Patents Represented by Attorney Paul L. Sabatine

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  • Dispenser for delivering drug to livestock
    Patent number: 4927633
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) heat responsive means containing a beneficial agent in the spece, (3) means for increasing the amount of beneficial agent delivered from the device in the space, (4) expandable means in the space, (5) an optional dense means in the space, and (6) means in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: June 24, 1987
    Date of Patent: May 22, 1990
    Assignee: Alza Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Transdermal drug delivery device
    Patent number: 4917895
    Abstract: A diffusional drug delivery device is described which can provide shelf life stability of the system components, elimination of the initial burst of drug and hence irritation, delayed onset of therapeutic effect and delivery of a therapeutic agent at an optimum rate. A metal layer and an activating means are inert when dry. Moisture activates the system whereby the activating means provides release of an eroding agent which erodes the metal layer through which the therapeutic agent diffuses and is subsequently delivered.
    Type: Grant
    Filed: July 14, 1988
    Date of Patent: April 17, 1990
    Assignee: ALZA Corporation
    Inventors: Eun S. Lee, David Edgren, Su I. Yum
  • Dosage form for delivering a drug at two different rates
    Patent number: 4915954
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Maureen L. Jordan, Paul R. Magruder, David E. Edgren
  • Composition comprising drug, HPC, HPMC and PEO
    Patent number: 4915952
    Abstract: A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.
    Type: Grant
    Filed: February 15, 1989
    Date of Patent: April 10, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Lawrence G. Hamel
  • Parenteral delivery system comprising a vial containing a beneficial agent
    Patent number: 4915689
    Abstract: A parenteral delivery system for delivering a beneficial agent is disclosed. The delivery system comprises a reservoir containing a medical fluid, a vial containing a beneficial solid agent, and a manifold for establishing fluid communication between the reservoir and the vial.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: April 10, 1990
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Dispenser with movable matrix comprising a plurality of tiny pills
    Patent number: 4915949
    Abstract: A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: Alza Corporation
    Inventors: Patrick S.-L. Wong, Felix Theeuwes, Richard Cortese, James B. Eckenhoff
  • Dosage form for delivering acetaminophen or phenylpropanolamine
    Patent number: 4915953
    Abstract: A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: April 10, 1990
    Assignee: ALZA Corporation
    Inventors: Maureen L. Jordan, Atul D. Ayer, Paul R. Magruder, David E. Edgren
  • Apparatus comprising dual reservoirs for parenteral infusion of fluid containing beneficial agent
    Patent number: 4908019
    Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a primary container of a medical fluid; (b) a primary drip chamber in fluid communication with the primary container; (c) a primary formulation chamber in fluid communication with the primary drip chamber and housing an agent dispensing device or a beneficial agent; (d) a secondary container of a medical fluid; (e) a secondary drip chamber in fluid communication with the secondary container; (f) a secondary formulation chamber in fluid communication with the secondary drip chamber and housing an agent dispensing device or a beneficial agent; and (g) a common tubing in communication with the primary formulation chamber and the secondary formulation chamber for communicating the system with the recipient.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: March 13, 1990
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Delivery of drug to colon by oral disage form
    Patent number: 4904474
    Abstract: A drug delivery device is disclosed for delivering a drug to the colon. The device comprises means for delaying the delivery of drug in the stomach, means for delaying delivery of drug in the small intestine, and means for delivering drug in the colon.
    Type: Grant
    Filed: January 25, 1988
    Date of Patent: February 27, 1990
    Assignee: Alza Corporation
    Inventors: Felix Theeuwes, George V. Guittard, Patrick S. L. Wong
  • Dosage form for administering nilvadipine for treating cardiovascular symptoms
    Patent number: 4902514
    Abstract: A dosage form is disclosed comprising nilvadipine for administering to a patient in need of cardiovascular therapy.
