Patents Represented by Attorney Paul L. Sabatine

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  • Method of administering drug by using cell comprising drug
    Patent number: 4865585
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for parenteral use including intravenous delivery for delivering an agent formulation to a patient.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: September 12, 1989
    Assignee: ALZA Corporation
    Inventor: Felix Theeuwes
  • Release rate adjustment of osmotic or diffusional delivery devices
    Patent number: 4865845
    Abstract: A sleeve shaped structure covers a portion of the transport area of a diffusional or osmotic delivery device. The structure is durable and inert to the use environment. Markings on the structure indicate where breaking or cutting will produce a predictable alteration in delivery rate. Among other attachment means, a water soluble adhesive maintains the structure on the delivery device.
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: September 12, 1989
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, John Urquhart
  • Dispensing system for administering beneficial agent
    Patent number: 4865598
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition in the space, (3) an aqueous sensitive beneficial agent formulation in the space, and (4) at least one passageway in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: February 2, 1988
    Date of Patent: September 12, 1989
    Assignee: ALZA Corporation
    Inventor: James B. Eckenhoff
  • Intestine drug delivery
    Patent number: 4863744
    Abstract: A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.
    Type: Grant
    Filed: March 16, 1987
    Date of Patent: September 5, 1989
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Dosage form with improved delivery capability
    Patent number: 4863456
    Abstract: A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: September 5, 1989
    Assignee: ALZA Corporation
    Inventors: Sally I. Stephens, Patrick S. L. Wong
  • Dosage form for delivering diltiazem
    Patent number: 4859470
    Abstract: A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.
    Type: Grant
    Filed: June 2, 1988
    Date of Patent: August 22, 1989
    Assignee: Alza Corporation
    Inventors: George V. Guittard, Patrick S. L. Wong, Felix Theeuwes, Richard Cortese
  • Intravenous system for delivering a beneficial agent
    Patent number: 4857052
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: August 15, 1989
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Chlorpheniramine therapy
    Patent number: 4857330
    Abstract: An osmotic dosage form is disclosed for delivering chlorpheniramine.
    Type: Grant
    Filed: April 1, 1988
    Date of Patent: August 15, 1989
    Assignee: Alza Corporation
    Inventors: Sally I. Stephens, Lawrence G. Hamel, Glen E. Barclay, Patrick S. L. Wong
  • Device comprising means for protecting and dispensing fluid sensitive medicament
    Patent number: 4855141
    Abstract: A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the device and means in the space for shielding the beneficial agent from fluid.
    Type: Grant
    Filed: March 25, 1988
    Date of Patent: August 8, 1989
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Judy A. Magruder, Richard Cortese, John R. Peery, Jeremy C. Wright
  • Composition comprising a therapeutic agent and a modulating agent
    Patent number: 4851229
    Abstract: An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: July 25, 1989
    Assignee: ALZA Corporation
    Inventors: Paul R. Magruder, Brian Barclay, Patrick S. L. Wong, Felix Theeuwes
  • Drug delivery system with means for obtaining desirable in vivo release rate pattern
    Patent number: 4851232
    Abstract: A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: July 25, 1989
    Assignee: Alza Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • System for delivering drug in selected environment of use
    Patent number: 4851231
    Abstract: A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.
    Type: Grant
    Filed: March 16, 1987
    Date of Patent: July 25, 1989
    Assignee: ALZA Corporation
    Inventors: John Urquhart, Felix Theeuwes
  • Method for increasing oxygen supply by administering vasodilator
    Patent number: 4849226
    Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
    Type: Grant
    Filed: December 14, 1987
    Date of Patent: July 18, 1989
    Assignee: Alza Corporation
    Inventor: Robert M. Gale
  • Dosage form with means for governing rate of gas formation
    Patent number: 4847093
    Abstract: An osmotic device is disclosed comprising a release rate controlling wall that surrounds a carbon dioxide generating compound.
    Type: Grant
    Filed: June 19, 1986
    Date of Patent: July 11, 1989
    Assignee: ALZA Corporation
    Inventors: Atul D. Ayer, Patrick S. L. Wong
  • Method for treating ischemic conditions
    Patent number: 4846826
    Abstract: A method is disclosed for treating an ischemic condition. The method comprises coadministering topically and internally a vasodilator to a patient having the condition for treating the condition.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: July 11, 1989
    Assignee: Alza Corporation
    Inventors: Jane Shaw, Robert M. Gale
  • Dispensing system with means for increasing delivery of beneficial agent from the system
    Patent number: 4844984
    Abstract: A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.
    Type: Grant
    Filed: March 24, 1988
    Date of Patent: July 4, 1989
    Assignee: ALZA Corporation
    Inventors: James B. Eckenhoff, Richard Cortese, Felix A. Landrau
  • Pulsed drug delivery of doxylamine
    Patent number: 4842867
    Abstract: A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
    Type: Grant
    Filed: May 9, 1986
    Date of Patent: June 27, 1989
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Felix Theeuwes, Patrick S. Wong
  • Dosage form for dispensing drug for human therapy
    Patent number: 4837111
    Abstract: An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: June 6, 1989
    Assignee: ALZA Corporation
    Inventors: Joseph C. Deters, Patrick S. L. Wong, Brian L. Barclay, Felix Theeuwes, David R. Swanson
  • Medical bandage for administering beneficial drug
    Patent number: 4834979
    Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
    Type: Grant
    Filed: December 14, 1987
    Date of Patent: May 30, 1989
    Assignee: ALZA Corporation
    Inventor: Robert M. Gale
  • Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
    Patent number: 4832953
    Abstract: A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.
    Type: Grant
    Filed: August 13, 1987
    Date of Patent: May 23, 1989
    Assignee: Alza Corporation
    Inventors: Patricia S. Campbell, David J. Enscore, Robert M. Gale, Arnold Kaufman