surface or membrane to administer a drug by permeation through the body surface or membrane, the composition comprising, in combination the drug to be administered, in a therapeutically effective amount; and a permeation enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters, present in specific concentrations.
    Type: Grant
    Filed: March 15, 1996
    Date of Patent: May 12, 1998
    Inventors: Lina Tormen Taskovich, Su Il Yum, Eun Soo Lee, Nieves Marzan Crisologo
  • Monoglyceride/lactate ester permeation enhancer for oxybutynin
    Patent number: 5747065
    Abstract: A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination the oxybutynin to be administered, in a therapeutically effective amount; and a permeation enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters, present in specific concentrations.
    Type: Grant
    Filed: March 15, 1996
    Date of Patent: May 5, 1998
    Inventors: Eun Soo Lee, Tyler Watanabe, Robert M. Gale, Terry L. Burkoth
  • Exit means in dosage form
    Patent number: 5718700
    Abstract: A dosage form is disclosed comprising a wall that surrounds a bilayer core with exit passageway for communicating with the bilayer core in the wall.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: February 17, 1998
    Assignee: ALZA Corporation
    Inventors: David Emil Edgren, Robert Raymond Skluzacek, Brian L. Barclay, Gurdish Kaur Bhatti
  • Delivery system comprising means for governing fluid ingress into the system
    Patent number: 5714160
    Abstract: A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: February 3, 1998
    Assignee: ALZA Corporation
    Inventors: Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery
  • Sustained antiepileptic therapy
    Patent number: 5707663
    Abstract: This invention pertains to a dosage form for the management of epilepsies wherein the dosage form comprises administering valproic acid or a valproic acid derivative at a continuous rate over an extended time.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: January 13, 1998
    Assignee: Alza Corporation
    Inventors: Atul Devatt Ayer, Richard L.-C. Yieh, Brenda J. Pollock, Patrick S.-L. Wong
  • Hydromorphone therapy
    Patent number: 5702725
    Abstract: A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: December 30, 1997
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul Devdatt Ayer, Navjot Chadha, Anthony L. Kuczynski
  • Tacrine therapy
    Patent number: 5698224
    Abstract: A dosage form is disclosed for administering 10 ng to 1200 mg tacrine to a patient in need of tacrine therapy.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: December 16, 1997
    Assignee: Alza Corporation
    Inventors: George V. Guittard, Jerry D. Childers, Patrick S. -L. Wong, Fernando E. Gumucio, David J. Kidney
  • Antidepressive therapy
    Patent number: 5688518
    Abstract: A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: November 18, 1997
    Assignee: Alza Corporation
    Inventors: Atul Devdatt Ayer, Dana Ridzon
  • Dosage form comprising oxybutynin
    Patent number: 5674895
    Abstract: A composition comprising oxybutynin and a device comprising oxybutynin are disclosed for oxybutynin therapy.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: October 7, 1997
    Assignee: Alza Corporation
    Inventors: George V. Guittard, Francisco Jao, Susan M. Marks, David J. Kidney, Fernando Gumucio
  • Morphine therapy
    Patent number: 5667805
    Abstract: A composition comprising morphine; and a dosage form comprising morphine are disclosed for morphine therapy. A method of using the composition and the dosage form are disclosed and indicated for morphine therapy.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: September 16, 1997
    Assignee: Alza Corporation
    Inventors: Sonya Merrill, Atul Devdatt Ayer, Paul Hwang, Anthony L. Kuczynski
  • Effective therapy for epilepsies
    Patent number: 5660861
    Abstract: A dosage form is disclosed for delivering an antiepileptic drug, which dosage form comprises for maintaining the integrity of the dosage form and of the antiepileptic drug.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: August 26, 1997
    Assignee: ALZA Corporation
    Inventors: Frank Jao, Patrick S.-L. Wong, Evangeline Cruz, Eduardo C. Sy, Anthony L. Kuczynski
  • Implantable delivery dispenser comprising exit port
    Patent number: 5660847
    Abstract: An implantable dispenser is enclosed comprising a wall surrounding a compartment containing a first composition comprising a beneficial agent, an oil, a cosolvent and a polymer gellant, a second expandable composition, a third boundary maintaining composition between the first and second composition, and an exit port.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: August 26, 1997
    Assignee: ALZA Corporation
    Inventors: Judy A. Magruder, James B. Eckenhoff, Jeremy C. Wright
  • Dosage form for delivering drug at a controlled rate to the intestine and to the colon
    Patent number: 5650170
    Abstract: A drug delivery device is disclosed for delivering a drug to the intestine and the colon. The device comprises external means for delaying the delivery of drug in the stomach, and hydrophobic means for preventing the passage of fluid through the delay means.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: July 22, 1997
    Assignee: Alza Corporation
    Inventors: Jeremy Corwin Wright, George V. Guittard