Abstract: A hormone replacement composition, a hormone replacement dosage form, and a method of hormone replacement are disclosed and indicated for the management of hormone replacement therapy.
Type:
Grant
Filed:
August 4, 1994
Date of Patent:
May 27, 1997
Assignee:
ALZA Corporation
Inventors:
Liang C. Dong, Patrick S.-L. Wong, Steven Espinal
Abstract: A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
Type:
Grant
Filed:
March 1, 1994
Date of Patent:
May 20, 1997
Assignee:
ALZA Corporation
Inventors:
Judy A. Magruder, James B. Eckenhoff, Richard Cortese, Jeremy C. Wright, John R. Peery
Abstract: A hormone replacement composition, a hormone replacement dosage form, and a method of hormone replacement are disclosed and indicated for the management of hormone replacement therapy.
Type:
Grant
Filed:
May 16, 1995
Date of Patent:
April 15, 1997
Assignee:
ALZA Corporation
Inventors:
Liang C. Dong, Patrick S.-L. Wong, Steven Espinal
Abstract: A device for the transdermal administration of oxybutynin comprising a microporous tie layer located between the oxybutynin reservoir and the contact adhesive. The tie layer eliminates blooming and delamination and has no appreciable adverse effect on either the oxybutynin flux or release rate from the device.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
March 25, 1997
Assignee:
ALZA Corporation
Inventors:
Robert M. Gale, Eun Soo Lee, Lina T. Taskovich, Terry L. Burkoth
Abstract: A dosage form is disclosed for delivering pentoxifylline to a patient in need of pentoxifylline therapy. A method is discussed for delivery pentoxifylline to a patient at a dosage form controlled rate over an extended period of time.
Type:
Grant
Filed:
May 24, 1995
Date of Patent:
February 18, 1997
Assignee:
ALZA Corporation
Inventors:
Patrick S. L. Wong, George V. Guittard, Atul D. Ayer
Abstract: A process is disclosed and claimed for preparing a therapeutic composition comprising asteroid or a dosage form comprising the composition, which therapeutic composition or dosage form is indicated for human administration.
Type:
Grant
Filed:
November 10, 1994
Date of Patent:
January 21, 1997
Assignee:
Alza Corporation
Inventors:
Jeri D. Wright, Brian L. Barclay, Linda E. Atkinson
Abstract: A therapeutic tablet comprising morphine, poly(alkylene oxide) and poly(vinylpyrrolidone) encased by a composition comprising a cellulose polymer.
Type:
Grant
Filed:
May 24, 1995
Date of Patent:
January 14, 1997
Assignee:
ALZA Corporation
Inventors:
Sonya Merrill, Atul D. Ayer, Paul Hwang, Anthony L. Kuczynski
Abstract: The invention disclosed comprises a method for administering the antidiabetic drug glipizide to a patient in need of glipizide in need of antidiabetic therapy.
Type:
Grant
Filed:
May 16, 1995
Date of Patent:
January 7, 1997
Assignee:
ALZA Corporation
Inventors:
Anthony L. Kuczynski, Atul D. Ayer, Patrick S.-L. Wong
Abstract: Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
Type:
Grant
Filed:
April 30, 1993
Date of Patent:
November 12, 1996
Assignee:
ALZA Corporation
Inventors:
Darrel F. Untereker, Joseph B. Phipps, Gary A. Lattin
Abstract: A dosage form is disclosed for delivering pentoxifylline to a patient in need of pentoxifylline therapy. A method is discussed for delivery pentoxifylline to a patient at a dosage form controlled rate over an extended period of time.
Type:
Grant
Filed:
January 18, 1994
Date of Patent:
July 2, 1996
Assignee:
ALZA Corporation
Inventors:
Patrick S.-L. Wong, George V. Guittard, Atul D. Ayer
Abstract: A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.
Type:
Grant
Filed:
July 7, 1994
Date of Patent:
June 25, 1996
Assignee:
Alza Corporation
Inventors:
Sonya Merrill, Atul D. Ayer, Navjot Chadha, Anthony L. Kuczynski
Abstract: A process for delivering a biocide to a container comprising admitting a biocide delivery device through an exit port of a urine container where the device is sized for passage through the exit port is disclosed.
Type:
Grant
Filed:
January 8, 1992
Date of Patent:
February 6, 1996
Assignee:
Alza Corporation
Inventors:
Tyler Watanabe, Su I. Yum, Eun S. Lee, Ivan W. Chin
Abstract: A fluid-activated delivery device is disclosed comprising a housing defining an internal compartment, a beneficial agent formulation in the compartment, exit means in the housing for delivering the beneficial agent formulation from the delivery device, and wherein the formulation comprises an active agent in an amount of 50 wt % or greater blended with a glyceride or a mixture of glycerides of a fatty acid.
Type:
Grant
Filed:
April 28, 1994
Date of Patent:
October 31, 1995
Assignee:
Alza Corporation
Inventors:
John P. Carr, Steven D. Larsen, James B. Eckenhoff
Abstract: A bilayer comprising a morphine layer of morphine, poly(alkylene oxide) and poly(vinylpyrrolidone); and an expandable contacting layer of coated granules of a higher molecular weight poly(alkylene oxide) and a hydroxyalkylcellulose, which bilayer is disclosed for morphine therapy. A method is disclosed for using the bilayer composition.
Type:
Grant
Filed:
June 27, 1994
Date of Patent:
October 24, 1995
Assignee:
Alza Corporation
Inventors:
Sonya Merrill, Atul D. Ayer, Paul Hwang, Anthony L. Kuczynski
Abstract: The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.
Type:
Grant
Filed:
July 30, 1993
Date of Patent:
June 13, 1995
Assignee:
Alza Corporation
Inventors:
Heechung Yang, Vu A. Nguyen, Liang C. Dong, Patrick S.-L. Wong
Abstract: The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use.
Type:
Grant
Filed:
January 21, 1994
Date of Patent:
May 23, 1995
Assignee:
Alza Corporation
Inventors:
Patrick S. L. Wong, Felix Theeuwes, Steven D. Larsen, Liang C. Dong
Abstract: The invention disclosed and claimed an apparatus that relates to a delivery system comprising a biocide, with the delivery system designed and shaped for passages through the exit port of a urine container into the container. The invention disclosed and claim pertains also to a method of preventing infection in a patient by using the apparatus connected to a patient through a catheter.
Type:
Grant
Filed:
January 8, 1992
Date of Patent:
May 23, 1995
Assignee:
Alza Corporation
Inventors:
Tyler Watanabe, Su I. Yum, Fun S. Lee, Ivan W. Chin