Patents Represented by Attorney, Agent or Law Firm R. Scott Meece
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Patent number: 5789461Abstract: An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.Type: GrantFiled: July 18, 1996Date of Patent: August 4, 1998Assignee: Ciba Vision CorporationInventors: Paul Clement Nicolson, Richard Carlton Baron, Peter Chabrecek, John Court, Angelika Domschke, Hans Jorg Griesser, Arthur Ho, Jens Hopken, Bronwyn Glenice Laycock, Qin Liu, Dieter Lohmann, Gordon Francis Meijs, Eric Papaspiliotopoulos, Judy S. Riffle, Klaus Schindhelm, Deborah Sweeney, Wilson Leonard Terry, Jr., Jurgen Vogt, Lynn Cook Winterton
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Patent number: 5789464Abstract: The invention relates to a novel process for the manufacture of mouldings, especially contact lenses, in which a soluble prepolymer comprising crosslinkable groups is crosslinked in solution, and also to mouldings, especially contact lenses, obtainable in accordance with that process. The present invention relates also to novel prepolymers that can be used in the process according to the invention, especially derivatives of a polyvinyl alcohol having a molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprise from approximately 0.5 to approximately 80% of units of formula I ##STR1## wherein R is lower alkylene having up to 8 carbon atoms,R.sup.1 is hydrogen or lower alkyl andR.sup.Type: GrantFiled: December 22, 1995Date of Patent: August 4, 1998Assignee: CIBA Vision CorporationInventor: Beat Muller
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Patent number: 5782460Abstract: In a process for the manufacture of mouldings, especially optical lenses, specifically contact lenses (CL), a starting material that is crosslinkable by the impingement of suitable energy is introduced into a mould (1) having a cavity (15), which mould is at least partially permeable to the energy concerned. The starting material is introduced into the cavity in a still at least partially uncrosslinked state, the mould cavity determining the shape of the moulding (CL) to be produced. By means of impingement of the energy concerned, the starting material is crosslinked to an extent sufficient for it to be possible for the moulding (CL) to be released from the mould. The filling of the mould cavity is carried out in the starting material that is still at least partially in the uncrosslinked state.Type: GrantFiled: August 13, 1996Date of Patent: July 21, 1998Assignee: CIBA Vision CorporationInventors: Otto Kretzschmar, Sharla Borghorst, John Golby, Peter Hagmann, Peter Herbrechtsmeier, Bernhard Seiferling, Beat Muller
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Patent number: 5776381Abstract: In a process for the production of optical lenses, in particular contact lenses, a lens material is introduced between two mould halves. The mould halves each have a moulding surface and enclose a cavity in the closed state of the mould. After the lens material has been introduced the two moulding surfaces are moved towards each other and the lens material is enclosed in the cavity. If necessary, the lens material enclosed in the cavity is then polymerised. The first moulding surface is provided on the one mould half and the other mould half includes a mould part that is movable inside it with a close fit in the manner of a piston and on which the second moulding surface is provided, so that by moving that mould part towards the first moulding surface the cavity is closed. For this purpose, the two mould halves are first assembled, then the movable mould part which has the second moulding surface is moved in the direction towards the first moulding surface.Type: GrantFiled: January 29, 1997Date of Patent: July 7, 1998Assignee: CIBA Vision CorporationInventor: Lothar Haase
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Patent number: 5776999Abstract: An ophthalmic lens screening method suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.Type: GrantFiled: July 17, 1996Date of Patent: July 7, 1998Assignee: CIBA Vision CorporationInventors: Paul Clement Nicolson, Richard Carlton Baron, Peter Chabrecek, John Court, Angelika Domschke, Hans Jorg Griesser, Arthur Ho, Jens Hopken, Bronwyn Glenice Laycock, Qin Liu, Dieter Lohmann, Gordon Francis Meijs, Eric Papaspiliotopoulos, Judy Smith Riffle, Klaus Schindhelm, Deborah Sweeney, Wilson Leonard Terry, Jr., Jurgen Vogt, Lynn Cook Winterton
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Patent number: 5773608Abstract: A process for sterilizing a polysaccharide composition containing chitosan, a chitosan derivative or a chitin derivative without substantially degrading the polysaccharide. The process has the steps of blending the polysaccharide in a solvent to form a solution or suspension; sterilizing the solution or suspension; dissolving suspended particles, if present; and then aseptically adjusting the pH of the sterilized solution. There is additionally provided a polyol stabilizing agent suitable for the polysaccharide composition.Type: GrantFiled: July 3, 1996Date of Patent: June 30, 1998Assignee: CIBA Vision CorporationInventors: Shasy-Fong Yen, Mary Sou
