Patents Represented by Attorney Salvatore C. Mitri

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  • Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
    Patent number: 4585755
    Abstract: Cyclic and bridged cyclic somatostatin analogs have been found to be useful as local anti-inflammatory agents in the treatment of such conditions, as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: April 29, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Evan R. Morgan, Sanford L. Steelman
  • Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
    Patent number: 4584294
    Abstract: The invention relates to fused tricyclic lactams and related compounds which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: November 7, 1984
    Date of Patent: April 22, 1986
    Assignee: Merck & Co., Inc.
    Inventor: William V. Ruyle
  • Substituted and bridged tetrahydropyridines useful as calcium entry blockers
    Patent number: 4579851
    Abstract: Substituted dihydropyridines and substituted and bridged tetrahydropyridines are disclosed which are useful as calcium entry blockers.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: April 1, 1986
    Assignee: Merck & Co., Inc.
    Inventor: David A. Claremon
  • Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
    Patent number: 4578509
    Abstract: A process is disclosed for obtaining manipulated proportions of the (+) and (-) enantiomers of [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]aceti c acid by asymmetric chiral phase transfer catalysis.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: March 25, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Ulf H. Dolling, Seemon H. Pines, Edward J. J. Grabowski
  • Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl moiety
    Patent number: 4574127
    Abstract: Novel substituted aminohydroxypropoxyphenyl oxazole and thiazole compounds and methods for their preparation are disclosed. These compounds, and their salts exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive, cardioprotective, antiarrhythmic and antianginal agents.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: March 4, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • .beta.-Adrenergic 2-[4-(3-amino-2-hydroxypropoxy)phenyl]imidazoles
    Patent number: 4567276
    Abstract: Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: January 28, 1986
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Substituted-aminohydroxypropoxy-thiadiazoles, .beta.-blocking compositions and use
    Patent number: 4562184
    Abstract: Novel substituted-aminohydroxypropoxy-thiadiazoles and pharmaceutically acceptable salts thereof exhibit .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: April 2, 1984
    Date of Patent: December 31, 1985
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Cardiovascular composition
    Patent number: 4558037
    Abstract: A cardiovascular composition is disclosed which comprises either dibenzo-thiepin derivatives alone or the combination of dibenzo-thiepin derivatives and angiotensin converting enzyme (ACE) inhibitors. These compositions represent a novel therapeutic approach to thromboembolic disease in man.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: December 10, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Chi-Chung Chan, Anthony W. Ford-Hutchinson
  • N.sup.2 -(Substituted)carboxymethyl-N.sup.6 -(substituted)-lysyl-and .alpha..epsilon.-aminoalkyl)glycyl amino acid antihypertensive agents
    Patent number: 4555503
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.2 is ##STR2## wherein k is 2 to 5; R.sup.3 is hydrogen; loweralkyl and substituted loweralkyl where the substituents are carboxy, hydroxy, and amino; or aralkyl, substituted aralkyl, heteroaralkyl, and substituted heteroaralkyl where the aryl and heteroaryl substituents are carboxy, hydroxy, and amino; and C is COOR; CONH.sub.2 ; or CH.sub.2 OH; and a pharmaceutically acceptable salt thereof; are inhibitors of angiotensin I converting enzyme useful as antihypertensive agents.
    Type: Grant
    Filed: February 18, 1983
    Date of Patent: November 26, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • Aminoacyl-containing dipeptide derivatives useful as antihypertensives
    Patent number: 4555502
    Abstract: The invention relates to aminoacyl-containing dipeptide derivatives and related compounds which are useful angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: November 26, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • Substituted and bridged pyridines useful as calcium channel blocker
    Patent number: 4552881
    Abstract: Novel substituted and bridged pyridines useful as calcium channel blockers, pharmaceutical compositions thereof and methods of treatment are disclosed.
    Type: Grant
    Filed: August 1, 1984
    Date of Patent: November 12, 1985
    Assignee: Merck & Co., Inc.
    Inventor: David A. Claremon
  • 1,5-Methano-1H-4-benzazonine dicarboxylates, process for preparing and use as calcium blockers
    Patent number: 4548941
    Abstract: There are disclosed novel substituted and bridged pyridines which are useful as calcium channel blockers.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: October 22, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Wasyl Halczenko, George D. Hartman
  • 4-Substituted amino-3-[3-alkylindoloamino-2-hydroxypropoxy] thiadiazoles, compositions and pharmaceutical use
    Patent number: 4539317
    Abstract: Novel 4-substituted amino-3-[3-alkylindoloamino-2-hydroxypropoxy] thiadiazole compounds and methods for their preparation are disclosed. These compounds and their salts exhibit pharmacological activity including antihypertensive and .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: September 3, 1985
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use
    Patent number: 4539318
    Abstract: Novel tertiary aminohydroxypropoxy substituted thiadiazole compounds exhibit .alpha..sub.1 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: September 3, 1985
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Process for preparing certain substituted 4-thiazolidinones
    Patent number: 4535164
    Abstract: A process is disclosed for preparing 4-thiazolidinones having the formula: ##STR1## by cyclizing a compound of the formula:(R.sup.2 --NHCO--CH.sub.2 S).sub.2 ----CRR.sup.1in an aprotic reaction medium in the presence of a metal catalyst.
    Type: Grant
    Filed: March 30, 1983
    Date of Patent: August 13, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Robert M. Di Pardo, Mark G. Bock
  • Substituted caprolactam derivatives as antihypertensives
    Patent number: 4520021
    Abstract: Substituted caprolactam derivatives are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: June 16, 1983
    Date of Patent: May 28, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Eugene D. Thorsett
  • Dipeptides containing thialysine and related amino acids as antihypertensives
    Patent number: 4512979
    Abstract: The invention relates to dipeptide compounds containing thialysine and related amino acids which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: April 23, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • Process for preparing polypeptides
    Patent number: 4510083
    Abstract: A process for producing polypeptides is disclosed wherein potassium, rubidium, or cesium serves as the counterion for both the carbonate buffer system and the amino acid or peptide salts employed.
    Type: Grant
    Filed: May 31, 1983
    Date of Patent: April 9, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Thomas J. Blacklock, Richard F. Shuman
  • Process for preparing sulfamylamidine antisecretory agents
    Patent number: 4496737
    Abstract: A process is disclosed for preparing intermediates which are useful for obtaining sulfamylamidine antisecretory agents.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: January 29, 1985
    Assignee: Merck & Co., Inc.
    Inventor: Jacob M. Hoffman, Jr.
  • Aminoalkyl pyridine derivatives
    Patent number: 4490533
    Abstract: There are disclosed novel compounds described as aminoalkyl pyridine derivatives in which the aminoalkyl pyridine is connected to a guanidine moiety or a functional equivalent thereof, either directly or through a linear connecting group. Processes for the preparation of such compounds are also disclosed. The compounds are useful for the suppression of gastirc acid secretions in mammals and compositions for such uses are also disclosed.
    Type: Grant
    Filed: September 29, 1981
    Date of Patent: December 25, 1984
    Assignee: Merck & Co., Inc.
    Inventors: William A. Bolhofer, Jacob M. Hoffman