Abstract: A hardenable composition suitable for flooring and for coating concrete surfaces comprising(a) an acrylic binder comprising a (meth)acrylic ester of the formula ##STR1## where R.sub.1 is C.sub.2-6 alkylene, n is 0-3 and R.sub.2 is a radical of an aromatic or alicyclic dicarboxylic acid ester or a dicyclopentenyl radical, n being 0 only when R.sub.2 is a dicyclopentenyl radical, and(b) a component which is one or both (preferably both) of carbon black and a polyfunctional aliphatic or aromatic polyester- or polyether- urethane oligomer. The composition also preferably comprises aggregate such as sand. The compositions have excellent impact resistance and flexural strength.
Abstract: The present invention provides a pharmaceutical composition for the transdermal systemic administration of an active agent characterized in that the active agent is bopindolol or methysergide. Also the present invention provides a pharmaceutical composition for the transdermal systemic administration of a pharmacologically active agent characterized in that it contains bopindolol, tizanidine, clemastine, ketotifen or methysergide as active agent in a reservoir comprising a hydrophilic polymer. Furthermore a pharmaceutical composition for the transdermal systemic administration of pharmacologically active agents characterized in that the pharmacologically active agent is in a reservoir comprising a polyacrylate polymer containing cationic ester groups.
Type:
Grant
Filed:
September 28, 1994
Date of Patent:
January 14, 1997
Assignee:
Sandoz Ltd.
Inventors:
Thomas Kissel, Henriette Schrank, Hans-Rainer Hoffmann
Abstract: Rapid setting cementitious compositions comprise hydraulic cement and at least 4% by weight based on the weight of the cement of a water-soluble malate or citramalate such as an alkali metal malate or alkali metal citramalate.
Abstract: A cephalosporin intermediate of the formula ##STR1## where R.sub.3 is carboxyl, carboxylate, or a carboxylic acid ester group and,R.sub.8 and R.sub.9 are each independently hydrogen, halogen,(C.sub.1-4) alkyl, hydroxy, carboxamido,(C.sub.1-4) alkoxycarbonyl, amino,mono- (C.sub.1-4) alkylamino, di- (C.sub.1-4) alkylamino, ortogether are a 5 or 6-membered carbocyclic ring or an alkali metal, alkaline earth metal, or acid addition salt thereof. Valuable cephalosporin antibiotics can be produced from the cephalosporin intermediate products of formula I.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
December 17, 1996
Assignee:
Biochemie Gesellschaft m.b.h.
Inventors:
Gerd Ascher, Hubert Sturm, Heinrich Thaler, Werner Veit
Abstract: Microcapsules containing a solution or dispersion of a colorant, especially a solution of an oil-solubilized sulfur dye, in an organic liquid having a vapor pressure below 20 mm Hg at 25.degree. C. can be coated on a side of a sheet of paper for use in pressure-sensitive carbonless copy systems. The solutions of the oil-solubilized sulfur dyes, i.e. 1) colored products of the oxidation of a leuco sulfur dye, leuco sulfurized vat dye or reaction product of a leuco dye or sulfurized vat dye with a cationic compound and 2) colored reaction products of a solubilized sulfur dye with a cationic compound also constitute an aspect of the invention, as do microcapsules whose walls contain an opacifying agent incorporated therein.
Type:
Grant
Filed:
March 2, 1995
Date of Patent:
December 17, 1996
Assignee:
Sandoz Ltd.
Inventors:
Lynn Hosie, Niraj Agarwal, Maria W. Sie, David A. Whitley
Abstract: Fibre-reactive 1:1 copper complexes of the formula ##STR1## which compounds are in free acid or salt form, and mixtures thereof, are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, for example leather and fibre material comprising natural or synthetic polyamides or natural or regenerated cellulose; the most preferred substrate is a textile material comprising cotton.
Abstract: Complexes and pharmaceutical preparations containing complexes of the pleuromutilin derivative of formula I ##STR1## in free base or in acid addition or quaternary salt form and cyclodextrin are described.They can be prepared by complexing the above pleuromutilin compound with an appropriate cyclodextrin.They are indicated for use as pharmaceuticals, e.g. as antibiotics, especially in veterinary medicine, e.g. as feed additives.
Abstract: A method for reducing or suppressing the acute phase response in a patient receiving IL-6 treatment which comprises co-administering with the IL-6 an effective amount of granulocyte macrophage colony stimulating factor (GM-CSF).
Abstract: A pharmaceutical composition adapted for nasal administration and comprising hPTH or a N-terminal fragment thereof. Preferred carriers are optionally coated celluloses.
Type:
Grant
Filed:
August 25, 1993
Date of Patent:
November 26, 1996
Assignee:
Sandoz Ltd.
Inventors:
Fran.cedilla.ois Cardinaux, Christine Oechslein, Andreas Rummelt
Abstract: Fibre-reactive monoazo compounds of the formula ##STR1## which compounds are in free acid or salt form, and mixtures thereof, are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, for example leather and fibre material comprising natural or synthetic polyamides or natural or regenerated cellulose; the most preferred substrate is a textile material comprising cotton.
Abstract: The invention relates to a new process for the production of the disodium salt hemiheptahydrate of ceftriaxone by reacting 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio] methyl}-3-cephem-4-carboxylic acid with 2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetic acid-(2-benzthiazolyl)thiolester in the presence of a base, characterized in that the reaction and the crystallization of the disodium salt hemiheptahydrate of ceftriaxone are carried out in aqueous acetone.
