Patents Represented by Attorney Paul L. Sabatine

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  • Dispensing system for administering beneficial agent formulation to ruminants
    Patent number: 4963141
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition in the space, (3) an aqueous sensitive beneficial agent formulation in the space, and (4) at least one passageway in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: July 17, 1989
    Date of Patent: October 16, 1990
    Assignee: Alza Corporation
    Inventor: James B. Eckenhoff
  • Plurality of tiny pills in liquid dosage form
    Patent number: 4961932
    Abstract: A delivery system is disclosed for delivering a beneficial agent to an environment of use. The delivery system comprises a plurality of tiny dosage forms comprising a beneficial agent. The delivery system also comprises means for maintaining (a) the physical and chemical integrity of the dosage form and for (b) inhibiting delivery of the beneficial agent during non-performance of the delivery system.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: October 9, 1990
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Method for the management of hyperplasia
    Patent number: 4961931
    Abstract: The invention is for a vaginal dispenser comprising a wall surrounding an internal lumen and having a pair of ends with one end placed inside the other end to form a closed dispenser. A vaginally administrable beneficial agent is housed in the lumen for release by the dispenser over time.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: October 9, 1990
    Assignee: Alza Corporation
    Inventor: Patrick S.-L. Wong
  • Dosage form with improved delivery capability
    Patent number: 4960416
    Abstract: A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.
    Type: Grant
    Filed: July 10, 1989
    Date of Patent: October 2, 1990
    Assignee: ALZA Corporation
    Inventors: Sally I. Stephens, Patrick S. L. Wong
  • Method for delivering somatotropin to an animal
    Patent number: 4959218
    Abstract: A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the device and means in the space for shielding the beneficial agent from fluid.
    Type: Grant
    Filed: December 28, 1988
    Date of Patent: September 25, 1990
    Assignee: Alza Corporation
    Inventors: James B. Eckenhoff, Judy A. Magruder, Richard Cortese, John R. Peery, Jeremy C. Wright
  • Multi-layer delivery system
    Patent number: 4957494
    Abstract: A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: September 18, 1990
    Assignee: ALZA Corporation
    Inventors: Patrick S. L. Wong, Felix Theeuwes, James B. Eckenhoff
  • Ruminant dispensing device
    Patent number: 4955881
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comprising a beneficial agent and a non-toxic heat responsive carrier in the space, and (4) a passageway in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: July 25, 1989
    Date of Patent: September 11, 1990
    Assignee: Alza Corporation
    Inventor: James B. Eckenhoff
  • Method for treating nocturnal angina
    Patent number: 4954344
    Abstract: A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.
    Type: Grant
    Filed: November 10, 1988
    Date of Patent: September 4, 1990
    Assignee: Alza Corporation
    Inventor: Robert M. Gale
  • Dosage form for treating cardiovascular diseases
    Patent number: 4950486
    Abstract: An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: August 21, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, David R. Swanson, Anthony L. Kuczynski
  • Pulsed drug delivery
    Patent number: 4948592
    Abstract: A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: August 14, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, Felix Theeuwes, Patrick S. L. Wong
  • Osmotic dosage form comprising an estrogen and a progestogen
    Patent number: 4948593
    Abstract: An osmotic device is disclosed comprising an estrogenic and a progestogenic steroid that are delivered as a contraceptive pair for fertility regulation in a female.
    Type: Grant
    Filed: May 15, 1989
    Date of Patent: August 14, 1990
    Assignee: Alza Corporation
    Inventors: Jeri D. Wright, Jerry D. Childers, Brian L. Barcley, Patrick S. L. Wong, Linda E. Atkinson
  • Cellulosic dosage form
    Patent number: 4946685
    Abstract: A bilaminate dosage form is disclosed comprising a first lamina and a second lamina with each lamina comprising a cellulose ether composition, and wherein a drug is present in at least one of the lamina. An optional coat is disclosed that surrounds the bilaminate form.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: August 7, 1990
    Assignee: Alza Corporation
    Inventors: David E. Edgren, Judy A. Magruder, Gurdish K. Bhatti
  • Dosage form for treating cardiovascular diseases
    Patent number: 4946687
    Abstract: An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: August 7, 1990
    Assignee: Alza Corporation
    Inventors: Atul D. Ayer, David R. Swanson, Anthony L. Kuczynski
  • Dispenser comprising displaceable matrix with solid state properties
    Patent number: 4940465
    Abstract: A dispenser is enclosed for delivering a beneficial agent to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first means in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: July 10, 1990
    Inventors: Felix Theeuwes, Patrick S.-L. Wong, Richard Cortese, James B. Eckenhoff
  • Skin permeation enhancer compositions using sucrose esters
    Patent number: 4940586
    Abstract: A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: July 10, 1990
    Assignee: Alza Corporation
    Inventors: Yu-Ling Cheng, Robert M. Gale, Edna Sugihara, Harold F. Sanders
  • Elastomeric bladders for medical infusers
    Patent number: 4938751
    Abstract: Elastomeric bladders having improved resistance to spontaneous rupture when inflated are made by vulcanizing a homogeneous mixture of synthetic polyisoprene having 90% to 98% cis-1,4 linkages, 3 to 10 phr fumed silicon dioxide, and vulcanizing agent while simultaneously forming the mixture into hollow cylindrical bodies. After being formed the bodies are solvent extracted to remove unreacted vulcanizing agent and the degradation products of the vulcanizing agent. Following the solvent extraction about 0.2 to 2 phr of a nontoxic, nonleachable antioxidant are imbibed into the bodies by contacting the bodies with a liquid solution of the antioxidant.
    Type: Grant
    Filed: July 21, 1988
    Date of Patent: July 3, 1990
    Assignee: Alza Corporation
    Inventors: Harold M. Leeper, George V. Guittard
  • Transdermal delivery device having a rate controlling adhesive
    Patent number: 4938759
    Abstract: A transdermal delivery device having a release-rate controlling-adhesive is disclosed having improved delivery characteristics. The device employs a polyisobutylene/mineral oil adhesive formulation and an ethylene/viny acetate (EVA) drug reservoir formulation. The device is useful in delivering a wide variety of transdermally administrable drugs, particularly those which are moderately soluble in mineral oil. Preferred embodiments deliver timolol base and atropine base from an EVA (40% VA) reservoir formulation.
    Type: Grant
    Filed: September 2, 1986
    Date of Patent: July 3, 1990
    Assignee: Alza Corporation
    Inventors: David J. Enscore, Eun S. Lee, Su I. Yum
  • Urinary drainage container comprising external source of biocide
    Patent number: 4938748
    Abstract: A patient-care apparatus comprising a container for receiving a biological fluid, and a delivery device on the outside of the container, which device comprises a biocide that is released to the container for preventing the multiplication of and/or eliminating the presence of unwanted pathogens in the container.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: July 3, 1990
    Inventors: Su I. Yum, Felix Theeuwes
  • Aqueous based pharmaceutical coating composition for dosage forms
    Patent number: 4931285
    Abstract: A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
    Type: Grant
    Filed: April 28, 1988
    Date of Patent: June 5, 1990
    Assignee: ALZA Corporation
    Inventors: David E. Edgren, Felix Theeuwes
  • Selective pulsed drug delivery system
    Patent number: 4927632
    Abstract: This invention pertains to a programmable delivery system.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: May 22, 1990
    Assignee: Alza Corporation
    Inventor: Patrick S.-L. Wong