Patents Represented by Attorney Robert S. Honor
  • Patent number: 5615975
    Abstract: The present invention is a method for the detoxification and/or chemical remediation of soil contaminated with volatile organic compounds. The process comprises treating the soil with the sodium and calcium salts of naphthalene sulfonates, lignosulfonates, their derivatives and mixtures thereof. The volatile organics are then forced from the soil as the soil is more attracted to the admixture than it is to the volatile organic contaminants.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: April 1, 1997
    Assignee: Sandoz Ltd.
    Inventors: Hugh H. Wang, John Parker, Paul Przygocki, Mike Ameel
  • Patent number: 5616473
    Abstract: The gene encoding the ligninase rLDM.TM. 6 has been cloned and expressed. The ligninases produced via the processes disclosed herein are useful to degrade or modify lignin in pulp operations.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: April 1, 1997
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Roberta L. Farrell, Paul Gelep, Algis Anilionis, Kashayar Javaherian, Theodore E. Maione, James Rusche, Bruce A. Sadownick, Jennifer A. Jackson
  • Patent number: 5616778
    Abstract: The compound of the formula ##STR1## having the following CIELAB values: L*=82.55a*=11.53b*=90.49C*=91.22 andH*=82.74.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: April 1, 1997
    Assignee: Sandoz Ltd.
    Inventors: J urgen Goldmann, Bansi L. Kaul
  • Patent number: 5616636
    Abstract: A composition comprising:a) a compound containing a phosphite or phosphonite group and at least one 2,2,6,6-tetraalkylpiperidinyl group, andb) a polyolefin which has been produced in the presence of a catalyst which is eitheri) a supported Zeigler catalyst orii) a metallocene catalyst,from which polyolefin the catalyst has not been removed.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: April 1, 1997
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Peter Staniek, Klaus Stoll, Wolf D. Habicher, Uwe Hahner
  • Patent number: 5612060
    Abstract: An improved immunomodulatory therapy for enhancement of depressed host defense mechanisms as shown by improved allograft survival rates is disclosed. The therapy comprises the synergistic combination of an immunomodulatory diet consisting of an amino acid such as arginine, ornithine and their salts, a nucleotide such as RNA and fish oil as a source of omega-3-fatty acids together with an immunosuppressive treatment comprising the administration of a donor specific transfusion and cyclosporine.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: March 18, 1997
    Inventor: J. Wesley Alexander
  • Patent number: 5611818
    Abstract: By reducing a sulphur dye (S) in aqueous medium with a reducing carbonyl compound in the presence of alkali metal hydroxide and optionally alkali metal (bi)sulphite at temperatures above 60.degree. C. and drying the reaction mixture, there are obtained very stable leuco sulphur dyes (L), which are practically free of sulphides and polysulphides, are readily and completely soluble in water and are usable for the dyeing of substrates dyeable with sulphur dyes, by which a disturbing development of H.sub.2 S or a disturbing inorganic sulphide occurrance in the waste water can be efficiently avoided; by spray-drying in a drying time <4 minutes as described there are obtained sulphide-free, stable leuco sulphur dyes (L) readily soluble in water and particularly suitable for sulphide-free dyeing, in particular for the dyeing of polyamidic fibrous substrates, especially of wool.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: March 18, 1997
    Assignee: Sandoz Ltd.
    Inventor: Manuel J. Domingo
  • Patent number: 5612396
    Abstract: A random copolymer in free acid or salt form having the following types and numbers of monomer units; ##STR1## in which M is hydrogen or a residue of a hydrophobic polyalkylene glycol or polysiloxane,R is an C.sub.2-6 alkylene radical,R.sub.1 is a C.sub.1-20 alkyl, C.sub.6-9 cycloalkyl or phenyl group,x,y and z are numbers from 1 to 100,m is a number from 1 to 100,n is a number from 10 to 100,with the provisos, thati) the ratio of x to (y+z) is from 1:10 to 10:1 inclusive,ii) the ratio of z:y is from 5:1 to 100:1, andiii) m+n=15-100.The copolymers are useful as additives in cementitious compositions.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 18, 1997
    Assignee: Sandoz Ltd.