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Patent number: 5770669Abstract: Copolymers formed from dimethacrylates of polyalkylene glycols and vinylic reactive silicones having up to 20 silicon atoms in the substantial absence of additional cross-linking agents. The copolymers may include a hydrophilicity-modifying monomer. The preferred silicon is TRIS (i.e., 3-methacryloxypropyl tris(trimethylsiloxy) silane), while the preferred polyalkylene glycol is polypropylene glycol dimethacrylate. The copolymers are especially suited to use in the fabrication of soft contact lenses because of the good durability and high oxygen permeability and transmissibility. Oxygen transmissibilities of greater than 70 barrers/mm are preferred.Type: GrantFiled: April 10, 1996Date of Patent: June 23, 1998Assignee: CIBA Vision CorporationInventors: J. Richard Robertson, Cheryl R. Allen
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Patent number: 5760100Abstract: An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.Type: GrantFiled: December 8, 1995Date of Patent: June 2, 1998Assignees: CIBA Vision Corporation, Commonwealth Scientific and Industrial Research OrganisationInventors: Paul Clement Nicolson, Richard Carlton Baron, Peter Chabrecek, John Court, Angelika Domschke, Hans Jorg Griesser, Arthur Ho, Jens Hopken, Bronwyn Glenice Laycock, Qin Liu, Dieter Lohmann, Gordon Francis Meijs, Eric Papaspiliotopoulos, Judy Smith Riffle, Klaus Schindhelm, Deborah Sweeney, Wilson Leonard Terry, Jr., Jurgen Vogt, Lynn Cook Winterton
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Patent number: 5760870Abstract: Contact lenses, especially toric and bifocal, which are rotationally stabilized and methods of stabilizing contact lenses. Contact lenses are stabilized, with respect to rotation while in place on the eye, by providing the lenses with a non-circular shape. In a preferred embodiment, a toric contact lens is rotationally stabilized by providing the lens with an oval shape. Also disclosed are methods of providing non-circular lenses with appropriate shapes for proper fit to a patient's eye.Type: GrantFiled: March 31, 1997Date of Patent: June 2, 1998Assignee: CIBA Vision CorporationInventors: Rick Edward Payor, Xiaoxiao Zhang, Lewis Williams, Gary Lafferty
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Patent number: 5756044Abstract: An article treatment system which provides improved solution mixing and concentration uniformity. The treatment system includes a container, a closure and a channel for guiding fluid flow. The treatment system is especially advantageous for use with effervescent tablets and for use in treating contact lenses. Cleaning and disinfecting of articles is improved by use of a tubular channel which guides upwardly gas and other components released from an effervescent tablet which is located at the bottom of the treatment container. The upward central flow through the channel induces a downward flow between the container walls, the exterior walls of the channel, and the article-retaining means and towards the bottom of the container.Type: GrantFiled: April 9, 1996Date of Patent: May 26, 1998Assignee: CIBA Vision CorporationInventors: Mary Mowrey-McKee, Rafael Victor Andino, David N. Ku, Paul J. Mulhauser, David R. Schiff
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Patent number: 5725887Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.Type: GrantFiled: September 5, 1996Date of Patent: March 10, 1998Assignee: CIBA Vision CorporationInventors: Stephen M. Martin, Fu-Pao Tsao
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Patent number: 5713957Abstract: Corneal onlays for use in surgical implantation into or onto the cornea of a mammal are described. The corneal onlays according to the invention have an optical axis region with optical characteristics which provide visual acuity therethrough and are comprised of a non-biodegradable non-hydrogel ocularly biocompatible material, characterized in that the onlay has a porosity sufficient to allow passage therethrough of tissue fluid components having a molecular fluid weight greater than 10,000 daltons so as to provide for a flux of tissue fluid between cells anterior of the implanted onlay and cells posterior thereof. The porosity of the optical axis region is such that it allows the flux of tissue fluid components whilst excluding ingrowth of ocular tissue. The onlay is further characterized by being adapted for epithelial recolonization.Type: GrantFiled: May 16, 1996Date of Patent: February 3, 1998Assignees: CIBA Vision Corporation, The Commonwealth of Australia Commonwealth Scientific and Industrial Research OrganizationInventors: John Gerard Steele, Brien A. Holden, Deborah Sweeney, Dan O'Leary, Klaus Schindhelm, Antti Vannas, Graham Johnson
