Patents Represented by Attorney Salvatore C. Mitri

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  • Substituted dihydroazepines useful as calcium channel blockers
    Patent number: 4677101
    Abstract: Substituted dihydroazepines, their preparation, and the use thereof as calcium channel blockers are disclosed.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: June 30, 1987
    Assignee: Merck & Co., Inc.
    Inventors: David A. Claremon, David E. McClure
  • Substituted pyrimidines useful as calcium channel blockers
    Patent number: 4675321
    Abstract: Pharmaceutical compositions of specific substituted pyrimidines and methods of treatment of certain cardiovascular disorders are disclosed. Also disclosed are novel substituted acrylated pyrimidines which are useful as calcium channel blockers.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: June 23, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Steven M. Pitzenberger, David E. McClure
  • Substituted lactams useful as angiotensin converting enzyme inhibitors
    Patent number: 4666901
    Abstract: Substituted lactams and related compounds and methods for their preparation are disclosed. These compounds are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: May 19, 1987
    Assignee: Merck & Co., Inc.
    Inventor: William H. Parsons
  • .beta.-adrenergic blocking imidazolylphenoxy propanolamines
    Patent number: 4642311
    Abstract: Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: February 10, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
    Patent number: 4634716
    Abstract: Compounds of the formula: ##STR1## where R.sup.3 is ##STR2## where n is 1-3 and the R.sup.a 's and R.sup.b 's are independently hydrogen or loweralkyl; and pharmaceutically acceptable salts thereof; are inhibitors or angiotensin I converting enzyme useful as antihypertensive agents.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: January 6, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, David Taub
  • Aza analogs of carboxyalkyl dipeptide derivatives as antihypertensives
    Patent number: 4634715
    Abstract: There are disclosed aza analogs of carboxyalkyl dipeptide derivatives and related compounds which are useful as converting enzyme inhibitors and as antihypertensives said compounds being represented by the general formula: ##STR1## wherein A and B can be joined together to form various ring structures.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: January 6, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Eugene D. Thorsett
  • Substituted caprolactam derivatives as antihypertensives
    Patent number: 4629787
    Abstract: The invention in its broad aspects relates to caprolactam derivatives which are useful as angiotensin converting enxyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: December 16, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds, pharmaceutical compositions and methods
    Patent number: 4626542
    Abstract: Pharmaceutical compositions comprising 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds and the use of 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds for treatment of certain cardiovascular disorders are disclosed.
    Type: Grant
    Filed: April 5, 1984
    Date of Patent: December 2, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Stella W. King, David C. Remy
  • Amino acid derivatives as enzyme inhibitors
    Patent number: 4626545
    Abstract: Compounds of the formula ##STR1## and their use as angiotensin converting enzyme inhibitors and antihypertensives are disclosed.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: December 2, 1986
    Assignee: Merck & Co., Inc.
    Inventor: David Taub
  • O-sulfate derivatives of avermectins and milbemycins having improved water solubility
    Patent number: 4622313
    Abstract: There are disclosed novel O-sulfate derivatives of avermectin and milbemycin. The avermectin and milbemycin O-sulfate derivatives have improved water solubility compared to the parent avermectin and milbemycin compounds and have utility as anti-parasitic agents and as potent insecticides against agricultural pests.
    Type: Grant
    Filed: August 1, 1985
    Date of Patent: November 11, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Matthew J. Wyvratt, Jr.
  • Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
    Patent number: 4617301
    Abstract: Sulfoxide and sulfone derivatives of bicyclic lactams are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: June 22, 1983
    Date of Patent: October 14, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Matthew J. Wyvratt, Jr.
  • 5-acetyl-3,4,5,6-tetrahydro-4-oxo-2,6-methano-2H-1,3,5-benzothiazoci ne(benzodiazocine)-11-carboxylates useful as calcium channel blockers
    Patent number: 4609494
    Abstract: Novel substituted and bridged pyrimidine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: September 2, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, David E. McClure
  • N-carboxymethyl substituted lysyl and .alpha.-(.epsilon.-aminoalkyl) glycyl amino acid antihypertensive agents
    Patent number: 4602002
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.2 is --(CH.sub.2).sub.k --X--(CH.sub.2).sub.j --NHR.sup.3 ; wherein k is 0 to 3, j is 1 or 2; X is F or OH; and, R.sup.3 is hydrogen; loweralkyl or loweraralkyl which may be substituted by hydroxy, carboxy, carbamoyl, or carbalkoxy; or, acyl; and, a pharmaceutically acceptable salt thereof; are inhibitors of angiotensin I converting enzyme useful as antihypertensive agents.
    Type: Grant
    Filed: February 7, 1983
    Date of Patent: July 22, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • Novel substituted imidazoles, their preparation and use
    Patent number: 4602093
    Abstract: Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive agents, cardioprotective agents, antiarrythmic agents, antianginal agents with reduced side effects; e.g., they are devoid of intrinsic sympathomimetic activity.
    Type: Grant
    Filed: February 8, 1984
    Date of Patent: July 22, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello, Marcia E. Christy
  • 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
    Patent number: 4598149
    Abstract: The novel compounds of this invention and their pharmaceutically acceptable salts exhibit cardioselective .beta.-adrenergic blocking activity, with a direct relaxing effect on the .beta..sub.2 -adrenergic receptors and are useful as antihypertensive, cardioprotective, antiarrhythmic and, antianginal agents.
    Type: Grant
    Filed: March 2, 1984
    Date of Patent: July 1, 1986
    Assignee: Merck & Co., Inc.
    Inventor: Gerald S. Ponticello
  • Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives as antihypertensives
    Patent number: 4594341
    Abstract: There are disclosed perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives and related compounds which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: June 10, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Yak-Fa Cheung, Eugene D. Thorsett, Arthur A. Patchett
  • Preparation of epihalohydrin enantiomers
    Patent number: 4588824
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: June 16, 1983
    Date of Patent: May 13, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Bridged pyridine compounds useful as calcium channel blockers and analgesics
    Patent number: 4587253
    Abstract: Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Wasyl Halczenko, George D. Hartman
  • Substituted caprylolactam derivatives as anti-hypertensives
    Patent number: 4587238
    Abstract: The invention in its broad aspects relates to caprylolactam derivatives which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 9, 1982
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • Substituted enantholactam derivatives as antihypertensives
    Patent number: 4587050
    Abstract: The invention in its broad aspects relates to enantholactam derivatives which are useful as angiotensin converting enzyme inhibitors and antihypertensives.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Eugene D. Thorsett, Arthur A. Patchett