    Inventors: Salvatore Valenti, Bernhard Leikauf, Akira Ohta
  • Patent number: 5612464
    Abstract: The invention is concerned with compounds according to the formula ##STR1## and their salts whereinR.sub.1 represents hydrogen or --SO.sub.3 H,R.sub.2 represents hydrogen, methyl, --NHCONH.sub.2 or --NHCOCH.sub.3 and,R.sub.3 represents hydrogen, C.sub.1-4 alkyl, preferably methyl or ethyl, or C.sub.1-4 alkyl substituted with CN, OH, Cl, F or --SO.sub.3 H.These compounds are useful as fiber-reactive dyestuffs in dyeing and printing hydroxy-group-containing and nitrogen-containing organic substrates.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: March 18, 1997
    Assignee: Clariant Fiance (BVI) Limited
    Inventor: Rainer Nusser
  • Patent number: 5609724
    Abstract: Ascospores of wood-penetrating, pitch-grading fungi of the class of Ascomycotina and Deuteromycotina, eg. Ophiostromas, may be screened to provide fungi combining the properties of good growth on non-sterile wood substrates and minimized or even enhanced brightness effects for use in pitch reduction of wood substrates, eg. logs and wood chips. A new and improved method of isolating such ascospores involving effective suspension in an oil consumable by the fungus, eg. a vegetable oil, and then treatment of the oil with a dispersing agent is also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 11, 1997
    Assignee: Sandoz Ltd
    Inventors: Roberta L. Farrell, Yitzhak Hadar, Philip A. Wendler, Wendy Zimmerman
  • Patent number: 5609681
    Abstract: A process for modifying the slump of a concrete or mortar by the addition at different times of a water-soluble poly(alkylene oxide) and a .beta.-naphthalene sulphonate-formaldehyde condensate, a plasticizer or superplasticizer which is selected from lignosulphonates, melamine sulphonate formaldehyde condensates, carboxylates and selected styrene-maleic anhydride copolymers. The poly(alkylene oxide) is preferably partially replaced by a (hydroxy)alkyl cellulose. The process is advantageously used in shotcreting.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 11, 1997
    Assignee: Sandoz Ltd.
    Inventors: Josef F. Drs, Tom Melbye, Odd M. Tjugum, Salvatore Valenti
  • Patent number: 5608055
    Abstract: A new process is described for the production of 7-alpha-aminoacyl-cephalosporin free from halogen-containing solvents by acylating 7-amino-ceph-3-em-4-carboxylic acid or a derivative thereof in a halogen-free solvent.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 4, 1997
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Jose Diago, Johannes Ludescher
  • Patent number: 5607855
    Abstract: This invention relates to fungi having particularly desirable overall properties for reducing the pitch content of pulpwoods and pulps, and to the preparation and use of such fungi. In particular, the present invention provides a biologically pure cultures of the fungus Ophiostoma piliferum which are characterized by not only growing white or colorless and by having good growth virulence, but which also exhibit exceptional pitch degradation properties.
    Type: Grant
    Filed: June 28, 1994
    Date of Patent: March 4, 1997
    Assignee: Sandoz Ltd.
    Inventors: Wendy C. Zimmerman, Roberta L. Farrell
  • Patent number: 5602176
    Abstract: The (S)-N-ethyl-3-[(1-dimethylamino)ethyl]-N-methyl-phenylncarbamate in free base or acid addition salt form is useful as pharmaceutical, particularly for systemic transdermal administration.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 11, 1997
    Assignee: Sandoz Ltd.
    Inventor: Albert Enz
  • Patent number: 5601746
    Abstract: Aqueous dispersions (D) of a wax (W) dispersed in the aqueous phase by means of a dispersant (B), wherein in (D)the wax (W) is(A) an oxidized hydrocarbon wax or a mixture of oxidized hydrocarbon waxesor a mixture or (A) and at least one non-oxidized hydrocarbon wax (P), the acid number of which is.gtoreq.5,and the dispersant (B) isa non-ionogenic, anionic, cationic or amphoteric surfactant or a mixture of two or more of these surfactants, which displays an HLB.gtoreq.7,and the dispersion (D) optionally contains at least one protective colloid (C), at least one agent (E) for pH-adjustment, at least one antifreeze agent (F) and/or at least one preserving agent (D), but is substantially free of other waxes than (A) and (P) and of other surfactants than (B) and (C),are eminently suitable as wet lubricants that are very stable to temperature modifications and to high electrolyte concentrations, especially as occurring in pretreatment and in dyeing of cellulosic substrates.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: February 11, 1997
    Assignee: Sandoz Ltd.
