Patents Represented by Attorney Roman Saliwanchik

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  • Process for preparing 9.alpha.-OH BN acid methyl ester
    Patent number: 4223092
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: September 16, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for preparing 9.alpha.-OH testosterone
    Patent number: 4221868
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: September 9, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for preparing erythromycin succinate
    Patent number: 4219641
    Abstract: A rapid and efficient process for preparing the useful antibiotic erythromycin ethyl succinate in high yield which comprises reacting erythromycin USP quality free base with ethyl succinyl chloride in a two phase system consisting of an organic solvent which is capable of forming two phases with water or an aqueous base, and an aqueous base.
    Type: Grant
    Filed: June 14, 1979
    Date of Patent: August 26, 1980
    Assignee: The Upjohn Company
    Inventors: Francis E. Desposato, Edward J. Hessler
  • Process for preparing 9.alpha.-OH BN alcohol
    Patent number: 4214052
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: July 22, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for preparing 9.alpha.-OH BN acid methyl ester
    Patent number: 4214051
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: July 22, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for microbial transformation of steroids
    Patent number: 4211841
    Abstract: Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propionic acid]-7a.beta.-methylhexahydro-1,5-indanedione having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: July 8, 1980
    Assignee: The Upjohn Company
    Inventors: Candice B. Biggs, Thomas R. Pyke, Merle G. Wovcha
  • Dihydrosteffimycin compounds
    Patent number: 4209611
    Abstract: Antibiotics 10-dihydrosteffimycin (U-58,875), and 10-dihydrosteffimycin B (U-58,874) are produced by carbon 10 ketonic carbonyl reduction in fermentation processes using the known antibiotics steffimycin and steffimycin B, respectively, as starting materials. These novel antibiotics are active against various microorganisms, for example, Bacillus subtilis, Bacillus cereus, Sarcina lutea, Streptococcus pyogenes, and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
    Type: Grant
    Filed: April 6, 1979
    Date of Patent: June 24, 1980
    Assignee: The Upjohn Company
    Inventors: Vincent P. Marshall, David W. Elrod, Paul F. Wiley
  • Process for the recovery of spectinomycin
    Patent number: 4203903
    Abstract: An improved process for recovering the antibiotic spectinomycin from an aqueous concentrate containing the same. This improvement concerns the use of benzoic acid, or a salt thereof, to remove inorganic salts which interfere with the recovery of spectinomycin from an aqueous concentrate.
    Type: Grant
    Filed: May 10, 1979
    Date of Patent: May 20, 1980
    Assignee: The Upjohn Company
    Inventor: Timothy W. Evans
  • Oxazole [2,3-c]-coumarin
    Patent number: 4199507
    Abstract: Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: April 22, 1980
    Assignee: The Upjohn Company
    Inventor: Herman Hoeksema
  • Antibiotics 7(S)-O-alkylnogarols
    Patent number: 4183860
    Abstract: Novel antibiotics, 7(S)--O--alkylnogarols, prepared by acidic alcoholysis of nogamycin, which are active against various microorganisms, for example, Bacillus subtilis, Streptococcus pyogenes, and Mycobacterium avium. Thus, they can be used to inhibit the growth of the above microorganisms in various environments.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: January 15, 1980
    Assignee: The Upjohn Company
    Inventors: Paul F. Wiley, David J. Houser
  • Nitrosugar
    Patent number: 4182855
    Abstract: Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: January 8, 1980
    Assignee: The Upjohn Company
    Inventor: Herman Hoeksema
  • Process for preparing 3a.alpha.-H-4.alpha.-[3'-propanol]-7a.beta.-methylhexahydro-1,5-indanedi one hemiketal
    Patent number: 4177106
    Abstract: Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propanol]-7a.beta.-methylhexahydro-1,5-indaned ione hemiketal having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: December 4, 1979
    Assignee: The Upjohn Company
    Inventors: Thomas R. Pyke, Marion P. Salmond
  • Steroid intermediates
    Patent number: 4176123
    Abstract: Novel compounds prepared by microbial transformation using novel mutants to selectively degrade steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive. These compounds can be used as intermediates to make useful steroids.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: November 27, 1979
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • Composition of matter and process
    Patent number: 4175006
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.--OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.--OH BN alcohol) and 9.alpha.---hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.--OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: October 21, 1977
    Date of Patent: November 20, 1979
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Novel degradation products of rubradirin and rubradirin B
    Patent number: 4171437
    Abstract: Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: October 16, 1979
    Assignee: The Upjohn Company
    Inventor: Herman Hoeksema
  • Novel degradation products of rubradirin and rubradirin B and process for such degradation
    Patent number: 4171436
    Abstract: Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: October 16, 1979
    Assignee: The Upjohn Company
    Inventor: Herman Hoeksema
  • Composition of matter and process
    Patent number: 4169888
    Abstract: Novel antibiotic CC-1065 producible in a fermentation under controlled conditions using the new microorganism Streptomyces zelensis, NRRL 11,183. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Sarcina lutea, and Streptococcus faecalis. It is also active against Gram-negative bacteria, for example, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella pullorum. Thus, antibiotic CC-1065 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: October 2, 1979
    Assignee: The Upjohn Company
    Inventors: Ladislav J. Hanka, David G. Martin
  • Pyridine compounds
    Patent number: 4154940
    Abstract: Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacterial. Also, some of these products can be used as intermediates to make useful antibacterials.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: May 15, 1979
    Assignee: The Upjohn Company
    Inventor: Herman Hoeksema
  • Pyridine compounds
    Patent number: 4154938
    Abstract: Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: May 15, 1979
    Assignee: The Upjohn Company
    Inventor: Herman Hoeksema
  • Pyridine compounds
    Patent number: 4154939
    Abstract: Disclosed are degradation products of the antibiotics rubradirin and rubradirin B and processes for their preparation. Some of these products have antibacterial activity, and, thus, can be used in various environments to inhibit susceptible bacteria. Also, some of these products can be used as intermediates to make useful antibacterials.
    Type: Grant
    Filed: August 31, 1978
    Date of Patent: May 15, 1979
    Assignee: The Upjohn Company
    Inventor: Herman Hoeksema