Patents Represented by Attorney Robert S. Honor
  • Patent number: 5955468
    Abstract: Compounds of formula I ##STR1## wherein A, B, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description, are useful for the treatment of conditions where prevention or delay of progressive atrophy of the optic nerve is desirable.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 21, 1999
    Assignee: Sandoz Ltd.
    Inventor: Rudolf Markstein
  • Patent number: 5719123
    Abstract: Pulmonary administration of Ciclosporin in orthorhombic crystal form (designated "CY-A/X-III"), e.g. for the treatment of obstructive or inflammatory airways disease, e.g. asthma, as well as crystalline Ciclosporin, e.g. CY-A/X-III, in spheroidal particulate form, processes for its preparation and its pharmaceutical use, e.g. for pulmonary administration. Pharmaceutical compositions comprising CY-A/X-III and crystalline Ciclosporin, e.g. CY-A/X-III, in spheroidal particulate form as well as Ciclosporin in solution in aerosol propellants are also provided.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: February 17, 1998
    Assignee: Sandoz Ltd.
    Inventors: John Morley, Andreas Rummelt, Martin List
  • Patent number: 5679733
    Abstract: A solid solution composition comprisinga) a 2,2,6,6-tetraalkylpiperidinyl compound having a low molecular weight; andb) a 2,2,6,6-tetraalkylpiperidinyl compound having a high molecular weightthat have been mixed in the melt, is an excellent stabilizer for polymeric materials.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 21, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Jan Malik, Sona Pallayova, Peter Danko
  • Patent number: 5674371
    Abstract: A process for providing a variety of light to medium colors of anodized aluminum or aluminum alloy which comprises the steps of anodizing an aluminum or aluminum alloy workpiece in an aqueous strong acid electrolyte solution such as a sulfuric acid solution by application of direct current at a current density of 5 to about 25 amperes per square foot and a temperature of from 55.degree. F. to 90.degree. F. to form on the workpiece a porous anodic oxide film having a thickness of at least about 3 microns; subjecting the resulting anodized workpiece to alternating current at a voltage of about 5 to about 25 volts for about 1 to 25 minutes in an aqueous strong acid electrolyte solution such as a sulfuric acid solution comprising about 1 to 15 volume percent of an organic carboxylic acid containing at least one reactive group in the alpha-position, wherein said reactive group is a hydroxy, amino, keto or carboxyl group; and electrolytically coloring the workpiece.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 7, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventor: Pinakin Patel
  • Patent number: 5670685
    Abstract: A process for preparing carboxylates of polyoxyalkylene siloxanes and -amines, alkylpolyoxyalkylenes, polyoxyalkylene block polymers, alkylamidepolyoxyalkylenes and alkylpolyglucosides comprising subjecting a primary hydroxyl group-containing polyoxyalkylene compound or alkylpolyglucoside to mild oxidiation. The invention also relates to the novel polyoxyalkylene amine and alkylamidepolyoxyalkylene carboxylates prepared by the process.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 23, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Parfait J. M. Likibi, Robert V. Casciani, Gregory L. McCraw
  • Patent number: 5668261
    Abstract: A process for preparing carboxylates of polyoxyalkylene siloxanes and -amines, alkylpolyoxyalkylenes, polyoxyalkylene block polymers, alkylamidepolyoxyalkylenes and alkylpolyglucosides comprising subjecting a primary hydroxyl group-containing polyoxyalkylene compound or alkylpolyglucoside to mild oxidiation. The invention also relates to the novel polyoxyalkylene amine and alkylamidepolyoxyalkylene carboxylates prepared by the process.
