Patents Represented by Attorney Salvatore C. Mitri

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  • Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
    Patent number: 5039814
    Abstract: A process utilizes the tetrazole functional group to direct lithiation at the ortho position of a phenyltetrazole and generate a nucleophilic aryllithium species which then undergoes reaction with an electrophile to generate a 2-substituted 1-(tetrazol-5-yl)benzene. The process is useful in the production of intermediates in the synthesis of angiotensin II antagonists. This novel process is a more cost effective and versatile route for the large-scale preparation of these key intermediates.
    Type: Grant
    Filed: May 2, 1990
    Date of Patent: August 13, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Richard F. Shuman, Anthony O. King, Robert K. Anderson
  • Ivermectin derivative compounds and process for preparing the same
    Patent number: 4963667
    Abstract: There are disclosed novel ivermectin compounds and a process for preparing them, the novel ivermectin compounds containing straight chain or branched fatty acid residues of from about C.sub.2 to about C.sub.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: October 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Shuet-Hing L. Chiu, Josephine R. Carlin, Rae Taub
  • Process for preparing benzylpyruvic acids and esters
    Patent number: 4956490
    Abstract: There is disclosed a continuous, non-isolation process for preparing benzylpyruvic acids and benzylpyruvic esters. The benzylpyruvic acids and esters obtained are useful as intermediates to prepare carboxyalkyl dipeptide compounds which are used as angiotension converting enzyme (ACE) inhibitors to treat hypertension.
    Type: Grant
    Filed: March 9, 1989
    Date of Patent: September 11, 1990
    Assignee: Merck & Co., Inc.
    Inventors: James W. McManus, John F. Genus
  • Fishing rod holder
    Patent number: 4932152
    Abstract: There is disclosed a fishing rod holder the primary members of which can be rotated through circular planes that are perpendicular to each other enabling the fishing rod holder to accommodate any variety of fishing circumstances.
    Type: Grant
    Filed: September 12, 1989
    Date of Patent: June 12, 1990
    Inventors: Joseph Barlotta, Robert W. Jorgensen, Donald E. McCormick
  • Sandwich blister package for tablets and similar articles
    Patent number: 4911304
    Abstract: There is disclosed a novel sandwich blister package for tablets and similar articles which generally comprises a plastic film having a plurality of heat-formed cavities which contain tablets or similar articles; and, a plastic film/aluminum foil laminate sheet superimposed upon and heat sealed to the plastic film to form a blister card of pre-set size, each blister card being bonded to another blister card so that the aluminum foil forms the outer protective cover with the plastic film sandwiched between them.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: March 27, 1990
    Assignee: Merck & Co., Inc.
    Inventor: Leonid Bunin
  • Bottle and cap closure system
    Patent number: 4886175
    Abstract: There is disclosed a novel bottle and cap closure system for dropper bottles and the like which comprises a set of lugs or cams and a snap bead provided in the cap and a set of lugs or cams provided on the neck portion of the bottle. After the bottle is filled, the cap is secured to the bottle by having the snap bead on the cap engage the lugs or cams on the bottle. The snap bead in the cap is carried on the circumferential lower edge of a tear-away band. After the tear-away band is removed to use the contents of the bottle, the cap is re-secured to the bottle by engaging the lugs or cams in the cap to the lugs or cams on the bottle.
    Type: Grant
    Filed: April 10, 1989
    Date of Patent: December 12, 1989
    Assignee: Merck & Co., Inc.
    Inventor: Thomas E. Schlaudecker
  • Anti-inflammatory and antidegenrative compounds isolated from L-681,512
    Patent number: 4874755
    Abstract: There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of soil microorganism L-681,512 under controlled fermentation conditions.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: October 17, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Bonnie M. Ashe, Daniel S. Fletcher
  • Benzofused lactams as antihypertensives
    Patent number: 4873235
    Abstract: Benzofused lactams of the formula: ##STR1## and their use as angiotensin converting enzyme inhibitors and antihypertensive agents are disclosed.
    Type: Grant
    Filed: March 16, 1983
    Date of Patent: October 10, 1989
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, Arthur A. Patchett, Eugene D. Thorsett
  • Anti-inflammatory and antidegenerative compounds isolated from L-681,512
    Patent number: 4871727
    Abstract: There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of sail microorganism L-681,512 under controlled fermentation conditions.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: October 3, 1989
    Assignee: Merck & Co, Inc.
