Abstract: Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and drugs.

Abstract: A very fast, memory efficient, highly expandable, highly efficient CCNUMA processing system based on a hardware architecture that minimizes system bus contention, maximizes processing forward progress by maintaining strong ordering and avoiding retries, and implements a full-map directory structure cache coherency protocol. A Cache Coherent Non-Uniform Memory Access (CCNUMA) architecture is implemented in a system comprising a plurality of integrated modules each consisting of a motherboard and two daughterboards. The daughterboards, which plug into the motherboard, each contain two Job Processors (JPs), cache memory, and input/output (I/O) capabilities. Located directly on the motherboard are additional integrated I/O capabilities in the form of two Small Computer System Interfaces (SCSI) and one Local Area Network (LAN) interface. The motherboard includes main memory, a memory controller (MC) and directory DRAMs for cache coherency.

Abstract: Empty viral capsids, particularly animal parvoviral empty capsids, induce protective antibody response against the virus. The empty viral capsids are obtained by recombinant DNA techniques. Expression vectors are constructed containing structural genes encoding capsid proteins in self assembling form. Eukaryotic transfectants express self-assembled empty viral capsids which can be used to vaccinate against the virus or antigenically related species of the virus.

Abstract: A security system for a computer system imposes specific limitations on who has access to the computer system and to exactly what operations and data. Viruses are securely contained and prevented from expanding into areas where they can destroy stored programs or data. Viruses are also prevented from being introduced or executed in a large number of instances. The totality of computer functions is broken up into a set of events with an associated set of capabilities and different capabilities are assigned to each user depending on the particular job which that user is to do on the computer system. Also, security labels are placed on each data file and other system resources, and on each process. Further, a range of hierarchy/category labels (MAC labels) is assigned to each process to define a sub-lattice in which special capabilities can apply.

Abstract: Recombinant avipox viral vectors which express heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The recombinant avipox viruses can be used to produce significant amounts of the heterologous polypeptides in avian or non-avian cells. Preferably, the recombinant avipox virus is a fowlpox virus. The viral particles can also be used as immunogens and for targeted delivery of heterologous gene products and drugs.

Abstract: Protective waterproofing membrane particularly for exterior and/or interior coatings, of walls and pavings generally, of the types made in plastic material and comprising a plurality of protrusions all of the same side, in which, limited to the overlapping area or along the vertical junction edges, protrusions (2, 2') are provided having a different configuration in respect to the remaining surface of a sheet from a pre-determined width, said protrusions constituting respectively a male and female closure provided with a seal, which development requires both on the left and right side, an ensemble of cylindrical forms joined in groups of five, where one or the other provides a series of forms (5) also cylindrical but of a smaller diameter to the preceding and interposed in rows that are vertical to said groups.

Abstract: The present invention provides recombinant DNA viral vectors which co-express lentivirus genes encoding structural and enzymatic polypeptides capable of assembling into defective nonself-propagating viral particles. The viral DNA vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and genes.

Abstract: Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective non-self-propagating lentiviral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and drugs.

Abstract: A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method, a stannylated pyrimidine nucleoside or nucleotide is contacted in an aqueous solution with a radioactive iodide, bromide, chlorine or astatine ion in the presence of an acidic hydrogen peroxide oxidizing solution comprising at least a 3:1 ratio of 30% hydrogen peroxide to 1N acid (v/v), whereby a water soluble pyrimidine nucleoside or nucleotide labeled with radioactive iodine, bromine, chlorine or astatine is formed. Kits suitable for practicing the method are also disclosed.

Abstract: The present invention relates to a recombinant carcinoembryonic antigen (CEA)/vaccinia virus or other viral vector which expresses CEA on the surface of infected cells and which elicits an immune response in vivo directed against CEA or cells expressing CEA and a pharmaceutical composition containing same.

Abstract: The ability of viruses to undergo recombination within tandemly arranged homologous sequences can be utilized to generate chimeric genes and proteins. Tandemly arranged homologous sequences will rapidly degenerate in a random fashion to yield a single copy comprised of portions of both original sequences. Therefore, a recombinant virus which contains two related but non-identical genes in tandem array yields a population of recombinant viruses which contain a spectrum of hybrid sequences derived from recombination between the original genes. The viruses, therefore, contain hybrid DNA sequences that encode proteins with new epitopes or different combinations of epitopes. Vaccines are derived which may afford protection against a broad spectrum of antigen types.

