Patents Represented by Attorney Paul L. Sabatine

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  • Dispenser with movable matrix comprising a plurality of tiny pills
    Patent number: 4824675
    Abstract: A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: April 25, 1989
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, Richard Cortese, James B. Eckenhoff
  • Dosage form for treating cardiovascular diseases comprising isradipine
    Patent number: 4816263
    Abstract: An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: March 28, 1989
    Assignee: ALZA Corporation
    Inventors: Atul D. Ayer, David R. Swanson, Anthony L. Kuczynski
  • Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container
    Patent number: 4814180
    Abstract: A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
    Type: Grant
    Filed: December 15, 1986
    Date of Patent: March 21, 1989
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Felix Theeuwes, Joseph C. Deters
  • Dosage form comprising fast agent delivery followed by slow agent delivery
    Patent number: 4814181
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: March 21, 1989
    Assignee: ALZA Corporation
    Inventors: Maureen L. Jordan, Atul D. Ayer, Paul R. Magruder, David E. Edgren
  • Method for lessening the incidence of anginal attacks
    Patent number: 4812313
    Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
    Type: Grant
    Filed: December 14, 1987
    Date of Patent: March 14, 1989
    Assignee: ALZA Corporation
    Inventor: Robert M. Gale
  • Pseudoephedrine brompheniramine therapy
    Patent number: 4810502
    Abstract: A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.
    Type: Grant
    Filed: February 27, 1987
    Date of Patent: March 7, 1989
    Assignee: ALZA Corporation
    Inventors: Atul D. Ayer, Lawrence G. Hamel
  • Pseudoephedrine dosage form
    Patent number: 4801461
    Abstract: A dosage form is disclosed for delivering the beneficial drug pseudoephedrine to a biological environment of use.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: January 31, 1989
    Assignee: ALZA Corporation
    Inventors: Larry G. Hamel, Felix A. Landrau, George V. Guittard, Patrick S. L. Wong
  • Process for making dispenser with cooperating elements
    Patent number: 4800056
    Abstract: A method of forming a dispenser for delivering a beneficial agent to a biological environment. A beneficial agent and an expandable composition are placed in a capsule made of fluid dissolvable material. The capsule is closed and surrounded by a semipermeable wall which is permeable to fluid but not to the beneficial agent. Then a passageway is drilled in the capsule between the exterior and the interior which contains the beneficial agent.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: January 24, 1989
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Felix Theeuwes, Joseph C. Deters
  • Parenteral agent dispensing equipment with drug releasing member
    Patent number: 4790820
    Abstract: A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.
    Type: Grant
    Filed: October 25, 1984
    Date of Patent: December 13, 1988
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Programmable agent delivery system
    Patent number: 4786500
    Abstract: This invention pertains to a programmable delivery system.
    Type: Grant
    Filed: June 26, 1986
    Date of Patent: November 22, 1988
    Assignee: ALZA Corporation
    Inventor: Patrick S.-L. Wong
  • Dosage form comprising parallel lamine
    Patent number: 4786503
    Abstract: A bilaminated dosage form is disclosed comprising at least 30 weight percent cellulose ether, a first lamina and a second lamina with each lamina comprising a different cellulose ether formulation, and a drug in at least one of the lamina.
    Type: Grant
    Filed: April 6, 1987
    Date of Patent: November 22, 1988
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Judy A. Magruder, Gurdish K. Bhatti
  • Osmotic system comprising plurality of members for dispensing drug
    Patent number: 4783337
    Abstract: An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme inhibitor and nonsteroidal antiinflammatory drugs, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: November 8, 1988
    Assignee: ALZA Corporation
    Inventors: Patrick S.-L. Wong, Brian L. Barclay, Joseph C. Oeters, Felix Theeuwes
  • Dispenser for delivering thermo-responsive composition
    Patent number: 4781714
    Abstract: A dispenser is disclosed for delivering a beneficial agent formulation to a warm, fluid environment of use. The dispenser comprises an outer semipermeable wall surrounding and laminating an inner hydrophilic, swellable wall. The walls define an interior space for containing a thermo-responsive beneficial agent formulation. A passageway through the semipermeable wall connects the exterior of the dispenser through an opening in the inside wall with the interior of the dispenser.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: November 1, 1988
    Assignee: Alza Corporation
    Inventors: J. Benjamin Eckenhoff, Felix Theeuwes, Deters, Joseph C.
  • Constant release system with pulsed release
    Patent number: 4777049
    Abstract: An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
    Type: Grant
    Filed: January 8, 1987
    Date of Patent: October 11, 1988
    Assignee: ALZA Corporation
    Inventors: Paul R. Magruder, Brian Barclay, Patrick S. L. Wong, Felix Theeuwes
  • Primary delivery system comprising secondary dosage form
    Patent number: 4773907
    Abstract: A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of dosage delivery devices. The wall is formed of an environment sensitive material that releases the dosage forms into the environment. The dosage forms comprise a semipermeable wall surrounding a compartment containing drug. A passageway through the semipermeable wall releases drug from the dosage form to the environment.
    Type: Grant
    Filed: April 13, 1987
    Date of Patent: September 27, 1988
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Dispenser with internal arrangement of lamina means for dispensing beneficial agent
    Patent number: 4772474
    Abstract: A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.
    Type: Grant
    Filed: August 11, 1986
    Date of Patent: September 20, 1988
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Osmotic device for administering certain drugs
    Patent number: 4765989
    Abstract: An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
    Type: Grant
    Filed: September 2, 1986
    Date of Patent: August 23, 1988
    Assignee: Alza Corporation
    Inventors: Patrick S. L. Wong, Brian L. Barclay, Joseph C. Deters, Felix Theeuwes
  • Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills
    Patent number: 4764380
    Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: August 16, 1988
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuews
  • Dosage form comprising solubility regulating member
    Patent number: 4755180
    Abstract: An osmotic dosage form is disclosed comprising a polymeric olefin, vinyl, condensation, addition or silicon film that surrounds a member selected from the group consisting of a buffer and osmogent which member is released by the film as a means for governing the solubility of a beneficial agent in the dosage form.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: July 5, 1988
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Patrick S. L. Wong
  • Self-driven pump
    Patent number: 4753651
    Abstract: A self-driven pump that delivers a flowable composition at a constant baseline rate and may be manipulated to supplement the baseline rate with one or more pulses of the composition. One pump embodiment consists of a rigid hollow housing with one fixed end wall and one axially moveable end wall; an axially slideable water imbibing assembly mounted transversely in the housing lumen that divides the lumen into a first compartment containing the composition to be dispersed and a second liquid to be imbibed, preferably water, containing compartment. An outlet port extends through the wall of the housing into the first compartment. In operation the subassembly imbibes water from the second compartment and expands into the first compartment to displace the composition therefrom through the outlet at the baseline rate.
    Type: Grant
    Filed: August 30, 1982
    Date of Patent: June 28, 1988
    Assignee: ALZA Corporation
    Inventor: James B. Eckenhoff