    Inventors: Richard W. Burg, Eugene L. Dulaney, Otto D. Hensens, Jerrold M. Liesch, John G. Ondeyka, Carol F. Wichmann
  • Carboxyalkyl urea compounds and derivatives thereof useful as angiotensin converting enzyme inhibitors and as antihypertensives
    Patent number: 4866087
    Abstract: Carboxyalkyl urea compounds and derivatives thereof are disclosed which are useful as angiotensin converting enzyme (ACE) inhibitors and as antihypertensives. These compounds and derivatives are represented by the general formula: ##STR1## An illustrative specie falling within this general formula is:N-(2-carboxy-4-phenylbutyl-N-isopropylaminocarbonyl-L-tryptophan.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: September 12, 1989
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, David G. Hangauer, Jr., Arthur A. Patchett
  • Fused polycyclic and bridged compounds useful as calcium channel blockers
    Patent number: 4808718
    Abstract: Novel fused polycyclic and bridged compounds are disclosed which are useful as calcium entry blockers.
    Type: Grant
    Filed: May 6, 1986
    Date of Patent: February 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Wasyl Halczenko, Brian T. Phillips
  • Flotable and adjustable marine fender device
    Patent number: 4804296
    Abstract: There is disclosed a flotable marine fender device having means to movably secure the device to a dock, piling or bulkhead so that the entire assemblage is free to rise and fall with flooding and ebbing tides enabling the marine fender to protect the sides or hulls of boats approaching, leaving or made fast to the docks, pilings or bulkheads.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: February 14, 1989
    Inventor: John R. Smath
  • Lactams and bicyclic lactams useful as cholecystokinin antagonists
    Patent number: 4757068
    Abstract: This invention relates to lactams, bicyclic lactams and related compounds which are useful as cholecystokinin antagonists.
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: July 12, 1988
    Assignee: Merck & Co., Inc.
    Inventor: William H. Parsons
  • Compounds having somatostatin-like activity useful as local anti-inflammatory agents
    Patent number: 4748153
    Abstract: Compounds having somatostatin-like activity have been found to be useful as local anti-inflammatory agents in the treatment of such conditions as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions. Particularly useful are cyclic and bridged somatostatin analogs.
    Type: Grant
    Filed: September 2, 1987
    Date of Patent: May 31, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Evan R. Morgan, Daniel F. Veber, Sanford L. Steelman
  • Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
    Patent number: 4735956
    Abstract: Novel substituted 4-heteroaryl-1,4-dihydropyridine compounds useful as calcium channel blockers, pharmaceutical compositions therof, and methods of treatment are disclosed.
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: April 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Wasyl Halczenko, George D. Hartman, Brian T. Phillips
  • Bicyclic lactams as antihypertensives
    Patent number: 4731444
    Abstract: There are disclosed bicyclic lactams and derivatives thereof which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: August 3, 1984
    Date of Patent: March 15, 1988
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, Matthew J. Wyvratt, Jr.
  • Self-cleaning gutter device
    Patent number: 4709516
    Abstract: There is disclosed a novel device for cleaning gutters that can be either power driven or manually operated. This device comprises an elongated, self-supporting, flexible member which is placed into and along the length of a gutter. When activated, this member causes debris within the gutter to be transported to a discharge outlet.Also disclosed is a novel gutter having a configuration to receive and maximize the efficiency of operation of the self-cleaning gutter member.
    Type: Grant
    Filed: December 9, 1985
    Date of Patent: December 1, 1987
    Assignee: Ropol, Inc.
    Inventor: Geoffrey H. Gleaves
  • Benzofused lactams as cholecystokinin antagonists
    Patent number: 4684645
    Abstract: Benzofused lactams and their use as antagonists of cholecystokinin are disclosed.
    Type: Grant
    Filed: November 18, 1985
    Date of Patent: August 4, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Raymond S. L. Chang, William H. Parsons
  • Substituted caprolactam derivatives as antihypertensives
    Patent number: 4680392
    Abstract: The invention in its broad aspects relates to caprolactam derivatives which are useful as angiotensin converting enxyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: May 19, 1986
    Date of Patent: July 14, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • Substituted diazapines and derivatives thereof useful in the treatment of cardiovascular disorders
    Patent number: 4677102
    Abstract: There are disclosed novel diazapines and derivatives thereof which are useful in the treatment of cardiovascular disorders.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: June 30, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure, David A. Claremon