    Type: Grant
    Filed: March 7, 1996
    Date of Patent: September 16, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Parfait J. M. Likibi, Robert V. Casciani, Gregory L. McCraw
  • Patent number: 5668259
    Abstract: Compounds of the formula ##STR1## iron complexes thereof and mixtures of such iron complexes, wherein D is a monocyclic or bicyclic aromatic diazo component radical of the benzene series containing one --SO.sub.3 M group or is ##STR2## R.sub.1 is hydrogen, methyl or ethyl, and R.sub.4 is hydrogen, chloro or C.sub.1-2 alkyl,wherein R' is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 hydroxyalkyl, methoxy(C.sub.2-4 alkyl) or ##STR3## R" is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 hydroxyalkyl or methoxy(C.sub.2-4 alkyl), or--NR'R" is a saturated 5- or 6-membered ring,R.sub.5 is hydrogen, chloro or C.sub.1-2 alkyl, andX is hydrogen or hydroxy,wherein each R.sub.2 is independently hydrogen, chloro, hydroxy, C.sub.1-2 alkyl, C.sub.1-2 alkoxy or --SO.sub.2 NR.sub.o R.sub.o, andeach R.sub.3 is independently hydrogen, C.sub.1-2 alkyl, C.sub.1-2 alkoxy, --COOM, trifluoromethyl or --NR"'R"",wherein each R"' and R"" is independently C.sub.1-4 alkyl, C.sub.2-4 hydroxyalkyl, methoxy(C.sub.2-4 alkyl) or carbamoyl(C.sub.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: September 16, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Jordi Berenuger Barra, Herbert Holliger, Jose Rocas Sorolla
  • Patent number: 5665681
    Abstract: The invention discloses compounds of formula I ##STR1## wherein X is oxygen or sulfur,R is hydrogen, chlorine or fluorine,R.sub.1 is fluorine, chlorine, bromine, cyano or methyl,R.sub.2 is halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylcarbonyloxy, C.sub.3-6 cycloalkoxy, C.sub.3-6 alkynyloxy, C.sub.3-6 alkenyloxy, --COOH, --CO--R.sub.3, --CO--NR.sub.4 R.sub.5, --NR.sub.6 R.sub.7, C.sub.2-6 alkenyl, N-pyrrolyl, 2-oxo-3-tetrahydrofuranyl or isC.sub.1-6 alkyl substituted with halogen, COOH, --CO--R.sub.3, --CO--NR.sub.8 R.sub.9, .dbd.N--OH, .dbd.N--C.sub.1-4 alkoxy, --O--CO--R.sub.3 or --O--C.sub.2-3 alkylene-O--; or isC.sub.2-6 alkenyl substituted with halogen, COOH, --CO--R.sub.3, --CO--NR.sub.8 R.sub.9 or C.sub.1-4 alkoxy; or isC.sub.1-6 alkoxy substituted with cyano, --CO--R.sub.3, C.sub.1-4 alkoxy, C.sub.3-6 cycloalkyl, oxiranyl, orC.sub.1-4 alkoxy or halogen; or isC.sub.3-6 alkenyloxy substituted by C.sub.2-5 alkynyl;R.sub.3 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.1-6 cyanoalkyl, C.sub.
    Type: Grant
    Filed: June 20, 1995
    Date of Patent: September 9, 1997
    Assignee: Sandoz Ltd.
    Inventors: Karl Seckinger, Sasank Sekhar Mohanty, Karlheinz Milzner, Fred Kuhnen
  • Patent number: 5665772
    Abstract: Novel derivatives of rapamycin, particularly 9-deoxorapamycins, 26-dihydro-rapamycins, and 40-0-substituted and 28,40-0,0-di-substituted rapamycins, are found to have pharmaceutical utility, particularly as an immunosuppressants.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: September 9, 1997
    Assignee: Sandoz Ltd.
    Inventors: Sylvain Cottens, Richard Sedrani
  • Patent number: 5665871
    Abstract: The invention relates to mixtures comprisingone or more phthalocyanine dyes of formula I ##STR1## wherein CuPc is the radical of a Cu-phthalocyanine dye,A is selected from the group consisting of optionally substituted, linear or branched C.sub.2 -C.sub.6 -alkylene groups,R.sub.1 and R.sub.2 independently of one another, are selected from the group consisting of hydrogen or optionally substituted, linear or branched C.sub.1 -C.sub.6 -alkyl,M is selected from the group consisting of hydrogen, lithium, sodium, potassium, ammonium or substituted ammonium,x and y is 1 to 3, with the provision that the sum of x+y is 3 to 4, and; one or more azo dyes of formula II: ##STR2## wherein R.sub.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: September 9, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventor: Reinhard Pedrazzi
  • Patent number: 5665727
    Abstract: The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: September 9, 1997
    Assignee: Sandoz Ltd.
    Inventors: Maximilian Grassberger, Josef Gottfried Meingassner, Anton Stutz, Peter Stutz
  • Patent number: 5659030
    Abstract: A p-toluenesulphonic acid salt of 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroximino-acetamido]-3-N,N-dimethylcarb amoyloxymethyl-3-cephem-4-carboxylic acid (isopropoxycarbonyloxy)ethylester, e.g. of formula ##STR1## its use in the production of other salts and a pharmaceutical composition containing it.
    Type: Grant
    Filed: June 14, 1995
    Date of Patent: August 19, 1997
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Rainer Pucher, Siegfried Wolf
  • Patent number: 5656721
    Abstract: The present invention provides a sugar derivative of a biologically active peptide, which derivative has a prolonged duration of action when compared to the non-sugar modified peptide, and contains at least on one of the amino acid units a sugar residue which is attached to an amino group thereof by a coupling other than a direct N-glycosidic bond, and additionally, when it is a condensation product of a carboxyl group containing sugar and a peptide with less than 8 amino acid units, by a coupling other than a direct amide bond.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: August 12, 1997
    Assignee: Sandoz Ltd.
