Abstract: Substituted enantholactam dipeptides and derivatives thereof are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
Type:
Grant
Filed:
September 4, 1981
Date of Patent:
August 2, 1983
Assignee:
Merck & Co., Inc.
Inventors:
Elbert E. Harris, David Taub, Eugene D. Thorsett
Abstract: Novel substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts, certain intermediates and their preparation are disclosed. These pyridines have pharmaceutically useful properties such as .beta.-adrenergic blocking activity.
Abstract: There are disclosed substituted phosphonamides and related compounds which are useful as converting enzyme inhibitors and as antihypertensives.
Type:
Grant
Filed:
November 5, 1981
Date of Patent:
April 5, 1983
Assignee:
Merck & Co., Inc.
Inventors:
William J. Greenlee, Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
Abstract: Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a heterocyclic ring which may be substituted with one or more loweralkyl groups. The urea is also substituted with loweralkyl and a lower-alkylamino loweralkyl group. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
Abstract: Improved process for preparing esters of .alpha.-methyl-3,4-dihydroxyphenylalanine having pharmaceutical activity via novel N-(tert-butoxycarbonyl) intermediates.
Abstract: Filled thermoplastic resin compositions are provided wherein the filler component is compatible with and does not deleteriously affect the physical properties of the resin. The filler employed is a particulate, solid sphere which can be pre-treated with a surface active agent prior to being incorporated in the resin. The resin composition can also contain other ingredients such as impact modifiers, glass fillers, and the like.
Abstract: A process is disclosed for producing copolyester-carbonates by direct polymerization of a dihydric phenol and an acid dichloride at a single pH profile level.
Abstract: A transparent to translucent flame-retardant polycarbonate composition comprising a mixture of an aromatic carbonate polymer and a flame-retardant additive which can be the metal salts of organic sulfonic acids and a coadditive which can be a solvent for said metal salts.
Abstract: A plasticized polycarbonate composition comprising in admixture a high molecular weight aromatic carbonate polymer and a minor amount of a silane plasticizer.
Abstract: Novel thermoplastic molding compositions are disclosed which comprise(a) a bisphenol-A polycarbonate;(b) an alcohol terminated polyester of neopentyl glycol (2,2-dimethyl-1,3-propane-diol) and adipic acid; in admixture with(c) a minor amount of at least one component selected from the group comprising polyolefins, olefin based copolymers and olefin based terpolymers, such as, ethylene-propylene copolymers, ethylene-butadiene copolymers, propylene-butadiene copolymers, ethylene-propylene-butadiene terpolymers, ethylene-acrylic acid copolymers, propylene-acrylic acid copolymers, ethylene-ethyl acrylate copolymers, ethylene-vinyl acetate copolymers and ethylene-propylene-acrylic acid terpolymers; or(d) an amount of at least one component selected from the group comprising methyl methacrylate-butadiene-styrene copolymers, methyl methacrylate-acrylonitrile-butadiene-styrene copolymers and acrylonitrile-butadiene-styrene copolymers.
Abstract: Filled polycarbonate compositions are disclosed having improved impact properties and which comprise an admixture of a high molecular weight aromatic polycarbonate, a filler, and an organopolysiloxane-polycarbonate block copolymer additive.
Abstract: Resistance to high heat distortion is imparted to high molecular weight aromatic polycarbonate resins by controlling the degree to which particular diphenols are halogenated so that there are obtained either highly pure dihalogenated diphenols or predetermined statistical mixtures comprising predominantly mono- and dihalogenated diphenols together with some unreacted diphenol.
Abstract: Improved flame retardance and improved water vapor transmission are imparted to high molecular weight aromatic polycarbonate resins by selecting appropriate diphenols and controlling the degree to which these particular diphenols are halogenated.