Patents Represented by Attorney Roman Saliwanchik

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  • Biologically pure culture of Nocardiopsis trehalosei sp. nov.
    Patent number: 4306028
    Abstract: Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov., NRRL 12026.This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: October 9, 1980
    Date of Patent: December 15, 1981
    Assignee: The Upjohn Company
    Inventors: Lester A. Dolak, Alice L. Laborde, Thomas M. Castle
  • Composition of matter and process
    Patent number: 4306021
    Abstract: Novel antibiotic U-60, 394 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces woolenses, Dietz and Li sp.n., NRRL 12113. This antibiotic is strongly active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus hemolyticus. It is also strongly active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-60, 394 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: April 10, 1980
    Date of Patent: December 15, 1981
    Assignee: The Upjohn Company
    Inventors: Lester A. Dolak, LeRoy E. Johnson
  • Process for the microbial transformation of steroids
    Patent number: 4304860
    Abstract: Novel compounds prepared by microbial transformation using novel mutants to selectively degrade steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive. These compounds can be used as intermediates to make useful steroids.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: December 8, 1981
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • Composition of matter and process
    Patent number: 4293646
    Abstract: Mutant which is used in a novel microbiological process to selectively transform steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to yield androst-4-ene-3,17-dione (AD) as essentially the sole transformed product. AD is a valuable intermediate to make useful steroids.
    Type: Grant
    Filed: August 7, 1978
    Date of Patent: October 6, 1981
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Kevin E. Brooks
  • Process for producing antibiotic using saccharopolyspora
    Patent number: 4293651
    Abstract: A process for preparing the antibiotic U-59,760. The process is a microbiological process using a biologically pure culture of the novel microbe Saccharopolyspora hirsuta strain 367, NRRL 12045. The antibiotic produced by the process is active against various microorganisms, for example, Staphylococcus aureus, Streptococcus pyogenes, and Klebsiella pneumoniae. Thus, antibiotic U-59,760 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: October 2, 1979
    Date of Patent: October 6, 1981
    Assignee: The Upjohn Company
    Inventors: Howard A. Whaley, John H. Coats
  • Process for preparing androst-4-ene-3,17-dione
    Patent number: 4293644
    Abstract: Mutant which is used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to yield predominantly androst-4-ene-3,17-dione (AD) and small amounts of androsta-1,4-diene-3,17-dione (ADD). AD is a valuable intermediate to make useful steroids.
    Type: Grant
    Filed: October 9, 1977
    Date of Patent: October 6, 1981
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Candice B. Biggs
  • Process for preparing androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione
    Patent number: 4293645
    Abstract: Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: October 6, 1981
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Candice B. Biggs, Thomas R. Pyke
  • Method of treating malaria
    Patent number: 4293547
    Abstract: A process for treating a protozoan disease, for example, malaria, by the systemic administration to a subject hosting a malarial parasite of a novel analog of the well-known antibiotics lincomycin and clindamycin. These analogs are prepared by condensing a cyclic acid with a sugar amine.
    Type: Grant
    Filed: August 25, 1980
    Date of Patent: October 6, 1981
    Assignee: The Upjohn Company
    Inventors: Charles Lewis, Robert D. Birkenmeyer
  • Biologically pure culture of Paecilomyces abruptus
    Patent number: 4282327
    Abstract: New antibiotic U-53,946 produced by the controlled fermentation of the new microorganism Paecilomyces abruptus sp. nov., NRRL 11110. This antibiotic is active against Gram-positive bacteria, for example, Sarcina lutea, Staphylococcus aureus, Bacillus subtilis, Mycobacterium avium, and Streptococcus pyogenes, and the yeast Saccharomyces pastorianus. Accordingly, they can be used in various environments to eradicate or control these microorganisms.
    Type: Grant
    Filed: June 21, 1978
    Date of Patent: August 4, 1981
    Assignee: The Upjohn Company
    Inventors: Ladislav J. Hanka, Paul F. Wiley
  • Lincomycin compounds
    Patent number: 4278789
    Abstract: Novel useful analogs of the well known antibiotics lincomycin and clindamycin. These analogs are prepared by condensing a cyclic acid with a sugar amine.
