Patents Represented by Attorney, Agent or Law Firm Robert L. Starnes
  • Polypeptides having lipase activity and nucleic acids encoding same
    Patent number: 6686189
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: February 3, 2004
    Assignee: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Golightly
  • Polypeptides having phospholipase activity and nucleic acids encoding same
    Patent number: 6682922
    Abstract: The present invention relates to isolated polypeptides having lysophospholipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: January 27, 2004
    Assignees: Novozymes Biotech, Inc., Novozymes Bioindustry, Ltd.
    Inventors: Randy M. Berka, Michael W. Rey, Tony Byun, Ryoko Itami, Noriko Tsutsumi, Alan Klotz
  • Polypeptides having aminopeptidase activity and nucleic acids encoding same
    Patent number: 6673571
    Abstract: The present invention relates to isolated polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: January 6, 2004
    Assignee: Novozymes Biotech, Inc.
    Inventors: Alexander Blinkovsky, Tony S. Byun, Alan V. Klotz, Alan Sloma, Kimberly Brown, Maria Tang, Mikio Fujii, Chigusa Marumoto, Lene Venke Kofod
  • Polypeptides having acid phosphatase activity and nucleic acids encoding same
    Patent number: 6667169
    Abstract: The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 23, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having dipeptidyl aminopeptidase activity and nucleic acids encoding same
    Patent number: 6664092
    Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: December 16, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventors: Alexander Blinkovsky, Kimberly Brown, Michael W. Rey, Alan Klotz, Tony Byun
  • Methods for making popcorn kernels with improved flake production
    Patent number: 6555147
    Abstract: The present invention relates to methods for making enzyme-treated unpopped popcorn kernels, comprising: (a) contacting the popcorn kernels with an aqueous solution comprising an effective amount of one or more hull wall-degrading enzymes for a period of time sufficient to weaken the hull wall of the kernels; and (b) recovering the enzyme-treated popcorn kernels. The present invention also relates to popcorn kernels obtained by the methods of the present invention.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: April 29, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventor: Feng Xu
  • Morphological mutants of filamentous fungi
    Patent number: 6544774
    Abstract: The present invention relates to methods of obtaining a mutant cell from a filamentous fungal parent cell, comprising: (a) obtaining mutant cells of the parent cell; (b) identifying the mutant cell which exhibits a more restricted colonial phenotype and/or a more extensive hyphal branching than the parent cell; and (c) identifying the mutant cell which has an improved property for production of a heterologous polypeptide than the parent cell, when the mutant and parent cells are cultured under the same conditions.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: April 8, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventors: Jeffrey R. Shuster, John C. Royer
  • Polypeptides having lysophospholipase activity and nucleic acids encoding same
    Patent number: 6489154
    Abstract: The present invention relates to isolated polypeptides having lysophospholipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: December 3, 2002
    Assignees: Novozymes Biotech, Inc., Novozymes Bioindustry, Ltd.
    Inventors: Randy M. Berka, Michael W. Rey, Tony Byun, Ryoko Itami, Noriko Tsutsumi, Alan Klotz
  • Methods for using lactonohydrolases in baking
    Patent number: 6485761
    Abstract: The present invention relates to methods for preparing a dough, comprising incorporating into the dough a composition comprising an effective amount of one or more lactonohydrolases which improve one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions comprising an effective amount of one or more lactonohydrolases for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: November 26, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventor: Feng Xu
  • Methods for producing a polypeptide using a consensus translational initiator sequence
    Patent number: 6461837
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a consensus translational initiator sequence foreign to the nucleic acid sequence; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated consensus translational initiator sequences and to constructs, vectors, and fungal host cells comprising the consensus translational initiator sequences operably linked to nucleic acid sequences encoding polypeptides.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: October 8, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie S. Yaver, Daniel Alan Bellini
  • Polypeptides having lipase activity and nucleic acids encoding same
    Patent number: 6432898
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: August 13, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Golightly
  • Polypeptides having lactonohydrolase activity and nucleic acids encoding same
    Patent number: 6395529
    Abstract: The present invention relates to isolated polypeptides having lactonohydrolase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides. The present invention further relates to methods for preventing microbial biofilm development.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: May 28, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey
  • Polypeptides having peroxidase activity and nucleic acids encoding same
    Patent number: 6372464
    Abstract: The present invention relates to isolated polypeptides having peroxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: April 16, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie S. Yaver, Barbara McArdle
  • Promoters for expressing genes in a fungal cell
    Patent number: 6361973
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO:1, nucleotides 1 to 938 of SEQ ID NO:2, and nucleotides 1 to 3060 of SEQ ID NO:3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: March 26, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Kimberly Brown, Stephen H. Brown
  • Methods for modifying the production of a polypeptide
    Patent number: 6323002
    Abstract: The present invention relates to methods for modifying the production of a polypeptide, comprising: (a) introducing a nucleic acid construct into a cell, wherein the cell comprises a DNA sequence encoding a polypeptide, under conditions in which the nucleic acid construct integrates into the genome of the cell at a locus not within the DNA sequence encoding the polypeptide to produce a mutant cell, wherein the integration of the nucleic acid construct modifies the production of the polypeptide by the mutant cell relative to the cell when the mutant cell and the cell are cultured under the same conditions; and (b) identifying the mutant cell with the modified production of the polypeptide.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: November 27, 2001
    Assignee: Novozymes Biotech, Inc
    Inventors: Howard Brody, Deborah S. Yaver, Michael Lamsa, Kim Hansen
  • Polypeptides having choline oxidase activity and nucleic acids encoding same
    Patent number: 6320103
    Abstract: The present invention relates to isolated polypeptides having choline oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: November 20, 2001
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having acid phosphatase activity and nucleic acids encoding same
    Patent number: 6309869
    Abstract: The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: October 30, 2001
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having glucoamylase activity and nucleic acids encoding same
    Patent number: 6309872
    Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: October 30, 2001
    Assignee: Novozymes Biotech, Inc
    Inventors: Michael W. Rey, Elizabeth J. Golightly
  • Methods for using dehydrogenases in baking
    Patent number: 6306445
    Abstract: The present invention relates to methods for preparing a dough, including incorporating into the dough a composition containing an effective amount of one or more dehydrogenases which improve one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions containing an effective amount of one or more dehydrogenases for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: October 23, 2001
    Assignees: Novozymes Biotech Inc., Novozymes A/S
    Inventors: Feng Xu, Peter Wagner
  • Aspergillus porphobilinogen synthases and nucleic acids encoding same
    Patent number: 6306630
    Abstract: The present invention relates to Aspergillus porphobilinogen synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the porphobilinogen synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the porphobilinogen synthases.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: October 23, 2001
    Assignee: Novozymes Biotech, Inc.
    Inventors: Aubrey Jones, Joel R. Cherry