Abstract: An apparatus is disclosed comprising in combination (1) a container for receiving a fluid, and having an exit port, and (2) a delivery system designed for passage through the exit port into the container for releasing a biocide inside the container.
Type:
Grant
Filed:
January 8, 1992
Date of Patent:
May 23, 1995
Assignee:
Alza Corporation
Inventors:
Tyler Watanabe, Su I. Yum, Eun S. Lee, Ivan W. Chin
Abstract: An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
Type:
Grant
Filed:
February 18, 1994
Date of Patent:
May 9, 1995
Assignee:
Alza Corporation
Inventors:
Patrick S. L. Wong, Felix Theeuwes, Brian L. Barclay, Michael H. Dealey
Abstract: A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
Type:
Grant
Filed:
May 11, 1993
Date of Patent:
February 21, 1995
Assignee:
ALZA Corporation
Inventors:
Patrick S. L. Wong, Felix Theeuwes, James B. Eckenhoff, Steven D. Larsen, Hoa T. Huynh
Abstract: A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
Type:
Grant
Filed:
October 21, 1992
Date of Patent:
September 20, 1994
Assignee:
Alza Corporation
Inventors:
Liang C. Dong, Michael H. Dealey, Terry L. Burkoth, Patrick S. L. Wong, Jerry D. Childers, Brian L. Barclay
Abstract: Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation, and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and preferably at least 75% initial equilibrated agent loading is in the reservoir layer.
Type:
Grant
Filed:
June 16, 1993
Date of Patent:
September 6, 1994
Assignee:
ALZA Corporation
Inventors:
David J. Enscore, Patricia S. Campbell, James L. Osborne, Melinda K. Smart, Su I. Yum
Abstract: Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation, and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and preferably at least 75% initial equilibrated agent loading is in the reservoir layer.
Type:
Grant
Filed:
June 18, 1993
Date of Patent:
August 30, 1994
Assignee:
Alza Corporation
Inventors:
David J. Enscore, Patricia S. Campbell, James L. Osborne, Melinda K. Smart, Su I. Yum
Abstract: A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
Type:
Grant
Filed:
July 8, 1993
Date of Patent:
August 23, 1994
Assignee:
Alza Corporation
Inventors:
Patrick S. L. Wong, Felix Theeuwes, James B. Eckenhoff, Steven D. Larsen, Hoa T. Huynh
Abstract: A dosage form is disclosed comprising a first layer and a second layer. The first layer provides immediate therapy and comprises a drug stereoisomer and the second layer provides prolonged therapy and comprises a drug racemate.
Type:
Grant
Filed:
December 21, 1992
Date of Patent:
August 16, 1994
Assignee:
Alza Corporation
Inventors:
David E. Edgren, Gurdish K. Bhatti, Judy A. Magruder
Abstract: A dosage form is disclosed comprising a wall surrounding a compartment, which comprises a first composition comprising a carboxymethylcellulose and a second composition comprising a higher molecular weight carboxymethylcellulose. The first composition comprises a dosage amount of drug that delivers from the dosage form at a controlled rate over time.
Type:
Grant
Filed:
September 4, 1992
Date of Patent:
July 5, 1994
Assignee:
ALZA Corporation
Inventors:
Jeri D. Wright, Brian L. Barclay, David R. Swanson
Abstract: An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
Type:
Grant
Filed:
April 2, 1990
Date of Patent:
June 28, 1994
Assignee:
Alza Corporation
Inventors:
Patrick S. L. Wong, Felix Theeuwes, Brian L. Barclay, Michael H. Dealey
Abstract: A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
Type:
Grant
Filed:
November 7, 1991
Date of Patent:
June 14, 1994
Assignee:
Alza Corporation
Inventors:
Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery
Abstract: The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) together with, optionally, a suitable permeation enhancer.
Type:
Grant
Filed:
February 12, 1993
Date of Patent:
June 14, 1994
Assignee:
ALZA Corporation
Inventors:
Robert M. Gale, Diane E. Nedberge, Linda E. Atkinson
Abstract: A drug delivery capsule from which the delivery of the drug is driven by the osmotic infusion of moisture by the capsule from a physiological environment is provided with a delivery orifice which opens intermittently to achieve a pulsatile delivery effect. The wall in which the orifice is formed is constructed of an elastic material, preferably an elastomer, which stretches under a pressure differential caused by the pressure rise inside the capsule as the osmotic infusion progresses. The orifice is small enough that when the elastic wall is relaxed, the flow rate of drug through the orifice is substantially zero, but that when the elastic wall is stretched due to the pressure differential across the wall exceeding a threshold, the orifice expands sufficiently to allow the release of the drug at a physiologically beneficial rate.
Type:
Grant
Filed:
December 1, 1992
Date of Patent:
June 7, 1994
Assignee:
ALZA Corporation
Inventors:
Andreas Linkwitz, Judy A. Magruder, Sonya Merrill
Abstract: The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with, optionally, a suitable permeation enhancer.
Type:
Grant
Filed:
March 26, 1993
Date of Patent:
May 24, 1994
Assignee:
Alza Corporation
Inventors:
Robert M. Gale, Diane E. Nedberge, Linda E. Atkinson
Abstract: The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use.
Type:
Grant
Filed:
January 31, 1992
Date of Patent:
May 17, 1994
Inventors:
Patrick S.-L. Wong, Felix Theeuwes, Steven D. Larsen
Abstract: The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The delivery of the agent formulation from the dispensing device, once begun, is continued over a predetermined prolonged period of time.
Abstract: Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.
Type:
Grant
Filed:
May 5, 1993
Date of Patent:
May 3, 1994
Assignee:
Alza Corporation
Inventors:
Stephen M. Balaban, James B. Pike, Jonathan P. Smith, Clifton A. Baile