    Type: Grant
    Filed: May 19, 1980
    Date of Patent: July 14, 1981
    Assignee: The Upjohn Company
    Inventor: Robert D. Birkenmeyer
  • 3-Trehalosamine compounds
    Patent number: 4276412
    Abstract: Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov., NRRL 12026.This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: September 17, 1979
    Date of Patent: June 30, 1981
    Assignee: The Upjohn Company
    Inventors: Lester A. Dolak, Alice L. Laborde, Thomas M. Castle
  • Plasmid and process of isolating same
    Patent number: 4273875
    Abstract: A novel chemical compound, essentially pure plasmid pUC6, which is obtainable from a biologically pure culture of the microorganism Streptomyces espinosus biotype 23724a, NRRL 11439. The pUC6 plasmid is useful as a cloning vehicle in recombinant DNA work. For example, using DNA methodology, a desired gene, for example, the insulin gene, can be inserted into pUC6 and the resulting plasmid can then be transformed into a suitable host microbe which, upon culturing, produces the desired insulin.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: June 16, 1981
    Assignee: The Upjohn Company
    Inventor: Jack J. Manis
  • Process for preparing lincomycin
    Patent number: 4271266
    Abstract: Microbiological process for preparing the antibiotic lincomycin at temperatures ranging from 18.degree. C. to 45.degree. C. using the newly discovered microorganism Streptomyces vellosus. The subject process advantageously results in the preparation of lincomycin without the concomitant production of lincomycin B (4'-depropyl-4'-ethyllincomycin). The absence of lincomycin B production results in increased lincomycin recovery efficiency.
    Type: Grant
    Filed: June 10, 1974
    Date of Patent: June 2, 1981
    Assignee: The Upjohn Manufacturing Company
    Inventors: Malcolm E. Bergy, John H. Coats, Vedpal S. Malik
  • Process for producing 10.dbd.dihydrosteffimycin and 10.dbd.dihydrosteffimycin B and microorganisms for producing same
    Patent number: 4264726
    Abstract: Antibiotics 10-dihydrosteffimycin (U-58,875), and 10-dihydrosteffimycin B (U-58,874) are produced by carbon 10 ketonic carbonyl reduction in fermentation processes using the known antibiotics steffimycin and steffimycin B, respectively, as starting materials. These novel antibiotics are active against various microorganisms, for example, Bacillus subtilis, Bacillus cereus, Sarcina lutea, Streptococcus pyogenes, and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
    Type: Grant
    Filed: March 12, 1980
    Date of Patent: April 28, 1981
    Assignee: The Upjohn Company
    Inventors: Vincent P. Marshall, David W. Elrod, Paul F. Wiley
  • Antibiotic acanthomycin and process for preparing
    Patent number: 4259450
    Abstract: Antibiotic acanthomycin (U-53,827) produced by the controlled fermentation of the microorganism Streptomyces espinosus subsp. acanthus, NRRL 11081. This antibiotic and its base addition salts are active against Gram-positive bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: March 31, 1981
    Assignee: The Upjohn Company
    Inventors: Alexander D. Argoudelis, Thomas F. Brodasky, Fritz Reusser
  • Process for precipitating aminoglycosides
    Patent number: 4256876
    Abstract: A highly efficient process for the precipitation of an amorphous (non-crystalline) aminoglycoside antibiotic salt during the purification process. Illustratively, there are disclosed processes for precipitating gentamicin, neomycin, and sisomicin salts.
    Type: Grant
    Filed: February 4, 1980
    Date of Patent: March 17, 1981
    Assignee: The Upjohn Company
    Inventors: Roger G. Harrison, Jr., Thomas H. Prichard
  • Chromatographic process
    Patent number: 4252971
    Abstract: A chromatographic process for separation of an aminoglycoside antibiotic from impurities. Illustratively, there is disclosed a chromatographic process for separation of the gentamicin complex (C.sub.1, C.sub.2 and C.sub.1a) from impurities. The subject process gives a gentamicin complex recovery of more than double the recovery of the best known prior art gentamicin chromatography process.
    Type: Grant
    Filed: July 30, 1979
    Date of Patent: February 24, 1981
    Assignee: The Upjohn Company
    Inventor: Roger G. Harrison, Jr.
  • Antibiotic and fermentation process of preparing
    Patent number: 4251511
    Abstract: Novel antibiotic U-59,761 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against various microorganisms, for example, Staphylococcus aureus, Streptococcus pyogenes, Sarcina lutea, Klebsiella pneumoniae, Mycobacterium avium, and Bacteroides fragilis. Thus, antibiotic U-59,761 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: October 2, 1979
    Date of Patent: February 17, 1981
    Assignee: The Upjohn Company
    Inventors: Howard A. Whaley, John H. Coats
  • Antibiotics 7(R)-O-alkylnogalarols
    Patent number: 4238398
    Abstract: Novel antibiotics, 7(R)-0-alkylnogalarols, prepared by acidic alcoholysis of nogalamycin of nogalarol, which are active against various microorganisms, for example, Bacillus subtilis, Streptococcus pyogenes, Sarcina lutea, Bacteroides fragilis, Clostridium perfringens, and Mycobacterium avium. Thus, they can be used to inhibit the growth of the above microorganisms in various environments. Further, the invention compounds possess unexpected superior activity against P388 leukemia infection in laboratory mice. Thus, the compounds of the invention can be used to treat laboratory mice infected with P388 leukemia.
    Type: Grant
    Filed: October 31, 1979
    Date of Patent: December 9, 1980
    Assignee: The Upjohn Company
    Inventors: Paul F. Wiley, David J. Houser
  • Process for preparing 9.alpha.-OH BN alcohol
    Patent number: 4226936
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: October 7, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek