Patents Represented by Attorney Roman Saliwanchik

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  • Use of rLDM.TM. 1-6 and other ligninolytic enzymes in the treatment of mechanical pulps
    Patent number: 4687745
    Abstract: Disclosed is a novel process for enhancing the strength properties and brightness stability of mechanical pulps. The process uses novel enzymes called rLDM.TM. and other ligninolytic enzymes present in the extracellular growth medium of a fermentation of Phanerochaete chrysosporium.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: August 18, 1987
    Assignee: Repligen Corporation
    Inventor: Roberta L. Farrell
  • Novel enzymes which catalyze the degradation and modification of lignin
    Patent number: 4687741
    Abstract: Novel lignin-degrading enzymes designated rLDM.TM.1, rLDM.TM.2, rLDM.TM.3, rLDM.TM.4, rLDM.TM.5, and rLDM.TM.6 are isolated and purified to the essentially pure form, wherein each rLDM.TM. is substantially free of other rLDM.TM. and native proteins, from the extracellular medium of a novel mutant microbe. The novel mutant, designated SC26, produces large amounts of the rLDM.TM., thus facilitating the isolation and purification of them. These rLDM.TM. are useful in pulping processes to degrade and/or modify lignin.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: August 18, 1987
    Assignees: Repligen Corporation, The United States of America as represented by the Secretary of Agriculture
    Inventors: Roberta L. Farrell, Thomas K. Kirk, Ming Tien
  • Process for converting 1,2-saturated steroids to 1,2-dehydro steroids
    Patent number: 4684610
    Abstract: Disclosed and claimed is an improved microbial bioconversion to produce 1,2-dehydro steroids from their corresponding 1,2-saturated derivatives by use of a water-immiscible solvent comprising an aromatic hydrocarbon in the reaction procedure.
    Type: Grant
    Filed: April 17, 1985
    Date of Patent: August 4, 1987
    Assignee: The Upjohn Company
    Inventor: Timothy W. Evans
  • Bioherbicide for Florida beggarweed
    Patent number: 4643756
    Abstract: The subject invention concerns a novel bioherbicide and its use to control a major weed found in many fields in the Southeastern United States where peanuts and soybeans are grown. Specifically, Colletotrichum truncatum (Schw.) Andrus & Moore, in an agricultural composition, can be used to effectively control Florida beggarweed without adversely affecting field crops, e.g., peanuts and soybeans. Further, C. truncatum (Schw.) Andrus & Moore in a mixture with Alternaria cassiae can be used to control Florida beggarweed and other undesired vegetation, such as sicklepod, showy crotalaria and coffee senna.
    Type: Grant
    Filed: March 22, 1985
    Date of Patent: February 17, 1987
    Assignees: Mycogen Corporation, Univ. of Georgia Research Foundation, Inc., The United States of America as represented by the Secretary of Agriculture
    Inventors: John Cardina, Robert H. Littrell, Larry J. Stowell
  • Chromatographic separation of tropicamide O-.beta.-D-glucuronide diastereomers
    Patent number: 4629792
    Abstract: An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-.beta.-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-.beta.-D-glucuronide and (-)-tropicamide O-.beta.-D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also, the products can be used to protect the skin against burning by sunlight.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: December 16, 1986
    Assignee: Repligen Corporation
    Inventors: Walter C. Herlihy, Thomas H. Fraser
  • Process for tanning the skin
    Patent number: 4609544
    Abstract: The subject invention concerns a novel, unobvious, and useful composition of matter and method for tanning the human epidermis. The composition comprises a suitable dye precursor, peroxidase and H.sub.2 O.sub.2. These ingredients, when reacted together on the skin, result in the formation of melanin-like dyes which tan the skin.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: September 2, 1986
    Assignee: Repligen Corporation
    Inventor: Walter C. Herlihy
  • Antibiotic compound and process for recovery thereof from a fermentation broth
    Patent number: 4595770
    Abstract: Novel antibiotic U-56,407 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces hagronensis strain 360, NRRL 15064. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-56,407 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: June 17, 1986
    Assignee: The Upjohn Company
    Inventors: Thomas F. Brodasky, David W. Stroman
  • Enzymatic process for preparing glucuronides
    Patent number: 4588686
    Abstract: An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-.beta.-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-.beta.-D-glucuronide and (-)-tropicamide O-.beta.-D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also, the products can be used to protect the skin against burning by sunlight.
    Type: Grant
    Filed: January 31, 1984
    Date of Patent: May 13, 1986
    Assignee: Repligen Corporation
    Inventors: Walter C. Herlihy, Thomas H. Fraser
  • Isolates of pythium species which are antagonistic to Pythium ultimum
    Patent number: 4574083
    Abstract: Novel isolates of Pythium are provided which are antagonistic to indigenous plant pathogenic species of Pythium ultimum from soil. The isolates suppress the growth of P. ultimum when added to soil and are particularly useful to protect seedlings from damping-off disease caused by P. ultimum.