    Inventors: Rainer Albert, Wilfried Bauer, Francois Cardinaux, Monika Mergler, Janos Pless, Walter Prikoszovich
  • Patent number: 5654410
    Abstract: Fibre-reactive monoazo compounds of the formula ##STR1## which compounds are in free acid or salt form, and mixtures thereof, are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, for example leather and fibre material comprising natural or synthetic polyamides or natural or regenerated cellulose; the most preferred substrate is a textile material comprising cotton.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: August 5, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Rainer Nusser, Roland Wald
  • Patent number: 5652212
    Abstract: Pharmaceutical compositions comprising a cyclosporin as active ingredient, a fatty acid triglyceride, a glycerol fatty acid partial ester or propylene glycol or sorbitol complete or partial ester, preferably, and a tenside having an HLB of at least 10.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 29, 1997
    Inventors: Thomas Cavanak, Ulrich Posanski
  • Patent number: 5650134
    Abstract: Somatostatin peptides bearing a chelating group selected from a bifunctional N.sub.4 -chelating group particularly suitable for Tc, Rh, Cu, Co or Re-labelling, and a bifunctional polyamino-polycarboxylic acid chelating group are complexed with a .alpha.-, .beta.-, .gamma.- or positron-emitting nuclide or a nuclide with Auger-e.sup.- -cascades and are useful as radiopharmaceuticals.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: July 22, 1997
    Assignee: Novartis AG (formerly Sandoz Ltd.)
    Inventors: Rainer Albert, Helmut Macke
  • Patent number: 5649904
    Abstract: The use, in sequence, of a cytotoxic, but stem cell sparing, agent and granulocyte-macrophage colony stimulating factor as a means to harvest very high numbers of multipotential haemopoietic precursor cells and in reducing the period of myeloid recovery after high dose chemo- or radiotherapy of cancer.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: July 22, 1997
    Assignees: Sandoz Ltd., Instituto Nazionale Per Lo Studio E La Cura Dei Tumori
    Inventor: Alessandro M. Gianni
  • Patent number: 5650515
    Abstract: Salts of the formulaF.sub.n.Awherein F is an anion of a metal-free anionic dye having m acid groupswhereinm is 1 to 4, inclusive,A is a cation of an amine containing 1 to 6 sterically hindered amine groups, andn is 1 or 2,with the proviso that the salt contains 1 to n.times.m groups selected from ammonium and immonium groups, useful as pigments, particularly for the coloring of solvent-free and solvent-containing plastic materials, lacquers and printing inks.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 22, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Bansi Lal Kaul, Angelos-Elie Vougioukas
  • Patent number: 5647875
    Abstract: A desired color shade is produced on a textile substrate by treating a dyed textile substrate, which has an initial color shade which is partly due to color caused by the presence thereon of a vat dye and partly due to color caused by the presence thereon of a sulfur dye, with a chlorine-free decolorizing agent, such as hydrogen peroxide in an aqueous alkaline medium, whereby the color shade of the substrate is changed from said initial color shade to said desired color shade by removal therefrom of a proportion of the color attributable to the sulfur dye without removing as large a proportion of the color attributable to the vat dye.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: July 15, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventor: Michael W. Dixon
  • Patent number: 5643870
    Abstract: A cyclosporin of the formula ##STR1## wherein A is a residue of the formula ##STR2## wherein R is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy or C.sub.1-3 alkylthio; halo-substituted-C.sub.1-3 alkyl, -C.sub.1-3 alkoxy or -C.sub.1-3 alkylthio; hydroxy-substituted-C.sub.1-3 alkyl, -C.sub.2-3 alkoxy or -C.sub.2-3 alkylthio; or amino or mono- or di-(C.sub.1-2 alkyl)-amino,X is oxygen or sulphur,--x--y-- is --CH.dbd.CH-- (trans) or --CH.sub.2 --CH.sub.2 --,B is -.alpha.Abu-, -Val-, -Thr- or -Nva- andQ is -(D)Ala-; -(D)Ser-; -[O-(2-hydroxyethyl)(D)Ser]-; or -[O-acyl(D)Ser]- or -[O-(2-acyloxy ethyl)(D)Ser]-in which the acyl residue is physiologically hydrolysable and acceptable, are useful in the topical treatment of asthma.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: July 1, 1997
    Assignee: Sandoz Ltd.
    Inventors: Johann Jakob Boelsterli, Marcel Karl Eberle, Reto Naef, Trevor Glyn Payne