    Type: Grant
    Filed: July 21, 1988
    Date of Patent: February 20, 1990
    Assignee: ALZA Corporation
    Inventors: Brian L. Barclay, Patrick S. L. Wong, Jeri D. Wright, Jerry D. Childers
  • Skin permeation enhancer compositions using sucrose esters
    Patent number: 4900555
    Abstract: A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominatly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: February 13, 1990
    Assignee: Alza Corporation
    Inventors: Yu-Ling Cheng, Robert M. Gale, Edna Sugihara, Harold F. Sanders
  • Juxtaposed laminated arrangement
    Patent number: 4892778
    Abstract: A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
    Type: Grant
    Filed: May 27, 1987
    Date of Patent: January 9, 1990
    Assignee: ALZA Corporation
    Inventors: Felix Theeuwes, Patrick S. L. Wong, Richard Cortese, James B. Eckenhoff
  • Process for forming dispensing device
    Patent number: 4883667
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (4) a passageway in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: November 28, 1989
    Assignee: ALZA Corporation
    Inventor: James B. Eckenhoff
  • Multi-layer delivery system
    Patent number: 4874388
    Abstract: A dispenser for use in a fluid environment having a rigid housing containing a fluid activated driving member, a plurality of drug containing layers and an outlet means by which drug is dispensed to the environment. The housing adjacent to the layers is fluid impermeable and the housing adjacent to the driving member is fluid permeable or has an open area by which fluid can contact the driving member.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: October 17, 1989
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, James B. Eckenhoff
  • Ruminant dispensing device
    Patent number: 4871544
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (4) a passageway in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: October 3, 1989
    Assignee: ALZA Corporation
    Inventor: James B. Eckenhoff
  • System for intravenous delivery of a beneficial drug at a regulated rates
    Patent number: 4871360
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a space containing a beneficial agent. The formulation chamber has an inlet for admitting a fluid into the chamber and an outlet for letting the fluid containing the agent leave the chamber. The chamber can additionally comprise a film for regulating the rate of release from the chamber, and optionally a filter. The chamber is adapted for use in an intraveous delivery system for delivering the fluid containing the agent to a patient. A method also is disclosed for using the formulation chamber.
    Type: Grant
    Filed: April 21, 1986
    Date of Patent: October 3, 1989
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Controlled release dosage form comprising different cellulose ethers
    Patent number: 4871548
    Abstract: A dosage form is disclosed comprising a low number average molecular weight hydroxypropylmethylcellulose, a high number average molecular weight hydroxypropylmethylcellulose, and a beneficial drug.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: October 3, 1989
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Judy A. Magruder, Gurdish K. Bhatti
  • Transdermal drug delivery device
    Patent number: 4867982
    Abstract: A medical device for the transdermal delivery of an active agent through sensitive intact skin is provided. The device comprises a matrix containing the drug having reinforcing means, preferably in the form of a fabric, embedded in the upper surface of the matrix. The matrix is formed of an agent permeable material which is tacky but does not adhesively bond to the skin. The device is sufficiently flexible and deformable that the combination of tackiness, flexibility, and deformation permits the device to be maintained in agent transmitting relationship upon skin at such sensitive areas as the scrotum, labia, breast, or penis, for example. In certain embodiments, the skin distal surface is provided with a layer of an agent impermeable material to reduce transfer of the agent from the patient to others.
    Type: Grant
    Filed: January 26, 1988
    Date of Patent: September 19, 1989
    Assignee: ALZA Corporation
    Inventors: Patricia S. Campbell, James B. Eckenhoff, Virgil A. Place
  • Hydrogel formulation for administering non-steroidal drugs
    Patent number: 4867969
    Abstract: A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: September 19, 1989
    Assignee: ALZA Corporation
    Inventors: Paul R. Magruder, Patrick S. Wong, Felix Theeuwes, George V. Guittard
  • Skin permeation enhancer compositions using sucrose esters
    Patent number: 4865848
    Abstract: A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: September 12, 1989
    Assignee: ALZA Corporation
    Inventors: Yu-Ling Cheng, Robert M. Gale, Edna Sugihara, Harold F. Sanders