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Patent number: 5712356Abstract: The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerisation product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.Type: GrantFiled: November 14, 1994Date of Patent: January 27, 1998Assignee: CIBA Vision CorporationInventors: Harald Bothe, Achim Muller, Bernhard Seiferling, Sharla Borghorst, John Golby, Peter Hagmann, Peter Herbrechtsmeier, Otto Kretzschmar
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Patent number: 5693768Abstract: The present invention relates to polymerisable derivatives of carbohydrates comprising a compound of formula (I)R.sup.1 --(COO--Alk).sub.m -(OCONH--R).sub.n -(NHCO).sub.p Y--Z (I)whereinR.sup.1 is a radically polymerisable hydrocarbon group; m, n and p are 0 or 1; Alk is alkylene having up to 10 carbon atoms; R is a diradical, having up to 20 carbon atoms, of an organic diisocyanate; Z is a monovalent radical, minus a single hydroxy group, of a mono-, di- or tri-saccharide, of an oligosaccharide, of a cyclodextrin (CD) or of an anhydrosaccharide; and Y is --O-- or --NH--; with the proviso that when p is zero, m and n are also zero and Y is --NH--; to homopolymers, copolymers, block copolymers, graft copolymers and polymeric networks thereof, to moulded articles, for example contact lenses or biomedicinal articles, comprising the mentioned polymers, as well as to processes for the preparation of the mentioned polymers and articles.Type: GrantFiled: February 13, 1995Date of Patent: December 2, 1997Assignee: Ciba Vision CorporationInventors: Frank Bachmann, Dieter Lohmann, Peter Chabrecek
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Patent number: 5683993Abstract: Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound such as diethylene triamine penta(methylene phosphonic acid). These biocompatible compositions are especially useful in the ophthalmic field.Type: GrantFiled: June 22, 1995Date of Patent: November 4, 1997Assignee: CIBA Vision CorporationInventor: Fu-Pao Tsao
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Patent number: 5683709Abstract: A package containing an aqueous drug composition containing an insoluble resin comprising benzalkonium salt units in an amount sufficient to inhibit growth of microbes in said aqueous drug solution. Typically, the insoluble resin is a polymer having repeating units of the formula:--?CH.sub.2 --CH(Ar)!--wherein Ar=a group of the formula:-Phe-CH.sub.2 --N.sup.+ (CH.sub.3).sub.2 R X.sup.-wherein R=long chain alkyl such as C.sub.8-18 alkyl, Phe=phenylene, and X.sup.- is a pharmaceutically acceptable counter anion such as Cl.sup.-.Type: GrantFiled: May 5, 1994Date of Patent: November 4, 1997Assignee: CIBA Vision CorporationInventors: Akira Yamada, Teresa H. Kuan, Ajay Vasudev Pandurangi
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Patent number: 5665420Abstract: An apparatus and method for uniformly contacting an article with a treatment solution. Preferred embodiments are methods of uniformly tinting of contact lenses or uniformly surface modifying contact lenses. The method involves suspending the lens in the treatment solution by application of fluid flow, preferably sinusoidal or pulsed, in a direction opposite the stagnant force (i.e., sum of buoyancy and gravity forces) on the article. The fluid flow prevents the lens from contacting the container structure for periods sufficient to cause non-uniform treatment conditions, while continuously mixing the treatment solution to maintain uniform concentrations throughout.Type: GrantFiled: December 5, 1994Date of Patent: September 9, 1997Assignee: Ciba Vision CorporationInventors: Robert A. Janssen, Barbara L. Heyl, Roger J. Hoffman, Thomas E. Shank
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Patent number: 5665840Abstract: The present invention describes a water-soluble crosslinkable prepolymer that comprises, in the copolymer chain, units derived from the following monomeric structural units: a vinyl lactam (a), vinyl alcohol (b), optionally a lower alkanecarboxylic acid vinyl ester (c), a vinylic crosslinking agent (d) and optionally a vinylic photoinitiator (e); a process for the preparation of the novel prepolymers; crosslinked water-insoluble polymeric networks therefrom; hydrogels and moulded articles made from the crosslinked water-insoluble polymeric networks, especially contact lenses; and a process for the manufacture of hydrogels and finished contact lenses using the mentioned crosslinkable water-soluble prepolymers.Type: GrantFiled: November 3, 1995Date of Patent: September 9, 1997Assignee: Novartis CorporationInventors: Thomas Pohlmann, Achim Muller, Bernhard Seiferling
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Patent number: D380898Type: GrantFiled: January 26, 1995Date of Patent: July 15, 1997Inventor: Francis John Lovell
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Patent number: D395600Type: GrantFiled: January 19, 1996Date of Patent: June 30, 1998Assignee: CIBA Geigy Corp.Inventors: Sharla Borghorst, Erich Bauman, Peter Herbrechtsmeier, David Pietrobon, Michele De Lucchi, Torsten Fritze, Masahiko Kubo