Abstract: This invention relates to a disposable cassette having a pumping chamber therein and with a controlled positive displacing pump driving apparatus for use with the cassette, for performing intravenous or intra-arterial infusions. More particularly, it pertains to disposable cassettes which include an exposed flexible diaphragm forming one wall of the pump chamber and adapted to be engaged by a plunger or piston member driven and controlled by the driver apparatus to pump fluid through the cassette.

Abstract: A reference electrode is disclosed for use in potentiometric analysis of ion activity in a solution.

Abstract: A process for producing racemic or optically active compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 to C.sub.6 alkyl or benzyl; and Z is amino or substituted amino. Also disclosed are intermediates useful in the process and methods for producing the intermediates.

Abstract: A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any digoxin present in the test sample, is added a solid phase material having an immobilized ouabain triacetate derivative compound capable of binding any excess labeled antibody. The solid phase material is chosen to rapidly settle whereby a solid and liquid phase is formed. The liquid phase can then be extracted to measure the amount of digoxin-labeled antibody present therein. Ouabain triacetate derivative compounds possess sufficient affinity for anti-digoxin antibodies, and are therefore useful in a solid phase separation based digoxin immunoassay for settling out such antibodies without contributing to undesired background interference.

Abstract: A ski carrier is disclosed, which includes a frame, a locking bar and a plurality of elongated tubes into which skis are placed and locked in position by the locking bar.

Abstract: The present invention is directed to a fluorescence polarization method for monitoring fetal lung maturity, to various components needed for preparing and carrying out such monitoring, and to methods of making these components.

Abstract: The invention is an integral container system designed for separately storing a liquid, such as a diluent, and a second substance, such as a medicament, and subsequently adding the second substance to the liquid in a simple and sterile operation. In one embodiment, a flexible I.V. bag is provided with a second substance dispensing cup containing a powdered medicament, which cup fits slidably in a sleeve passing through the walls of the bag. Fitted in the open end of the cup is a pierceable plunger. A hollow needle is held in position to pierce the plunger when the cup is pushed toward the needle. The needle is slidably held so that when it is pushed by the plunger, it will also pierce a diaphragm fitting over the sleeve. When both the plunger and the diaphragm are pierced, fluid access between the cup and the bag is had through the hollow needle. Diluent can then be injected into the cup to dissolve or slurry the powdered medicament.

Abstract: An enzyme conjugate composition comprising an enzyme conjugate, a calcium salt and a polyethylene glycol is disclosed. The enzyme conjugate composition is effectively stabilized by the presence of the calcium salt and the polyethylene glycol.

Abstract: An method of carrying out a fluorescence polarization immunoassay is disclosed wherein the immunoassay is conducted in the presence of from about 0.001 to about 1.0 percent (weight/volume) of dioctyl sodium sulfosuccinate. Also disclosed are reagents useful in the practice of the immunoassay method.

Abstract: An improved method and reagents are disclosed for determining a ligand in an assay solution containing the ligand, a reagent system and a luminescent compounds, wherein the intensity of the light emitted by the assay solution is related to the change in the transmittive properties of the assay solution produced by the interaction of the ligand to be determined and a reagent system capable of producing a change in the transmittive properties of the assay solution in the presence of the ligand.

Abstract: A plug is provided within a port in a flexible container. Extending from the port is a piece of flexible tubing which is used to connect with other tubing in a fluid system. Fluid is dispensed from the flexible container by grasping the end of the plug extending into the flexible container. The plug is then pulled into the interior of the container so that the opposite end of the plug which seals the flexible tubing extending from the port is unseated. The flexible tubing extending from the port is now open to the flow of fluid from the flexible container.

Abstract: A fluid infusion positive displacement pump includes a plunger driven by a stepping motor which is operated by a motor control system. The control system advances the plunger to expel liquid in a series of incremental steps at a user-set pumping rate and until a preset total dosage has been delivered with the pumping rate being determined by the waiting time between each step. In order to minimize shock to the patient, the pump is operated at a plurality of increasing fractional rates during the start of pumping and at a plurality of decreasing fractional rates at the termination of pumping with the user-set (maximum) pumping rate occurring between such fractional rate pumping periods.

Abstract: A liquid flow regulator has a housing including an axial bore, an inlet, an outlet and a plurality of axial grooves opening endwise of the inlet and laterally of the housing into the bore. The grooves, which have different axial lengths, taper axially so that the cross-sectional area of each groove gradually decreases from the inlet to nothing at a point where the groove merges with the bore. An elastomeric stock fits within the bore. A plunger for expanding the sock radially outward into sealing engagement with the housing adjacent the bore is axially movable within the bore. Flow through the grooves and the bore is regulated by the axial position of the plunger and the minimum cross-sectional area of the tapered, axial grooves at the axial location where the sock seals the bore. Axial adjustment of the plunger sequentially opens and closes passage from the grooves through the bore to the bore outlet.

Abstract: An optical module for coupling a fiberoptic catheter to a catheter oximeter processing apparatus. The optical module includes a plurality of light emitting diodes, each of which is mounted on a flat surface at the free end portion of a respective bracket. A plurality of optical fibers, which are adapted to be optically connected to the catheter, have their free ends secured to a mounting substrate in spaced positions and in closely spaced alignment with the diodes. The diodes are each individually provided with electrical connections that can be selectively actuated by the processing apparatus. The brackets, which are fixed at one end, are constructed of thin flexible material so that the diodes can each be adjusted generally in the plane of the receiving end faces of the optical fibers so as to obtain maximum light energy transfer therebetween.

Abstract: This invention relates to novel isoxazolo-pyrido-phenoxazine and isothiazolo-pyridophenoxazine derivatives having antibacterial properties and compositions containing methods of treating mammalian patients with these new derivatives.