Abstract: An expandable memory system and a method for operating a memory system having a variable number of memory banks are described. The memory system can utilize a variable number of separately replaceable memory banks which can be implemented with memory element, such as dynamic random access memory chips, which are of differing speeds and or sizes. The memory system implements an interleaving of memory addresses among the memory banks as a function of the number of banks actually present so that successive memory accesses are not unnecessarily delayed by the recovery times of the memory elements. The memory system includes a programmable address decoder having a writable memory which provides bank address signals. Each of the banks includes a respective delay line for providing an output signal a respective presettable time after address signals are received by that bank for signalling to the host that data is ready to be transferred.

Abstract: We have discovered that using non-integrative viral vectors having low replicative efficiency for insertion of a gene into a cell such as a lymphocyte or a tumor cell is a preferred system for transforming such cells for use in somatic cell therapy or gene therapy. These vectors are preferably cytoplasmic viral vectors, as opposed to nuclear viral vectors. Preferred cytoplasmic vectors include DNA viruses such as pox viruses and iridoviruses and RNA viruses such as picornavirus, calicivirus and togavirus. More preferably the virus used will not be capable of sustained replication in the target cell. For example, a preferred pox virus for human cells will be an avipox, or suipox in contrast to an orthopox virus such as vaccinia.

Abstract: Recombinant avipox viral vectors which express heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The recombinant avipox viruses can be used to produce significant amounts of the heterologous polypeptides in avian or non-avian cells. Preferably, the recombinant avipox virus is a fowlpox virus. The viral particles can also be used as immunogens and for targeted delivery of heterologous gene products and drugs.

Abstract: Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted delivery of heterologous gene products and drugs.

Abstract: A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method an aqueous solution (i) a radioactive iodide, bromide, chlorine or astatide ion and (ii) a water soluble halomercuri pyrimidine nucleoside or nucleotide is contacted with an oxidizing agent, whereby a water soluble pyrimidine nucleoside or nucleotide labeled with radioactive iodine, bromine, chlorine or astatine is formed. Kits suitable for practicing the method are also disclosed.

Abstract: A technique for permitting data transfers between a high speed bus and a low speed bus which operate independently and asynchronously wherein when the low speed bus requires access to the high speed bus, the busy status of the latter bus is determined and transfers are made to the high speed bus at high speed when such bus is not busy. When the high speed bus requires access to the low speed bus, if the low speed bus is busy the requesting master on the high speed bus is temporarily placed in a pending status and is removed from its tenure on the high speed bus, so that the high speed bus is free to handle other requests. When the low speed bus is free, the highest priority pending requestor is provided access to the low speed bus on a priority basis over all then current requestors.

Abstract: A method for handling data in a plurality of data storage disks having user data sectors and corresponding parity sectors, the method being used when the disks are being operated in a non-degraded or a degraded mode wherein a non-volatile RAM is used in an array control processor which controls the operation of such disks. When new data is to be written into the array, the non-volatile RAM stores information identifying the array, the starting sector into which data is to be written and the number of sectors to be used for writing the new data so that parity and data entries in corresponding sectors can be matched when a power failure occurs. Further, when opening a new array, the data and parity entries in corresponding sectors can be matched and verified, the operation for such matching being performed in between other operations that are being performed by the control processors (i.e., in the "background" thereof).

Abstract: The invention pertains to self-assembled replication defective hybrid virus-like particles having capsid and membrane glycoproteins from at least two different virus types and method of making same. Recombinant viral vectors as well as the viral particles can be used as immunogens and drug delivery vehicles.

Abstract: A method for handling data in a plurality of data storage disks having user data sectors and corresponding parity sectors, the method being used when the disks are being operated in a degraded mode wherein data in sectors of an inoperative user data disk are reconstructed from data in the corresponding sectors of the other user data disks and the corresponding parity entry. The reconstructed user data in a user data sector of the inoperative disk is written into the corresponding parity sector in place of the parity entry therein, before any new data is written into the corresponding sector of an operative disk. Information identifying the inoperative disk is written into a specified identification region of the parity disk to indicate that such operation has occurred. The new data is then written into the corresponding sector of the operative disk.