    Type: Grant
    Filed: November 29, 1983
    Date of Patent: March 4, 1986
    Assignee: Colorado State University Research Foundation
    Inventors: Ralph Baker, Ran Lifshitz
  • Composition of matter and process
    Patent number: 4565699
    Abstract: Novel antibiotic U-68,204 is produced in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces thiolactonus, NRRL 15439. This antibiotic is active against various Gram-positive bacteria. Thus, antibiotic U-68,204 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: July 18, 1983
    Date of Patent: January 21, 1986
    Assignee: The Upjohn Company
    Inventors: Lester A. Dolak, Alice L. Laborde, Oldrich K. Sebek, Thomas M. Castle, Thomas F. Brodasky
  • Composition of matter and process
    Patent number: 4548814
    Abstract: Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses. Further, these antibiotics can be used to treat animals and humans hosting a neoplastic disease.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: October 22, 1985
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Kenneth L. Rinehart, Jr.
  • Anticholinergic glucuronides and antiperspirant use thereof
    Patent number: 4546096
    Abstract: This invention concerns novel and useful human antiperspirant compounds which are glucuronides of phenolic anticholinergics or the phenolic derivatives of anticholinergic compounds. These antiperspirant compounds, advantageously, do not have mydriatic properties possessed by the parent anticholinergic compounds.
    Type: Grant
    Filed: February 24, 1984
    Date of Patent: October 8, 1985
    Assignees: Repligen Corporation, The Gillette Company
    Inventors: Walter C. Herlihy, David M. Epstein, Carl B. Felger
  • Composition of matter and process
    Patent number: 4540661
    Abstract: Antibiotic U-66,026 is produced in a fermentation under controlled conditions using the microorganism Alcaligenes sp., NRRL B-15269. Enhanced fermentation of titers U-66,026 are obtained when Alcaligenes sp., NRRL B-15269, is cultivated in mixture with Streptomyces plicatus strain 395, NRRL 15273.Antibiotic U-66,026 is a useful antibiotic which has antifungal activity.
    Type: Grant
    Filed: February 24, 1983
    Date of Patent: September 10, 1985
    Assignee: The Upjohn Company
    Inventors: Betty R. Hannon, Fritz Reusser, Lester A. Dolak, Alexander D. Argoudelis, Thomas M. Castle
  • Process for preparing 1,2-dehydro steroids
    Patent number: 4524134
    Abstract: Disclosed and claimed is an improved microbial bioconversion to produce 1,2-dehydro steroids from their corresponding 1,2-saturated derivatives.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: June 18, 1985
    Assignee: The Upjohn Company
    Inventors: Leo A. Kominek, Holly J. Wolf
  • Paulomycin derivatives
    Patent number: 4520191
    Abstract: Novel and useful compounds are obtained by the degradation of antibiotics paulomycin A and paulomycin B. These novel compounds are useful as ultraviolet light filters in plastics, cloth, and the like.
    Type: Grant
    Filed: November 8, 1983
    Date of Patent: May 28, 1985
    Assignee: The Upjohn Company
    Inventor: Paul F. Wiley
  • In vitro enzymatic process for preparing glucuronides of ester-containing anticholinergics
    Patent number: 4518691
    Abstract: An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.
    Type: Grant
    Filed: May 4, 1984
    Date of Patent: May 21, 1985
    Assignee: Repligen Corporation
    Inventor: Walter C. Herlihy
  • Skin tanning composition and method
    Patent number: 4515773
    Abstract: The subject invention concerns a novel, unobvious, and useful composition of matter and method for tanning the human epidermis. The composition comprises a suitable dye precursor and tyrosinase. These ingredients, when reacted together on the skin, result in the formation of melanin-like dyes which tan the skin.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: May 7, 1985
    Assignee: Repligen Corporation
    Inventor: Walter C. Herlihy
  • Antibiotic 273.sub.a1
    Patent number: 4505895
    Abstract: Novel and useful antibiotics designated 273a.sub.1.spsb..alpha. and 273a.sub.1.spsb..beta. can be produced in a fermentation using Streptomyces paulus, strain 273, NRRL 12251. These antibiotics are active against various Gram-positive bacteria. Also, these antibiotics are, advantageously, soluble in aqueous solutions.
    Type: Grant
    Filed: March 30, 1983
    Date of Patent: March 19, 1985
    Assignee: The Upjohn Company
    Inventors: Alexander D. Argoudelis, Vincent P. Marshall, Paul F. Wiley
  • Dolastatins A and B cell growth inhibitory substances
    Patent number: 4486414
    Abstract: Potent cell growth inhibitory substances have been obtained from the Indian Ocean sea hare Dolabella. These substances have been given the names dolastatin A and dolastatin B. These compounds are characterized by physical and chemical parameters.
    Type: Grant
    Filed: March 21, 1983
    Date of Patent: December 4, 1984
    Assignee: Arizona Board of Reagents
    Inventor: George R. Pettit
  • In vitro enzymatic process for producing glucuronides
    Patent number: 4478936
    Abstract: An in vitro enzymatic process for preparing O-.beta.-D-glucuronides which comprises reacting a solution of D-glucuronic acid with a solution of a compound which has a primary alcohol, and a solution of .beta.-glucuronidase for a time sufficient to form the desired glucuronide. The glucuronides can be used for the following purposes: antiperspirants, cardiotonic agents, gastric acid inhibitors, vitamin D derivatives, treatment of psoriasis, and as antitumor agents.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: October 23, 1984
    Assignee: Repligen Corporation
    Inventor: Walter C. Herlihy