    Inventors: Bernard Danner, Francis Palacin
  • Patent number: 5599536
    Abstract: A method for ameliorating or suppressing the acute phase response in a patient receiving IL-6 treatment comprises co-administering with the IL-6 an effective amount of granulocyte colony stimulating factor.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: February 4, 1997
    Assignee: Sandoz Ltd.
    Inventor: Laurie A. Myers
  • Patent number: 5597914
    Abstract: A process for etherifying the hydroxymethyl group in position 3 of a cephalosporin by reaction of a 3-hydroxymethyl cephalosporin with an dioxycarbenium-tetrafluoroborate.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: January 28, 1997
    Assignee: BIOCHEMIE Gesellschaft m.b.H.
    Inventor: Johann Danklmaier
  • Patent number: 5597903
    Abstract: Compounds of the formula ##STR1## salts thereof, and mixtures of such compounds and salts, wherein D.sub.1 is ##STR2## wherein R.sub.1 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, --SO.sub.3 H or --COOH,R.sub.2 is --COOH, --CONR.sub.6 R.sub.7, --SO.sub.2 NR.sub.6 R.sub.7 or --SO.sub.2 --X, wherein each of R.sub.6 and R.sub.7 is independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 -hydroxyalkyl or C.sub.2-4 sulfatoalkyl, or--NR.sub.6 R.sub.7 is a saturated 5- or 6-membered heterocyclic ring containing no hetero atom in addition to the nitrogen atom to which R.sub.6 and R.sub.7 are attached or containing one hetero atom selected from nitrogen and oxygen in addition to said nitrogen atom, which ring is unsubstituted or substituted by 1 to 3 C.sub.1-4 alkyl groups, andm is 0, 1 or 2, andD.sub.2 is ##STR3## wherein R.sub.3 is hydrogen, --SO.sub.3 H or --COOH,R.sub.4 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by hydroxy, halo, cyano, --SO.sub.3 H, --OSO.sub.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 28, 1997
    Assignee: Sandoz Ltd.
    Inventor: Markus Gisler
  • Patent number: 5596094
    Abstract: A process for alkylating the 2'-OH of N.sup.6 -modified adenosine comprising the reacting of an unprotected N.sup.6 -alkyl adenosine with dimethyl sulfate and tetrabutylammonium hydrogen sulfate in a non-polar solvent, preferably dichloromethane, and 5% sodium hydroxide. The products of the reaction are useful as anti-diabetic, hypolipidemic, and analgesic agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 21, 1997
    Assignee: Sandoz Ltd.
    Inventors: Mahavir Prashad, Prasad K. Kapa
  • Patent number: 5595175
    Abstract: An inhaler for administering powdered medicaments comprising a one-piece, elongate body that has an elongate magazine in a magazine passage extending through the elongate body. The elongate body also has an air inlet, a mouthpiece, and a capsule cutter. The elongate magazine has a plurality of capsule chambers defined in it and spaced along its length, each capsule chamber having an air inlet alignable with the air inlet to the elongate body and an air outlet alignable with the mouthpiece. The magazine is slidable step-wise along the magazine passage to align a capsule chamber with the air inlet to the elongate body, the mouthpiece and the capsule cutter. The capsule cutter, upon activation, pierces both ends of a capsule in the capsule chamber.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: January 21, 1997
    Assignee: Sandoz Ltd.
    Inventors: Eric Malcher, Kurt Zechner
  • Patent number: 5595594
    Abstract: An anti-efflorescence admixture for concrete products comprising a tall oil fatty acid and a fatty acid, a portion of the acid content of the tall oil fatty acid and/or fatty acid optionally being present in salt form with an alkanolamine or alkylamine, which admixture is effective in controlling both primary and secondary efflorescence.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 21, 1997
    Assignee: Sandoz Ltd
    Inventors: Jie-Yi Dong, David F. Factor, Hamid Farzammehr, Kenneth Sroka