Type:
Grant
Filed:
February 19, 1993
Date of Patent:
November 12, 1996
Assignee:
BIOCHEMIE Gesellschaft m.b.H.
Inventors:
Johann Danklmaier, Ingolf Macher, Bernhard Prager
Abstract: An improved electrochemical process for thiocyanating aminobenzene compounds (e.g., 3,4-dichloroaniline), and in particular a process for preparing 2-aminobenzothiazole compounds, is disclosed which provides attractive yields under relatively favorable temperature conditions, and with reduced or minimal cyanide formation. In a further aspect, use of quaternary ammonium salts in the thiocyanation medium has been found to inhibit cathodic corrosion.
Abstract: Aqueous microemulsions of protonated aminopolysiloxanes (.alpha.) comprising an amphoteric surfactant (.beta.) and optionally at least one non-ionic emulsifier (.gamma.) and optionally hydrotropics (.delta.) and/or cationic emulsifiers (.eta.) and the pH of which is .ltoreq.7 are suitable as finishing agents of good stability, in particular stability to shearing forces, for the treatment of fibrous material, in particular textile material.
Abstract: An additive for cementitious compositions comprises at least one sulfated polysaccharide obtained by the sulfation of a polysaccharide, preferably under moderate conditions. The additive enhances the fluidity and workability of cementitious mixes, and gives higher final compressive strength.
Abstract: 2,2-di(C.sub.1-5 alkyl)- and trans-2,2-di(C.sub.1-5 alkyl)-3,4-dihydro-3-hydroxy-6-(pyridin-4-yl)-2H-1-benzopyrans, e.g. of formula ##STR1## in which R.sub.1 and R.sub.2 =H, alkyl, hydroxyalkyl or alkoxyalkyl, at least one being other than H, R.sub.3 =typically a 2-piperidinone group, R.sub.4 =H and R.sub.5 =--OH or R.sub.4 +R.sub.5 =an additional bond, and R.sub.6, R.sub.7 are alkyl and R.sub.8 is H or alkyl, and N-oxides, esters and salts thereof, processes for their production and their uses as pharmaceuticals e.g. as K.sup.+ -channel openers, bronchodilators and asthma prophylactic agents.
Abstract: A textile treatment composition which comprises; a textile binding agent which forms a chemical bond with the outer layer of the textile according to the formula (Ia): ##STR1## and, a barrier agent which forms a chemical bond with the textile binding agent and which increases the surface tension of the textile. Methods for treating textiles with the treatment composition, and kits comprising the components are also provided.
Type:
Grant
Filed:
January 11, 1996
Date of Patent:
November 5, 1996
Assignee:
Invicta Group Industries Pty Ltd.
Inventors:
Arthur D. Fisher, Dieter Reinehr, Jorg Binz, Sven Strunk
Abstract: Salts of the formulaF.sub.n.A,wherein F is an anion of a metal-free anionic dye having m acid groupswherein m is 1 to 4, inclusive,A is a cation of an amine containing 1 to 6 sterically hindered amine groups, andn is 1 or 2,with the proviso that the salt contains 1 to n.times.m groups selected from ammonium and immonium groups, useful as pigments, particularly for the coloring of solvent-free and solvent-containing plastic materials, lacquers and printing inks.
Abstract: New powder coatings or powder coating compositions comprisingA) a binder systemB) specific powder coating additivesC) at least one compound of formula I ##STR1## in which R.sub.1 is methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl or tert-butyl and optionallyD) additional compounds selected from the group consisting of antioxidants, UV-stabilizers, UV-absorbers, acid scavengers, radical scavengers, pigments, dyes, UV-quenchers, processing stabilizers, fillers, and tribocharging additivesexibit advantages during their production. Compounds according to formula I can be used as UV-absorbers and can be incorporated even in greater amounts and dispersed homogeneously at the manufacture of the powder coating compositions in an extruder. It is a further advantage of these compounds that they do not volatilize during stoving of the coatings.
Abstract: Triphendioxazine compounds of formula I, ##STR1## in which R.sub.1 and R.sub.2 are either both hydrogen or form a single chain linking the 8,9-; 9,10- or 10,11-positions, the single chain having the formula --NR.sub.5 ---(CO).sub.m --NH--, --CR.sub.5 .dbd.CH--CO--NH--, --CO--CH.sub.2 --CO--NH--, --CO--CH.dbd.CR.sub.5 --NH--, --CO--NH--CO--NH--, --CO--NH--CR.sub.6 .dbd.N--, --CR.sub.6 .dbd.N--CO--NH--, --NR.sub.5--(CO).sub.m --O--or --NH--CR.sub.5 .dbd.N--whereR.sub.5 is hydrogen, C.sub.1-4 alkyl or phenyl, R.sub.6 is hydrogen, C.sub.1-4 alkyl or phenyl;m is 1 or 2 and R.sub.3 and R.sub.4 are either both hydrogen or form a single chain linking the 1,2-, 2,3- or 3,4-positions, the single chain having a formula selected from --NR.sub.5 --(CO).sub.m --NH--, --CR.sub.5 .dbd.CH--CO--NH--, --O--CH.sub.2 --CO--NH--, --CO--CH.dbd.CR.sub.5 --NH--, --CO--NH--CO--NH--, --CONH--CR.sub.6 .dbd.N--, --CR.sub.6 .dbd.N--CO--NH--, --NR.sub.5 --(CO).sub.m --O--or --NH--CR.sub.5 .dbd.N--where the symbols R.sub.5, R.sub.